A-kinase anchor protein 13 (AKAP13, also known as AKAP-Lbc) belongs to the AKAP family, which contains functionally related proteins involved in the targeting of the PKA holoenzyme towards specific physiological substrates []. AKAP13 anchors cAMP-dependent protein kinase (PKA) and acts as a guanine nucleotide exchange factor (GEF) that activates the GTPase RhoA []. The Rho-GEF activity of AKAP13 can be inhibited by protein 14-3-3 when it adopts an oligomeric conformation []. AKAP13 has been shown to be essential for cardiac development in mice []. It also plays a role in osteogenesis [].
