Junctional adhesion molecule 2 (JAM2), also known as VE-JAM or JAM-B, is a type I integral membrane protein that contains two Ig-like folds and three N-linked glycosylation sites in the extracellular domain []. JAM2 was initially identified as an endothelial adhesion molecule that plays a role in the architecture of interendothelial junctions and control leukocyte migration to inflammatory sites []. JAM2 interacts with T, NK, and dendritic cells through JAM3 [].