Growth arrest-specific protein 2 (GAS2) belongs to the GAS2 family, whose members mediate the crosstalk between filamentous actin (F-actin) and microtubules. GAS2 regulates multiple cellular functions including cell cycle, apoptosis and calpain activities [, ]. It is up-regulated in chronic myeloid leukemia cells and required for their growth [].
The GAR (Gas2-related) domain is common in plakin family members and Gas2 family members. It has been shown to bind to microtubules [, , ]probably through the flexible, positively charged central β-sheet formed by by five antiparallel β-strands [].
The GAR (Gas2-related) domain is common in plakin family members and Gas2 family members. It has been shown to bind to microtubules [, , ]probably through the flexible, positively charged central β-sheet formed by by five antiparallel β-strands [].This domain has an α-β(5)-α fold with two layers (α/β) consisting of meander antiparallel sheet.
