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Search results 201 to 300 out of 310 for Hck

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Type Details Score
Publication
18794338 | J:140111
First Author: Zarbock A
Year: 2008
Journal: J Exp Med
Title: PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcR gamma to induce slow leukocyte rolling.
Volume: 205
Issue: 10
Pages: 2339-47
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Publication
22511754 | J:186204
First Author: Shao B
Year: 2012
Journal: J Biol Chem
Title: Signal-dependent slow leukocyte rolling does not require cytoskeletal anchorage of P-selectin glycoprotein ligand-1 (PSGL-1) or integrin αLβ2.
Volume: 287
Issue: 23
Pages: 19585-98
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Publication
21860019 | J:178397
First Author: Shao B
Year: 2011
Journal: Blood
Title: Carcinoma mucins trigger reciprocal activation of platelets and neutrophils in a murine model of Trousseau syndrome.
Volume: 118
Issue: 15
Pages: 4015-23
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Publication
21220696 | J:169168
First Author: Nelson MP
Year: 2011
Journal: J Immunol
Title: IL-33 and M2a alveolar macrophages promote lung defense against the atypical fungal pathogen Pneumocystis murina.
Volume: 186
Issue: 4
Pages: 2372-81
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Publication
17218386 | J:145325
First Author: Cain JA
Year: 2007
Journal: Blood
Title: Myeloproliferative disease induced by TEL-PDGFRB displays dynamic range sensitivity to Stat5 gene dosage.
Volume: 109
Issue: 9
Pages: 3906-14
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Publication
19920076 | J:155567
First Author: Yokoyama N
Year: 2009
Journal: J Cell Sci
Title: Dishevelled-2 docks and activates Src in a Wnt-dependent manner.
Volume: 122
Issue: Pt 24
Pages: 4439-51
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Publication
9890970 | J:200344
First Author: Hunter S
Year: 1999
Journal: J Biol Chem
Title: Fyn associates with Cbl and phosphorylates tyrosine 731 in Cbl, a binding site for phosphatidylinositol 3-kinase.
Volume: 274
Issue: 4
Pages: 2097-106
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Publication
12896983 | J:86730
First Author: Khadaroo RG
Year: 2003
Journal: J Biol Chem
Title: Oxidative stress reprograms lipopolysaccharide signaling via Src kinase-dependent pathway in RAW 264.7 macrophage cell line.
Volume: 278
Issue: 48
Pages: 47834-41
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Publication
9687507 | J:114192
First Author: Meng F
Year: 1998
Journal: EMBO J
Title: A beta 1 integrin signaling pathway involving Src-family kinases, Cbl and PI-3 kinase is required for macrophage spreading and migration.
Volume: 17
Issue: 15
Pages: 4391-403
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Publication
7750469 | J:25937
First Author: Song WC
Year: 1995
Journal: Endocrinology
Title: Molecular characterization of a testis-specific estrogen sulfotransferase and aberrant liver expression in obese and diabetogenic C57BL/KsJ-db/db mice.
Volume: 136
Issue: 6
Pages: 2477-84
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Publication
27032818 | J:235781
 
First Author: Németh T
Year: 2016
Journal: Nat Commun
Title: Neutrophil-specific deletion of the CARD9 gene expression regulator suppresses autoantibody-induced inflammation in vivo.
Volume: 7
Pages: 11004
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Publication
19273622 | J:147080
First Author: Jakus Z
Year: 2009
Journal: J Exp Med
Title: Critical role of phospholipase Cgamma2 in integrin and Fc receptor-mediated neutrophil functions and the effector phase of autoimmune arthritis.
Volume: 206
Issue: 3
Pages: 577-93
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Publication
26777396 | J:259937
First Author: Volmering S
Year: 2016
Journal: Immunity
Title: The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation.
Volume: 44
Issue: 1
Pages: 73-87
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Publication
- | J:55945
First Author: Wang JP
Year: 1998
Journal: Biomed Res
Title: Expression of Src family during development of the mouse nervous system.
Volume: 19
Issue: 5
Pages: 315-325
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Publication
10051567 | J:53333
First Author: Valenzuela DM
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Angiopoietins 3 and 4: diverging gene counterparts in mice and humans.
Volume: 96
Issue: 5
Pages: 1904-9
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Publication
8535092 | J:28731
First Author: Reith AD
Year: 1995
Journal: Mamm Genome
Title: Isolation and chromosomal location of Nsk1, a novel murine putative receptor tyrosine kinase.
Volume: 6
Issue: 9
Pages: 689
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Publication
15814670 | J:98164
First Author: Kitaura J
Year: 2005
Journal: J Immunol
Title: Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases.
Volume: 174
Issue: 8
Pages: 4495-504
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Publication
2759422 | J:9913
First Author: Siracusa LD
Year: 1989
Journal: Genetics
Title: Recombinant inbred strain and interspecific backcross analysis of molecular markers flanking the murine agouti coat color locus.
Volume: 122
Issue: 3
Pages: 669-79
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Publication
1612587 | J:912
First Author: Avraham KB
Year: 1992
Journal: Genomics
Title: Murine chromosomal location of four hepatocyte-enriched transcription factors: HNF-3 alpha, HNF-3 beta, HNF-3 gamma, and HNF-4.
Volume: 13
Issue: 2
Pages: 264-8
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Publication
8093609 | J:4560
First Author: Huppi K
Year: 1993
Journal: Immunogenetics
Title: Genes associated with immunoglobulin V(D)J recombination are linked on mouse chromosome 2 and human chromosome 11.
Volume: 37
Issue: 4
Pages: 288-91
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Publication
8034026 | J:19199
First Author: Larsson-Blomberg L
Year: 1994
Journal: FEBS Lett
Title: Isolation of tyrosine kinase related genes expressed in the early hematopoietic system.
Volume: 348
Issue: 2
Pages: 119-25
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Publication
8943574 | J:36874
First Author: Rinke de Wit TF
Year: 1996
Journal: Int Immunol
Title: Expression of tyrosine kinase gene in mouse thymic stromal cells.
Volume: 8
Issue: 11
Pages: 1787-95
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Publication
15769905 | J:99312
First Author: Jerez-Timaure NC
Year: 2005
Journal: Physiol Genomics
Title: Fine mapping of a QTL region with large effects on growth and fatness on mouse chromosome 2.
Volume: 21
Issue: 3
Pages: 411-22
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Publication
26453377 | J:233863
First Author: Yi T
Year: 2015
Journal: Immunity
Title: Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses.
Volume: 43
Issue: 4
Pages: 764-75
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Publication
1970329 | J:10439
First Author: Siracusa LD
Year: 1990
Journal: Genomics
Title: A molecular genetic linkage map of mouse chromosome 2.
Volume: 6
Issue: 3
Pages: 491-504
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Publication
1916246 | J:11464
First Author: Siracusa LD
Year: 1991
Journal: Genetics
Title: Interspecific backcross mice show sex-specific differences in allelic inheritance.
Volume: 128
Issue: 4
Pages: 813-21
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Publication
7893599 | J:22208
First Author: Ruiz JC
Year: 1994
Journal: Mech Dev
Title: Identification of novel protein kinases expressed in the myocardium of the developing mouse heart.
Volume: 48
Issue: 3
Pages: 153-64
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Publication
- | J:237905
     
First Author: Sabrautzki S
Year: 2017
Journal: MGI Direct Data Submission
Title: Alleles produced by the Munich ENU mutagenesis project
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Publication
23616926 | J:194960
First Author: Tai G
Year: 2013
Journal: Biol Open
Title: FAK-Src signalling is important to renal collecting duct morphogenesis: discovery using a hierarchical screening technique.
Volume: 2
Issue: 4
Pages: 416-23
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Publication
7542761 | J:27414
First Author: Sommers CL
Year: 1995
Journal: Oncogene
Title: Murine txk: a protein tyrosine kinase gene regulated by T cell activation.
Volume: 11
Issue: 2
Pages: 245-51
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Publication
16829211 | J:115165
First Author: Hecht J
Year: 2007
Journal: Gene Expr Patterns
Title: Detection of novel skeletogenesis target genes by comprehensive analysis of a Runx2(-/-) mouse model.
Volume: 7
Issue: 1-2
Pages: 102-12
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Publication
11114734 | J:66153
First Author: Robinson DR
Year: 2000
Journal: Oncogene
Title: The protein tyrosine kinase family of the human genome.
Volume: 19
Issue: 49
Pages: 5548-57
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:345476
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2023
Title: TreeGrafter-generated GO annotations
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
10799548 | -
First Author: Scholz G
Year: 2000
Journal: J Biol Chem
Title: Hck enhances the adherence of lipopolysaccharide-stimulated macrophages via Cbl and phosphatidylinositol 3-kinase.
Volume: 275
Issue: 19
Pages: 14615-23
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Publication
19897576 | -
First Author: Cougoule C
Year: 2010
Journal: Blood
Title: Three-dimensional migration of macrophages requires Hck for podosome organization and extracellular matrix proteolysis.
Volume: 115
Issue: 7
Pages: 1444-52
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UniProt Feature
UniProt Feature
Begin: 178
Description: Phosphotyrosine; by HCK
Type: modified residue
End: 178
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UniProt Feature
UniProt Feature
Begin: 395
Description: Phosphotyrosine; by HCK
Type: modified residue
End: 395
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UniProt Feature
UniProt Feature
Begin: 511
Description: Phosphotyrosine; by HCK
Type: modified residue
End: 511
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UniProt Feature
UniProt Feature
Begin: 720
Description: Phosphotyrosine; by HCK
Type: modified residue
End: 720
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UniProt Feature
UniProt Feature
Begin: 216
Description: Phosphotyrosine; by HCK
Type: modified residue
End: 216
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UniProt Feature
UniProt Feature
Begin: 18
Description: Phosphotyrosine; by HCK
Type: modified residue
End: 18
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UniProt Feature
UniProt Feature
Begin: 2
Description: Tyrosine-protein kinase HCK
Type: chain
End: 524
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Gene
373700 | hck.L
Type: gene
Organism: frog, African clawed
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Publication
10934191 | -
First Author: Johnson TM
Year: 2000
Journal: J Biol Chem
Title: Modulation of the catalytic activity of the Src family tyrosine kinase Hck by autophosphorylation at a novel site in the unique domain.
Volume: 275
Issue: 43
Pages: 33353-64
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Publication
14551197 | -
First Author: Shivakrupa R
Year: 2003
Journal: J Biol Chem
Title: Physical and functional interaction between Hck tyrosine kinase and guanine nucleotide exchange factor C3G results in apoptosis, which is independent of C3G catalytic domain.
Volume: 278
Issue: 52
Pages: 52188-94
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Publication
9400828 | -
First Author: English BK
Year: 1997
Journal: J Leukoc Biol
Title: Bacterial LPS and IFN-gamma trigger the tyrosine phosphorylation of vav in macrophages: evidence for involvement of the hck tyrosine kinase.
Volume: 62
Issue: 6
Pages: 859-64
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Protein
P08103
Organism: Mus musculus/domesticus
Length: 524  
Fragment?: false
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Protein
P08103-2
Organism: Mus musculus/domesticus
Length: 503  
Fragment?: false
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Publication
30337619 | J:268573
First Author: Ochieng P
Year: 2018
Journal: Sci Rep
Title: Phospholipid transfer protein and alpha-1 antitrypsin regulate Hck kinase activity during neutrophil degranulation.
Volume: 8
Issue: 1
Pages: 15394
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UniProt Feature
UniProt Feature
Begin: 736
Description: Phosphotyrosine; by HCK and LCK
Type: modified residue
End: 736
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UniProt Feature
UniProt Feature
Begin: 716
Description: Phosphotyrosine; by HCK and LCK
Type: modified residue
End: 716
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UniProt Feature
UniProt Feature
Begin: 25
Description: Phosphotyrosine; by SRC and HCK
Type: modified residue
End: 25
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Publication
20944008 | J:165625
First Author: Samayawardhena LA
Year: 2010
Journal: J Immunol
Title: PTPalpha activates Lyn and Fyn and suppresses Hck to negatively regulate FcepsilonRI-dependent mast cell activation and allergic responses.
Volume: 185
Issue: 10
Pages: 5993-6002
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Publication
1875927 | -
First Author: Lock P
Year: 1991
Journal: Mol Cell Biol
Title: Two isoforms of murine hck, generated by utilization of alternative translational initiation codons, exhibit different patterns of subcellular localization.
Volume: 11
Issue: 9
Pages: 4363-70
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Publication
16809022 | -
First Author: Achuthan A
Year: 2006
Journal: Cell Signal
Title: CpG DNA enhances macrophage cell spreading by promoting the Src-family kinase-mediated phosphorylation of paxillin.
Volume: 18
Issue: 12
Pages: 2252-61
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Interaction Experiment
Scholz G (2000)
Description: Hck enhances the adherence of lipopolysaccharide-stimulated macrophages via Cbl and phosphatidylinositol 3-kinase.
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Publication
10092522 | -
First Author: Howlett CJ
Year: 1999
Journal: Biochem Biophys Res Commun
Title: The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase.
Volume: 257
Issue: 1
Pages: 129-38
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Publication
16684964 | -
First Author: Heiss E
Year: 2006
Journal: Blood
Title: Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2.
Volume: 108
Issue: 5
Pages: 1542-50
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Protein
Q6NV72
Organism: Mus musculus/domesticus
Length: 663  
Fragment?: false
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Protein
A0A1W2P880
Organism: Mus musculus/domesticus
Length: 540  
Fragment?: true
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Protein
A0A1Y7VJP4
Organism: Mus musculus/domesticus
Length: 710  
Fragment?: false
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Publication
25469238 | -
First Author: Yokoyama N
Year: 2015
Journal: Biomed Rep
Title: Molecular characterization of WDCP, a novel fusion partner for the anaplastic lymphoma tyrosine kinase ALK.
Volume: 3
Issue: 1
Pages: 9-13
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Publication
18538446 | -
First Author: Guiet R
Year: 2008
Journal: Eur J Cell Biol
Title: Hematopoietic cell kinase (Hck) isoforms and phagocyte duties - from signaling and actin reorganization to migration and phagocytosis.
Volume: 87
Issue: 8-9
Pages: 527-42
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Protein Domain
IPR028041 | WDCP
Type: Family
Description: This family includes WD repeat and coiled-coil-containing protein (WDCP, previously known as C2orf44), which is found in eukaryotes and consists of around 721 amino acids. The N-terminal contains two WD (tryptophan-aspartic acid) repeats (WD1 and WD2). WD repeats may be involved in a range of biological functions including apoptosis, transcriptional regulation and signal transduction. The C-terminal contains a proline-rich sequence (PPRLPQR), and is predicted to have leucine-rich coiled coil region (CC) [].WDCP was identified in a proteomic screen to find signalling components that interact with Hck (hematopoietic cell kinase), a non-receptor tyrosine kinase. WDCP was shown to bind tightly and specifically to the SH3 domain of Hck in U937 human monocytic cells. WDCP was also shown to exist as an oligomer when expressed in mammalian cells. While the function of WDCP is unknown, it has been identified in a gene fusion event with anaplastic lymphoma kinase (ALK) in colorectal cancer patients [].
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Protein Domain
IPR035851 | HCK_SH2
Type: Domain
Description: HCK is a member of the Src non-receptor type tyrosine kinase (SFK) family. HCK is expressed as two isoforms, p59Hck and p61Hck, in phagocytes. It plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration [, ]. Like the other members of the Src family the SH2 domain in addition to binding the target, also plays an autoinhibitory role by binding to its C-terminal tail []. This entry represents the SH2 domain of HCK.The Src non-receptor type tyrosine kinase (SFK) family members have an unique N-terminal domain, an SH3 domain, an SH2 domain, a kinase domain and a regulatory tail. The SH2 domain of SFKs is involved in kinase autoinhibition and T-cell receptor signaling. The binding SH2 domains to phosphotyrosine (pY) sites is critical for the autoinhibition and substrate recognition of the SFKs [].
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Publication
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