This entry includes RBBP5 from animals, RBL from plants and Swd1 from yeasts. Swd1 is a component of the SET1C/COMPASS complex, a complex that methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres [, ].Retinoblastoma-binding protein 5 (RBBP5) is important for development in embryonic stem cells, regulating gene induction and H3 'Lys-4' methylation at key developmental loci []. It is a component of the SET1 histone methyltransferase complex [], and methyltransferase-containing (COMPASS) complexes MLL1, MLL2/3 and MLL4 [, ].Arabidopsis RBL is also a component of a COMPASS-like complex that mediates histone H3 lysine-4 trimethylation to control floral transition and plant development [].
This entry represents the RNA recognition motif (RRM) of Setd1A (also known as Set1A), a ubiquitously expressed vertebrates histone methyltransferase that exhibits high homology to yeast Set1. Set1A is localized to euchromatic nuclear speckles and associates with a complex containing six human homologs of the yeast Set1/COMPASS complex, including CXXC finger protein 1 (CFP1; homologous to yeast Spp1), Rbbp5 (homologous to yeast Swd1), Ash2 (homologous to yeast Bre2), Wdr5 (homologous to yeast Swd3), and Wdr82 (homologous to yeast Swd2) []. Set1A contains an N-terminal RNA recognition motif (RRM), an N-SET domain, and a C-terminal catalytic SET domain followed by a post-SET domain. In contrast to Set1B, Set1A additionally contains an HCF-1 binding motif that interacts with HCF-1 in vivo.
This entry represents the RNA recognition motif (RRM) of Setd1B (also known as Set1B), a ubiquitously expressed vertebrates histone methyltransferase that exhibits high homology to yeast Set1. Set1B is localised to euchromatic nuclear speckles and associates with a complex containing six human homologues of the yeast Set1/COMPASS complex, including CXXC finger protein 1 (CFP1; homologous to yeast Spp1), Rbbp5 (homologous to yeast Swd1), Ash2 (homologous to yeast Bre2), Wdr5 (homologous to yeast Swd3), and Wdr82 (homologous to yeast Swd2). Set1B complex is a histone methyltransferase that produces trimethylated histone H3 at Lys4 [, ]. Set1B contains an N-terminal RNA recognition motif (RRM), an N-SET domain, and a C-terminal catalytic SET domain followed by a post-SET domain.
