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Search results 101 to 135 out of 135 for Mms19

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Type Details Score
UniProt Feature
UniProt Feature
Begin: 2
Description: MMS19 nucleotide excision repair protein homolog
Type: chain
End: 1031
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Publication
8943333 | -
First Author: Lauder S
Year: 1996
Journal: Mol Cell Biol
Title: Dual requirement for the yeast MMS19 gene in DNA repair and RNA polymerase II transcription.
Volume: 16
Issue: 12
Pages: 6783-93
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Allele
Mms19<+> | MGI:2440739
   
Name: MMS19 cytosolic iron-sulfur assembly component; wild type
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Publication
22678362 | -
First Author: Stehling O
Year: 2012
Journal: Science
Title: MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity.
Volume: 337
Issue: 6091
Pages: 195-9
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Protein
Q9D071-3
Organism: Mus musculus/domesticus
Length: 988  
Fragment?: false
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Protein
Q9D071-2
Organism: Mus musculus/domesticus
Length: 889  
Fragment?: false
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Protein
E9PUY8
Organism: Mus musculus/domesticus
Length: 75  
Fragment?: false
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Allele
Mms19<Gt(XL529)Byg> | MGI:4128529
 
Name: MMS19 cytosolic iron-sulfur assembly component; gene trap XL529, BayGenomics
Allele Type: Gene trapped
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Allele
Mms19<Gt(XC411)Byg> | MGI:4125072
 
Name: MMS19 cytosolic iron-sulfur assembly component; gene trap XC411, BayGenomics
Allele Type: Gene trapped
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Allele
Mms19<Gt(YTC112)Byg> | MGI:3883847
 
Name: MMS19 cytosolic iron-sulfur assembly component; gene trap YTC112, BayGenomics
Allele Type: Gene trapped
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Allele
Mms19<Gt(CSI125)Byg> | MGI:3879296
 
Name: MMS19 cytosolic iron-sulfur assembly component; gene trap CSI125, BayGenomics
Allele Type: Gene trapped
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Publication
23585563 | -
First Author: Seki M
Year: 2013
Journal: J Biol Chem
Title: IOP1 protein is an external component of the human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in the MMS19 protein-dependent CIA pathway.
Volume: 288
Issue: 23
Pages: 16680-9
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Allele
Mms19<em1Gpt> | MGI:7302381
Name: MMS19 cytosolic iron-sulfur assembly component; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Mms19<tm2a(KOMP)Wtsi> | MGI:4419728
Name: MMS19 cytosolic iron-sulfur assembly component; targeted mutation 2a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Mms19<tm2e(KOMP)Wtsi> | MGI:4419690
Name: MMS19 cytosolic iron-sulfur assembly component; targeted mutation 2e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Mms19<em8Gpt> | MGI:7302382
Name: MMS19 cytosolic iron-sulfur assembly component; endonuclease-mediated mutation 8, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Mms19<Gt(DA0041)Wtsi> | MGI:3869797
 
Name: MMS19 cytosolic iron-sulfur assembly component; gene trap DA0041, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
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Allele
Mms19<Gt(A048A06)Wrst> | MGI:4335711
 
Name: MMS19 cytosolic iron-sulfur assembly component; gene trap A048A06, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Mms19<Gt(GC0384)Mist> | MGI:3853941
 
Name: MMS19 cytosolic iron-sulfur assembly component; gene trap GC0384, Telethon Institute of Genetics and Medicine
Allele Type: Gene trapped
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Allele
Mms19<Gt(F032E02)Wrst> | MGI:4123101
 
Name: MMS19 cytosolic iron-sulfur assembly component; gene trap F032E02, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Mms19<tm1e(KOMP)Wtsi> | MGI:4363935
Name: MMS19 cytosolic iron-sulfur assembly component; targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Strain
MGI:6768482 | C57BL/6JGpt-Mms19<em1Gpt>/Gpt
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:6768481 | C57BL/6JGpt-Mms19<em8Gpt>/Gpt
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Publication
21725325 | -
First Author: Li F
Year: 2011
Journal: Nature
Title: Coordination of DNA replication and histone modification by the Rik1-Dos2 complex.
Volume: 475
Issue: 7355
Pages: 244-8
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Publication
32632277 | -
First Author: Kassube SA
Year: 2020
Journal: Nat Struct Mol Biol
Title: Structural insights into Fe-S protein biogenesis by the CIA targeting complex.
Volume: 27
Issue: 8
Pages: 735-742
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Protein Domain
IPR024687 | MMS19_C
Type: Domain
Description: This entry represents the C-terminal domain of MMS19. This domain shares homology with some HEAT repeat sequences. MMS19 is a key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity [, , ]. In humans, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription [, ]. It is also part of the MMXD (MMS19-MIP18-XPD) complex, which plays a role in chromosome segregation,probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD [].In budding yeasts, the mms19 mutants were originally isolated in a screening for mutants hypersensitive to the alkylating agent methyl methanesulfonate (MMS) []. Different from human MMS19, Mms19 in budding yeasts (also known as Met18) does not participate directly in NER []. In fission yeast, Mms19 is part of a silencing complex named Rik1-Dos2 complex, which contains Dos2, Rik1, Mms19 and Cdc20. This complex regulates RNA Pol II activity in heterochromatin, and is required for DNA replication and heterochromatin assembly [].
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Protein Domain
IPR029240 | MMS19_N
Type: Domain
Description: This entry represents the N-terminal domain of MMS19. MMS19 is a key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity [, ]. In humans, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription [, ]. It is also part of the MMXD (MMS19-MIP18-XPD) complex, which plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD [].In budding yeasts, the mms19 mutants were originally isolated in a screening for mutants hypersensitive to the alkylating agent methyl methanesulfonate (MMS) []. Different from human MMS19, Mms19 in budding yeasts (also known as Met18) does not participate directly in NER []. In fission yeast, Mms19 is part of a silencing complex named Rik1-Dos2 complex, which contains Dos2, Rik1, Mms19 and Cdc20. This complex regulates RNA Pol II activity in heterochromatin, and is required for DNA replication and heterochromatin assembly [].
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Protein Domain
IPR039920 | MET18/MMS19
Type: Family
Description: This entry includes proteins with an MMS19, N-terminal domain. Most homologues also contain an MMS19, C-terminal domain.MMS19 is a key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity [, ]. In humans, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair (NER) and RNA polymerase II (POL II) transcription [, ]. It is also part of the MMXD (MMS19-MIP18-XPD) complex, which plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD [].In budding yeasts, the mms19 mutants were originally isolated in a screening for mutants hypersensitive to the alkylating agent methyl methanesulfonate (MMS) []. Different from human MMS19, Mms19 in budding yeasts (also known as Met18) does not participate directly in NER []. In fission yeast, Mms19 is part of a silencing complex named Rik1-Dos2 complex, which contains Dos2, Rik1, Mms19 and Cdc20. This complex regulates RNA Pol II activity in heterochromatin, and is required for DNA replication and heterochromatin assembly [].
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Publication
20797633 | -
First Author: Ito S
Year: 2010
Journal: Mol Cell
Title: MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation.
Volume: 39
Issue: 4
Pages: 632-40
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Publication
9676426 | J:48686
First Author: Bois P
Year: 1998
Journal: Genomics
Title: Isolation and characterization of mouse minisatellites.
Volume: 50
Issue: 3
Pages: 317-30
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Publication
- | J:94790
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Mouse Synonym Curation
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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Publication
19468303 | -
First Author: Church DM
Year: 2009
Journal: PLoS Biol
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
Volume: 7
Issue: 5
Pages: e1000112
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