Spp1 is a component of the COMPASS (Set1C) complex []. It promotes meiotic DNA double-strand break formation in promoters by tethering histone H3K4 methylation sites to chromosome axes []. This entry also includes CXXC-type zinc finger protein 1 (also known as CFP1) from animals [].CXXC-type zinc finger protein 1 (CXXC1 or CFP1) is a component of the SETD1 histone H3K4 methyltransferase complex. CXXC1 directs the complex to a chromatin region via its CXXC zinc finger with a specificity for a CpG unmethylated motif, particularly CpGG [, ].The COMPASS (Complex Proteins Associated with Set1 or Set1C) is the yeast homologue of the human MLL complex, which is required for mono-, di-, and trimethylation of lysine 4 of histone H3 []. It is required in telomeric transcriptional silencing []. The complex consists of Set1, Bre2, Spp1, Sdc1, Shg1, Swd1, Swd2, and Swd3 [, ].
