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Search results 101 to 132 out of 132 for Drc1

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Type Details Score
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
11937031 | -
First Author: Noguchi E
Year: 2002
Journal: Curr Biol
Title: CDK phosphorylation of Drc1 regulates DNA replication in fission yeast.
Volume: 12
Issue: 7
Pages: 599-605
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Publication
21593208 | -
First Author: Fukuura M
Year: 2011
Journal: Mol Biol Cell
Title: CDK promotes interactions of Sld3 and Drc1 with Cut5 for initiation of DNA replication in fission yeast.
Volume: 22
Issue: 14
Pages: 2620-33
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Publication
23354437 | -
First Author: Wirschell M
Year: 2013
Journal: Nat Genet
Title: The nexin-dynein regulatory complex subunit DRC1 is essential for motile cilia function in algae and humans.
Volume: 45
Issue: 3
Pages: 262-8
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Publication
11807498 | -
First Author: Masumoto H
Year: 2002
Journal: Nature
Title: S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast.
Volume: 415
Issue: 6872
Pages: 651-5
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Publication
24307213 | -
First Author: Bruck I
Year: 2014
Journal: J Biol Chem
Title: The replication initiation protein Sld2 regulates helicase assembly.
Volume: 289
Issue: 4
Pages: 1948-59
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Protein Domain
IPR040203 | Sld2
Type: Family
Description: This entry includes Sld2 from budding yeasts and Drc1 from fission yeasts. Sld2 is required for the initiation of DNA replication. Its association with DNA is required for the assembly of the Cdc45-Mcm2-7-GINS (CMG) replicative helicase complex in S phase []. Sld2 can be regulated by S-Cdk-dependent phosphorylation []. Similarly, Drc1 is regulated by Cdk phosphorylation and is required for DNA replication []. Drc1 interacts with Cut5 and plays a role in the loading of Cut5 onto origins of replication [].
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Allele
Drc1<b2b2237Clo> | MGI:5552738
 
Name: dynein regulatory complex subunit 1; Bench to Bassinet Program (B2B/CVDC), mutation 2237 Cecilia Lo
Allele Type: Chemically induced (ENU)
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DO Term
DOID:0110596 | primary ciliary dyskinesia 21
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Protein
Q3UXA4
Organism: Mus musculus/domesticus
Length: 171  
Fragment?: false
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Protein Domain
IPR039750 | DRC1/DRC2
Type: Family
Description: DRC1 is a key component of the nexin-dynein regulatory complex (N-DRC), essential for N-DRC integrity. It is required for the assembly and regulation of specific classes of inner dynein arm motors. It may also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending []. Mutations of DRC1 gene cause Ciliary dyskinesia, primary, 21 (CILD21), which is a disorder characterised by abnormalities of motile cilia []. DRC2, also known as CCDC65, is an essential component of the nexin-dynein regulatory complex (N-DRC)[]. DRC2 is necessary for the co-assembly of DRC2 and DRC1 to form the base plate of N-DRC.
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Protein
Q3USS3
Organism: Mus musculus/domesticus
Length: 753  
Fragment?: false
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Allele
Drc1<b2b1654Clo> | MGI:5438062
 
Name: dynein regulatory complex subunit 1; Bench to Bassinet Program (B2B/CVDC), mutation 1654 Cecilia Lo
Allele Type: Chemically induced (ENU)
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Genotype
Genotype
Symbol: Drc1/Drc1
Background: C57BL/6J-Drc1
Zygosity: hm
Has Mutant Allele: true
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Protein
Q8VHI7
Organism: Mus musculus/domesticus
Length: 493  
Fragment?: false
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Protein
A0A2R8W6P2
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: false
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Protein
A0A2R8W6H5
Organism: Mus musculus/domesticus
Length: 195  
Fragment?: false
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Publication
17167415 | -
First Author: Tanaka S
Year: 2007
Journal: Nature
Title: CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast.
Volume: 445
Issue: 7125
Pages: 328-32
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Publication
15317757 | -
First Author: Yin J
Year: 2004
Journal: Hum Mol Genet
Title: RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway.
Volume: 13
Issue: 20
Pages: 2421-30
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Publication
29080750 | -
 
First Author: Mo D
Year: 2018
Journal: Cancer Lett
Title: Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells.
Volume: 413
Pages: 1-10
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Protein Domain
IPR021110 | DNA_rep_checkpnt_protein
Type: Family
Description: Genome duplication is precisely regulated by cyclin-dependent kinases CDKs, which bring about the onset of S phase by activating replication origins and then prevent relicensing of origins until mitosis is completed. The optimum sequence motif for CDK phosphorylation is S/T-P-K/R-K/R, and Drc1-Sld2 is found to have at least 11 potential phosphorylation sites. Drc1 is required for DNA synthesis and S-M replication checkpoint control. Drc1 associates with Cdc2 and is phosphorylated at the onset of S phase when Cdc2 is activated. Thus Cdc2 promotes DNA replication by phosphorylating Drc1 and regulating its association with Cut5 []. Sld2 and Sld3 represent the minimal set of S-CDK substrates required for DNA replication [].This entry also includes ATP-dependent DNA helicase Q4, which may be involved in chromosome segregation and has been associated with various diseases [, ].
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Protein Domain
IPR029440 | DRC1_C
Type: Domain
Description: This entry represents the C-terminal domain of dynein regulatory complex protein 1 (DRC1, also known as CCDC164). DRC1 is a key component of the nexin-dynein regulatory complex (N-DRC), essential for N-DRC integrity. It is required for the assembly and regulation of specific classes of inner dynein arm motors. It may also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending []. Mutations of DRC1 gene cause Ciliary dyskinesia, primary, 21 (CILD21), which is a disorder characterised by abnormalities of motile cilia [].
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Protein Domain
IPR039505 | DRC1/2_N
Type: Domain
Description: This entry represents the N-terminal domain of dynein regulatory complex protein 1/2 (DRC1/2). DRC1 is a key component of the nexin-dynein regulatory complex (N-DRC), essential for N-DRC integrity. It is required for the assembly and regulation of specific classes of inner dynein arm motors. It may also function to restrict dynein-driven microtubule sliding, thus aiding in the generation of ciliary bending []. Mutations of DRC1 gene cause Ciliary dyskinesia, primary, 21 (CILD21), which is a disorder characterised by abnormalities of motile cilia []. DRC2, also known as CCDC65, is an essential component of the nexin-dynein regulatory complex [].
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Genotype
Genotype
Symbol: Drc1/Drc1
Background: C57BL/6J-Drc1
Zygosity: hm
Has Mutant Allele: true
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Publication
24094744 | -
First Author: Austin-Tse C
Year: 2013
Journal: Am J Hum Genet
Title: Zebrafish Ciliopathy Screen Plus Human Mutational Analysis Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary Dyskinesia.
Volume: 93
Issue: 4
Pages: 672-86
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Protein
Q75NR7
Organism: Mus musculus/domesticus
Length: 1216  
Fragment?: false
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Protein
A3KMF3
Organism: Mus musculus/domesticus
Length: 1214  
Fragment?: true
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Protein
A0A0R4J0J3
Organism: Mus musculus/domesticus
Length: 1216  
Fragment?: false
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