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Search results 1 to 100 out of 626 for Mafa

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Type Details Score
Gene
389692 | MAFA
Type: gene
Organism: human
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Gene
746440 | MAFA
Type: gene
Organism: chimpanzee
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Gene
618421 | MAFA
Type: gene
Organism: cattle
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Gene
100684427 | MAFA
Type: gene
Organism: dog, domestic
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Gene
395881 | MAFA
Type: gene
Organism: chicken
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Gene
114467 | mafa
Type: gene
Organism: zebrafish
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Gene
613050 | mafa
Type: gene
Organism: frog, western clawed
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Gene
106999985 | MAFA
Type: gene
Organism: macaque, rhesus
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Protein Domain
IPR028562 | MafA
Type: Family
Description: Maf transcription factors form a distinct family of the basic leucine zipper (bZip) transcription factors. The Maf family is divided into two subclasses, large Mafs (c-maf, mafB, and mafA/L-maf, nrl) and small Mafs (MafF, MafK and MafG). Both subclasses contain leucine-zipper motifs, which allow homodimerisation as well as heterodimerisation with a variety of other bZip proteins. In contrast to the small Mafs, the large Maf proteins contain a transactivator domain in their amino terminus []. The small Maf proteins might contribute to oncogenic processes by participating in antioxidant responses, while large Maf proteins have been directly implicated in carcinogenesis []. This entry represents MafA. MafA plays a critical role in the regulation of crystalline genes and lens development [, ]. It also binds the insulin enhancer element RIPE3b and regulates the insulin gene transcription [, , ].
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Gene
366949 | Mafa
Type: gene
Organism: rat
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Protein Coding Gene
MGI:2673307 | Mafa
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
15923615 | J:99126
First Author: Zhang C
Year: 2005
Journal: Mol Cell Biol
Title: MafA is a key regulator of glucose-stimulated insulin secretion.
Volume: 25
Issue: 12
Pages: 4969-76
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Publication
15665000 | -
First Author: Zhao L
Year: 2005
Journal: J Biol Chem
Title: The islet beta cell-enriched MafA activator is a key regulator of insulin gene transcription.
Volume: 280
Issue: 12
Pages: 11887-94
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GXD Expression
GXD Expression
Probe: MGI:6449789
Assay Type: Immunohistochemistry
Annotation Date: 2020-08-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750321
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:6449813
Age: embryonic day 13.5
Image: S1 E13.5 MafA
Note: Expression overlaps with that of Myt1.
Specimen Label: S1 E13.5 MafA
Detected: true
Specimen Num: 4
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GXD Expression
GXD Expression
Probe: MGI:6449789
Assay Type: Immunohistochemistry
Annotation Date: 2020-08-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3292723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:6449813
Age: embryonic day 15.5
Image: S1 E15.5 MafA
Note: Expression overlaps with that of Myt1.
Specimen Label: S1 E15.5 MafA
Detected: true
Specimen Num: 5
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Protein
Q8CF90
Organism: Mus musculus/domesticus
Length: 359  
Fragment?: false
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GXD Expression
GXD Expression
     
Probe: MGI:5789282
Assay Type: RT-PCR
Annotation Date: 2016-08-18
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1716320
Stage: TS20
Assay Id: MGI:5789314
Age: embryonic day 12.5
Specimen Label: mafA
Detected: true
Specimen Num: 1
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Gene
104326051 | MAFA-AS1
Type: gene
Organism: human
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Publication
19143053 | -
First Author: Eychène A
Year: 2008
Journal: Nat Rev Cancer
Title: A new MAFia in cancer.
Volume: 8
Issue: 9
Pages: 683-93
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Publication
9525857 | -
First Author: Ogino H
Year: 1998
Journal: Science
Title: Induction of lens differentiation by activation of a bZIP transcription factor, L-Maf.
Volume: 280
Issue: 5360
Pages: 115-8
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Publication
12011435 | -
First Author: Olbrot M
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA.
Volume: 99
Issue: 10
Pages: 6737-42
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Publication
9674710 | -
First Author: Benkhelifa S
Year: 1998
Journal: Oncogene
Title: mafA, a novel member of the maf proto-oncogene family, displays developmental regulation and mitogenic capacity in avian neuroretina cells.
Volume: 17
Issue: 2
Pages: 247-54
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Publication
12368292 | J:80902
First Author: Kataoka K
Year: 2002
Journal: J Biol Chem
Title: MafA is a glucose-regulated and pancreatic beta-cell-specific transcriptional activator for the insulin gene.
Volume: 277
Issue: 51
Pages: 49903-10
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Publication
14680841 | J:86942
First Author: Kajihara M
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Mouse MafA, homologue of zebrafish somite Maf 1, contributes to the specific transcriptional activity through the insulin promoter.
Volume: 312
Issue: 3
Pages: 831-42
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Publication
20213756 | J:164344
First Author: Lecoin L
Year: 2010
Journal: Dev Neurobiol
Title: MafA transcription factor identifies the early ret-expressing sensory neurons.
Volume: 70
Issue: 7
Pages: 485-97
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Publication
12917329 | J:85091
First Author: Matsuoka TA
Year: 2003
Journal: Mol Cell Biol
Title: Members of the large Maf transcription family regulate insulin gene transcription in islet beta cells.
Volume: 23
Issue: 17
Pages: 6049-62
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Publication
25126749 | J:218982
First Author: Eto K
Year: 2014
Journal: PLoS One
Title: MafA is required for postnatal proliferation of pancreatic β-cells.
Volume: 9
Issue: 8
Pages: e104184
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Publication
31235823 | J:278637
First Author: Singh T
Year: 2019
Journal: Sci Rep
Title: Loss of MafA and MafB expression promotes islet inflammation.
Volume: 9
Issue: 1
Pages: 9074
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GXD Expression
GXD Expression
Probe: MGI:6449762
Assay Type: Immunohistochemistry
Annotation Date: 2020-08-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750321
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:6449800
Age: embryonic day 13.5
Image: S1 E13.5 MafA
Note: Expression overlaps with expression of Mafa.
Specimen Label: S1 E13.5 MafA
Detected: true
Specimen Num: 21
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GXD Expression
GXD Expression
 
Probe: MGI:6449762
Assay Type: Immunohistochemistry
Annotation Date: 2020-08-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3292723
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:6449800
Age: embryonic day 15.5
Image: S1 E15.5 MafA
Specimen Label: S1 E15.5 MafA
Detected: true
Specimen Num: 25
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Publication
24520122 | J:229341
First Author: Hang Y
Year: 2014
Journal: Diabetes
Title: The MafA transcription factor becomes essential to islet β-cells soon after birth.
Volume: 63
Issue: 6
Pages: 1994-2005
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Publication
16154098 | J:129682
First Author: Kitamura YI
Year: 2005
Journal: Cell Metab
Title: FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction.
Volume: 2
Issue: 3
Pages: 153-63
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Publication
20424231 | J:169353
First Author: Matsuoka TA
Year: 2010
Journal: Diabetes
Title: Regulation of MafA expression in pancreatic beta-cells in db/db mice with diabetes.
Volume: 59
Issue: 7
Pages: 1709-20
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Publication
19576197 | J:152238
First Author: Nishimura W
Year: 2009
Journal: Dev Biol
Title: Expression of MafA in pancreatic progenitors is detrimental for pancreatic development.
Volume: 333
Issue: 1
Pages: 108-20
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Publication
18515495 | J:138415
First Author: Artner I
Year: 2008
Journal: J Endocrinol
Title: MafA is a dedicated activator of the insulin gene in vivo.
Volume: 198
Issue: 2
Pages: 271-9
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Publication
25645923 | J:264471
First Author: Matsuoka TA
Year: 2015
Journal: J Biol Chem
Title: Preserving Mafa expression in diabetic islet β-cells improves glycemic control in vivo.
Volume: 290
Issue: 12
Pages: 7647-57
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Publication
25500951 | J:219768
First Author: Nishimura W
Year: 2015
Journal: Diabetologia
Title: MafA is critical for maintenance of the mature beta cell phenotype in mice.
Volume: 58
Issue: 3
Pages: 566-74
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Publication
20064392 | J:157721
First Author: Bourane S
Year: 2009
Journal: Neuron
Title: Low-threshold mechanoreceptor subtypes selectively express MafA and are specified by Ret signaling.
Volume: 64
Issue: 6
Pages: 857-70
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Publication
30911681 | J:278108
 
First Author: Luan C
Year: 2019
Journal: Commun Biol
Title: The calcium channel subunit gamma-4 is regulated by MafA and necessary for pancreatic beta-cell specification.
Volume: 2
Pages: 106
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Publication
20682694 | J:169341
First Author: Noso S
Year: 2010
Journal: Diabetes
Title: Insulin transactivator MafA regulates intrathymic expression of insulin and affects susceptibility to type 1 diabetes.
Volume: 59
Issue: 10
Pages: 2579-87
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Publication
20627934 | J:169626
First Author: Artner I
Year: 2010
Journal: Diabetes
Title: MafA and MafB regulate genes critical to beta-cells in a unique temporal manner.
Volume: 59
Issue: 10
Pages: 2530-9
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Publication
16580660 | J:108721
First Author: Nishimura W
Year: 2006
Journal: Dev Biol
Title: A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells.
Volume: 293
Issue: 2
Pages: 526-39
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Publication
28223284 | J:247091
First Author: Matsuoka TA
Year: 2017
Journal: Diabetes
Title: Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet α-Cells Into β-Cells In Vivo.
Volume: 66
Issue: 5
Pages: 1293-1300
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Publication
23775071 | J:201764
First Author: Yamamoto K
Year: 2013
Journal: J Biol Chem
Title: A novel function of Onecut1 protein as a negative regulator of MafA gene expression.
Volume: 288
Issue: 30
Pages: 21648-58
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Publication
26180087 | J:247098
First Author: Scoville DW
Year: 2015
Journal: Diabetes
Title: MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function.
Volume: 64
Issue: 11
Pages: 3772-83
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Publication
19819955 | J:158220
First Author: Harmon JS
Year: 2009
Journal: Endocrinology
Title: beta-Cell-specific overexpression of glutathione peroxidase preserves intranuclear MafA and reverses diabetes in db/db mice.
Volume: 150
Issue: 11
Pages: 4855-62
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Publication
31980627 | J:283948
First Author: Zhu K
Year: 2020
Journal: Nat Commun
Title: Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice.
Volume: 11
Issue: 1
Pages: 484
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Publication
34644565 | J:328241
First Author: Walker EM
Year: 2021
Journal: Cell Rep
Title: Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males.
Volume: 37
Issue: 2
Pages: 109813
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Publication
22733810 | J:345465
First Author: Zhao X
Year: 2012
Journal: J Biol Chem
Title: MicroRNA-30d induces insulin transcription factor MafA and insulin production by targeting mitogen-activated protein 4 kinase 4 (MAP4K4) in pancreatic β-cells.
Volume: 287
Issue: 37
Pages: 31155-64
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Publication
26546820 | J:233194
First Author: Ganic E
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Islet-specific monoamine oxidase A and B expression depends on MafA transcriptional activity and is compromised in type 2 diabetes.
Volume: 468
Issue: 4
Pages: 629-35
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Publication
- | J:236516
     
First Author: Birchmeier C
Year: 2016
Journal: MGI Direct Data Submission
Title: Submission for a Mafa-cre
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Publication
14973194 | -
First Author: Matsuoka TA
Year: 2004
Journal: Proc Natl Acad Sci U S A
Title: The MafA transcription factor appears to be responsible for tissue-specific expression of insulin.
Volume: 101
Issue: 9
Pages: 2930-3
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Publication
35672398 | J:325444
First Author: Lecoin L
Year: 2022
Journal: Nat Commun
Title: Mafa-dependent GABAergic activity promotes mouse neonatal apneas.
Volume: 13
Issue: 1
Pages: 3284
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Publication
19715672 | J:153523
First Author: Shimohata H
Year: 2009
Journal: Biochem Biophys Res Commun
Title: MafA-deficient and beta cell-specific MafK-overexpressing hybrid transgenic mice develop human-like severe diabetic nephropathy.
Volume: 389
Issue: 2
Pages: 235-40
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Publication
24183936 | J:205335
First Author: He KH
Year: 2014
Journal: Dev Biol
Title: Differentiation of pancreatic endocrine progenitors reversibly blocked by premature induction of MafA.
Volume: 385
Issue: 1
Pages: 2-12
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Publication
20718938 | J:169733
First Author: Kanai K
Year: 2010
Journal: Genes Cells
Title: SUMOylation negatively regulates transcriptional and oncogenic activities of MafA.
Volume: 15
Issue: 9
Pages: 971-82
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Publication
25273397 | J:242187
First Author: Nishimura W
Year: 2015
Journal: Endocr J
Title: Generation and characterization of MafA-Kusabira Orange mice.
Volume: 62
Issue: 1
Pages: 37-51
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Publication
26904947 | J:278277
First Author: Ganic E
Year: 2016
Journal: Cell Rep
Title: MafA-Controlled Nicotinic Receptor Expression Is Essential for Insulin Secretion and Is Impaired in Patients with Type 2 Diabetes.
Volume: 14
Issue: 8
Pages: 1991-2002
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Publication
23975026 | J:202036
First Author: Xu G
Year: 2013
Journal: Nat Med
Title: Thioredoxin-interacting protein regulates insulin transcription through microRNA-204.
Volume: 19
Issue: 9
Pages: 1141-6
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Publication
32764399 | J:302369
 
First Author: Deng Z
Year: 2020
Journal: Int J Mol Sci
Title: An Inducible Diabetes Mellitus Murine Model Based on MafB Conditional Knockout under MafA-Deficient Condition.
Volume: 21
Issue: 16
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Publication
25763640 | J:227449
First Author: Nomoto H
Year: 2015
Journal: Endocrinology
Title: Inhibition of Small Maf Function in Pancreatic β-Cells Improves Glucose Tolerance Through the Enhancement of Insulin Gene Transcription and Insulin Secretion.
Volume: 156
Issue: 10
Pages: 3570-80
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Publication
19624757 | J:158257
First Author: Takeuchi T
Year: 2009
Journal: Genes Cells
Title: Neither MafA/L-Maf nor MafB is essential for lens development in mice.
Volume: 14
Issue: 8
Pages: 941-7
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Publication
27989460 | J:253253
First Author: Arcourt A
Year: 2017
Journal: Neuron
Title: Touch Receptor-Derived Sensory Information Alleviates Acute Pain Signaling and Fine-Tunes Nociceptive Reflex Coordination.
Volume: 93
Issue: 1
Pages: 179-193
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Publication
31208980 | J:289313
 
First Author: Xiafukaiti G
Year: 2019
Journal: Mol Cell Biol
Title: MafB Is Important for Pancreatic β-Cell Maintenance under a MafA-Deficient Condition.
Volume: 39
Issue: 17
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Publication
34730998 | J:319932
First Author: Xu Q
Year: 2021
Journal: Sci Adv
Title: Astrocytes contribute to pain gating in the spinal cord.
Volume: 7
Issue: 45
Pages: eabi6287
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Publication
25912440 | J:316658
First Author: Abdellatif AM
Year: 2015
Journal: Exp Anim
Title: Role of large MAF transcription factors in the mouse endocrine pancreas.
Volume: 64
Issue: 3
Pages: 305-12
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Publication
23863625 | J:201414
First Author: Guo S
Year: 2013
Journal: J Clin Invest
Title: Inactivation of specific β cell transcription factors in type 2 diabetes.
Volume: 123
Issue: 8
Pages: 3305-16
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Publication
26495868 | J:234058
First Author: Galloway JR
Year: 2015
Journal: Mol Endocrinol
Title: SSBP3 Interacts With Islet-1 and Ldb1 to Impact Pancreatic β-Cell Target Genes.
Volume: 29
Issue: 12
Pages: 1774-86
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Publication
23927931 | J:210724
First Author: ZeRuth GT
Year: 2013
Journal: Mol Endocrinol
Title: The Krüppel-like protein Gli-similar 3 (Glis3) functions as a key regulator of insulin transcription.
Volume: 27
Issue: 10
Pages: 1692-705
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Publication
17202186 | J:119914
First Author: Doyle MJ
Year: 2007
Journal: Development
Title: Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet.
Volume: 134
Issue: 3
Pages: 515-23
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Publication
19805515 | J:154990
First Author: Kang HS
Year: 2009
Journal: Mol Cell Biol
Title: Transcription factor Glis3, a novel critical player in the regulation of pancreatic beta-cell development and insulin gene expression.
Volume: 29
Issue: 24
Pages: 6366-79
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Publication
17360442 | J:120055
First Author: Artner I
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: MafB is required for islet beta cell maturation.
Volume: 104
Issue: 10
Pages: 3853-8
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Publication
32404350 | J:296911
First Author: Wang Y
Year: 2020
Journal: Diabetes
Title: m6A mRNA Methylation Controls Functional Maturation in Neonatal Murine β-Cells.
Volume: 69
Issue: 8
Pages: 1708-1722
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Publication
24258027 | J:321229
First Author: Murakami-Kawaguchi S
Year: 2014
Journal: Cell Tissue Res
Title: Expression of Ins1 and Ins2 genes in mouse fetal liver.
Volume: 355
Issue: 2
Pages: 303-14
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Publication
26554594 | J:235909
First Author: Conrad E
Year: 2016
Journal: Am J Physiol Endocrinol Metab
Title: The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cells.
Volume: 310
Issue: 1
Pages: E91-E102
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Publication
26631740 | J:246400
First Author: Paul L
Year: 2016
Journal: Diabetes
Title: Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-Cells.
Volume: 65
Issue: 3
Pages: 687-98
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Publication
18199433 | J:132598
First Author: Nishimura W
Year: 2008
Journal: Dev Biol
Title: Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice.
Volume: 314
Issue: 2
Pages: 443-56
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Publication
22514301 | J:184447
First Author: Hu J
Year: 2012
Journal: J Neurosci
Title: c-Maf is required for the development of dorsal horn laminae III/IV neurons and mechanoreceptive DRG axon projections.
Volume: 32
Issue: 16
Pages: 5362-73
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Publication
21081123 | J:168019
First Author: Plank JL
Year: 2011
Journal: Dev Biol
Title: Influence and timing of arrival of murine neural crest on pancreatic beta cell development and maturation.
Volume: 349
Issue: 2
Pages: 321-30
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Publication
29324782 | J:256730
First Author: Shawki HH
Year: 2018
Journal: PLoS One
Title: MAFB is dispensable for the fetal testis morphogenesis and the maintenance of spermatogenesis in adult mice.
Volume: 13
Issue: 1
Pages: e0190800
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Publication
36529318 | J:332289
 
First Author: Dobosz AM
Year: 2022
Journal: Mol Metab
Title: Inhibition of stearoyl-CoA desaturase 1 in the mouse impairs pancreatic islet morphogenesis and promotes loss of β-cell identity and α-cell expansion in the mature pancreas.
Volume: 67
Pages: 101659
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Publication
37536498 | J:339475
 
First Author: Toren E
Year: 2023
Journal: Mol Metab
Title: The SSBP3 co-regulator is required for glucose homeostasis, pancreatic islet architecture, and beta-cell identity.
Volume: 76
Pages: 101785
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Protein Coding Gene
MGP_CAROLIEiJ_G0019896 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0021958 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0021916 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0021899 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0021925 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0021697 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2673307 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0022365 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0021216 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0021664 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_DBA2J_G0021789 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_FVBNJ_G0021770 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_LPJ_G0021860 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_NODShiLtJ_G0021794 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_NZOHlLtJ_G0022385 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PWKPhJ_G0020957 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_WSBEiJ_G0021268 | -
Type: protein_coding_gene
Organism: mouse, laboratory
•
•
•
•
•
Protein Coding Gene
MGP_PahariEiJ_G0019904 | -
Type: protein_coding_gene
Organism: Mus pahari
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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