This entry includes MISP/MISP3 from animals. MISP is an actin-binding protein that functions in spindle orientation probably by linking the astral microtubules (MTs) to the actin cytoskeleton [, ]. It has been shown to regulate IQGAP1 and Cdc42 to ensure proper mitotic progression and correct spindle orientation []. The function of MISP3 is not clear.