Roquin-2 is an E3 ubiquitin ligase required for ROS-induced ubiquitination and degradation of ASK1 (Apoptosis signal-regulating kinase 1) []. It also mediates mRNA deadenylation by recognising a conserved class of stem-loop RNA degradation motifs []. Its structure has been revealed [].Roquin-2 and its paralogue, Roquin-1 (Rc3h1), have been found to redundantly repress the mRNAs controlling T follicular helper cells and systemic inflammation [, ].
