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Search results 1 to 100 out of 248 for Ptk2b

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Hits by Pathway

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Hits by Category

Type Details Score
Gene
2185 | PTK2B
Type: gene
Organism: human
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Gene
464073 | PTK2B
Type: gene
Organism: chimpanzee
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Gene
486102 | PTK2B
Type: gene
Organism: dog, domestic
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Gene
541008 | PTK2B
Type: gene
Organism: cattle
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Gene
421998 | PTK2B
Type: gene
Organism: chicken
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Gene
712787 | PTK2B
Type: gene
Organism: macaque, rhesus
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Gene
496459 | ptk2b
Type: gene
Organism: frog, western clawed
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Gene
50646 | Ptk2b
Type: gene
Organism: rat
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Protein Domain
IPR030610 | PTK2B
Type: Family
Description: Protein-tyrosine kinase 2-beta (PTK2B), also known as focal adhesion kinase 2 (FAK2), proline-rich tyrosine kinase 2 (PYK2), related adhesion focal tyrosine kinase (RAFTK), or calcium-dependent tyrosine kinase (CADTK), is a non-receptor protein-tyrosine kinase that is structurally similar to FAK []. FAK and PYK2 may be involved in several overlapping signalling pathways [, ]. FAK is expressed ubiquitously, whereas PYK2 expression is restricted to the endothelium, central nervous system, and hematopoietic lineages. PYK2 contains a central tyrosine kinase domain flanked by an N-terminal FERM domain, which mediates the binding of PYK2 to multiple proteins, and a C-terminal focal adhesion targeting (FAT) domain []. PYK2 is sensitive to intracellular Ca+ signalling and G-protein-coupled receptors [, ].PYK2 plays a critical role in the migration of multiple cell lineages induced by growth factor, cytokine and integrin receptors. PYK2 alters the migratory ability of these cells by directly phosphorylating proteins that link focal adhesions to the actin cytoskeleton. It also recruits Src family kinases and other signalling proteins to focal adhesions, and directly alters actin cytoskeleton rearrangement via regulating the activity of Rac [, , ]. It has roles in T-cells [], macrophages [], bone formation [, , ],and vascular function [].
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Protein Coding Gene
MGI:104908 | Ptk2b
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
12960403 | J:99741
First Author: Okigaki M
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration.
Volume: 100
Issue: 19
Pages: 10740-5
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Publication
17846174 | J:134795
First Author: Gil-Henn H
Year: 2007
Journal: J Cell Biol
Title: Defective microtubule-dependent podosome organization in osteoclasts leads to increased bone density in Pyk2(-/-) mice.
Volume: 178
Issue: 6
Pages: 1053-64
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Publication
17537919 | J:122285
First Author: Buckbinder L
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Proline-rich tyrosine kinase 2 regulates osteoprogenitor cells and bone formation, and offers an anabolic treatment approach for osteoporosis.
Volume: 104
Issue: 25
Pages: 10619-24
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Publication
18391070 | J:134671
First Author: Weis SM
Year: 2008
Journal: J Cell Biol
Title: Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK.
Volume: 181
Issue: 1
Pages: 43-50
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Publication
17698736 | J:139849
First Author: Matsui A
Year: 2007
Journal: Circulation
Title: Central role of calcium-dependent tyrosine kinase PYK2 in endothelial nitric oxide synthase-mediated angiogenic response and vascular function.
Volume: 116
Issue: 9
Pages: 1041-51
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Publication
37989995 | J:342961
First Author: Lin Y
Year: 2023
Journal: Nat Commun
Title: PTK2B promotes TBK1 and STING oligomerization and enhances the STING-TBK1 signaling.
Volume: 14
Issue: 1
Pages: 7567
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Publication
29750960 | J:271421
First Author: Ni B
Year: 2018
Journal: Biochem Biophys Res Commun
Title: A novel role for PTK2B in cultured beige adipocyte differentiation.
Volume: 501
Issue: 4
Pages: 851-857
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Publication
24667605 | J:219473
First Author: Luo J
Year: 2014
Journal: Biochem Biophys Res Commun
Title: PTK2b function during fertilization of the mouse oocyte.
Volume: 450
Issue: 3
Pages: 1212-7
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Publication
32608523 | J:307509
First Author: Cong Y
Year: 2021
Journal: J Cell Physiol
Title: Ptk2b deletion improves mice folliculogenesis and fecundity via inhibiting follicle loss mediated by Erk pathway.
Volume: 236
Issue: 2
Pages: 1043-1053
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Protein
Q9QVP9
Organism: Mus musculus/domesticus
Length: 1009  
Fragment?: false
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Protein
F7CCX1
Organism: Mus musculus/domesticus
Length: 382  
Fragment?: true
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Protein
Q8C9L4
Organism: Mus musculus/domesticus
Length: 474  
Fragment?: false
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Protein
Q8C2G0
Organism: Mus musculus/domesticus
Length: 967  
Fragment?: false
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Protein
K7QD41
Organism: Mus musculus/domesticus
Length: 1009  
Fragment?: false
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Protein
E9Q2A6
Organism: Mus musculus/domesticus
Length: 967  
Fragment?: false
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Protein
Q8C6R5
Organism: Mus musculus/domesticus
Length: 449  
Fragment?: true
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Protein
Q3UDE9
Organism: Mus musculus/domesticus
Length: 1005  
Fragment?: false
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Publication
7544443 | -
First Author: Lev S
Year: 1995
Journal: Nature
Title: Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions.
Volume: 376
Issue: 6543
Pages: 737-45
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Publication
20332118 | -
First Author: Schaller MD
Year: 2010
Journal: J Cell Sci
Title: Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions.
Volume: 123
Issue: Pt 7
Pages: 1007-13
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Publication
8849729 | -
First Author: Dikic I
Year: 1996
Journal: Nature
Title: A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation.
Volume: 383
Issue: 6600
Pages: 547-50
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Publication
9774338 | -
First Author: Sieg DJ
Year: 1998
Journal: EMBO J
Title: Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration.
Volume: 17
Issue: 20
Pages: 5933-47
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Publication
19648005 | -
First Author: Allen JG
Year: 2009
Journal: Bioorg Med Chem Lett
Title: Identification of small molecule inhibitors of proline-rich tyrosine kinase 2 (Pyk2) with osteogenic activity in osteoblast cells.
Volume: 19
Issue: 17
Pages: 4924-8
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Publication
20381867 | -
First Author: Collins M
Year: 2010
Journal: Mol Immunol
Title: T cell receptor activation leads to two distinct phases of Pyk2 activation and actin cytoskeletal rearrangement in human T cells.
Volume: 47
Issue: 9
Pages: 1665-74
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Publication
15888917 | -
First Author: Ostergaard HL
Year: 2005
Journal: Immunol Res
Title: Focal adhesion kinase-related protein tyrosine kinase Pyk2 in T-cell activation and function.
Volume: 31
Issue: 3
Pages: 267-82
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Publication
10704819 | -
First Author: Avraham H
Year: 2000
Journal: Cell Signal
Title: RAFTK/Pyk2-mediated cellular signalling.
Volume: 12
Issue: 3
Pages: 123-33
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Publication
18765415 | -
First Author: Sun CK
Year: 2008
Journal: Carcinogenesis
Title: Proline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activation.
Volume: 29
Issue: 11
Pages: 2096-105
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Publication
35501917 | J:332722
First Author: Brody AH
Year: 2022
Journal: Mol Neurodegener
Title: Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy.
Volume: 17
Issue: 1
Pages: 32
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Publication
20737507 | J:164222
First Author: Beverdam A
Year: 2010
Journal: Dev Dyn
Title: Protein tyrosine kinase 2 beta (PTK2B), but not focal adhesion kinase (FAK), is expressed in a sexually dimorphic pattern in developing mouse gonads.
Volume: 239
Issue: 10
Pages: 2735-41
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Protein Coding Gene
MGP_CAROLIEiJ_G0019437 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0021493 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0021452 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0021428 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0021458 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0021235 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_104908 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0021897 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0020752 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0021202 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0021325 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0021304 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0021400 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0021333 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0021920 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0020496 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0020805 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0030455 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0020329 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
10881171 | J:63286
First Author: Guinamard R
Year: 2000
Journal: Nat Immunol
Title: Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response.
Volume: 1
Issue: 1
Pages: 31-6
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Publication
30518596 | J:270037
First Author: Salazar SV
Year: 2019
Journal: J Neurosci
Title: Alzheimer's Disease Risk Factor Pyk2 Mediates Amyloid-β-Induced Synaptic Dysfunction and Loss.
Volume: 39
Issue: 4
Pages: 758-772
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Publication
- | J:265543
     
First Author: Suo L
Year: 2017
Journal: bioRxiv
Title: Pyk2 suppresses contextual fear memory in a kinase-independent manner
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Publication
26663135 | J:229315
First Author: Giralt A
Year: 2016
Journal: Glia
Title: Pyk2 is essential for astrocytes mobility following brain lesion.
Volume: 64
Issue: 4
Pages: 620-34
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Publication
24598361 | J:211002
First Author: Koppel AC
Year: 2014
Journal: Am J Physiol Cell Physiol
Title: Delayed skin wound repair in proline-rich protein tyrosine kinase 2 knockout mice.
Volume: 306
Issue: 10
Pages: C899-909
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Publication
28754799 | J:247753
First Author: Llewellyn RA
Year: 2017
Journal: J Leukoc Biol
Title: The nonreceptor protein tyrosine kinase Pyk2 promotes the turnover of monocytes at steady state.
Volume: 102
Issue: 4
Pages: 1069-1080
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Publication
29428397 | J:265937
 
First Author: Posritong S
Year: 2018
Journal: Mol Cell Endocrinol
Title: Pyk2 deficiency potentiates osteoblast differentiation and mineralizing activity in response to estrogen or raloxifene.
Volume: 474
Pages: 35-47
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Publication
28527703 | J:246620
First Author: Wang H
Year: 2017
Journal: Dev Biol
Title: Sperm-oocyte contact induces outside-in signaling via PYK2 activation.
Volume: 428
Issue: 1
Pages: 52-62
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Publication
31081900 | J:277604
First Author: Sato AY
Year: 2019
Journal: Endocrinology
Title: Glucocorticoid-Induced Bone Fragility Is Prevented in Female Mice by Blocking Pyk2/Anoikis Signaling.
Volume: 160
Issue: 7
Pages: 1659-1673
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Publication
21666110 | J:176931
First Author: Lang D
Year: 2011
Journal: Am J Physiol Heart Circ Physiol
Title: Role of Pyk2 in cardiac arrhythmogenesis.
Volume: 301
Issue: 3
Pages: H975-83
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Publication
16039993 | J:99955
First Author: Yu Y
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Role of PYK2 in the development of obesity and insulin resistance.
Volume: 334
Issue: 4
Pages: 1085-91
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Publication
23175689 | J:194220
First Author: Canobbio I
Year: 2013
Journal: Blood
Title: Impaired thrombin-induced platelet activation and thrombus formation in mice lacking the Ca(2+)-dependent tyrosine kinase Pyk2.
Volume: 121
Issue: 4
Pages: 648-57
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Publication
31677798 | J:291442
First Author: Matsubara L
Year: 2020
Journal: Biochem Biophys Res Commun
Title: Translin restricts the growth of pubertal mammary epithelial cells estrogen-independently in mice.
Volume: 521
Issue: 3
Pages: 562-568
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Publication
22157654 | J:196552
First Author: Sonomura K
Year: 2012
Journal: Kidney Int
Title: The kinase Pyk2 is involved in renal fibrosis by means of mechanical stretch-induced growth factor expression in renal tubules.
Volume: 81
Issue: 5
Pages: 449-57
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Publication
24713463 | J:224957
 
First Author: Koshman YE
Year: 2014
Journal: J Mol Cell Cardiol
Title: Cardiomyocyte-specific expression of CRNK, the C-terminal domain of PYK2, maintains ventricular function and slows ventricular remodeling in a mouse model of dilated cardiomyopathy.
Volume: 72
Pages: 281-91
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Publication
18198130 | J:131388
First Author: Park MH
Year: 2008
Journal: FEBS Lett
Title: Induction of proline-rich tyrosine kinase2 (Pyk2) through C/EBPbeta is involved in PMA-induced monocyte differentiation.
Volume: 582
Issue: 3
Pages: 415-22
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Publication
18084294 | J:131641
First Author: Wang L
Year: 2008
Journal: Nat Immunol
Title: 'Tuning' of type I interferon-induced Jak-STAT1 signaling by calcium-dependent kinases in macrophages.
Volume: 9
Issue: 2
Pages: 186-93
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Publication
18635666 | J:139802
First Author: Xie J
Year: 2008
Journal: Mol Endocrinol
Title: Analysis of the calcium-dependent regulation of proline-rich tyrosine kinase 2 by gonadotropin-releasing hormone.
Volume: 22
Issue: 10
Pages: 2322-35
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Publication
19047047 | J:147222
First Author: Chen J
Year: 2009
Journal: J Biol Chem
Title: alpha- and gamma-Protocadherins negatively regulate PYK2.
Volume: 284
Issue: 5
Pages: 2880-90
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Publication
22811489 | J:188502
First Author: Fisher KD
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: Pyk2 regulates H+-ATPase-mediated proton secretion in the outer medullary collecting duct via an ERK1/2 signaling pathway.
Volume: 303
Issue: 9
Pages: F1353-62
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Publication
27086609 | J:234935
First Author: Meng XQ
Year: 2016
Journal: J Reprod Dev
Title: Subcellular localization of proline-rich tyrosine kinase 2 during oocyte fertilization and early-embryo development in mice.
Volume: 62
Issue: 4
Pages: 351-8
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Publication
29678998 | J:291015
First Author: Zacchia M
Year: 2018
Journal: J Am Soc Nephrol
Title: Acid Stimulation of the Citrate Transporter NaDC-1 Requires Pyk2 and ERK1/2 Signaling Pathways.
Volume: 29
Issue: 6
Pages: 1720-1730
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Publication
30664624 | J:295621
First Author: Montalban E
Year: 2019
Journal: Transl Psychiatry
Title: Pyk2 in the amygdala modulates chronic stress sequelae via PSD-95-related micro-structural changes.
Volume: 9
Issue: 1
Pages: 3
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Publication
34381140 | J:331206
First Author: Mastrolia V
Year: 2021
Journal: Sci Rep
Title: Pyk2 in dorsal hippocampus plays a selective role in spatial memory and synaptic plasticity.
Volume: 11
Issue: 1
Pages: 16357
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GXD Expression
GXD Expression
   
Probe: MGI:6383971
Assay Type: RT-PCR
Annotation Date: 2020-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:318643
Stage: TS03
Assay Id: MGI:6383973
Age: embryonic day 2.0
Image: 1
Specimen Label: 4-cell
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6383971
Assay Type: RT-PCR
Annotation Date: 2020-01-09
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160331
Stage: TS01
Assay Id: MGI:6383973
Age: embryonic day 0.5
Image: 1
Specimen Label: 1-cell
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5302197
Assay Type: Western blot
Annotation Date: 2012-01-23
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1610528
Stage: TS28
Assay Id: MGI:5302412
Age: postnatal
Specimen Label: Not shown
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5313379
Assay Type: Western blot
Annotation Date: 2012-03-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:5313441
Age: embryonic day 8.5
Specimen Label: FAK+/+p53+/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:5313379
Assay Type: Western blot
Annotation Date: 2012-03-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:5313441
Age: embryonic day 8.5
Specimen Label: FAK+/-p53+/+
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
     
Probe: MGI:5313379
Assay Type: Western blot
Annotation Date: 2012-03-29
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1603913
Stage: TS13
Assay Id: MGI:5313441
Age: embryonic day 8.5
Specimen Label: FAK-/-p53+/+
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:5301873
Assay Type: RT-PCR
Annotation Date: 2012-01-19
Strength: Present
Sex: Male
Emaps: EMAPS:1685717
Stage: TS17
Assay Id: MGI:5301994
Age: embryonic day 10.5
Image: 1
Specimen Label: XY
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:5301873
Assay Type: RT-PCR
Annotation Date: 2012-01-19
Strength: Present
Sex: Female
Emaps: EMAPS:1685717
Stage: TS17
Assay Id: MGI:5301994
Age: embryonic day 10.5
Image: 1
Specimen Label: XX
Detected: true
Specimen Num: 8
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GXD Expression
GXD Expression
     
Probe: MGI:7429224
Assay Type: Western blot
Annotation Date: 2023-01-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:7430760
Age: embryonic day 14.5
Specimen Label: +/+
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
     
Probe: MGI:7429224
Assay Type: Western blot
Annotation Date: 2023-01-31
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1684622
Stage: TS22
Assay Id: MGI:7430760
Age: embryonic day 14.5
Specimen Label: delta/delta
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:5301873
Assay Type: RT-PCR
Annotation Date: 2012-01-19
Strength: Present
Sex: Male
Emaps: EMAPS:1797220
Stage: TS20
Assay Id: MGI:5301994
Age: embryonic day 12.5
Image: 1
Specimen Label: XY
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:5301873
Assay Type: RT-PCR
Annotation Date: 2012-01-19
Strength: Present
Sex: Male
Emaps: EMAPS:1797221
Stage: TS21
Assay Id: MGI:5301994
Age: embryonic day 13.5
Image: 1
Specimen Label: XY
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:5301873
Assay Type: RT-PCR
Annotation Date: 2012-01-19
Strength: Present
Sex: Male
Emaps: EMAPS:1797222
Stage: TS22
Assay Id: MGI:5301994
Age: embryonic day 14.5
Image: 1
Specimen Label: XY
Detected: true
Specimen Num: 5
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5301873
Assay Type: RT-PCR
Annotation Date: 2012-01-19
Strength: Present
Sex: Male
Emaps: EMAPS:1797223
Stage: TS23
Assay Id: MGI:5301994
Age: embryonic day 15.5
Image: 1
Specimen Label: XY
Detected: true
Specimen Num: 6
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5301873
Assay Type: RT-PCR
Annotation Date: 2012-01-19
Strength: Present
Sex: Male
Emaps: EMAPS:1797224
Stage: TS24
Assay Id: MGI:5301994
Age: embryonic day 16.5
Image: 1
Specimen Label: XY
Detected: true
Specimen Num: 7
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5301873
Assay Type: RT-PCR
Annotation Date: 2012-01-20
Strength: Present
Sex: Male
Emaps: EMAPS:1797221
Stage: TS21
Assay Id: MGI:5302092
Age: embryonic day 13.5
Image: 2
Specimen Label: WT
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5301873
Assay Type: RT-PCR
Annotation Date: 2012-01-20
Strength: Present
Sex: Male
Emaps: EMAPS:1797221
Stage: TS21
Assay Id: MGI:5302092
Age: embryonic day 13.5
Image: 2
Specimen Label: We
Detected: true
Specimen Num: 2
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5301873
Assay Type: RT-PCR
Annotation Date: 2012-01-20
Strength: Present
Sex: Male
Emaps: EMAPS:1797220
Stage: TS20
Assay Id: MGI:5302112
Age: embryonic day 12.5
Image: 3
Specimen Label: XY +/+
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5301873
Assay Type: RT-PCR
Annotation Date: 2012-01-20
Strength: Present
Sex: Male
Emaps: EMAPS:1797220
Stage: TS20
Assay Id: MGI:5302112
Age: embryonic day 12.5
Image: 3
Specimen Label: XY -/-
Detected: true
Specimen Num: 2
•
•
•
•
•




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