Type |
Details |
Score |
Gene |
Type: |
gene |
Organism: |
human |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
zebrafish |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
frog, western clawed |
|
•
•
•
•
•
|
Gene |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chimpanzee |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
dog, domestic |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
cattle |
|
•
•
•
•
•
|
Gene |
Type: |
gene |
Organism: |
chicken |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Publication |
First Author: |
Nguyen T |
Year: |
2023 |
Journal: |
J Exp Med |
Title: |
Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 2. |
Volume: |
220 |
Issue: |
6 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kuo T |
Year: |
2017 |
Journal: |
Diabetes |
Title: |
Pik3r1 Is Required for Glucocorticoid-Induced Perilipin 1 Phosphorylation in Lipid Droplet for Adipocyte Lipolysis. |
Volume: |
66 |
Issue: |
6 |
Pages: |
1601-1610 |
|
•
•
•
•
•
|
Publication |
First Author: |
McCurdy CE |
Year: |
2012 |
Journal: |
Diabetes |
Title: |
Attenuated Pik3r1 expression prevents insulin resistance and adipose tissue macrophage accumulation in diet-induced obese mice. |
Volume: |
61 |
Issue: |
10 |
Pages: |
2495-505 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen TC |
Year: |
2021 |
Journal: |
J Biol Chem |
Title: |
The role of striated muscle Pik3r1 in glucose and protein metabolism following chronic glucocorticoid exposure. |
|
|
Pages: |
100395 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cohran V |
Year: |
2016 |
Journal: |
Am J Pathol |
Title: |
Epithelial PIK3R1 (p85) and TP53 Regulate Survivin Expression during Adaptation to Ileocecal Resection. |
Volume: |
186 |
Issue: |
7 |
Pages: |
1837-46 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6180639 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689421 |
Pattern: |
Not Specified |
Stage: |
TS21 |
Assay Id: |
MGI:6191081 |
Age: |
embryonic day 13.5 |
|
|
Specimen Label: |
Table S2 - E13.5 - Pik3r1 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6180639 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689424 |
Pattern: |
Not Specified |
Stage: |
TS24 |
Assay Id: |
MGI:6191081 |
Age: |
embryonic day 15.5 |
|
|
Specimen Label: |
Table S2 - E15.5 - Pik3r1 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6180639 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6191081 |
Age: |
postnatal day 4 |
|
|
Specimen Label: |
Table S2 - P4 - Pik3r1 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6180639 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6191081 |
Age: |
postnatal day 14 |
|
|
Specimen Label: |
Table S2 - P14 - Pik3r1 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6180639 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Not Specified |
Emaps: |
EMAPS:1689419 |
Pattern: |
Not Specified |
Stage: |
TS19 |
Assay Id: |
MGI:6191081 |
Age: |
embryonic day 11.5 |
|
|
Specimen Label: |
Table S2 - E11.5 - Pik3r1 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6180639 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689426 |
Pattern: |
Not Specified |
Stage: |
TS26 |
Assay Id: |
MGI:6191081 |
Age: |
embryonic day 18.5 |
|
|
Specimen Label: |
Table S2 - E18.5 - Pik3r1 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
Probe: |
MGI:6180639 |
Assay Type: |
RNA in situ |
Annotation Date: |
2018-07-25 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6191081 |
Age: |
postnatal day 28 |
|
|
Specimen Label: |
Table S2 - P28 - Pik3r1 |
Detected: |
true |
Specimen Num: |
7 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
25
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen D |
Year: |
2004 |
Journal: |
Mol Cell Biol |
Title: |
p50alpha/p55alpha phosphoinositide 3-kinase knockout mice exhibit enhanced insulin sensitivity. |
Volume: |
24 |
Issue: |
1 |
Pages: |
320-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thorpe LM |
Year: |
2017 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
PI3K-p110α mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85α. |
Volume: |
114 |
Issue: |
27 |
Pages: |
7095-7100 |
|
•
•
•
•
•
|
Publication |
First Author: |
Taniguchi CM |
Year: |
2010 |
Journal: |
Cancer Res |
Title: |
The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling. |
Volume: |
70 |
Issue: |
13 |
Pages: |
5305-15 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mauvais-Jarvis F |
Year: |
2002 |
Journal: |
J Clin Invest |
Title: |
Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes. |
Volume: |
109 |
Issue: |
1 |
Pages: |
141-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kharas MG |
Year: |
2004 |
Journal: |
Blood |
Title: |
Phosphoinositide 3-kinase signaling is essential for ABL oncogene-mediated transformation of B-lineage cells. |
Volume: |
103 |
Issue: |
11 |
Pages: |
4268-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Taniguchi CM |
Year: |
2006 |
Journal: |
Cell Metab |
Title: |
Divergent regulation of hepatic glucose and lipid metabolism by phosphoinositide 3-kinase via Akt and PKClambda/zeta. |
Volume: |
3 |
Issue: |
5 |
Pages: |
343-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kaneko K |
Year: |
2010 |
Journal: |
Cell Metab |
Title: |
Class IA phosphatidylinositol 3-kinase in pancreatic β cells controls insulin secretion by multiple mechanisms. |
Volume: |
12 |
Issue: |
6 |
Pages: |
619-32 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fruman DA |
Year: |
2000 |
Journal: |
Nat Genet |
Title: |
Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha. |
Volume: |
26 |
Issue: |
3 |
Pages: |
379-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ivanovic I |
Year: |
2011 |
Journal: |
Invest Ophthalmol Vis Sci |
Title: |
Phosphoinositide 3-kinase signaling in retinal rod photoreceptors. |
Volume: |
52 |
Issue: |
9 |
Pages: |
6355-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Winnay JN |
Year: |
2016 |
Journal: |
J Clin Invest |
Title: |
PI3-kinase mutation linked to insulin and growth factor resistance in vivo. |
Volume: |
126 |
Issue: |
4 |
Pages: |
1401-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ueki K |
Year: |
2002 |
Journal: |
Mol Cell Biol |
Title: |
Molecular balance between the regulatory and catalytic subunits of phosphoinositide 3-kinase regulates cell signaling and survival. |
Volume: |
22 |
Issue: |
3 |
Pages: |
965-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouta-Bellum C |
Year: |
2009 |
Journal: |
Dev Dyn |
Title: |
Organ-specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene-targeting of the PI3K regulatory isoforms p85alpha, p55alpha, and p50alpha. |
Volume: |
238 |
Issue: |
10 |
Pages: |
2670-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Solheim MH |
Year: |
2018 |
Journal: |
Diabetes |
Title: |
Mice Carrying a Dominant-Negative Human PI3K Mutation Are Protected From Obesity and Hepatic Steatosis but Not Diabetes. |
Volume: |
67 |
Issue: |
7 |
Pages: |
1297-1309 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kharas MG |
Year: |
2008 |
Journal: |
J Clin Invest |
Title: |
Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells. |
Volume: |
118 |
Issue: |
9 |
Pages: |
3038-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Z |
Year: |
2016 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice. |
Volume: |
113 |
Issue: |
42 |
Pages: |
E6418-E6426 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus caroli |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus pahari |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
Mus spretus |
|
•
•
•
•
•
|
Publication |
First Author: |
Escobedo JA |
Year: |
1991 |
Journal: |
Cell |
Title: |
cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF beta-receptor. |
Volume: |
65 |
Issue: |
1 |
Pages: |
75-82 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fruman DA |
Year: |
1996 |
Journal: |
Genomics |
Title: |
Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene. |
Volume: |
37 |
Issue: |
1 |
Pages: |
113-21 |
|
•
•
•
•
•
|
Publication |
First Author: |
Verkoczy L |
Year: |
2007 |
Journal: |
J Immunol |
Title: |
Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection. |
Volume: |
178 |
Issue: |
10 |
Pages: |
6332-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
SoRelle J |
Year: |
2018 |
Journal: |
MGI Direct Data Submission |
Title: |
Mutagenetix entry for anubis |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Huddleston H |
Year: |
2003 |
Journal: |
Blood |
Title: |
Functional p85alpha gene is required for normal murine fetal erythropoiesis. |
Volume: |
102 |
Issue: |
1 |
Pages: |
142-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Barbour LA |
Year: |
2005 |
Journal: |
J Biol Chem |
Title: |
Increased P85alpha is a potent negative regulator of skeletal muscle insulin signaling and induces in vivo insulin resistance associated with growth hormone excess. |
Volume: |
280 |
Issue: |
45 |
Pages: |
37489-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lu-Kuo JM |
Year: |
2000 |
Journal: |
J Biol Chem |
Title: |
Impaired kit- but not FcepsilonRI-initiated mast cell activation in the absence of phosphoinositide 3-kinase p85alpha gene products. |
Volume: |
275 |
Issue: |
8 |
Pages: |
6022-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Goretsky T |
Year: |
2016 |
Journal: |
J Biol Chem |
Title: |
A Cytosolic Multiprotein Complex Containing p85α Is Required for β-Catenin Activation in Colitis and Colitis-associated Cancer. |
Volume: |
291 |
Issue: |
8 |
Pages: |
4166-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
Acosta-MartÃnez M |
Year: |
2009 |
Journal: |
Endocrinology |
Title: |
Male-biased effects of gonadotropin-releasing hormone neuron-specific deletion of the phosphoinositide 3-kinase regulatory subunit p85alpha on the reproductive axis. |
Volume: |
150 |
Issue: |
9 |
Pages: |
4203-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhong X |
Year: |
2018 |
Journal: |
MGI Direct Data Submission |
Title: |
Mutagenetix entry for Rocket |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Munugalavadla V |
Year: |
2008 |
Journal: |
Mol Cell Biol |
Title: |
The p85alpha subunit of class IA phosphatidylinositol 3-kinase regulates the expression of multiple genes involved in osteoclast maturation and migration. |
Volume: |
28 |
Issue: |
23 |
Pages: |
7182-98 |
|
•
•
•
•
•
|
Publication |
First Author: |
Munugalavadla V |
Year: |
2005 |
Journal: |
Blood |
Title: |
p85alpha subunit of class IA PI-3 kinase is crucial for macrophage growth and migration. |
Volume: |
106 |
Issue: |
1 |
Pages: |
103-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhu W |
Year: |
2007 |
Journal: |
Mol Cell Neurosci |
Title: |
Phosphoinositide-3-kinase and mitogen activated protein kinase signaling pathways mediate acute NGF sensitization of TRPV1. |
Volume: |
34 |
Issue: |
4 |
Pages: |
689-700 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fukao T |
Year: |
2002 |
Journal: |
Nat Immunol |
Title: |
Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice. |
Volume: |
3 |
Issue: |
3 |
Pages: |
295-304 |
|
•
•
•
•
•
|
Publication |
First Author: |
Terauchi Y |
Year: |
2004 |
Journal: |
Diabetes |
Title: |
Increased serum leptin protects from adiposity despite the increased glucose uptake in white adipose tissue in mice lacking p85alpha phosphoinositide 3-kinase. |
Volume: |
53 |
Issue: |
9 |
Pages: |
2261-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Aoki K |
Year: |
2009 |
Journal: |
Am J Physiol Endocrinol Metab |
Title: |
Role of the liver in glucose homeostasis in PI 3-kinase p85alpha-deficient mice. |
Volume: |
296 |
Issue: |
4 |
Pages: |
E842-53 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hayashi S |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
PI3K p85α Subunit-deficient Macrophages Protect Mice from Acute Colitis due to the Enhancement of IL-10 Production. |
Volume: |
7 |
Issue: |
1 |
Pages: |
6187 |
|
•
•
•
•
•
|
Publication |
First Author: |
Eto K |
Year: |
2002 |
Journal: |
Diabetes |
Title: |
Phosphatidylinositol 3-kinase suppresses glucose-stimulated insulin secretion by affecting post-cytosolic [Ca(2+)] elevation signals. |
Volume: |
51 |
Issue: |
1 |
Pages: |
87-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ma P |
Year: |
2012 |
Journal: |
Leukemia |
Title: |
Role of intracellular tyrosines in activating KIT-induced myeloproliferative disease. |
Volume: |
26 |
Issue: |
7 |
Pages: |
1499-1506 |
|
•
•
•
•
•
|
Publication |
First Author: |
Doi T |
Year: |
2008 |
Journal: |
Int Immunol |
Title: |
PI3K is a negative regulator of IgE production. |
Volume: |
20 |
Issue: |
4 |
Pages: |
499-508 |
|
•
•
•
•
•
|
Publication |
First Author: |
Watanabe N |
Year: |
2003 |
Journal: |
Blood |
Title: |
Functional phenotype of phosphoinositide 3-kinase p85alpha-null platelets characterized by an impaired response to GP VI stimulation. |
Volume: |
102 |
Issue: |
2 |
Pages: |
541-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Krishnan S |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
Class I(A) PI3Kinase regulatory subunit, p85α, mediates mast cell development through regulation of growth and survival related genes. |
Volume: |
7 |
Issue: |
1 |
Pages: |
e28979 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhu K |
Year: |
2024 |
Journal: |
Biochim Biophys Acta Mol Basis Dis |
Title: |
p85α deficiency alleviates ischemia-reperfusion injury by promoting cardiomyocyte survival. |
Volume: |
1870 |
Issue: |
7 |
Pages: |
167318 |
|
•
•
•
•
•
|
Publication |
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2006 |
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J Immunol |
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TLR5-mediated phosphoinositide 3-kinase activation negatively regulates flagellin-induced proinflammatory gene expression. |
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First Author: |
Wu X |
Year: |
2011 |
Journal: |
J Biol Chem |
Title: |
p85alpha regulates osteoblast differentiation by cross-talking with the MAPK pathway. |
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286 |
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Yasui K |
Year: |
2002 |
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J Leukoc Biol |
Title: |
Granulocyte macrophage-colony stimulating factor delays neutrophil apoptosis and primes its function through Ia-type phosphoinositide 3-kinase. |
Volume: |
72 |
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Journal: |
Invest Ophthalmol Vis Sci |
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Iris Malformation and Anterior Segment Dysgenesis in Mice and Humans With a Mutation in PI 3-Kinase. |
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2019 |
Journal: |
MGI Direct Data Submission |
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First Author: |
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Year: |
2005 |
Journal: |
J Cell Biol |
Title: |
The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex. |
Volume: |
170 |
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Year: |
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J Cell Biol |
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Role of the PI3K regulatory subunit in the control of actin organization and cell migration. |
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FEBS Lett |
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Increased phosphoinositide 3-kinase activity induces a lymphoproliferative disorder and contributes to tumor generation in vivo. |
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Different effects of insulin and platelet-derived growth factor on phosphatidylinositol 3-kinase at the subcellular level in 3T3-L1 adipocytes. A possible explanation for their specific effects on glucose transport. |
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Proc Natl Acad Sci U S A |
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A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration. |
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