Junctional adhesion molecule-like (JAML) contains 2 extracellular immunoglobulin-like domains, a transmembrane segment, and a cytoplasmic tail. JAML mRNA is expressed in hematopoietic tissues and is localised at the cell plasma membrane in the areas of cell-cell contacts []. It is a receptor that controls the migration and activation of the epithelial gamma-delta T cells through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells []. During acute inflammation, neutrophils infiltrate the intestinal mucosa. JAML can be cleaved from the neutrophil surface by zinc metalloproteases during theneutrophil transepithelial migration (TEM) []. These neutrophil-derived soluble JAML can bind to the epithelial tight junction protein coxsackie-adenovirus receptor (CAR) and decrease epithelial proliferation, inhibiting wound repair and promoting the recruitment of leukocytes [].
