This entry represents U4/U6.U5 tri-snRNP-associated proteins, including SART1 from animals, Snu66 from yeasts and DOT2 from Arabidopsis. SART1 and its yeast homologue, Snu66, are part of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome [, , ]. DOT2 plays a role in root, shoot and flower development [, ].
The Hub1 interacting motif (HIND) is a short conserved motif found in 1 to 3 copies in spliceosomal proteins such as SART1 from animals and Snu66 in yeast (both components of the U4/U6-U5 tri-snRNP complex). The motif is bound by the Hub1 protein, playing a key role in the splicing process [, , ].
