Type |
Details |
Score |
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
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Title: |
GemPharmatech Website. |
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Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
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Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
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Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
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Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
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Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
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Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
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Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
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•
•
•
•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
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Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
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•
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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•
•
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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•
•
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•
•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
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•
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HT Experiment |
Series Id: |
GSE25615 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
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•
•
•
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Publication |
First Author: |
Yamada S |
Year: |
1997 |
Journal: |
Mamm Genome |
Title: |
Linkage mapping of rat Rb1 gene on chromosome 15. |
Volume: |
8 |
Issue: |
6 |
Pages: |
454-5 |
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•
•
•
•
•
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Publication |
First Author: |
Verma RS |
Year: |
1996 |
Journal: |
Mamm Genome |
Title: |
Mapping the homolog of the human Rb1 gene to chromosome 14 of higher primates. |
Volume: |
7 |
Issue: |
8 |
Pages: |
591-2 |
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•
•
•
•
|
Publication |
First Author: |
Li Y |
Year: |
2022 |
Journal: |
Cell Death Dis |
Title: |
Mice with Trp53 and Rb1 deficiency in chondrocytes spontaneously develop chondrosarcoma via overactivation of YAP signaling. |
Volume: |
13 |
Issue: |
6 |
Pages: |
570 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kang DW |
Year: |
2017 |
Journal: |
Cancer Res |
Title: |
Phospholipase D1 Acts through Akt/TopBP1 and RB1 to Regulate the E2F1-Dependent Apoptotic Program in Cancer Cells. |
Volume: |
77 |
Issue: |
1 |
Pages: |
142-152 |
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•
•
•
•
•
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Publication |
First Author: |
Moreno-Navarrete JM |
Year: |
2013 |
Journal: |
Diabetes |
Title: |
Decreased RB1 mRNA, protein, and activity reflect obesity-induced altered adipogenic capacity in human adipose tissue. |
Volume: |
62 |
Issue: |
6 |
Pages: |
1923-31 |
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•
•
•
•
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Publication |
First Author: |
Bian M |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Combination of ginsenoside Rb1 and Rd protects the retina against bright light-induced degeneration. |
Volume: |
7 |
Issue: |
1 |
Pages: |
6015 |
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•
•
•
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•
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Publication |
First Author: |
Chen J |
Year: |
2022 |
Journal: |
FASEB J |
Title: |
VNN1 contributes to the acute kidney injury-chronic kidney disease transition by promoting cellular senescence via affecting RB1 expression. |
Volume: |
36 |
Issue: |
9 |
Pages: |
e22472 |
|
•
•
•
•
•
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Publication |
First Author: |
Li Y |
Year: |
2022 |
Journal: |
Cells |
Title: |
Verteporfin Inhibits the Progression of Spontaneous Osteosarcoma Caused by Trp53 and Rb1 Deficiency in Ctsk-Expressing Cells via Impeding Hippo Pathway. |
Volume: |
11 |
Issue: |
8 |
|
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•
•
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•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Male |
Age: |
embryonic day 14.5 |
Stage: |
22 |
Structure . Name: |
germ cell of testis |
Notes: |
control; genotype either Rb1 fl/+ or Rb1 +/+ |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Male |
Age: |
embryonic day 14.5 |
Stage: |
22 |
Structure . Name: |
germ cell of testis |
Notes: |
control; genotype either Rb1 fl/+ or Rb1 +/+ |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Male |
Age: |
embryonic day 14.5 |
Stage: |
22 |
Structure . Name: |
germ cell of testis |
Notes: |
control; genotype either Rb1 fl/+ or Rb1 +/+ |
Curation Status: |
Curated |
|
•
•
•
•
•
|
Publication |
First Author: |
Witte MM |
Year: |
1997 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The proliferation potential protein-related (P2P-R) gene with domains encoding heterogeneous nuclear ribonucleoprotein association and Rb1 binding shows repressed expression during terminal differentiation. |
Volume: |
94 |
Issue: |
4 |
Pages: |
1212-7 |
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•
•
•
•
•
|
Interaction Experiment |
Description: |
Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin. |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE9144 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Publication |
First Author: |
Gonzalo S |
Year: |
2005 |
Journal: |
Nat Cell Biol |
Title: |
Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin. |
Volume: |
7 |
Issue: |
4 |
Pages: |
420-8 |
|
•
•
•
•
•
|
Allele |
Name: |
RB transcriptional corepressor 1; targeted mutation 2, Hein te Riele |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
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•
•
•
•
•
|
Publication |
First Author: |
Ghosh S |
Year: |
2010 |
Journal: |
Mol Cancer |
Title: |
LIMD1 is more frequently altered than RB1 in head and neck squamous cell carcinoma: clinical and prognostic implications. |
Volume: |
9 |
|
Pages: |
58 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang G |
Year: |
2022 |
Journal: |
J Ginseng Res |
Title: |
Antidepressant-like effect of ginsenoside Rb1 on potentiating synaptic plasticity via the miR-134-mediated BDNF signaling pathway in a mouse model of chronic stress-induced depression. |
Volume: |
46 |
Issue: |
3 |
Pages: |
376-386 |
|
•
•
•
•
•
|
Allele |
Name: |
RB transcriptional corepressor 1; targeted mutation 1, Tyler Jacks |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
RB transcriptional corepressor 1; targeted mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change |
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•
•
•
•
•
|
Allele |
Name: |
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1; targeted mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change |
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•
•
•
•
•
|
Publication |
First Author: |
Ewald D |
Year: |
1996 |
Journal: |
Science |
Title: |
Time-sensitive reversal of hyperplasia in transgenic mice expressing SV40 T antigen. |
Volume: |
273 |
Issue: |
5280 |
Pages: |
1384-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Windle JJ |
Year: |
1990 |
Journal: |
Nature |
Title: |
Retinoblastoma in transgenic mice. |
Volume: |
343 |
Issue: |
6259 |
Pages: |
665-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Piña Y |
Year: |
2012 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
Retinoblastoma treatment: utilization of the glycolytic inhibitor, 2-deoxy-2-fluoro-D-glucose (2-FG), to target the chemoresistant hypoxic regions in LH(BETA)T(AG) retinal tumors. |
Volume: |
53 |
Issue: |
2 |
Pages: |
996-1002 |
|
•
•
•
•
•
|
Publication |
First Author: |
Landreville S |
Year: |
2010 |
Journal: |
Curr Eye Res |
Title: |
Loss of Id2 potentiates the tumorigenic effect of Rb inactivation in a mouse model of retinoblastoma. |
Volume: |
35 |
Issue: |
5 |
Pages: |
435-9 |
|
•
•
•
•
•
|
Transgene |
Type: |
transgene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Held WA |
Year: |
1994 |
Journal: |
Cancer Res |
Title: |
Genetic analysis of liver tumorigenesis in SV40 T antigen transgenic mice implies a role for imprinted genes. |
Volume: |
54 |
Issue: |
24 |
Pages: |
6489-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Beermann F |
Year: |
1999 |
Journal: |
Pigment Cell Res |
Title: |
Transgenic mouse models for tumors of melanocytes and retinal pigment epithelium. |
Volume: |
12 |
Issue: |
2 |
Pages: |
71-80 |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE25732 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, targeted mutation, mutant strain |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant strain, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
congenic, mutant strain, targeted mutation |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rb1/Rb1 |
Background: |
involves: 129S2/SvPas * C57BL/6 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rb1/Rb1<+> |
Background: |
involves: 129S2/SvPas * C57BL/6 |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rb1/Rb1 |
Background: |
involves: 129S2/SvPas |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rb1/Rb1<+> |
Background: |
involves: 129S2/SvPas * C57BL/6J |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rb1/Rb1<+> |
Background: |
involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rb1/Rb1 |
Background: |
involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rb1/Rb1<+> |
Background: |
involves: 129S2/SvPas |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rb1/Rb1<+> Tg(S100b-v-erbB)4496Waw/? |
Background: |
involves: 129S2/SvPas * C57BL/6J * DBA/2J * FVB/N |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rb1/Rb1<+> Trim27/Trim27 |
Background: |
involves: 129P2/OlaHsd * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rb1/Rb1 Trim27/Trim27 |
Background: |
involves: 129P2/OlaHsd * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Allele |
Name: |
RB transcriptional corepressor 1; targeted mutation 2, Anton Berns |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rb1/Rb1<+> Trp53/Trp53<+> |
Background: |
involves: 129S2/SvPas * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rb1/Rb1 Trp53/Trp53 |
Background: |
involves: 129S2/SvPas |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
E2f4/E2f4 Rb1/Rb1<+> |
Background: |
involves: 129S2/SvPas * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
E2f4/E2f4<+> Rb1/Rb1<+> |
Background: |
involves: 129S2/SvPas * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rb1/Rb1 |
Background: |
involves: 129/Sv * 129S2/SvPas * C57BL/6 |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Men1/Men1<+> Rb1/Rb1<+> |
Background: |
involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J * FVB/N |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
E2f1/E2f1 Rb1/Rb1 |
Background: |
either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6) |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
E2f1/E2f1<+> Rb1/Rb1 |
Background: |
either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6) |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
E2f1/E2f1<+> Rb1/Rb1<+> |
Background: |
either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6) |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
E2f1/E2f1 Rb1/Rb1<+> |
Background: |
either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6) |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Kdm5a/Kdm5a<+> Rb1/Rb1<+> |
Background: |
involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Kdm5a/Kdm5a<+> Rb1/Rb1 |
Background: |
involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Kdm5a/Kdm5a Rb1/Rb1<+> |
Background: |
involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Kdm5a/Kdm5a Rb1/Rb1 |
Background: |
involves: 129S2/SvPas * 129S6/SvEvTac * FVB/N |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Rb1/Rb1<+> Smarca4/Smarca4<+> |
Background: |
involves: 129S/Sv * 129S2/SvPas * C57BL/6J * CD-1 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Cdkn2a/Cdkn2a Rb1/Rb1 |
Background: |
involves: 129S2/SvPas * 129X1/SvJ |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Nras/Nras<+> Rb1/Rb1<+> |
Background: |
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Nras/Nras Rb1/Rb1<+> |
Background: |
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
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•
•
•
•
•
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Genotype |
Symbol: |
Nras/Nras<+> Rb1/Rb1 |
Background: |
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
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•
•
•
•
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Genotype |
Symbol: |
Nras/Nras Rb1/Rb1 |
Background: |
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
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•
•
•
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•
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Genotype |
Symbol: |
E2f4/E2f4 Rb1/Rb1 |
Background: |
involves: 129S2/SvPas * C57BL/6 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
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Allele |
Name: |
RB transcriptional corepressor 1; targeted mutation 2, Tyler Jacks |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
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•
•
•
•
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Strain |
Attribute String: |
coisogenic, mutant strain, targeted mutation |
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Allele |
Name: |
RB transcriptional corepressor 1; targeted mutation 1, Martin L Hooper |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
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•
•
•
•
•
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Allele |
Name: |
RB transcriptional corepressor 1; targeted mutation 2, Martin L Hooper |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
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•
•
•
•
•
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Strain |
Attribute String: |
coisogenic, mutant strain, targeted mutation |
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Allele |
Name: |
transgene insertion X, Naoyuki Miura |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
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Allele |
Name: |
transgene insertion 66, Terry van Dyke |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
356
|
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
375
|
Fragment?: |
false |
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•
•
•
•
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Publication |
First Author: |
Xia C |
Year: |
2000 |
Journal: |
J Biol Chem |
Title: |
GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity. |
Volume: |
275 |
Issue: |
27 |
Pages: |
20942-8 |
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•
•
•
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•
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Publication |
First Author: |
Ma W |
Year: |
2007 |
Journal: |
J Cell Biochem |
Title: |
GCIP/CCNDBP1, a helix-loop-helix protein, suppresses tumorigenesis. |
Volume: |
100 |
Issue: |
6 |
Pages: |
1376-86 |
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•
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Protein Domain |
Type: |
Family |
Description: |
Cyclin-D1-binding protein 1 (CCNDBP1, also known as GCIP) is a helix-loop-helix protein that may negatively regulate cell cycle progression and could function in tumour suppression []. It may act, at least in part, via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription [, ]. |
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