Phospholipid-transporting ATPase VA (also known as ATP10A or ATP10C) belongs to the IV subfamily of the P-type ATPases (P4-ATPase) family. P4-ATPases are phospholipid flippases that translocate phospholipids from the exoplasmic (lumenal) to the cytoplasmic leaflet of lipid bilayers. ATP10A is a catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane. However, it has low flippase activity toward glucosylceramide (GlcCer) []. ATP10A has also been shown to initiate inward plasma membrane bending and recruitment of Bin/amphiphysin/Rvs (BAR) domain-containing proteins involved in membrane tubulation and cell trafficking []. ATP10A requires CDC50A for its exit from the endoplasmic reticulum (ER) and final subcellular localisation []. ATP10A has been linked to diseases such as Angelman syndrome []and type 2 diabetes [].
