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Search results 101 to 140 out of 140 for Dhps

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Type Details Score
GXD Expression
GXD Expression
   
Probe: MGI:7329826
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750328
Stage: TS28
Assay Id: MGI:7329891
Age: postnatal week 3
Image: 1
Specimen Label: Dhps PANC
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7329827
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750328
Stage: TS28
Assay Id: MGI:7329892
Age: postnatal week 3
Image: 1
Specimen Label: Dhps PANC
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7329828
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750328
Stage: TS28
Assay Id: MGI:7329893
Age: postnatal week 3
Image: 2
Specimen Label: Dhps PANC
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7329829
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750328
Stage: TS28
Assay Id: MGI:7329894
Age: postnatal week 3
Image: 2
Specimen Label: Dhps PANC
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7329830
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750328
Stage: TS28
Assay Id: MGI:7329895
Age: postnatal week 3
Image: 2
Specimen Label: Dhps PANC
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:6119653
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1750328
Stage: TS28
Assay Id: MGI:7329896
Age: postnatal week 3
Image: 2
Specimen Label: Dhps PANC
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7329826
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750322
Stage: TS22
Assay Id: MGI:7329898
Age: embryonic day 14.5
Image: 5
Specimen Label: Dhps PANC
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7329827
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750322
Stage: TS22
Assay Id: MGI:7329899
Age: embryonic day 14.5
Image: 5
Specimen Label: Dhps PANC
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:3577737
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750322
Stage: TS22
Assay Id: MGI:7329900
Age: embryonic day 14.5
Image: 5
Specimen Label: Dhps PANC
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:3577737
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750322
Stage: TS22
Assay Id: MGI:7329901
Age: embryonic day 14.5
Image: 5
Specimen Label: Dhps PANC
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
   
Probe: MGI:7329827
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329903
Age: embryonic day 18.5
Image: 6
Specimen Label: Dhps PANC
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:7329827
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329903
Age: embryonic day 18.5
Image: 6
Specimen Label: Dhps PANC
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:7329827
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329903
Age: embryonic day 18.5
Image: 6
Specimen Label: Dhps PANC
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:7329826
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329904
Age: embryonic day 18.5
Image: 6
Specimen Label: Dhps PANC
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:7329826
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329904
Age: embryonic day 18.5
Image: 6
Specimen Label: Dhps PANC
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:7329826
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329904
Age: embryonic day 18.5
Image: 6
Specimen Label: Dhps PANC
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:7329830
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329905
Age: embryonic day 18.5
Image: 6
Specimen Label: Dhps PANC
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:7329830
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329905
Age: embryonic day 18.5
Image: 6
Specimen Label: Dhps PANC
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:7329830
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329905
Age: embryonic day 18.5
Image: 6
Specimen Label: Dhps PANC
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:7329829
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329906
Age: embryonic day 18.5
Image: 6
Specimen Label: Dhps PANC
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:7329829
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329906
Age: embryonic day 18.5
Image: 6
Specimen Label: Dhps PANC
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:7329829
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329906
Age: embryonic day 18.5
Image: 6
Specimen Label: Dhps PANC
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:5825117
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329907
Age: embryonic day 18.5
Image: 6
Specimen Label: Dhps PANC
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:5825117
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329907
Age: embryonic day 18.5
Image: 6
Specimen Label: Dhps PANC
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:5825117
Assay Type: Western blot
Annotation Date: 2022-08-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750326
Stage: TS26
Assay Id: MGI:7329907
Age: embryonic day 18.5
Image: 6
Specimen Label: Dhps PANC
Detected: true
Specimen Num: 6
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GO Term
GO:0004156 | dihydropteroate synthase activity
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Publication
11007651 | -
First Author: Baca AM
Year: 2000
Journal: J Mol Biol
Title: Crystal structure of Mycobacterium tuberculosis 7,8-dihydropteroate synthase in complex with pterin monophosphate: new insight into the enzymatic mechanism and sulfa-drug action.
Volume: 302
Issue: 5
Pages: 1193-212
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Protein Domain
IPR011005 | Dihydropteroate_synth-like
Type: Homologous_superfamily
Description: All organisms require reduced folate cofactors for the synthesis of a variety of metabolites. The enzyme 7,8-dihydropteroate synthase (DHPS) () catalyses the condensation of para-aminobenzoic acid (pABA) with 6-hydroxymethyl-7, 8-dihydropterin-pyrophosphate to form 7,8-dihydropteroate and pyrophosphate. DHPS is essential for the de novo synthesis of folate in prokaryotes, lower eukaryotes, and in plants, but is absent in mammals []. By contrast, higher vertebrates possess an active transport system that enables them to use dietary folates. DHPS is the target of sulphonamides, which are substrate analogues that compete with pABA, but which do not affect vertebrates as they lack the DHPS enzyme. DHPS is a single domain protein that forms an eight-stranded TIM alpha/beta barrel, where the 7,8-dihydropterin pyrophosphate substrate binds in a deep cleft in the barrel []. In the lower eukaryote Pneumocystis carinii, DHPS is the C-terminal domain of a multifunctional folate synthesis enzyme (gene fas) [].Other proteins contain a DHPS-like domain, including members of the methyltetrahydrofolate (corrinoid iron-sulphur protein methyltransferase (MeTr)) family. MeTr catalyses a key step in the Wood-Ljungdahl pathway of carbon dioxide fixation []. Other members of this family that contain a DHPS-like domain include methionine synthase and methanogenic enzymes that activate the methyl group of methyltetrahydromethano(or -sarcino)pterin.
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Protein Domain
IPR006390 | DHP_synth_dom
Type: Domain
Description: This domain is present in sequences representing dihydropteroate synthase, the enzyme that catalyzes the second to last step in folic acid biosynthesis.Dihydropteroate synthase () (DHPS), a functional homodimer, catalyses the condensation of 6-hydroxymethyl-7,8-dihydropteridine pyrophosphate to para-aminobenzoic acid to form 7,8-dihydropteroate. This is the second step in the three-step pathway leading from 6-hydroxymethyl-7,8-dihydropterin to 7,8-dihydrofolate. DHPS is the target of sulfonamides, which are substrate analogues that compete with para-aminobenzoic acid. Bacterial DHPS (gene sul or folP) []is a protein of about 275 to 315 amino acid residues that is either chromosomally encoded or found on various antibiotic resistance plasmids. In the lower eukaryote Pneumocystis carinii, DHPS is the C-terminal domain of a multifunctional folate synthesis enzyme (gene fas) [].Prokaryotes (and some lower eukaryotes) must synthesize folate de novo, while higher eukaryotes are able to utilize dietary folate and therefore lack DHPS.
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Protein Domain
IPR045031 | DHP_synth
Type: Family
Description: Dihydropteroate synthase () (DHPS), a functional homodimer, catalyses the condensation of 6-hydroxymethyl-7,8-dihydropteridine pyrophosphate to para-aminobenzoic acid to form 7,8-dihydropteroate. This is the second step in the three-step pathway leading from 6-hydroxymethyl-7,8-dihydropterin to 7,8-dihydrofolate. DHPS is the target of sulfonamides, which are substrate analogues that compete with para-aminobenzoic acid. Bacterial DHPS (gene sul or folP) []is a protein of about 275 to 315 amino acid residues that is either chromosomally encoded or found on various antibiotic resistance plasmids. In the lower eukaryote Pneumocystis carinii, DHPS is the C-terminal domain of a multifunctional folate synthesis enzyme (gene fas) [].Prokaryotes (and some lower eukaryotes) must synthesize folate de novo, while higher eukaryotes are able to utilize dietary folate and therefore lack DHPS.
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Publication
2123867 | -
First Author: Slock J
Year: 1990
Journal: J Bacteriol
Title: An apparent Bacillus subtilis folic acid biosynthetic operon containing pab, an amphibolic trpG gene, a third gene required for synthesis of para-aminobenzoic acid, and the dihydropteroate synthase gene.
Volume: 172
Issue: 12
Pages: 7211-26
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Publication
1313386 | -
First Author: Volpe F
Year: 1992
Journal: Gene
Title: The multifunctional folic acid synthesis fas gene of Pneumocystis carinii appears to encode dihydropteroate synthase and hydroxymethyldihydropterin pyrophosphokinase.
Volume: 112
Issue: 2
Pages: 213-8
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Publication
9187658 | -
First Author: Achari A
Year: 1997
Journal: Nat Struct Biol
Title: Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase.
Volume: 4
Issue: 6
Pages: 490-7
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Publication
10997901 | -
First Author: Doukov T
Year: 2000
Journal: Structure
Title: Crystal structure of a methyltetrahydrofolate- and corrinoid-dependent methyltransferase.
Volume: 8
Issue: 8
Pages: 817-30
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Publication
15146240 | J:91092
First Author: Sinnegger-Brauns MJ
Year: 2004
Journal: J Clin Invest
Title: Isoform-specific regulation of mood behavior and pancreatic beta cell and cardiovascular function by L-type Ca 2+ channels.
Volume: 113
Issue: 10
Pages: 1430-9
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Publication
32208453 | J:286614
First Author: Mastracci TL
Year: 2020
Journal: PLoS One
Title: Hypusinated eIF5A is expressed in the pancreas and spleen of individuals with type 1 and type 2 diabetes.
Volume: 15
Issue: 3
Pages: e0230627
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Publication
18657556 | J:147006
First Author: Chen X
Year: 2009
Journal: Neuropharmacology
Title: Dihydropyridine inhibition of the glycine receptor: subunit selectivity and a molecular determinant of inhibition.
Volume: 56
Issue: 1
Pages: 318-27
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Publication
25261239 | J:217192
First Author: Fujimura K
Year: 2014
Journal: Cancer Res
Title: A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer.
Volume: 74
Issue: 22
Pages: 6671-81
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Protein
A6H5Y3
Organism: Mus musculus/domesticus
Length: 1253  
Fragment?: false
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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