Type |
Details |
Score |
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
360
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
412
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
757
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
745
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
152
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
530
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
595
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
228
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
208
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
657
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
143
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
208
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
795
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
58
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
177
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
905
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
193
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
246
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
208
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
200
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
187
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
178
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
385
|
Fragment?: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Lin SC |
Year: |
2010 |
Journal: |
Nature |
Title: |
Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. |
Volume: |
465 |
Issue: |
7300 |
Pages: |
885-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kawagoe T |
Year: |
2008 |
Journal: |
Nat Immunol |
Title: |
Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2. |
Volume: |
9 |
Issue: |
6 |
Pages: |
684-91 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
601
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
776
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
309
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
163
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Kaiser WJ |
Year: |
2013 |
Journal: |
J Biol Chem |
Title: |
Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL. |
Volume: |
288 |
Issue: |
43 |
Pages: |
31268-79 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oshiumi H |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to toll-like receptor 4 TICAM-1 that induces interferon-beta. |
Volume: |
278 |
Issue: |
50 |
Pages: |
49751-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ohnishi H |
Year: |
2012 |
Journal: |
PLoS One |
Title: |
TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88. |
Volume: |
7 |
Issue: |
6 |
Pages: |
e38423 |
|
•
•
•
•
•
|
Publication |
First Author: |
Radons J |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling. |
Volume: |
277 |
Issue: |
19 |
Pages: |
16456-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Paun A |
Year: |
2008 |
Journal: |
J Biol Chem |
Title: |
Functional characterization of murine interferon regulatory factor 5 (IRF-5) and its role in the innate antiviral response. |
Volume: |
283 |
Issue: |
21 |
Pages: |
14295-308 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu Y |
Year: |
2000 |
Journal: |
Nature |
Title: |
Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. |
Volume: |
408 |
Issue: |
6808 |
Pages: |
111-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou H |
Year: |
2013 |
Journal: |
EMBO J |
Title: |
IRAK-M mediates Toll-like receptor/IL-1R-induced NFκB activation and cytokine production. |
Volume: |
32 |
Issue: |
4 |
Pages: |
583-96 |
|
•
•
•
•
•
|
Publication |
First Author: |
James KR |
Year: |
2018 |
Journal: |
J Immunol |
Title: |
IFN Regulatory Factor 3 Balances Th1 and T Follicular Helper Immunity during Nonlethal Blood-Stage Plasmodium Infection. |
Volume: |
200 |
Issue: |
4 |
Pages: |
1443-1456 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang J |
Year: |
2018 |
Journal: |
Cereb Cortex |
Title: |
RIPK3/MLKL-Mediated Neuronal Necroptosis Modulates the M1/M2 Polarization of Microglia/Macrophages in the Ischemic Cortex. |
Volume: |
28 |
Issue: |
7 |
Pages: |
2622-2635 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kurowska-Stolarska M |
Year: |
2008 |
Journal: |
J Immunol |
Title: |
IL-33 induces antigen-specific IL-5+ T cells and promotes allergic-induced airway inflammation independent of IL-4. |
Volume: |
181 |
Issue: |
7 |
Pages: |
4780-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Savage AK |
Year: |
2017 |
Journal: |
J Immunol |
Title: |
The Development of Steady-State Activation Hubs between Adult LTi ILC3s and Primed Macrophages in Small Intestine. |
Volume: |
199 |
Issue: |
5 |
Pages: |
1912-1922 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shea-Donohue T |
Year: |
2008 |
Journal: |
Innate Immun |
Title: |
Mice deficient in the CXCR2 ligand, CXCL1 (KC/GRO-alpha), exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis. |
Volume: |
14 |
Issue: |
2 |
Pages: |
117-24 |
|
•
•
•
•
•
|
Publication |
First Author: |
Shao F |
Year: |
2016 |
Journal: |
Biochem Pharmacol |
Title: |
Andrographolide alleviates imiquimod-induced psoriasis in mice via inducing autophagic proteolysis of MyD88. |
Volume: |
115 |
|
Pages: |
94-103 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liese J |
Year: |
2007 |
Journal: |
Eur J Immunol |
Title: |
TLR9 signaling is essential for the innate NK cell response in murine cutaneous leishmaniasis. |
Volume: |
37 |
Issue: |
12 |
Pages: |
3424-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Baird JR |
Year: |
2013 |
Journal: |
Cancer Res |
Title: |
Avirulent Toxoplasma gondii generates therapeutic antitumor immunity by reversing immunosuppression in the ovarian cancer microenvironment. |
Volume: |
73 |
Issue: |
13 |
Pages: |
3842-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Perkins DJ |
Year: |
2018 |
Journal: |
Nat Immunol |
Title: |
Autocrine-paracrine prostaglandin E2 signaling restricts TLR4 internalization and TRIF signaling. |
Volume: |
19 |
Issue: |
12 |
Pages: |
1309-1318 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fan H |
Year: |
2005 |
Journal: |
Am J Physiol Cell Physiol |
Title: |
Lipopolysaccharide- and gram-positive bacteria-induced cellular inflammatory responses: role of heterotrimeric Galpha(i) proteins. |
Volume: |
289 |
Issue: |
2 |
Pages: |
C293-301 |
|
•
•
•
•
•
|
Publication |
First Author: |
Marichal T |
Year: |
2016 |
Journal: |
J Clin Invest |
Title: |
Guanine nucleotide exchange factor RABGEF1 regulates keratinocyte-intrinsic signaling to maintain skin homeostasis. |
Volume: |
126 |
Issue: |
12 |
Pages: |
4497-4515 |
|
•
•
•
•
•
|
Publication |
First Author: |
Greenblatt MB |
Year: |
2010 |
Journal: |
J Exp Med |
Title: |
Calcineurin regulates innate antifungal immunity in neutrophils. |
Volume: |
207 |
Issue: |
5 |
Pages: |
923-31 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guler R |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
IL-4Rα-dependent alternative activation of macrophages is not decisive for Mycobacterium tuberculosis pathology and bacterial burden in mice. |
Volume: |
10 |
Issue: |
3 |
Pages: |
e0121070 |
|
•
•
•
•
•
|
Publication |
First Author: |
Veleeparambil M |
Year: |
2018 |
Journal: |
J Immunol |
Title: |
Constitutively Bound EGFR-Mediated Tyrosine Phosphorylation of TLR9 Is Required for Its Ability To Signal. |
Volume: |
200 |
Issue: |
8 |
Pages: |
2809-2818 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lundberg AM |
Year: |
2013 |
Journal: |
Cardiovasc Res |
Title: |
Toll-like receptor 3 and 4 signalling through the TRIF and TRAM adaptors in haematopoietic cells promotes atherosclerosis. |
Volume: |
99 |
Issue: |
2 |
Pages: |
364-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mukherjee P |
Year: |
2018 |
Journal: |
J Lipid Res |
Title: |
Role of enterocyte stearoyl-Co-A desaturase-1 in LDLR-null mice. |
Volume: |
59 |
Issue: |
10 |
Pages: |
1818-1840 |
|
•
•
•
•
•
|
Publication |
First Author: |
Uluçkan Ö |
Year: |
2019 |
Journal: |
Cell Rep |
Title: |
Cutaneous Immune Cell-Microbiota Interactions Are Controlled by Epidermal JunB/AP-1. |
Volume: |
29 |
Issue: |
4 |
Pages: |
844-859.e3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Piao W |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
Inhibition of TLR4 signaling by TRAM-derived decoy peptides in vitro and in vivo. |
Volume: |
190 |
Issue: |
5 |
Pages: |
2263-72 |
|
•
•
•
•
•
|
Publication |
First Author: |
Goh ET |
Year: |
2012 |
Journal: |
Biochem J |
Title: |
Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system. |
Volume: |
441 |
Issue: |
1 |
Pages: |
339-46 |
|
•
•
•
•
•
|
Publication |
First Author: |
Buchta CM |
Year: |
2014 |
Journal: |
J Immunol |
Title: |
TRAF5 negatively regulates TLR signaling in B lymphocytes. |
Volume: |
192 |
Issue: |
1 |
Pages: |
145-50 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pascual-Itoiz MA |
Year: |
2020 |
Journal: |
Sci Rep |
Title: |
The mitochondrial negative regulator MCJ modulates the interplay between microbiota and the host during ulcerative colitis. |
Volume: |
10 |
Issue: |
1 |
Pages: |
572 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen Y |
Year: |
2017 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Cardiotonic Steroids Stimulate Macrophage Inflammatory Responses Through a Pathway Involving CD36, TLR4, and Na/K-ATPase. |
Volume: |
37 |
Issue: |
8 |
Pages: |
1462-1469 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gonuguntla S |
Year: |
2023 |
Journal: |
J Biol Chem |
Title: |
Stress-induced pseudokinase TRB3 augments IL1β signaling by interacting with Flightless homolog 1. |
Volume: |
299 |
Issue: |
8 |
Pages: |
104803 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kelsall IR |
Year: |
2019 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The E3 ligase HOIL-1 catalyses ester bond formation between ubiquitin and components of the Myddosome in mammalian cells. |
Volume: |
116 |
Issue: |
27 |
Pages: |
13293-13298 |
|
•
•
•
•
•
|
Publication |
First Author: |
Leichtle A |
Year: |
2010 |
Journal: |
J Immunol |
Title: |
CC chemokine ligand 3 overcomes the bacteriocidal and phagocytic defect of macrophages and hastens recovery from experimental otitis media in TNF-/- mice. |
Volume: |
184 |
Issue: |
6 |
Pages: |
3087-97 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kumar P |
Year: |
2014 |
Journal: |
Immunology |
Title: |
Mycobacterium indicus pranii and Mycobacterium bovis BCG lead to differential macrophage activation in Toll-like receptor-dependent manner. |
Volume: |
143 |
Issue: |
2 |
Pages: |
258-68 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jung DY |
Year: |
2005 |
Journal: |
J Immunol |
Title: |
TLR4, but not TLR2, signals autoregulatory apoptosis of cultured microglia: a critical role of IFN-beta as a decision maker. |
Volume: |
174 |
Issue: |
10 |
Pages: |
6467-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Suliman HB |
Year: |
2005 |
Journal: |
FASEB J |
Title: |
Toll-like receptor 4 mediates mitochondrial DNA damage and biogenic responses after heat-inactivated E. coli. |
Volume: |
19 |
Issue: |
11 |
Pages: |
1531-3 |
|
•
•
•
•
•
|
Publication |
First Author: |
Papadopoulos G |
Year: |
2013 |
Journal: |
J Immunol |
Title: |
Macrophage-specific TLR2 signaling mediates pathogen-induced TNF-dependent inflammatory oral bone loss. |
Volume: |
190 |
Issue: |
3 |
Pages: |
1148-57 |
|
•
•
•
•
•
|
Publication |
First Author: |
Roh YS |
Year: |
2015 |
Journal: |
Am J Physiol Gastrointest Liver Physiol |
Title: |
TLR2 and TLR9 contribute to alcohol-mediated liver injury through induction of CXCL1 and neutrophil infiltration. |
Volume: |
309 |
Issue: |
1 |
Pages: |
G30-41 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jung ID |
Year: |
2011 |
Journal: |
Cancer Res |
Title: |
Enhanced efficacy of therapeutic cancer vaccines produced by co-treatment with Mycobacterium tuberculosis heparin-binding hemagglutinin, a novel TLR4 agonist. |
Volume: |
71 |
Issue: |
8 |
Pages: |
2858-70 |
|
•
•
•
•
•
|
Publication |
First Author: |
Brown GJ |
Year: |
2022 |
Journal: |
Nature |
Title: |
TLR7 gain-of-function genetic variation causes human lupus. |
Volume: |
605 |
Issue: |
7909 |
Pages: |
349-356 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jana M |
Year: |
2008 |
Journal: |
J Immunol |
Title: |
Fibrillar amyloid-beta peptides activate microglia via TLR2: implications for Alzheimer's disease. |
Volume: |
181 |
Issue: |
10 |
Pages: |
7254-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Good DW |
Year: |
2012 |
Journal: |
J Biol Chem |
Title: |
Toll-like receptor 2 is required for LPS-induced Toll-like receptor 4 signaling and inhibition of ion transport in renal thick ascending limb. |
Volume: |
287 |
Issue: |
24 |
Pages: |
20208-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cole LE |
Year: |
2007 |
Journal: |
Infect Immun |
Title: |
Toll-like receptor 2-mediated signaling requirements for Francisella tularensis live vaccine strain infection of murine macrophages. |
Volume: |
75 |
Issue: |
8 |
Pages: |
4127-37 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bernthal NM |
Year: |
2011 |
Journal: |
J Orthop Res |
Title: |
Protective role of IL-1β against post-arthroplasty Staphylococcus aureus infection. |
Volume: |
29 |
Issue: |
10 |
Pages: |
1621-6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dasu MR |
Year: |
2010 |
Journal: |
Lab Invest |
Title: |
TLR2 expression and signaling-dependent inflammation impair wound healing in diabetic mice. |
Volume: |
90 |
Issue: |
11 |
Pages: |
1628-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Randall CM |
Year: |
2012 |
Journal: |
J Immunol |
Title: |
The MC159 protein from the molluscum contagiosum poxvirus inhibits NF-κB activation by interacting with the IκB kinase complex. |
Volume: |
188 |
Issue: |
5 |
Pages: |
2371-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bergin DA |
Year: |
2008 |
Journal: |
J Biol Chem |
Title: |
Activation of the epidermal growth factor receptor (EGFR) by a novel metalloprotease pathway. |
Volume: |
283 |
Issue: |
46 |
Pages: |
31736-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang W |
Year: |
2019 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Excessive CD11c+Tbet+ B cells promote aberrant TFH differentiation and affinity-based germinal center selection in lupus. |
Volume: |
116 |
Issue: |
37 |
Pages: |
18550-18560 |
|
•
•
•
•
•
|
Publication |
First Author: |
Filgueiras LR |
Year: |
2015 |
Journal: |
Sci Signal |
Title: |
Leukotriene B4-mediated sterile inflammation promotes susceptibility to sepsis in a mouse model of type 1 diabetes. |
Volume: |
8 |
Issue: |
361 |
Pages: |
ra10 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen Q |
Year: |
2006 |
Journal: |
J Immunol |
Title: |
Endogenous IL-1R1 signaling is critical for cognate CD4+ T cell help for induction of in vivo type 1 and type 2 antipolysaccharide and antiprotein Ig isotype responses to intact Streptococcus pneumoniae, but not to a soluble pneumococcal conjugate vaccine. |
Volume: |
177 |
Issue: |
9 |
Pages: |
6044-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Korfhagen TR |
Year: |
2012 |
Journal: |
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