This entry includes human transmembrane protein 41A/B (TMEM41A/B) and related proteins. TMEM41B is involved in early stages of autophagosome biogenesis at the ER membrane probably via mobilization of neutral lipids from lipid droplets []. TMEM41B and its homologues from fish are involved in motor neuron development []. It is also a critical host factor required for infection by human coronaviruses SARS-CoV-2, HCoV-OC43, HCoV-NL63, and HCoV-229E, as well as all flaviviruses tested such as Zika virus and Yellow fever virus [, ]. The function of TMEM41A is not clear.
