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Search results 501 to 574 out of 574 for Krit1

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Type Details Score
Publication
32502201 | J:290715
First Author: Li J
Year: 2020
Journal: PLoS Biol
Title: Targeting miR-27a/VE-cadherin interactions rescues cerebral cavernous malformations in mice.
Volume: 18
Issue: 6
Pages: e3000734
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20940147 | J:166925
First Author: McDonald DA
Year: 2011
Journal: Hum Mol Genet
Title: A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease.
Volume: 20
Issue: 2
Pages: 211-22
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Publication
20332120 | J:170050
First Author: Lampugnani MG
Year: 2010
Journal: J Cell Sci
Title: CCM1 regulates vascular-lumen organization by inducing endothelial polarity.
Volume: 123
Issue: Pt 7
Pages: 1073-80
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Publication
26612856 | J:229602
First Author: Cuttano R
Year: 2016
Journal: EMBO Mol Med
Title: KLF4 is a key determinant in the development and progression of cerebral cavernous malformations.
Volume: 8
Issue: 1
Pages: 6-24
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Publication
21859843 | J:177584
First Author: Boulday G
Year: 2011
Journal: J Exp Med
Title: Developmental timing of CCM2 loss influences cerebral cavernous malformations in mice.
Volume: 208
Issue: 9
Pages: 1835-47
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Publication
14500367 | J:95538
First Author: O'Hagan RC
Year: 2003
Journal: Cancer Res
Title: Array comparative genome hybridization for tumor classification and gene discovery in mouse models of malignant melanoma.
Volume: 63
Issue: 17
Pages: 5352-6
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Publication
31776290 | J:283508
 
First Author: Tang AT
Year: 2019
Journal: Sci Transl Med
Title: Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation.
Volume: 11
Issue: 520
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Publication
27027284 | J:232707
First Author: Zhou Z
Year: 2016
Journal: Nature
Title: Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling.
Volume: 532
Issue: 7597
Pages: 122-6
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Publication
28489816 | J:252526
First Author: Tang AT
Year: 2017
Journal: Nature
Title: Endothelial TLR4 and the microbiome drive cerebral cavernous malformations.
Volume: 545
Issue: 7654
Pages: 305-310
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Publication
25625206 | J:238897
First Author: Zhou Z
Year: 2015
Journal: Dev Cell
Title: The cerebral cavernous malformation pathway controls cardiac development via regulation of endocardial MEKK3 signaling and KLF expression.
Volume: 32
Issue: 2
Pages: 168-80
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Publication
21490399 | J:173947
First Author: Chan AC
Year: 2011
Journal: J Clin Invest
Title: Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice.
Volume: 121
Issue: 5
Pages: 1871-81
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Publication
34156031 | J:324862
 
First Author: Wang R
Year: 2021
Journal: JCI Insight
Title: Pdcd10-Stk24/25 complex controls kidney water reabsorption by regulating Aqp2 membrane targeting.
Volume: 6
Issue: 12
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26061019 | J:265042
First Author: Han R
Year: 2015
Journal: Organogenesis
Title: Endothelial Erg expression is required for embryogenesis and vascular integrity.
Volume: 11
Issue: 2
Pages: 75-86
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Publication
23918940 | J:201629
First Author: Faurobert E
Year: 2013
Journal: J Cell Biol
Title: CCM1-ICAP-1 complex controls β1 integrin-dependent endothelial contractility and fibronectin remodeling.
Volume: 202
Issue: 3
Pages: 545-61
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Publication
22898778 | J:187714
First Author: Zheng X
Year: 2012
Journal: Dev Cell
Title: Dynamic regulation of the cerebral cavernous malformation pathway controls vascular stability and growth.
Volume: 23
Issue: 2
Pages: 342-55
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Publication
20371769 | J:171969
First Author: He Y
Year: 2010
Journal: Sci Signal
Title: Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development.
Volume: 3
Issue: 116
Pages: ra26
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Publication
27306493 | J:253786
 
First Author: Hu X
Year: 2016
Journal: Sci Rep
Title: Phosphoinositide 3-Kinase (PI3K) Subunit p110δ Is Essential for Trophoblast Cell Differentiation and Placental Development in Mouse.
Volume: 6
Pages: 28201
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19723774 | J:155773
First Author: Tkatchenko TV
Year: 2009
Journal: Physiol Genomics
Title: Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease.
Volume: 39
Issue: 3
Pages: 160-8
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27626380 | J:236599
First Author: Dickinson ME
Year: 2016
Journal: Nature
Title: High-throughput discovery of novel developmental phenotypes.
Volume: 537
Issue: 7621
Pages: 508-514
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Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
23317506 | -
First Author: Liu W
Year: 2013
Journal: Mol Cell
Title: Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation.
Volume: 49
Issue: 4
Pages: 719-29
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DO Term
DOID:0080491 | cerebral cavernous malformation 1
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Publication
12172908 | -
First Author: Kehrer-Sawatzki H
Year: 2002
Journal: Acta Neuropathol
Title: Mutation and expression analysis of the KRIT1 gene associated with cerebral cavernous malformations (CCM1).
Volume: 104
Issue: 3
Pages: 231-40
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Protein Domain
IPR032022 | NUDIX
Type: Domain
Description: This domain is found in higher eukaryotes at the N terminus of KRIT1 or Krev interaction trapped proteins. KRIT1 is a 736 amino acid protein that contains three regions, an N-terminal NPxY motif-rich region, an ankyrin repeat domain (ARD) and a band four-point-one, ezrin, radixin, moesin (FERM) domain. The N-terminal region of KRIT1 contains three NPxY-like motifs and can bind ICAP1 (integrin cytoplasmic-associated protein 1 (ICAP1). In the absence of KRIT1, ICAP1 binds via its C-terminal PH/PTB fold domain to the integrin beta-1 cytoplasmic tail. Binding of KRIT1 to ICAP1 via this domain out-competes the binding of ICAP1 to integrin cytoplasmic tails such that ICAP1 is sequestered in the nucleus. Integrin activation is thus prevented. KRIT1 does not include the canonical "Nudix box"motif or other Nudix motifs but does, however, very clearly adopt a Nudix fold with a central β-sheet flanked by two α-helices [].
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Protein Domain
IPR043058 | NUDIX_sf
Type: Homologous_superfamily
Description: This domain is found in higher eukaryotes at the N terminus of KRIT1 or Krev interaction trapped proteins. KRIT1 is a 736 amino acid protein that contains three regions, an N-terminal NPxY motif-rich region, an ankyrin repeat domain (ARD) and a band four-point-one, ezrin, radixin, moesin (FERM) domain. The N-terminal region of KRIT1 contains three NPxY-like motifs and can bind ICAP1 (integrin cytoplasmic-associated protein 1 (ICAP1). In the absence of KRIT1, ICAP1 binds via its C-terminal PH/PTB fold domain to the integrin beta-1 cytoplasmic tail. Binding of KRIT1 to ICAP1 via this domain out-competes the binding of ICAP1 to integrin cytoplasmic tails such that ICAP1 is sequestered in the nucleus. Integrin activation is thus prevented. KRIT1 does not include the canonical "Nudix box"motif or other Nudix motifs but does, however, very clearly adopt a Nudix fold with a central β-sheet flanked by two α-helices [].
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Protein
A0A0G2JE71
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: true
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Publication
17954608 | -
First Author: Glading A
Year: 2007
Journal: J Cell Biol
Title: KRIT-1/CCM1 is a Rap1 effector that regulates endothelial cell cell junctions.
Volume: 179
Issue: 2
Pages: 247-54
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Publication
22577140 | -
First Author: Li X
Year: 2012
Journal: J Biol Chem
Title: Structural basis for small G protein effector interaction of Ras-related protein 1 (Rap1) and adaptor protein Krev interaction trapped 1 (KRIT1).
Volume: 287
Issue: 26
Pages: 22317-27
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Protein Domain
IPR041791 | KRIT1_FERM_C
Type: Domain
Description: KRIT1, also known as CCM1, a Rap1-binding protein, is expressed in endothelial cells where it is present in cell-cell junctions and associated with junctional proteins []. Together with CCM2/MGC4607 and CCM3/PDCD10, KRIT1 constitutes a set of proteins, mutations of which are found in cerebral cavernous malformations which are characterized by cerebral hemorrhages and vascular malformations in the central nervous system. KRIT-1 possesses four ankyrin repeats, a FERM domain, and multiple NPXY sequences, one of which is essential for integrin cytoplasmic domain-associated protein-1alpha (ICAP1alpha) binding and all of which mediate binding of CCM2. KRIT-1 localization is mediated by its FERM domain [].The FERM domain has a cloverleaf tripart structure composed of: (1) FERM_N (A-lobe or F1); (2) FERM_M (B-lobe, or F2); and (3) FERM_C (C-lobe or F3). The C-lobe/F3 within the FERM domain is part of the PH domain family. Like most other ERM members they have a phosphoinositide-binding site in their FERM domain. The FERM C domain is the third structural domain within the FERM domain. The FERM domain is found in the cytoskeletal-associated proteins such as ezrin, moesin, radixin, 4.1R, and merlin. These proteins provide a link between the membrane and cytoskeleton and are involved in signal transduction pathways. The FERM domain is also found in protein tyrosine phosphatases (PTPs) , the tyrosine kinases FAK and JAK, in addition to other proteins involved in signaling. This domain is structurally similar to the PH and PTB domains and consequently is capable of binding to both peptides and phospholipids at different sites [, ].
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Publication
37019926 | J:334827
First Author: Grdseloff N
Year: 2023
Journal: Sci Rep
Title: Impaired retinoic acid signaling in cerebral cavernous malformations.
Volume: 13
Issue: 1
Pages: 5572
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Publication
27548575 | J:240446
First Author: Jenny Zhou H
Year: 2016
Journal: Nat Med
Title: Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation.
Volume: 22
Issue: 9
Pages: 1033-1042
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Publication
25122144 | J:320210
First Author: Shenkar R
Year: 2015
Journal: Genet Med
Title: Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations.
Volume: 17
Issue: 3
Pages: 188-196
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Protein
Q6S5J6
Organism: Mus musculus/domesticus
Length: 736  
Fragment?: false
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Protein
B2RUA8
Organism: Mus musculus/domesticus
Length: 736  
Fragment?: false
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Publication
26417067 | J:229615
First Author: Marchi S
Year: 2015
Journal: EMBO Mol Med
Title: Defective autophagy is a key feature of cerebral cavernous malformations.
Volume: 7
Issue: 11
Pages: 1403-17
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Protein
A0A0G2JGG7
Organism: Mus musculus/domesticus
Length: 647  
Fragment?: false
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Publication
16582480 | J:222683
First Author: Kitano K
Year: 2006
Journal: Acta Crystallogr Sect F Struct Biol Cryst Commun
Title: Structure of dimerized radixin FERM domain suggests a novel masking motif in C-terminal residues 295-304.
Volume: 62
Issue: Pt 4
Pages: 340-5
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Publication
19596566 | -
First Author: Tepass U
Year: 2009
Journal: Curr Opin Genet Dev
Title: FERM proteins in animal morphogenesis.
Volume: 19
Issue: 4
Pages: 357-67
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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