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Search results 1 to 3 out of 3 for Ryr2

Category restricted to ProteinDomain (x)

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Category: ProteinDomain
Type Details Score
Protein Domain
Type: Domain
Description: This SPRY domain is the first of three structural repeats in all three isoforms of the ryanodine receptor (RyR), which are the major Ca2+ release channels in the membranes of sarcoplasmic reticulum (SR) []. There are three RyR genes in mammals; the skeletal RyR1, the cardiac RyR2 and the brain RyR3 []. The three SPRY domains are located in the N-terminal part of the cytoplasmic region of the RyRs []. The first domain may be involved in RyR2 dimerization [].
Protein Domain
Type: Domain
Description: This SPRY domain is the third of three structural repeats in all three isoforms of the ryanodine receptor (RyR), which are the major Ca2+ release channels in the membranes of sarcoplasmic reticulum (SR) []. There are three RyR genes in mammals; the skeletal RyR1, the cardiac RyR2 and the brain RyR3 []. The three SPRY domains are located in the N-terminal part of the cytoplasmic region of the RyRs, but no specific function has been found for this third SPRY domain of the RyRs [].
Protein Domain
Type: Domain
Description: This SPRY domain (SPRY2) is the second of three structural repeats in all three isoforms of the ryanodine receptor (RyR), which are the major Ca2+ release channels in the membranes of sarcoplasmic reticulum (SR). There are three RyR genes in mammals; the skeletal RyR1, the cardiac RyR2 and the brain RyR3. The three SPRY domains are located in the N-terminal part of the cytoplasmic region of the RyRs, The SPRY2 domain has been shown to bind to the dihydropryidine receptor (DHPR) II-III loop and the ASI region of RyR1 [, ].