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Search results 1501 to 1600 out of 1688 for Prnp

0.025s
Type Details Score
Genotype
Symbol: Prnp/Prnp Tg(Prnp*P101L)2866Sbp/?
Background: involves: 129S7/SvEvBrd * FVB/N
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Prnp/Prnp Tg(Prnp*P101L)2866Sbp/Tg(Prnp*P101L)2866Sbp
Background: involves: 129S7/SvEvBrd * FVB/N
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(Prnp-MAPT*P301L)#Ruvi/Tg(Prnp-MAPT*P301L)#Ruvi
Background: involves: C3HeB/FeJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Kuramoto T
Year: 1994
Journal: Biochem Biophys Res Commun
Title: Tremor and zitter, causative mutant genes for epilepsy with spongiform encephalopathy in spontaneously epileptic rat (SER), are tightly linked to synaptobrevin-2 and prion protein genes, respectively.
Volume: 200
Issue: 2
Pages: 1161-8
Publication
First Author: Essalmani R
Year: 2002
Journal: Gene
Title: Sequence determination and expression of the ovine doppel-encoding gene in transgenic mice.
Volume: 285
Issue: 1-2
Pages: 287-90
Strain
Attribute String: targeted mutation, transgenic
Strain
Attribute String: mutant stock, targeted mutation, transgenic
Strain
Attribute String: congenic, mutant strain, targeted mutation, transgenic
Strain
Attribute String: mutant stock, targeted mutation, transgenic
Strain
Attribute String: mutant stock, targeted mutation, transgenic
Publication
First Author: Choi DS
Year: 2002
Journal: J Neurosci
Title: Conditional rescue of protein kinase C epsilon regulates ethanol preference and hypnotic sensitivity in adult mice.
Volume: 22
Issue: 22
Pages: 9905-11
Publication
First Author: Castellano JM
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis.
Volume: 109
Issue: 38
Pages: 15502-7
Publication
First Author: Millecamps S
Year: 2007
Journal: J Neurosci
Title: Conditional NF-L transgene expression in mice for in vivo analysis of turnover and transport rate of neurofilaments.
Volume: 27
Issue: 18
Pages: 4947-56
Publication
First Author: Heikenwalder M
Year: 2007
Journal: J Neuroimmunol
Title: Germinal center B cells are dispensable in prion transport and neuroinvasion.
Volume: 192
Issue: 1-2
Pages: 113-23
Publication
First Author: Novoselov SS
Year: 2013
Journal: PLoS One
Title: Molecular chaperone mediated late-stage neuroprotection in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis.
Volume: 8
Issue: 8
Pages: e73944
Strain
Attribute String: transgenic, mutant strain, congenic
Publication
First Author: O'Mahony A
Year: 2006
Journal: Mol Cell Biol
Title: NF-kappaB/Rel regulates inhibitory and excitatory neuronal function and synaptic plasticity.
Volume: 26
Issue: 19
Pages: 7283-98
Strain
Attribute String: transgenic, mutant strain, congenic
Allele
Name: transgene insertion A12, Eileen McGowan
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Allele
Name: transgene insertion 1, Eileen McGowan
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Publication
First Author: Richards JG
Year: 2003
Journal: J Neurosci
Title: PS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation.
Volume: 23
Issue: 26
Pages: 8989-9003
Publication
First Author: Poirier R
Year: 2010
Journal: Neurobiol Dis
Title: Enhanced dentate gyrus synaptic plasticity but reduced neurogenesis in a mouse model of amyloidosis.
Volume: 40
Issue: 2
Pages: 386-93
Publication
First Author: Biechele G
Year: 2021
Journal: Theranostics
Title: Pre-therapeutic microglia activation and sex determine therapy effects of chronic immunomodulation.
Volume: 11
Issue: 18
Pages: 8964-8976
Publication  
First Author: Blume T
Year: 2022
Journal: Front Aging Neurosci
Title: Chronic PPARγ Stimulation Shifts Amyloidosis to Higher Fibrillarity but Improves Cognition.
Volume: 14
Pages: 854031
Publication      
First Author: Magusali N
Year: 2021
Journal: bioRxiv
Title: Genetic variability associated with OAS1 expression in myeloid cells increases the risk of Alzheimer's disease and severe COVID-19 outcomes.
Publication
First Author: Garringer HJ
Year: 2013
Journal: PLoS One
Title: Increased tau phosphorylation and tau truncation, and decreased synaptophysin levels in mutant BRI2/tau transgenic mice.
Volume: 8
Issue: 2
Pages: e56426
Allele
Name: transgene insertion, Adriano Aguzzi
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion F332, Zurich
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Publication
First Author: Hsiao KK
Year: 1990
Journal: Science
Title: Spontaneous neurodegeneration in transgenic mice with mutant prion protein.
Volume: 250
Issue: 4987
Pages: 1587-90
Allele
Name: transgene insertion G1, Roberto Chiesa
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Strain
Attribute String: transgenic, mutant strain, coisogenic
Strain
Attribute String: transgenic, mutant stock
Strain
Attribute String: transgenic, mutant strain, coisogenic
Allele
Name: transgene insertion 340, Juan Maria Torres
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Allele
Name: transgene insertion FFI-10, Roberto Chiesa
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion FFI-26, Roberto Chiesa
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 23, Michael Oldstone
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Genotype
Symbol: Prnp/Prnp Tg(Prnp)a19Cwe/?
Background: Not Specified
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Prnp/Prnp Tg(Prnp)a20Cwe/?
Background: Not Specified
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Prkce/Prkce Tg(Prnp-tTA)F959Sbp/? Tg(tetO-Prkce)T9Msg/?
Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J * FVB/N
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Prnp/Prnp Tg(Nefh-cre)22Jcol/? Tg(Prnp)37Jcol/?
Background: involves: 129/Sv * 129S7/SvEvBrd * C57BL/6 * FVB
Zygosity: cn
Has Mutant Allele: true
Genotype
Symbol: Tg(Prnp-ITM2B*)6Jckr/? Tg(Thy1-APP)3Somm/?
Background: B6.Cg-Tg(Prnp-ITM2B*)6Jckr Tg(Thy1-APP)3Somm
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Prnp/Prnp Tg(Prnp)a20Cwe/?
Background: involves: 129S7/SvEvBrd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(Prnp-tTA)F959Sbp/? Tg(TetO-Nfkbia*S32A*S36A)1Wcg/?
Background: involves: 129S7/SvEvBrd * DBA * FVB/N
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(Prnp*P101L)174Sbp/?
Background: involves: C57BL/6 * SJL
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(Prnp-ITM2B*)1Ruvi/Tg(Prnp-ITM2B*)1Ruvi Tg(Prnp-MAPT*P301L)#Ruvi/Tg(Prnp-MAPT*P301L)#Ruvi
Background: involves: C3HeB/FeJ * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Prnp/Prnp Tg(Prnp*S170N*N174T)1020Aag/?
Background: involves: 129S7/SvEvBrd * C57BL/6
Zygosity: cx
Has Mutant Allele: true
Publication
First Author: Naughton BJ
Year: 2013
Journal: PLoS One
Title: Amyloidosis, synucleinopathy, and prion encephalopathy in a neuropathic lysosomal storage disease: the CNS-biomarker potential of peripheral blood.
Volume: 8
Issue: 11
Pages: e80142
Publication
First Author: Carulla P
Year: 2011
Journal: Mol Biol Cell
Title: Neuroprotective role of PrPC against kainate-induced epileptic seizures and cell death depends on the modulation of JNK3 activation by GluR6/7-PSD-95 binding.
Volume: 22
Issue: 17
Pages: 3041-54
Publication
First Author: Lidón L
Year: 2020
Journal: Mol Neurobiol
Title: Tau Protein as a New Regulator of Cellular Prion Protein Transcription.
Volume: 57
Issue: 10
Pages: 4170-4186
Publication
First Author: Moreno CR
Year: 2003
Journal: Genetics
Title: Detection of new quantitative trait Loci for susceptibility to transmissible spongiform encephalopathies in mice.
Volume: 165
Issue: 4
Pages: 2085-91
Publication  
First Author: Ansoleaga B
Year: 2013
Journal: Neuroscience
Title: Dysregulation of brain olfactory and taste receptors in AD, PSP and CJD, and AD-related model.
Volume: 248
Pages: 369-82
Publication
First Author: Moore RC
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Doppel-induced cerebellar degeneration in transgenic mice.
Volume: 98
Issue: 26
Pages: 15288-93
Publication  
First Author: Windl O
Year: 1999
Journal: J Gen Virol
Title: Construction and characterization of murine neuroblastoma cell clones allowing inducible and high expression of the prion protein.
Volume: 80 ( Pt 1)
Pages: 15-21
Publication
First Author: Anderson L
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: Transgene-driven expression of the Doppel protein in Purkinje cells causes Purkinje cell degeneration and motor impairment.
Volume: 101
Issue: 10
Pages: 3644-9
Publication
First Author: Asante EA
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Dissociation of pathological and molecular phenotype of variant Creutzfeldt-Jakob disease in transgenic human prion protein 129 heterozygous mice.
Volume: 103
Issue: 28
Pages: 10759-64
Publication
First Author: Plinston C
Year: 2011
Journal: J Virol
Title: Increased susceptibility of human-PrP transgenic mice to bovine spongiform encephalopathy infection following passage in sheep.
Volume: 85
Issue: 3
Pages: 1174-81
Publication
First Author: Asante EA
Year: 2015
Journal: Nature
Title: A naturally occurring variant of the human prion protein completely prevents prion disease.
Volume: 522
Issue: 7557
Pages: 478-81
Publication
First Author: Ding NZ
Year: 2018
Journal: Biol Reprod
Title: Cellular prion protein is involved in decidualization of mouse uterus.
Volume: 99
Issue: 2
Pages: 319-325
Publication
First Author: Asante EA
Year: 2020
Journal: PLoS Biol
Title: Spontaneous generation of prions and transmissible PrP amyloid in a humanised transgenic mouse model of A117V GSS.
Volume: 18
Issue: 6
Pages: e3000725
Publication  
First Author: Avar M
Year: 2020
Journal: Life Sci Alliance
Title: Prion infection, transmission, and cytopathology modeled in a low-biohazard human cell line.
Volume: 3
Issue: 8
Publication    
First Author: Bistaffa E
Year: 2021
Journal: Elife
Title: PMCA-generated prions from the olfactory mucosa of patients with Fatal Familial Insomnia cause prion disease in mice.
Volume: 10
Publication
First Author: Schweighauser M
Year: 2023
Journal: Acta Neuropathol Commun
Title: Cryo-EM structures of tau filaments from the brains of mice transgenic for human mutant P301S Tau.
Volume: 11
Issue: 1
Pages: 160
Publication
First Author: Gilbert R
Year: 2003
Journal: Hum Mol Genet
Title: Prolonged dystrophin expression and functional correction of mdx mouse muscle following gene transfer with a helper-dependent (gutted) adenovirus-encoding murine dystrophin.
Volume: 12
Issue: 11
Pages: 1287-99
Publication
First Author: Shi Y
Year: 2021
Journal: Neuron
Title: Overexpressing low-density lipoprotein receptor reduces tau-associated neurodegeneration in relation to apoE-linked mechanisms.
Volume: 109
Issue: 15
Pages: 2413-2426.e7
Strain
Attribute String: targeted mutation, mutant stock, transgenic
Strain
Attribute String: mutant stock, transgenic
Strain
Attribute String: mutant stock, targeted mutation, transgenic
Strain
Attribute String: mutant stock, targeted mutation, transgenic
Strain
Attribute String: mutant stock, targeted mutation, transgenic
Strain
Attribute String: transgenic, targeted mutation, mutant stock
Publication
First Author: Mok SW
Year: 2012
Journal: J Immunol
Title: B cell-specific S1PR1 deficiency blocks prion dissemination between secondary lymphoid organs.
Volume: 188
Issue: 10
Pages: 5032-40
Publication  
First Author: Leparulo A
Year: 2019
Journal: Cells
Title: Dampened Slow Oscillation Connectivity Anticipates Amyloid Deposition in the PS2APP Mouse Model of Alzheimer's Disease.
Volume: 9
Issue: 1
Publication  
First Author: Fontana R
Year: 2017
Journal: Neurobiol Aging
Title: Early hippocampal hyperexcitability in PS2APP mice: role of mutant PS2 and APP.
Volume: 50
Pages: 64-76
Publication
First Author: Nakamura K
Year: 2012
Journal: Cell
Title: Proline isomer-specific antibodies reveal the early pathogenic tau conformation in Alzheimer's disease.
Volume: 149
Issue: 1
Pages: 232-44
Publication
First Author: Lim J
Year: 2008
Journal: J Clin Invest
Title: Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy.
Volume: 118
Issue: 5
Pages: 1877-89
Publication
First Author: Liu P
Year: 2015
Journal: PLoS One
Title: Characterization of a Novel Mouse Model of Alzheimer's Disease--Amyloid Pathology and Unique β-Amyloid Oligomer Profile.
Volume: 10
Issue: 5
Pages: e0126317
Publication
First Author: Nuber S
Year: 2008
Journal: J Neurosci
Title: Neurodegeneration and motor dysfunction in a conditional model of Parkinson's disease.
Volume: 28
Issue: 10
Pages: 2471-84
Publication
First Author: Odeh F
Year: 2011
Journal: Neuroimage
Title: Atlas of transgenic Tet-Off Ca2+/calmodulin-dependent protein kinase II and prion protein promoter activity in the mouse brain.
Volume: 54
Issue: 4
Pages: 2603-11
Publication
First Author: Ishihara T
Year: 1999
Journal: Neuron
Title: Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform.
Volume: 24
Issue: 3
Pages: 751-62
Publication
First Author: Nakashima H
Year: 2004
Journal: Free Radic Biol Med
Title: Effects of alpha-tocopherol on an animal model of tauopathies.
Volume: 37
Issue: 2
Pages: 176-86
Publication
First Author: Labbadia J
Year: 2012
Journal: Brain
Title: Suppression of protein aggregation by chaperone modification of high molecular weight complexes.
Volume: 135
Issue: Pt 4
Pages: 1180-96
Strain
Attribute String: congenic, mutant strain, targeted mutation, transgenic
Publication
First Author: Peretti D
Year: 2015
Journal: Nature
Title: RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration.
Volume: 518
Issue: 7538
Pages: 236-9
Publication
First Author: Restelli LM
Year: 2018
Journal: Cell Rep
Title: Neuronal Mitochondrial Dysfunction Activates the Integrated Stress Response to Induce Fibroblast Growth Factor 21.
Volume: 24
Issue: 6
Pages: 1407-1414
Publication
First Author: Zhu C
Year: 2016
Journal: J Exp Med
Title: A neuroprotective role for microglia in prion diseases.
Volume: 213
Issue: 6
Pages: 1047-59
Strain
Attribute String: transgenic, mutant strain, congenic
Publication
First Author: Lee SH
Year: 2021
Journal: Neuron
Title: Trem2 restrains the enhancement of tau accumulation and neurodegeneration by β-amyloid pathology.
Volume: 109
Issue: 8
Pages: 1283-1301.e6
Publication
First Author: Rhein V
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice.
Volume: 106
Issue: 47
Pages: 20057-62
Publication
First Author: Lee SH
Year: 2021
Journal: Cell Rep
Title: TREM2-independent oligodendrocyte, astrocyte, and T cell responses to tau and amyloid pathology in mouse models of Alzheimer disease.
Volume: 37
Issue: 13
Pages: 110158
Publication
First Author: Grueninger F
Year: 2010
Journal: Neurobiol Dis
Title: Phosphorylation of Tau at S422 is enhanced by Abeta in TauPS2APP triple transgenic mice.
Volume: 37
Issue: 2
Pages: 294-306
Strain
Attribute String: congenic, mutant strain, targeted mutation
Publication
First Author: Sandoval-Pistorius SS
Year: 2023
Journal: Sci Rep
Title: Ubiquilin-2 regulates pathological alpha-synuclein.
Volume: 13
Issue: 1
Pages: 293
Publication
First Author: Giliberto L
Year: 2009
Journal: PLoS One
Title: Generation and initial characterization of FDD knock in mice.
Volume: 4
Issue: 11
Pages: e7900
Strain
Attribute String: transgenic, mutant stock
Strain
Attribute String: transgenic, congenic
Publication  
First Author: Hendrix RD
Year: 2021
Journal: Neurobiol Aging
Title: Alzheimer amyloid-β- peptide disrupts membrane localization of glucose transporter 1 in astrocytes: implications for glucose levels in brain and blood.
Volume: 97
Pages: 73-88
Strain
Attribute String: congenic, transgenic
Strain
Attribute String: mutant stock, targeted mutation
Strain
Attribute String: transgenic, mutant strain, coisogenic