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Search results 501 to 533 out of 533 for Disc1

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Type Details Score
Protein Domain
IPR018799 | TRAF3IP1
Type: Family
Description: TRAF3-interacting protein 1 (TRAF3IP1) recruits TRAF3 (tumour necrosis factor receptor-associated factor 3) and DISC1 (Disrupted-In-Schizophrenia 1) to the microtubules and is conserved from worms to humans []. The N-terminal region is the microtubule binding domain and is well-conserved; the C-terminal 100 residues, also well-conserved, constitute the coiled-coil region which binds to TRAF3. The central region of the protein is rich in lysine and glutamic acid and carries KKE motifs which may also be necessary for tubulin-binding, but this region is the least well-conserved []. In humans, it plays an inhibitory role on IL13 signaling by binding to IL13RA1. It is involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding [, ].
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Strain
MGI:5660928 | 129S2/SvPasCrl-Disc1<del> Disc1<tm1(DISC1/DISC1FP1,DISC1FP1/DISC1,DISC1)Xzho>
Attribute String: coisogenic, mutant strain, spontaneous mutation, targeted mutation
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Strain
MGI:6287129 | B6.Cg-Tg(GFAP-tTA)110Pop Tg(tetO-DISC1*)1302BPlet
Attribute String: congenic, mutant strain, targeted mutation
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Allele
Tg(Camk2a-ESR1/Disc1*)2698.1Sva | MGI:3785794
Name: transgene insertion 2698.1, Alcino J Silva
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Genotype
Genotype
Symbol: Disc1/Disc1
Background: 129S2/SvPasCrl-Disc1 Disc1
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(GFAP-tTA)110Pop/? Tg(tetO-DISC1*)1302BPlet/?
Background: B6.Cg-Tg(GFAP-tTA)110Pop Tg(tetO-DISC1*)1302BPlet
Zygosity: cx
Has Mutant Allele: true
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Protein
Q149C2
Organism: Mus musculus/domesticus
Length: 625  
Fragment?: false
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Protein
A0A087WQD8
Organism: Mus musculus/domesticus
Length: 654  
Fragment?: false
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Publication
10791955 | -
First Author: Ling L
Year: 2000
Journal: J Biol Chem
Title: MIP-T3, a novel protein linking tumor necrosis factor receptor-associated factor 3 to the microtubule network.
Volume: 275
Issue: 31
Pages: 23852-60
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Publication
12935900 | -
First Author: Niu Y
Year: 2003
Journal: FEBS Lett
Title: MIP-T3 associates with IL-13Ralpha1 and suppresses STAT6 activation in response to IL-13 stimulation.
Volume: 550
Issue: 1-3
Pages: 139-43
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Protein Domain
IPR042576 | TRAF3IP1_N_sf
Type: Homologous_superfamily
Description: TRAF3-interacting protein 1 (TRAF3IP1) recruits TRAF3 (tumour necrosis factor receptor-associated factor 3) and DISC1 (Disrupted-In-Schizophrenia 1) to the microtubules and is conserved from worms to humans []. The N-terminal region is the microtubule binding domain and is well-conserved; the C-terminal 100 residues, also well-conserved, constitute the coiled-coil region which binds to TRAF3. The central region of the protein is rich in lysine and glutamic acid and carries KKE motifs which may also be necessary for tubulin-binding, but this region is the least well-conserved []. In humans, it plays an inhibitory role on IL13 signaling by binding to IL13RA1. It is involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding [, ].This superfamily represents the N-terminal domain of TRAF3-interacting protein 1.
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Protein Domain
IPR040468 | TRAF3IP1_N
Type: Domain
Description: TRAF3-interacting protein 1 (TRAF3IP1) recruits TRAF3 (tumour necrosis factor receptor-associated factor 3) and DISC1 (Disrupted-In-Schizophrenia 1) to the microtubules and is conserved from worms to humans []. The N-terminal region is the microtubule binding domain and is well-conserved; the C-terminal 100 residues, also well-conserved, constitute the coiled-coil region which binds to TRAF3. The central region of the protein is rich in lysine and glutamic acid and carries KKE motifs which may also be necessary for tubulin-binding, but this region is the least well-conserved []. In humans, it plays an inhibitory role on IL13 signaling by binding to IL13RA1. It is involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding [, ].This entry represents the N-terminal domain of TRAF3-interacting protein 1.
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Strain
MGI:3785833 | C57BL/6-Tg(Camk2a-ESR1/Disc1*)2698.1Sva/J
Attribute String: transgenic
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Genotype
Genotype
Symbol: Tg(Camk2a-ESR1/Disc1*)2698.1Sva/?
Background: involves: C57BL/6 * C57BL/6NTac
Zygosity: ot
Has Mutant Allele: true
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Publication
19778507 | J:154918
First Author: Enomoto A
Year: 2009
Journal: Neuron
Title: Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus.
Volume: 63
Issue: 6
Pages: 774-87
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Publication
18647754 | J:139974
First Author: Sakae N
Year: 2008
Journal: Hum Mol Genet
Title: Mice lacking the schizophrenia-associated protein FEZ1 manifest hyperactivity and enhanced responsiveness to psychostimulants.
Volume: 17
Issue: 20
Pages: 3191-203
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Publication
24726361 | J:211815
First Author: Watanabe Y
Year: 2014
Journal: Cell Rep
Title: Dendrite development regulated by the schizophrenia-associated gene FEZ1 involves the ubiquitin proteasome system.
Volume: 7
Issue: 2
Pages: 552-64
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Publication
35090617 | J:323973
First Author: Wilke SA
Year: 2022
Journal: Biol Psychiatry
Title: Convergence of Clinically Relevant Manipulations on Dopamine-Regulated Prefrontal Activity Underlying Stress Coping Responses.
Volume: 91
Issue: 9
Pages: 810-820
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Publication
23912123 | J:207522
 
First Author: Koyama Y
Year: 2013
Journal: J Chem Neuroanat
Title: DBZ (DISC1-binding zinc finger protein)-deficient mice display abnormalities in basket cells in the somatosensory cortices.
Volume: 53
Pages: 1-10
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Publication
21458426 | J:172509
 
First Author: Sekiguchi H
Year: 2011
Journal: Brain Res
Title: Impairment of the tyrosine hydroxylase neuronal network in the orbitofrontal cortex of a genetically modified mouse model of schizophrenia.
Volume: 1392
Pages: 47-53
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Publication
31892408 | J:301190
First Author: Li YC
Year: 2020
Journal: Biol Psychiatry
Title: Deletion of Glycogen Synthase Kinase-3β in D2 Receptor-Positive Neurons Ameliorates Cognitive Impairment via NMDA Receptor-Dependent Synaptic Plasticity.
Volume: 87
Issue: 8
Pages: 745-755
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Publication
21539806 | J:172382
First Author: Zoubovsky SP
Year: 2011
Journal: Biochem Biophys Res Commun
Title: Working memory deficits in neuronal nitric oxide synthase knockout mice: potential impairments in prefrontal cortex mediated cognitive function.
Volume: 408
Issue: 4
Pages: 707-12
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Publication
28928414 | J:255877
First Author: Bryant DT
Year: 2017
Journal: Sci Rep
Title: Disruption to schizophrenia-associated gene Fez1 in the hippocampus of HDAC11 knockout mice.
Volume: 7
Issue: 1
Pages: 11900
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Publication
29961565 | J:305154
First Author: Wilkinson B
Year: 2019
Journal: Biol Psychiatry
Title: Endogenous Cell Type-Specific Disrupted in Schizophrenia 1 Interactomes Reveal Protein Networks Associated With Neurodevelopmental Disorders.
Volume: 85
Issue: 4
Pages: 305-316
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Publication
27466199 | J:238570
First Author: Piñero-Martos E
Year: 2016
Journal: Hum Mol Genet
Title: Disrupted in schizophrenia 1 (DISC1) is a constituent of the mammalian mitochondrial contact site and cristae organizing system (MICOS) complex, and is essential for oxidative phosphorylation.
Volume: 25
Issue: 19
Pages: 4157-4169
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Publication
29155005 | J:258445
 
First Author: Scott D
Year: 2018
Journal: Behav Brain Res
Title: Effects of genetic and environmental risk for schizophrenia on hippocampal activity and psychosis-like behavior in mice.
Volume: 339
Pages: 114-123
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Publication
29197324 | J:277496
First Author: Campbell SL
Year: 2017
Journal: BMC Neurosci
Title: Altered phosphorylation, electrophysiology, and behavior on attenuation of PDE4B action in hippocampus.
Volume: 18
Issue: 1
Pages: 77
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Publication
21945076 | J:178483
First Author: Berbari NF
Year: 2011
Journal: Dev Biol
Title: Mutations in Traf3ip1 reveal defects in ciliogenesis, embryonic development, and altered cell size regulation.
Volume: 360
Issue: 1
Pages: 66-76
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Publication
27832597 | J:328445
First Author: Kassan A
Year: 2017
Journal: J Neurophysiol
Title: Caveolin-1 regulation of disrupted-in-schizophrenia-1 as a potential therapeutic target for schizophrenia.
Volume: 117
Issue: 1
Pages: 436-444
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Publication
26272049 | J:223217
First Author: McGirr A
Year: 2016
Journal: Neuropsychopharmacology
Title: Specific Inhibition of Phosphodiesterase-4B Results in Anxiolysis and Facilitates Memory Acquisition.
Volume: 41
Issue: 4
Pages: 1080-92
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Publication
28916331 | J:252320
 
First Author: Conti M
Year: 2017
Journal: Neuropharmacology
Title: Depressive-like phenotype induced by prenatal dexamethasone in mice is reversed by desipramine.
Volume: 126
Pages: 242-249
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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