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Search results 1801 to 1816 out of 1816 for Cdk7

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0.017s

Type

Details

Score

Publication

11447116 | -

First Author:	Larochelle S
Year:	2001
Journal:	EMBO J
Title:	T-loop phosphorylation stabilizes the CDK7-cyclin H-MAT1 complex in vivo and regulates its CTD kinase activity.
Volume:	20
Issue:	14
Pages:	3749-59

•

Publication

25490443 | J:217686

First Author:	Augert A
Year:	2014
Journal:	Cancer Cell
Title:	Treating transcriptional addiction in small cell lung cancer.
Volume:	26
Issue:	6
Pages:	783-784

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Protein Domain

IPR004575 | MAT1/Tfb3

Type:

Family

Description:

MAT1/Tfb3 acts as component of the general transcription and DNA repair factor IIH (TFIIH), which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA []. It is a RING finger protein with a characteristic C3HC4 motif located in the N-terminal domain. MAT1/Tfb3 stabilises the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex which then goes on to activate many of the CDK enzymes intimately involved in the cell cycle []. CDK7 forms a stable complex with cyclin H and MAT1/Tfb3 in vivo only when phosphorylated on either one of two residues (Ser164 or Thr170) in its T-loop. The requirement for MAT1/Tfb3 for the activation of CAK can be by-passed by the phosphorylation of CDK7 on the T-loop. The two mechanisms for CDK7 complex stabilisation and activation (MAT1 addition and T-loop phosphorylation), which can operate independently in vitro, actually cooperate under physiological conditions to maintain complex integrity. With prolonged exposure to elevated temperature, dissociation to monomeric subunits occurs in vivo when CDK7 is dephosphorylated, even in the presence of MAT1/Tfb3 [].

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Protein Domain

IPR015877 | Cdk-activating_kinase_MAT1_cen

Type:

Domain

Description:

MAT1 (menage a trois 1) is a RING finger protein with a characteristic C3HC4 motif located in the N-terminal domain. This entry represents the central region of MAT1. MAT1 stabilises the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex which then goes on to activate many of the CDK enzymes intimately involved in the cell cycle []. CDK7 forms a stable complex with cyclin H and MAT1 in vivo only when phosphorylated on either one of two residues (Ser164 or Thr170) in its T-loop. The requirement for MAT1 for the activation of CAK can be by-passed by the phosphorylation of CDK7 on the T-loop. The two mechanisms for CDK7 complex stabilisation and activation (MAT1 addition and T-loop phosphorylation), which can operate independently in vitro, actually cooperate under physiological conditions to maintain complex integrity. With prolonged exposure to elevated temperature, dissociation to monomeric subunits occurs in vivo when CDK7 is dephosphorylated, even in the presence of MAT1 []. The Cyclin H-MAT1-CDK7 complex also forms part of TFIIH, a multiprotein complex required for both transcription and DNA repair.

•

Publication

9235928 | J:42043

First Author:	Feaver WJ
Year:	1997
Journal:	J Biol Chem
Title:	Genes for Tfb2, Tfb3, and Tfb4 subunits of yeast transcription/repair factor IIH. Homology to human cyclin-dependent kinase activating kinase and IIH subunits.
Volume:	272
Issue:	31
Pages:	19319-27

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HT Experiment

E-GEOD-6662 | Transcription profiling of mouse heart from cardiac-specific conditional knockout deletion of menage-a-trios-1 (MAT1)

Series Id:	GSE6662
Experiment Type:	transcription profiling by array
Study Type:	WT vs. Mutant
Source:	ArrayExpress

•

Publication

7553872 | J:29185

First Author:	Fisher RP
Year:	1995
Journal:	Cell
Title:	Alternative mechanisms of CAK assembly require an assembly factor or an activating kinase.
Volume:	83
Issue:	1
Pages:	47-57

•

Publication

20637660 | J:162548

First Author:	Farlik M
Year:	2010
Journal:	Immunity
Title:	Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression.
Volume:	33
Issue:	1
Pages:	25-34

•

Publication

37527040 | J:338904

First Author:	Yu M
Year:	2023
Journal:	Cell Rep
Title:	FRMD8 targets both CDK4 activation and RB degradation to suppress colon cancer growth.
Volume:	42
Issue:	8
Pages:	112886

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Protein

A0A087WSQ7

Organism:	Mus musculus/domesticus
Length:	93
Fragment?:	false

•

Publication

15988019 | J:99359

First Author:	Compe E
Year:	2005
Journal:	Mol Cell Biol
Title:	Dysregulation of the peroxisome proliferator-activated receptor target genes by XPD mutations.
Volume:	25
Issue:	14
Pages:	6065-76

•

Publication

18624753 | J:156227

First Author:	Mascareno E
Year:	2009
Journal:	J Cell Mol Med
Title:	Down-regulation of cardiac lineage protein (CLP-1) expression in CLP-1 +/- mice affords.
Volume:	13
Issue:	8B
Pages:	2744-53

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Protein

P51949

Organism:	Mus musculus/domesticus
Length:	309
Fragment?:	false

•

Protein

A0A087WSG5

Organism:	Mus musculus/domesticus
Length:	249
Fragment?:	false

•

Protein

A4FUR7

Organism:	Mus musculus/domesticus
Length:	299
Fragment?:	true

•

Publication

23784961 | J:213391

First Author:	Beigi F
Year:	2013
Journal:	Circ Res
Title:	C3orf58, a novel paracrine protein, stimulates cardiomyocyte cell-cycle progression through the PI3K-AKT-CDK7 pathway.
Volume:	113
Issue:	4
Pages:	372-80

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