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Search results 101 to 113 out of 113 for Frmd6

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0.019s

Type

Details

Score

Publication

- | J:155221

First Author:	Mouse Genome Informatics
Year:	2010
Journal:	Database Release
Title:	Protein Ontology Association Load.

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Publication

- | J:90438

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2005

Title:	Obtaining and loading genome assembly coordinates from NCBI annotations

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Publication

- | J:144086

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform

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Publication

- | J:144087

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2009
Journal:	Database Download
Title:	Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform

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Publication

- | J:262123

First Author:	Allen Institute for Brain Science
Year:	2004
Journal:	Allen Institute
Title:	Allen Brain Atlas: mouse riboprobes

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Publication

22190428 | -

First Author:	Hong MG
Year:	2012
Journal:	Hum Mutat
Title:	Genome-wide and gene-based association implicates FRMD6 in Alzheimer disease.
Volume:	33
Issue:	3
Pages:	521-9

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Publication

20159598 | -

First Author:	Yu J
Year:	2010
Journal:	Dev Cell
Title:	Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded.
Volume:	18
Issue:	2
Pages:	288-99

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Publication

21785462 | -

First Author:	Visser-Grieve S
Year:	2012
Journal:	Oncogene
Title:	Human homolog of Drosophila expanded, hEx, functions as a putative tumor suppressor in human cancer cell lines independently of the Hippo pathway.
Volume:	31
Issue:	9
Pages:	1189-95

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Protein Domain

IPR041781 | FRMD6-FERM_C

Type:

Domain

Description:

This entry represents the C-lobe of FERM domain found in FRMD6. The Drosophilla FRMD6 homologue, Ex, is a regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, which plays a pivotal role in organ size control and is tumour suppression by restricting proliferation and promoting apoptosis []. However, human FRMD6 is thought to function independently of the Hippo pathway. Instead it may inhibit progression through the S phase of the cell cycle by upregulating p21(Cip1) and downregulating Cyclin A []. It has been implicated in the progression of Alzheimer disease []. FRMD6 contains asingle FERM domain which has a cloverleaf tripart structure composed of: (1) FERM_N (A-lobe or F1); (2) FERM_M (B-lobe, or F2); and (3) FERM_C (C-lobe or F3). The C-lobe is a member of the PH domain superfamily. The FERM domain is found in the cytoskeletal-associated proteins such as ezrin, moesin, radixin, 4.1R, and merlin. These proteins provide a link between the membrane and cytoskeleton and are involved in signal transduction pathways. The FERM domain is also found in protein tyrosine phosphatases (PTPs) , the tyrosine kinases FAK and JAK, in addition to other proteins involved in signaling. This domain is structurally similar to the PH and PTB domains and consequently is capable of binding to both peptides and phospholipids at different sites [, ].

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Publication

32451369 | J:289356

First Author:	Park J
Year:	2020
Journal:	Mol Cells
Title:	WWC1 and NF2 Prevent the Development of Intrahepatic Cholangiocarcinoma by Regulating YAP/TAZ Activity through LATS in Mice.
Volume:	43
Issue:	5
Pages:	491-499

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Publication

16582480 | J:222683

First Author:	Kitano K
Year:	2006
Journal:	Acta Crystallogr Sect F Struct Biol Cryst Commun
Title:	Structure of dimerized radixin FERM domain suggests a novel masking motif in C-terminal residues 295-304.
Volume:	62
Issue:	Pt 4
Pages:	340-5

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Publication

19596566 | -

First Author:	Tepass U
Year:	2009
Journal:	Curr Opin Genet Dev
Title:	FERM proteins in animal morphogenesis.
Volume:	19
Issue:	4
Pages:	357-67

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Publication

15489334 | -

First Author:	Gerhard DS
Year:	2004
Journal:	Genome Res
Title:	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume:	14
Issue:	10B
Pages:	2121-7

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