N-myc downstream regulated gene (NDRG) family members are characterised by an alpha/beta hydrolase-fold motif. NDRG proteins may function as tumour suppressors and may also play important roles in the development of neurological and electrophysiological diseases [, ]. This entry represents NDRG2. NDRG2 is expressed during dendritic cell (DC) differentiation, and silencing NDRG2 in DCs reduces the ability to induce T-cell proliferation [, ]. NDRG2 is also expressed in the central nervous system and may function in neural differentiation, synapse formation, and axon survival in response to glucocorticoids []. NDRG2 is associated with Alzheimer's disease []. The down-regulation of NDRG2 has been shown in a variety of human cancer cell lines and primary tumours []. The structure of NDRG2 has been solved [].
