|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 101 to 200 out of 1123 for Cftr

0.037s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Publication
First Author: Sehgal A
Year: 1996
Journal: Am J Respir Cell Mol Biol
Title: Developmental expression patterns of CFTR in ferret tracheal surface airway and submucosal gland epithelia.
Volume: 15
Issue: 1
Pages: 122-31
Publication
First Author: Hefferon TW
Year: 2002
Journal: Am J Hum Genet
Title: Atypical 5' splice sites cause CFTR exon 9 to be vulnerable to skipping.
Volume: 71
Issue: 2
Pages: 294-303
Publication
First Author: Wang Y
Year: 2006
Journal: EMBO J
Title: Slc26a6 regulates CFTR activity in vivo to determine pancreatic duct HCO3- secretion: relevance to cystic fibrosis.
Volume: 25
Issue: 21
Pages: 5049-57
Publication
First Author: Dalli J
Year: 2010
Journal: Am J Pathol
Title: CFTR inhibition provokes an inflammatory response associated with an imbalance of the annexin A1 pathway.
Volume: 177
Issue: 1
Pages: 176-86
Publication
First Author: Schiffhauer ES
Year: 2013
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Dual activation of CFTR and CLCN2 by lubiprostone in murine nasal epithelia.
Volume: 304
Issue: 5
Pages: L324-31
Publication
First Author: Chen Y
Year: 2019
Journal: Biol Reprod
Title: CFTR mutation compromises spermatogenesis by enhancing miR-15b maturation and suppressing its regulatory target CDC25A†.
Volume: 101
Issue: 1
Pages: 50-62
Publication
First Author: Walker NM
Year: 2016
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Cellular chloride and bicarbonate retention alters intracellular pH regulation in Cftr KO crypt epithelium.
Volume: 310
Issue: 2
Pages: G70-80
Publication
First Author: Lu M
Year: 2006
Journal: J Clin Invest
Title: CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidney.
Volume: 116
Issue: 3
Pages: 797-807
Publication
First Author: Gustafsson JK
Year: 2012
Journal: J Exp Med
Title: Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype.
Volume: 209
Issue: 7
Pages: 1263-72
Publication
First Author: Reynaert I
Year: 2000
Journal: Mol Reprod Dev
Title: Morphological changes in the vas deferens and expression of the cystic fibrosis transmembrane conductance regulator (CFTR) in control, deltaF508 and knock-out CFTR mice during postnatal life.
Volume: 55
Issue: 2
Pages: 125-35
Publication
First Author: Talbi K
Year: 2021
Journal: FASEB J
Title: The chloride channel CFTR is not required for cyst growth in an ADPKD mouse model.
Volume: 35
Issue: 10
Pages: e21897
Publication
First Author: Walker NM
Year: 2022
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Goblet cell hyperplasia is not epithelial-autonomous in the Cftr knockout intestine.
Volume: 322
Issue: 2
Pages: G282-G293
Publication
First Author: De Stefano D
Year: 2014
Journal: Autophagy
Title: Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation.
Volume: 10
Issue: 11
Pages: 2053-74
Publication
First Author: Fiorotto R
Year: 2011
Journal: Gastroenterology
Title: Loss of CFTR affects biliary epithelium innate immunity and causes TLR4-NF-κB-mediated inflammatory response in mice.
Volume: 141
Issue: 4
Pages: 1498-508, 1508.e1-5
Publication
First Author: Sellers ZM
Year: 2012
Journal: Eur J Pharmacol
Title: MRP4 and CFTR in the regulation of cAMP and β-adrenergic contraction in cardiac myocytes.
Volume: 681
Issue: 1-3
Pages: 80-7
Publication
First Author: Catalán MA
Year: 2010
Journal: J Physiol
Title: Cftr and ENaC ion channels mediate NaCl absorption in the mouse submandibular gland.
Volume: 588
Issue: Pt 4
Pages: 713-24
Publication
First Author: Strubberg AM
Year: 2018
Journal: Cell Mol Gastroenterol Hepatol
Title: Cftr Modulates Wnt/β-Catenin Signaling and Stem Cell Proliferation in Murine Intestine.
Volume: 5
Issue: 3
Pages: 253-271
Publication  
First Author: Cmielewski P
Year: 2021
Journal: Front Pharmacol
Title: Assessment of Lentiviral Vector Mediated CFTR Correction in Mice Using an Improved Rapid in vivo Nasal Potential Difference Measurement Protocol.
Volume: 12
Pages: 714452
Publication
First Author: Zhao L
Year: 2021
Journal: Front Biosci (Landmark Ed)
Title: CFTR deficiency aggravates Ang II induced vasoconstriction and hypertension by regulating Ca2+ influx and RhoA/Rock pathway in VSMCs.
Volume: 26
Issue: 12
Pages: 1396-1410
Publication  
First Author: Centorame A
Year: 2022
Journal: Front Pharmacol
Title: Treatment With LAU-7b Complements CFTR Modulator Therapy by Improving Lung Physiology and Normalizing Lipid Imbalance Associated With CF Lung Disease.
Volume: 13
Pages: 876842
Publication
First Author: Divangahi M
Year: 2009
Journal: PLoS Genet
Title: Lack of CFTR in skeletal muscle predisposes to muscle wasting and diaphragm muscle pump failure in cystic fibrosis mice.
Volume: 5
Issue: 7
Pages: e1000586
Publication  
First Author: Cohen JC
Year: 2004
Journal: BMC Genet
Title: The "Goldilocks effect" in cystic fibrosis: identification of a lung phenotype in the cftr knockout and heterozygous mouse.
Volume: 5
Pages: 21
Publication  
First Author: Xu X
Year: 2020
Journal: Biosci Rep
Title: Effect of lentivirus-mediated CFTR overexpression on oxidative stress injury and inflammatory response in the lung tissue of COPD mouse model.
Volume: 40
Issue: 1
Publication
First Author: van Heeckeren AM
Year: 2004
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Role of Cftr genotype in the response to chronic Pseudomonas aeruginosa lung infection in mice.
Volume: 287
Issue: 5
Pages: L944-52
Publication
First Author: Pan J
Year: 2006
Journal: Am J Respir Cell Mol Biol
Title: Pulmonary neuroendocrine cells, airway innervation, and smooth muscle are altered in Cftr null mice.
Volume: 35
Issue: 3
Pages: 320-6
Publication
First Author: Ruan YC
Year: 2014
Journal: J Cell Sci
Title: CFTR interacts with ZO-1 to regulate tight junction assembly and epithelial differentiation through the ZONAB pathway.
Volume: 127
Issue: Pt 20
Pages: 4396-408
Publication  
First Author: Fang D
Year: 2010
Journal: Respir Res
Title: Increased plasma membrane cholesterol in cystic fibrosis cells correlates with CFTR genotype and depends on de novo cholesterol synthesis.
Volume: 11
Pages: 61
Publication
First Author: Dhooghe B
Year: 2013
Journal: PLoS One
Title: Correction of chloride transport and mislocalization of CFTR protein by vardenafil in the gastrointestinal tract of cystic fibrosis mice.
Volume: 8
Issue: 10
Pages: e77314
Publication
First Author: Ntimbane T
Year: 2016
Journal: Am J Physiol Endocrinol Metab
Title: CFTR silencing in pancreatic β-cells reveals a functional impact on glucose-stimulated insulin secretion and oxidative stress response.
Volume: 310
Issue: 3
Pages: E200-12
Publication
First Author: Kravtsov DV
Year: 2012
Journal: Traffic
Title: Myosin Ia is required for CFTR brush border membrane trafficking and ion transport in the mouse small intestine.
Volume: 13
Issue: 8
Pages: 1072-82
Publication
First Author: Yang A
Year: 2018
Journal: Cell Death Dis
Title: Homocysteine activates autophagy by inhibition of CFTR expression via interaction between DNA methylation and H3K27me3 in mouse liver.
Volume: 9
Issue: 2
Pages: 169
Publication
First Author: Bickford JS
Year: 2013
Journal: J Cyst Fibros
Title: Effect of allergy and inflammation on eicosanoid gene expression in CFTR deficiency.
Volume: 12
Issue: 3
Pages: 258-65
Publication
First Author: Stalvey MS
Year: 2013
Journal: PLoS One
Title: Osteoblast CFTR inactivation reduces differentiation and osteoprotegerin expression in a mouse model of cystic fibrosis-related bone disease.
Volume: 8
Issue: 11
Pages: e80098
Publication  
First Author: Edlund A
Year: 2014
Journal: BMC Med
Title: CFTR and Anoctamin 1 (ANO1) contribute to cAMP amplified exocytosis and insulin secretion in human and murine pancreatic beta-cells.
Volume: 12
Pages: 87
Publication
First Author: Chang CT
Year: 2005
Journal: J Physiol
Title: Vasopressin-stimulated CFTR Cl- currents are increased in the renal collecting duct cells of a mouse model of Liddle's syndrome.
Volume: 562
Issue: Pt 1
Pages: 271-84
Publication
First Author: Yang D
Year: 2009
Journal: J Clin Invest
Title: IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic duct.
Volume: 119
Issue: 1
Pages: 193-202
Publication
First Author: Trapp S
Year: 2021
Journal: J Cell Mol Med
Title: Pancreatitis severity in mice with impaired CFTR function but pancreatic sufficiency is mediated via ductal and inflammatory cells-Not acinar cells.
Volume: 25
Issue: 10
Pages: 4658-4670
Publication
First Author: Veltman M
Year: 2016
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Correction of lung inflammation in a F508del CFTR murine cystic fibrosis model by the sphingosine-1-phosphate lyase inhibitor LX2931.
Volume: 311
Issue: 5
Pages: L1000-L1014
Publication
First Author: Morin G
Year: 2016
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Vitamin D attenuates inflammation in CFTR knockdown intestinal epithelial cells but has no effect in cells with intact CFTR.
Volume: 310
Issue: 8
Pages: G539-49
Publication
First Author: Chappe V
Year: 2005
Journal: EMBO J
Title: Phosphorylation of CFTR by PKA promotes binding of the regulatory domain.
Volume: 24
Issue: 15
Pages: 2730-40
Publication
First Author: Baker JM
Year: 2007
Journal: Nat Struct Mol Biol
Title: CFTR regulatory region interacts with NBD1 predominantly via multiple transient helices.
Volume: 14
Issue: 8
Pages: 738-45
Publication  
First Author: Wu YZ
Year: 2010
Journal: Respir Res
Title: Cytosolic phospholipase A2alpha mediates Pseudomonas aeruginosa LPS-induced airway constriction of CFTR -/- mice.
Volume: 11
Pages: 49
Publication
First Author: Pelaseyed T
Year: 2013
Journal: Am J Physiol Cell Physiol
Title: Carbachol-induced MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment in enterocytes.
Volume: 305
Issue: 4
Pages: C457-67
Publication
First Author: Kramer EL
Year: 2018
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Subacute TGFβ expression drives inflammation, goblet cell hyperplasia, and pulmonary function abnormalities in mice with effects dependent on CFTR function.
Volume: 315
Issue: 3
Pages: L456-L465
Publication
First Author: Delaney SJ
Year: 1994
Journal: Genomics
Title: Alternative splicing of the first nucleotide binding fold of CFTR in mouse testes is associated with specific stages of spermatogenesis.
Volume: 20
Issue: 3
Pages: 517-8
Publication
First Author: Wellmerling JH
Year: 2019
Journal: Respir Res
Title: Reduced expression of the Ion channel CFTR contributes to airspace enlargement as a consequence of aging and in response to cigarette smoke in mice.
Volume: 20
Issue: 1
Pages: 200
Publication
First Author: Beumer W
Year: 2019
Journal: PLoS One
Title: Evaluation of eluforsen, a novel RNA oligonucleotide for restoration of CFTR function in in vitro and murine models of p.Phe508del cystic fibrosis.
Volume: 14
Issue: 6
Pages: e0219182
Publication
First Author: Dorin JR
Year: 1994
Journal: Mamm Genome
Title: Long-term survival of the exon 10 insertional cystic fibrosis mutant mouse is a consequence of low level residual wild-type Cftr gene expression.
Volume: 5
Issue: 8
Pages: 465-72
Publication
First Author: Davidson H
Year: 2000
Journal: Genome Res
Title: Genomic sequence analysis of Fugu rubripes CFTR and flanking genes in a 60 kb region conserving synteny with 800 kb of human chromosome 7.
Volume: 10
Issue: 8
Pages: 1194-203
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Publication
First Author: Schütte A
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus.
Volume: 111
Issue: 34
Pages: 12396-401
Publication
First Author: Dennis EA
Year: 2015
Journal: PLoS One
Title: The Effects of CFTR and Mucoid Phenotype on Susceptibility and Innate Immune Responses in a Mouse Model of Pneumococcal Lung Disease.
Volume: 10
Issue: 10
Pages: e0140335
Publication  
First Author: Martinovich KM
Year: 2022
Journal: Front Pharmacol
Title: Investigating the Implications of CFTR Exon Skipping Using a Cftr Exon 9 Deleted Mouse Model.
Volume: 13
Pages: 868863
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: human
Publication
First Author: Phua YL
Year: 2019
Journal: Am J Physiol Renal Physiol
Title: Loss of miR-17~92 results in dysregulation of Cftr in nephron progenitors.
Volume: 316
Issue: 5
Pages: F993-F1005
Publication
First Author: Ostedgaard LS
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Cystic fibrosis transmembrane conductance regulator with a shortened R domain rescues the intestinal phenotype of CFTR-/- mice.
Volume: 108
Issue: 7
Pages: 2921-6
Publication
First Author: McHugh DR
Year: 2018
Journal: PLoS One
Title: A G542X cystic fibrosis mouse model for examining nonsense mutation directed therapies.
Volume: 13
Issue: 6
Pages: e0199573
Publication
First Author: Ratcliff R
Year: 1993
Journal: Nat Genet
Title: Production of a severe cystic fibrosis mutation in mice by gene targeting.
Volume: 4
Issue: 1
Pages: 35-41
Publication
First Author: Hyde SC
Year: 1993
Journal: Nature
Title: Correction of the ion transport defect in cystic fibrosis transgenic mice by gene therapy.
Volume: 362
Issue: 6417
Pages: 250-5
Publication
First Author: Wang G
Year: 2011
Journal: J Biol Chem
Title: The inhibition mechanism of non-phosphorylated Ser768 in the regulatory domain of cystic fibrosis transmembrane conductance regulator.
Volume: 286
Issue: 3
Pages: 2171-82
Protein Domain
Type: Domain
Description: Cystic fibrosis transmembrane conductance regulator (CFTR) that belongs tothe ATP-binding cassette (ABC) transporter superfamily. It is a member of the ABC-C subfamily, which also contains the SUR receptors and the multidrug-resistance associated proteins (MRP) []. The CFTR protein encodes a chloride ion channel, which is controlled by phosphorylation. It has a majorrole in electrolyte and fluid secretion. CFTR is important in the determination of fluid flow, ion concentration and transepithelial salttransport. Dysfunction of the CFTR channel causes the life-threateningdisease, cystic fibrosis, in which trans-epithelial ion transport is disrupted []. This entry represents the CFTR regulator domain [, , ].
Publication
First Author: Werner A
Year: 2004
Journal: J Lipid Res
Title: No indications for altered essential fatty acid metabolism in two murine models for cystic fibrosis.
Volume: 45
Issue: 12
Pages: 2277-86
Publication
First Author: Bijvelds MJ
Year: 2005
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Fat absorption in cystic fibrosis mice is impeded by defective lipolysis and post-lipolytic events.
Volume: 288
Issue: 4
Pages: G646-53
Publication
First Author: Kelly J
Year: 2022
Journal: Sci Rep
Title: Alterations of mucosa-attached microbiome and epithelial cell numbers in the cystic fibrosis small intestine with implications for intestinal disease.
Volume: 12
Issue: 1
Pages: 6593