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Search results 1 to 100 out of 338 for Atp2b1

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Type Details Score
Gene
Type: gene
Organism: human
Gene
Type: gene
Organism: chimpanzee
Gene
Type: gene
Organism: cattle
Gene
Type: gene
Organism: chicken
Gene
Type: gene
Organism: macaque, rhesus
Gene
Type: gene
Organism: frog, western clawed
Gene
Type: gene
Organism: rat
Gene
Type: gene
Organism: dog, domestic
Protein Domain
Type: Family
Description: Plasma membrane calcium-transporting ATPase 1 (ATP2B1, also known as PMCA1) belongs to the IIB subfamily of P-type ATPases, whose members are plasma membrane Ca2+ ATPases (PMCAs) that catalyse the hydrolysis of ATP coupled with the transport of calcium []. ATP2B1 is widely expressed in animal tissues during development []. Its auto-inhibitory C-terminal tail can be cleaved by a protease-calpain []. This activation by calpain may have a role in the activation of erythrocytes []. In breast cancer cells, ATP2B1 regulates cell death pathways in the presence of cell death stimuli []. It may also represent one of the sites of action of maitotoxin (MTX), one of the most potent toxins produced by the "red-tide"dinoflagellate Gambierdiscus toxicus. MTX-induced currents are significantly reduced by knockdown of ATP2B1, and the toxin may bind to and convert the PMCA pump into a Ca(2+)-permeable nonselective cation channel [].
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 372  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 914  
Fragment?: true
Gene
Type: gene
Organism: human
Publication
First Author: Zacharias DA
Year: 1999
Journal: Biochim Biophys Acta
Title: Developmental expression of the four plasma membrane calcium ATPase (Pmca) genes in the mouse.
Volume: 1428
Issue: 2-3
Pages: 397-405
GXD Expression    
Probe: MGI:6361678
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Female
Emaps: EMAPS:3102528
Stage: TS28
Assay Id: MGI:6362610
Age: postnatal
Image: Atp2b1
Specimen Label: oocyte
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:6361678
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360422
Stage: TS02
Assay Id: MGI:6362610
Age: embryonic day 1.0
Image: Atp2b1
Specimen Label: 2-cell
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:6361678
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360453
Stage: TS03
Assay Id: MGI:6362610
Age: embryonic day 3.0
Image: Atp2b1
Specimen Label: 16-cell
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:6361678
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160429
Stage: TS09
Assay Id: MGI:6362610
Age: embryonic day 6.5
Image: Atp2b1
Specimen Label: extraembryonic
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:6361678
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160519
Stage: TS09
Assay Id: MGI:6362610
Age: embryonic day 6.5
Image: Atp2b1
Specimen Label: visceral endoderm
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:6361678
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1604211
Stage: TS11
Assay Id: MGI:6362610
Age: embryonic day 7.5
Image: Atp2b1
Specimen Label: extraembryonic
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:6361678
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1608513
Stage: TS13
Assay Id: MGI:6362610
Age: embryonic day 8.5
Image: Atp2b1
Specimen Label: yolk sac
Detected: true
Specimen Num: 13
GXD Expression    
Probe: MGI:6361678
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3594928
Stage: TS28
Assay Id: MGI:6362610
Age: postnatal
Image: Atp2b1
Specimen Label: brain/kidney/liver
Detected: true
Specimen Num: 6
GXD Expression    
Probe: MGI:6361678
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3594928
Stage: TS28
Assay Id: MGI:6362610
Age: postnatal
Image: Atp2b1
Specimen Label: brain/kidney/liver
Detected: true
Specimen Num: 15
GXD Expression    
Probe: MGI:6361678
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360411
Stage: TS01
Assay Id: MGI:6362610
Age: embryonic day 0.5
Image: Atp2b1
Specimen Label: zygote
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:6361678
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:360464
Stage: TS04
Assay Id: MGI:6362610
Age: embryonic day 3.5
Image: Atp2b1
Specimen Label: blastocyst
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:6361678
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:160399
Stage: TS09
Assay Id: MGI:6362610
Age: embryonic day 6.5
Image: Atp2b1
Specimen Label: epiblast
Detected: false
Specimen Num: 10
GXD Expression    
Probe: MGI:6361678
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:6362610
Age: embryonic day 8.5
Image: Atp2b1
Specimen Label: embryonic
Detected: true
Specimen Num: 14
GXD Expression    
Probe: MGI:6361678
Assay Type: RT-PCR
Annotation Date: 2019-10-04
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603911
Stage: TS11
Assay Id: MGI:6362610
Age: embryonic day 7.5
Image: Atp2b1
Specimen Label: embryonic
Detected: true
Specimen Num: 12
Publication
First Author: Kobayashi Y
Year: 2012
Journal: Hypertension
Title: Mice lacking hypertension candidate gene ATP2B1 in vascular smooth muscle cells show significant blood pressure elevation.
Volume: 59
Issue: 4
Pages: 854-60
Publication
First Author: Fujiwara A
Year: 2014
Journal: J Hypertens
Title: Impaired nitric oxide production and increased blood pressure in systemic heterozygous ATP2B1 null mice.
Volume: 32
Issue: 7
Pages: 1415-23; discussion 1423
Publication
First Author: Okuyama Y
Year: 2018
Journal: Hypertens Res
Title: The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice.
Volume: 41
Issue: 2
Pages: 80-87
Publication
First Author: Sinkins WG
Year: 2009
Journal: Am J Physiol Cell Physiol
Title: Maitotoxin converts the plasmalemmal Ca(2+) pump into a Ca(2+)-permeable nonselective cation channel.
Volume: 297
Issue: 6
Pages: C1533-43
Publication
First Author: Guerini D
Year: 2003
Journal: J Biol Chem
Title: Expression, purification, and characterization of isoform 1 of the plasma membrane Ca2+ pump: focus on calpain sensitivity.
Volume: 278
Issue: 40
Pages: 38141-8
Publication
First Author: Brown CS
Year: 2007
Journal: Platelets
Title: Regulation of plasma membrane Ca2+-ATPase in human platelets by calpain.
Volume: 18
Issue: 3
Pages: 207-11
Publication
First Author: Curry MC
Year: 2012
Journal: J Biol Chem
Title: Distinct regulation of cytoplasmic calcium signals and cell death pathways by different plasma membrane calcium ATPase isoforms in MDA-MB-231 breast cancer cells.
Volume: 287
Issue: 34
Pages: 28598-608
Protein
Organism: Mus musculus/domesticus
Length: 175  
Fragment?: true
Publication
First Author: Giacomello M
Year: 2013
Journal: Int J Biochem Cell Biol
Title: Plasma membrane calcium ATPases and related disorders.
Volume: 45
Issue: 3
Pages: 753-62
Protein
Organism: Mus musculus/domesticus
Length: 279  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 317  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 290  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 1220  
Fragment?: false
Publication
First Author: Vernay A
Year: 2016
Journal: Hum Mol Genet
Title: A transgenic mouse expressing CHMP2Bintron5 mutant in neurons develops histological and behavioural features of amyotrophic lateral sclerosis and frontotemporal dementia.
Volume: 25
Issue: 15
Pages: 3341-3360
Publication  
First Author: Waegaert R
Year: 2020
Journal: Neurobiol Dis
Title: Longitudinal transcriptomic analysis of altered pathways in a CHMP2Bintron5-based model of ALS-FTD.
Volume: 136
Pages: 104710
Publication
First Author: Ehara Y
Year: 2018
Journal: Hypertens Res
Title: Reduced secretion of parathyroid hormone and hypocalcemia in systemic heterozygous ATP2B1-null hypertensive mice.
Volume: 41
Issue: 9
Pages: 699-707
Publication
First Author: Korthals M
Year: 2021
Journal: Eur J Immunol
Title: Plasma membrane Ca2+ ATPase 1 (PMCA1) but not PMCA4 is critical for B-cell development and Ca2+ homeostasis in mice.
Volume: 51
Issue: 3
Pages: 594-602
Protein
Organism: Mus musculus/domesticus
Length: 313  
Fragment?: true
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus caroli
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus pahari
Protein Coding Gene
Type: protein_coding_gene
Organism: Mus spretus
Publication
First Author: Ryan ZC
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Deletion of the intestinal plasma membrane calcium pump, isoform 1, Atp2b1, in mice is associated with decreased bone mineral density and impaired responsiveness to 1, 25-dihydroxyvitamin D3.
Volume: 467
Issue: 1
Pages: 152-6
Publication
First Author: Ono Y
Year: 2019
Journal: Sci Rep
Title: Expression of plasma membrane calcium ATPases confers Ca2+/H+ exchange in rodent synaptic vesicles.
Volume: 9
Issue: 1
Pages: 4289
Publication
First Author: Du Y
Year: 1995
Journal: Arch Biochem Biophys
Title: The mouse plasma membrane Ca2+ pump isoform 1 promoter: cloning and characterization.
Volume: 316
Issue: 1
Pages: 302-10
Publication
First Author: Prasad V
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Phenotypes of SERCA and PMCA knockout mice.
Volume: 322
Issue: 4
Pages: 1192-203
Publication
First Author: Little R
Year: 2017
Journal: Aging Cell
Title: Reduced expression of PMCA1 is associated with increased blood pressure with age which is preceded by remodelling of resistance arteries.
Volume: 16
Issue: 5
Pages: 1104-1113
GXD Expression      
Probe: MGI:3663005
Assay Type: Western blot
Annotation Date: 2006-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610515
Stage: TS15
Assay Id: MGI:3663006
Age: embryonic day 9.5
Specimen Label: +/-
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:3663005
Assay Type: Western blot
Annotation Date: 2006-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610515
Stage: TS15
Assay Id: MGI:3663006
Age: embryonic day 9.5
Specimen Label: -/-
Detected: true
Specimen Num: 2
GXD Expression      
Probe: MGI:3663005
Assay Type: Western blot
Annotation Date: 2006-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610515
Stage: TS15
Assay Id: MGI:3663006
Age: embryonic day 9.5
Specimen Label: +/-
Detected: true
Specimen Num: 3
GXD Expression      
Probe: MGI:3663005
Assay Type: Western blot
Annotation Date: 2006-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610515
Stage: TS15
Assay Id: MGI:3663006
Age: embryonic day 9.5
Specimen Label: -/-
Detected: true
Specimen Num: 4
GXD Expression      
Probe: MGI:3663005
Assay Type: Western blot
Annotation Date: 2006-10-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610515
Stage: TS15
Assay Id: MGI:3663006
Age: embryonic day 9.5
Specimen Label: +/+
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:3831770
Assay Type: RT-PCR
Annotation Date: 2009-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610522
Stage: TS22
Assay Id: MGI:3831807
Age: embryonic day 14.0
Image: 1
Specimen Label: E14
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:3831770
Assay Type: RT-PCR
Annotation Date: 2009-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610526
Stage: TS26
Assay Id: MGI:3831807
Age: embryonic day 18.0
Image: 1
Specimen Label: E18
Detected: true
Specimen Num: 2
GXD Expression    
Probe: MGI:3831770
Assay Type: RT-PCR
Annotation Date: 2009-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:3831807
Age: postnatal day 1
Image: 1
Specimen Label: PN1
Detected: true
Specimen Num: 3
GXD Expression    
Probe: MGI:3831770
Assay Type: RT-PCR
Annotation Date: 2009-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610527
Stage: TS27
Assay Id: MGI:3831807
Age: postnatal day 3
Image: 1
Specimen Label: PN3
Detected: true
Specimen Num: 4
GXD Expression    
Probe: MGI:3831770
Assay Type: RT-PCR
Annotation Date: 2009-02-14
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3831807
Age: postnatal month 3
Image: 1
Specimen Label: Adult
Detected: true
Specimen Num: 5
GXD Expression    
Probe: MGI:3831770
Assay Type: RT-PCR
Annotation Date: 2009-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610522
Stage: TS22
Assay Id: MGI:3832249
Age: embryonic day 14.0
Image: S7
Specimen Label: E14 wt h
Detected: true
Specimen Num: 8
GXD Expression    
Probe: MGI:3831770
Assay Type: RT-PCR
Annotation Date: 2009-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610522
Stage: TS22
Assay Id: MGI:3832249
Age: embryonic day 14.0
Image: S7
Specimen Label: E14 wt i
Detected: true
Specimen Num: 9
GXD Expression    
Probe: MGI:3831770
Assay Type: RT-PCR
Annotation Date: 2009-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3832249
Age: postnatal adult
Image: S7
Specimen Label: Adult +/+ j
Detected: true
Specimen Num: 10
GXD Expression    
Probe: MGI:3831770
Assay Type: RT-PCR
Annotation Date: 2009-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3832249
Age: postnatal adult
Image: S7
Specimen Label: Adult +/+ k
Detected: true
Specimen Num: 11
GXD Expression    
Probe: MGI:3831770
Assay Type: RT-PCR
Annotation Date: 2009-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3832249
Age: postnatal
Image: S7
Specimen Label: MBNL1 +/- l
Detected: true
Specimen Num: 12
GXD Expression    
Probe: MGI:3831770
Assay Type: RT-PCR
Annotation Date: 2009-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3832249
Age: postnatal
Image: S7
Specimen Label: MBNL1 +/- m
Detected: true
Specimen Num: 13
GXD Expression    
Probe: MGI:3831770
Assay Type: RT-PCR
Annotation Date: 2009-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3832249
Age: postnatal
Image: S7
Specimen Label: delta3/delta3 n
Detected: true
Specimen Num: 14
GXD Expression    
Probe: MGI:3831770
Assay Type: RT-PCR
Annotation Date: 2009-02-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:3832249
Age: postnatal
Image: S7
Specimen Label: delta3/delta3 o
Detected: true
Specimen Num: 15
GXD Expression      
Probe: MGI:5309550
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3516422
Stage: TS22
Assay Id: MGI:5422918
Age: embryonic day 14.5
Specimen Label: MH3356; Specimen C4404
Detected: false
Specimen Num: 1
GXD Expression      
Probe: MGI:5309550
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1716122
Stage: TS22
Assay Id: MGI:5422918
Age: embryonic day 14.5
Specimen Label: MH3356; Specimen C4404
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:5309550
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1691622
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422918
Age: embryonic day 14.5
Image: MH3356; Specimen C4404
Specimen Label: MH3356; Specimen C4404
Detected: true
Specimen Num: 1
GXD Expression      
Probe: MGI:5309550
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1760622
Stage: TS22
Assay Id: MGI:5422918
Age: embryonic day 14.5
Specimen Label: MH3356; Specimen C4404
Detected: false
Specimen Num: 1
GXD Expression  
Probe: MGI:5309550
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1737322
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422918
Age: embryonic day 14.5
Image: MH3356; Specimen C4404
Specimen Label: MH3356; Specimen C4404
Detected: true
Specimen Num: 1
GXD Expression    
Probe: MGI:5910444
Assay Type: RNA in situ
Annotation Date: 2017-09-27
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737326
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5910455
Age: embryonic day 18.5
Specimen Label: not shown
Detected: true
Specimen Num: 11
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691000
Age: postnatal adult
Image: UC Davis_1870269
Note: kidney
Specimen Label: UC Davis_1870269
Detected: true
Specimen Num: 9
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691000
Age: postnatal adult
Image: UC Davis_1870270
Note: kidney
Specimen Label: UC Davis_1870270
Detected: true
Specimen Num: 10
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691000
Age: postnatal adult
Image: UC Davis_1870301
Note: kidney
Specimen Label: UC Davis_1870301
Detected: true
Specimen Num: 36
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691000
Age: postnatal adult
Image: UC Davis_1870302
Note: kidney
Specimen Label: UC Davis_1870302
Detected: true
Specimen Num: 37
GXD Expression  
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1737328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6691000
Age: postnatal adult
Image: UC Davis_1870303
Note: kidney
Specimen Label: UC Davis_1870303
Detected: true
Specimen Num: 38