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Search results 1101 to 1200 out of 1403 for Son

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Type Details Score
Publication
29717063 | J:281880
 
First Author: Sisti F
Year: 2018
Journal: Sci Signal
Title: Nuclear PTEN enhances the maturation of a microRNA regulon to limit MyD88-dependent susceptibility to sepsis.
Volume: 11
Issue: 528
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Publication
35881617 | J:331769
First Author: Seo SM
Year: 2022
Journal: PLoS One
Title: Development of transgenic models susceptible and resistant to SARS-CoV-2 infection in FVB background mice.
Volume: 17
Issue: 7
Pages: e0272019
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HT Experiment
E-GEOD-25574 | Hypothalamic transcriptome plasticity in two rodent species reveals divergent differential gene expression but conserved pathways
Series Id: GSE25574
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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Publication
9546825 | J:47513
First Author: Amiel J
Year: 1998
Journal: Clin Dysmorphol
Title: Mutation of the MITF gene in albinism-deafness syndrome (Tietz syndrome).
Volume: 7
Issue: 1
Pages: 17-20
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Publication
- | J:170
 
First Author: Gower JS
Year: 1958
Journal: Mouse News Lett
Title: Kinky-waltzer
Volume: 19
Pages: 37
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Publication
25448678 | J:216946
First Author: Maejima Y
Year: 2014
Journal: FEBS Lett
Title: Oxytocinergic circuit from paraventricular and supraoptic nuclei to arcuate POMC neurons in hypothalamus.
Volume: 588
Issue: 23
Pages: 4404-12
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Publication
24646999 | J:208887
First Author: Smemo S
Year: 2014
Journal: Nature
Title: Obesity-associated variants within FTO form long-range functional connections with IRX3.
Volume: 507
Issue: 7492
Pages: 371-5
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Publication
37666819 | J:339871
First Author: Moon JS
Year: 2023
Journal: Nat Commun
Title: Lrig1-expression confers suppressive function to CD4(+) cells and is essential for averting autoimmunity via the Smad2/3/Foxp3 axis.
Volume: 14
Issue: 1
Pages: 5382
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Publication
33951416 | J:306906
First Author: Zhu B
Year: 2021
Journal: Immunity
Title: Uncoupling of macrophage inflammation from self-renewal modulates host recovery from respiratory viral infection.
Volume: 54
Issue: 6
Pages: 1200-1218.e9
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Publication
31908356 | J:310925
First Author: Yoo H
Year: 2020
Journal: Cell Death Dis
Title: Epigenetic priming by Dot1l in lymphatic endothelial progenitors ensures normal lymphatic development and function.
Volume: 11
Issue: 1
Pages: 14
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Publication
31533057 | J:282517
First Author: Li C
Year: 2019
Journal: Immunity
Title: The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality.
Volume: 51
Issue: 3
Pages: 491-507.e7
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Publication
32905785 | J:301376
First Author: Kwak H
Year: 2020
Journal: Neuron
Title: Astrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus.
Volume: 108
Issue: 4
Pages: 691-706.e10
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Publication
30554998 | J:272598
First Author: Yin WC
Year: 2019
Journal: Dev Cell
Title: Dual Regulatory Functions of SUFU and Targetome of GLI2 in SHH Subgroup Medulloblastoma.
Volume: 48
Issue: 2
Pages: 167-183.e5
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Publication
36282594 | J:333472
 
First Author: Du W
Year: 2022
Journal: J Clin Invest
Title: Pharmacological conversion of gut epithelial cells into insulin-producing cells lowers glycemia in diabetic animals.
Volume: 132
Issue: 24
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Publication
38016540 | J:343322
 
First Author: Park S
Year: 2023
Journal: Metabolism
Title: Tm4sf19 deficiency inhibits osteoclast multinucleation and prevents bone loss.
Volume: 151
Pages: 155746
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Publication
34115847 | J:315678
First Author: Lee S
Year: 2021
Journal: Blood
Title: Somatic uniparental disomy mitigates the most damaging EFL1 allele combination in Shwachman-Diamond syndrome.
Volume: 138
Issue: 21
Pages: 2117-2128
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Publication
22541435 | J:186194
First Author: Ying H
Year: 2012
Journal: Cell
Title: Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.
Volume: 149
Issue: 3
Pages: 656-70
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Publication
32312822 | J:288282
First Author: Wenderski W
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Loss of the neural-specific BAF subunit ACTL6B relieves repression of early response genes and causes recessive autism.
Volume: 117
Issue: 18
Pages: 10055-10066
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Publication
31243280 | J:278388
First Author: Kim D
Year: 2019
Journal: Nat Commun
Title: Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3.
Volume: 10
Issue: 1
Pages: 2811
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Publication
32196931 | J:305700
First Author: Lee JO
Year: 2020
Journal: FEBS J
Title: The myokine meteorin-like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPKα2.
Volume: 287
Issue: 10
Pages: 2087-2104
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Publication
33561544 | J:305673
 
First Author: Kim MJ
Year: 2021
Journal: Mol Metab
Title: Distinct roles of UVRAG and EGFR signaling in skeletal muscle homeostasis.
Volume: 47
Pages: 101185
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Publication
10866673 | J:63039
First Author: Sund NJ
Year: 2000
Journal: Mol Cell Biol
Title: Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte.
Volume: 20
Issue: 14
Pages: 5175-83
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Publication
24589777 | J:209629
First Author: Akbay EA
Year: 2014
Journal: Genes Dev
Title: D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice.
Volume: 28
Issue: 5
Pages: 479-90
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Publication
36323321 | J:332396
First Author: Chen X
Year: 2023
Journal: Neuron
Title: Mechanosensitive brain tumor cells construct blood-tumor barrier to mask chemosensitivity.
Volume: 111
Issue: 1
Pages: 30-48.e14
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Publication
33739968 | J:304564
First Author: Venkataramanappa S
Year: 2021
Journal: PLoS Genet
Title: The microcephaly gene Donson is essential for progenitors of cortical glutamatergic and GABAergic neurons.
Volume: 17
Issue: 3
Pages: e1009441
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Publication
35944541 | J:328270
First Author: Hu J
Year: 2022
Journal: Cell
Title: Melanopsin retinal ganglion cells mediate light-promoted brain development.
Volume: 185
Issue: 17
Pages: 3124-3137.e15
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Publication
10943841 | J:63426
First Author: Sibilia M
Year: 2000
Journal: Cell
Title: The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development.
Volume: 102
Issue: 2
Pages: 211-20
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Publication
16327782 | J:105254
First Author: Sharif Naeini R
Year: 2006
Journal: Nat Neurosci
Title: An N-terminal variant of Trpv1 channel is required for osmosensory transduction.
Volume: 9
Issue: 1
Pages: 93-8
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Publication
12574407 | J:124687
First Author: Koksma JJ
Year: 2003
Journal: J Neurosci
Title: Oxytocin regulates neurosteroid modulation of GABA(A) receptors in supraoptic nucleus around parturition.
Volume: 23
Issue: 3
Pages: 788-97
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Publication
19429099 | J:150447
First Author: Arai JA
Year: 2009
Journal: Neurosci Lett
Title: Sos2 is dispensable for NMDA-induced Erk activation and LTP induction.
Volume: 455
Issue: 1
Pages: 22-5
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Publication
8220432 | J:46321
First Author: Matthews CH
Year: 1993
Journal: Nat Genet
Title: Primary amenorrhoea and infertility due to a mutation in the beta-subunit of follicle-stimulating hormone.
Volume: 5
Issue: 1
Pages: 83-6
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Publication
8293576 | J:38724
First Author: Chen L
Year: 1993
Journal: Dev Genet
Title: A murine CDC25/ras-GRF-related protein implicated in Ras regulation.
Volume: 14
Issue: 5
Pages: 339-46
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Publication
18617019 | J:138310
First Author: Xu C
Year: 2008
Journal: Gene Expr Patterns
Title: Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei.
Volume: 8
Issue: 7-8
Pages: 502-7
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Publication
36669474 | J:344596
First Author: Meng JJ
Year: 2023
Journal: Cell
Title: Light modulates glucose metabolism by a retina-hypothalamus-brown adipose tissue axis.
Volume: 186
Issue: 2
Pages: 398-412.e17
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Publication
36282598 | J:344520
 
First Author: Benamar M
Year: 2023
Journal: J Clin Invest
Title: The Notch1/CD22 signaling axis disrupts Treg function in SARS-CoV-2-associated multisystem inflammatory syndrome in children.
Volume: 133
Issue: 1
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Publication
15854909 | -
First Author: Bandura JL
Year: 2005
Journal: Curr Biol
Title: humpty dumpty is required for developmental DNA amplification and cell proliferation in Drosophila.
Volume: 15
Issue: 8
Pages: 755-9
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Protein Domain
IPR024861 | Donson
Type: Family
Description: The downstream neighbour of Son (DONSON) protein, also known as protein humpty dumpy (Hd) in Drosophila, is essential for DNA amplification in the ovary, and is required for cell proliferation during development (the humpty dumpty name arises from the thin-eggshell phenotype of hd mutants) []. Depletion of the Hd protein has been shown to cause severe defects in genome replication and to result in DNA damage. Hd is largely found in nuclear foci; some may traverse the nuclear envelope. Its expression peaks during late G1 and S phase, and it responds to transcription factor E2F1/Dp []. The Hd protein sequence is conserved from plants to humans, and may constitute a new gene family required for cell proliferation in multicellular eukaryotes [].
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Publication
17234811 | J:119503
First Author: Ficarella R
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: A functional study of plasma-membrane calcium-pump isoform 2 mutants causing digenic deafness.
Volume: 104
Issue: 5
Pages: 1516-21
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Publication
9288969 | J:42612
First Author: Ruggiu M
Year: 1997
Journal: Nature
Title: The mouse Dazla gene encodes a cytoplasmic protein essential for gametogenesis.
Volume: 389
Issue: 6646
Pages: 73-7
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Publication
11071765 | J:65759
First Author: Wang W
Year: 2000
Journal: Dev Biol
Title: The murine Otp homeobox gene plays an essential role in the specification of neuronal cell lineages in the developing hypothalamus.
Volume: 227
Issue: 2
Pages: 432-49
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Publication
7895278 | J:23010
First Author: Della NG
Year: 1995
Journal: Cell Tissue Res
Title: Expression of Siah-2, a vertebrate homologue of Drosophila sina, in germ cells of the mouse ovary and testis.
Volume: 279
Issue: 2
Pages: 411-9
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Publication
19515986 | J:150718
First Author: Song Z
Year: 2009
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Role of purinergic P2Y1 receptors in regulation of vasopressin and oxytocin secretion.
Volume: 297
Issue: 2
Pages: R478-84
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Publication
21354131 | J:173124
First Author: Aujla PK
Year: 2011
Journal: Dev Biol
Title: The Notch effector gene Hes1 regulates migration of hypothalamic neurons, neuropeptide content and axon targeting to the pituitary.
Volume: 353
Issue: 1
Pages: 61-71
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Publication
30720883 | J:280858
First Author: Suire S
Year: 2019
Journal: J Leukoc Biol
Title: Frontline Science: TNF-α and GM-CSF1 priming augments the role of SOS1/2 in driving activation of Ras, PI3K-γ, and neutrophil proinflammatory responses.
Volume: 106
Issue: 4
Pages: 815-822
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Publication
26061727 | J:226947
First Author: Nahar J
Year: 2015
Journal: Endocrinology
Title: Rapid Nongenomic Glucocorticoid Actions in Male Mouse Hypothalamic Neuroendocrine Cells Are Dependent on the Nuclear Glucocorticoid Receptor.
Volume: 156
Issue: 8
Pages: 2831-42
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Publication
31825846 | J:299206
First Author: Rai R
Year: 2019
Journal: Cell Rep
Title: The Replisome Mediates A-NHEJ Repair of Telomeres Lacking POT1-TPP1 Independently of MRN Function.
Volume: 29
Issue: 11
Pages: 3708-3725.e5
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Publication
25774914 | J:232917
First Author: Perera BP
Year: 2015
Journal: PLoS One
Title: Yy1 gene dosage effect and bi-allelic expression of Peg3.
Volume: 10
Issue: 3
Pages: e0119493
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Publication
15610159 | J:101271
First Author: Theodosis DT
Year: 2004
Journal: Eur J Neurosci
Title: Oxytocin neuron activation in NCAM-deficient mice: anatomical and functional consequences.
Volume: 20
Issue: 12
Pages: 3270-80
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Publication
9784500 | J:50772
First Author: Michaud JL
Year: 1998
Journal: Genes Dev
Title: Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1.
Volume: 12
Issue: 20
Pages: 3264-75
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Publication
20092567 | J:157229
First Author: Duplan SM
Year: 2009
Journal: Eur J Neurosci
Title: Impact of Sim1 gene dosage on the development of the paraventricular and supraoptic nuclei of the hypothalamus.
Volume: 30
Issue: 12
Pages: 2239-49
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Publication
36429119 | J:332108
 
First Author: Barresi C
Year: 2022
Journal: Cells
Title: Inactivation of Autophagy in Keratinocytes Reduces Tumor Growth in Mouse Models of Epithelial Skin Cancer.
Volume: 11
Issue: 22
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Publication
9030684 | J:38321
First Author: Wang DZ
Year: 1997
Journal: Genes Dev
Title: Mutation in Sos1 dominantly enhances a weak allele of the EGFR, demonstrating a requirement for Sos1 in EGFR signaling and development.
Volume: 11
Issue: 3
Pages: 309-20
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Publication
20138121 | J:159920
First Author: Nagakura A
Year: 2010
Journal: Neurosci Lett
Title: Na(x)-deficient mice show normal vasopressin response to dehydration.
Volume: 472
Issue: 3
Pages: 161-5
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Publication
16635258 | J:144411
 
First Author: Potier MC
Year: 2006
Journal: J Neurochem
Title: Transcriptional disruptions in Down syndrome: a case study in the Ts1Cje mouse cerebellum during post-natal development.
Volume: 97 Suppl 1
Pages: 104-9
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Publication
30642627 | J:295113
First Author: Benabdesselam R
Year: 2019
Journal: Acta Histochem
Title: Effect of Dp71 deficiency on the oxytocin hypothalamic axis in osmoregulation function in mice.
Volume: 121
Issue: 3
Pages: 268-276
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Publication
21041952 | J:171873
First Author: Chen PC
Year: 2010
Journal: J Clin Invest
Title: Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation.
Volume: 120
Issue: 12
Pages: 4353-65
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Publication
19297548 | J:147993
First Author: Hayashi M
Year: 2009
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Progressive polyuria without vasopressin neuron loss in a mouse model for familial neurohypophysial diabetes insipidus.
Volume: 296
Issue: 5
Pages: R1641-9
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Publication
29364700 | J:262934
First Author: Sandgren JA
Year: 2018
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Angiotensin AT1A receptors expressed in vasopressin-producing cells of the supraoptic nucleus contribute to osmotic control of vasopressin.
Volume: 314
Issue: 6
Pages: R770-R780
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Publication
28129114 | J:331333
First Author: Wang C
Year: 2017
Journal: Mol Ther
Title: Macrophage-Derived mir-155-Containing Exosomes Suppress Fibroblast Proliferation and Promote Fibroblast Inflammation during Cardiac Injury.
Volume: 25
Issue: 1
Pages: 192-204
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Publication
31958497 | J:307328
First Author: Rolvien T
Year: 2020
Journal: Osteoarthritis Cartilage
Title: Skeletal deterioration in COL2A1-related spondyloepiphyseal dysplasia occurs prior to osteoarthritis.
Volume: 28
Issue: 3
Pages: 334-343
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Publication
8570203 | J:200737
First Author: Lee JM
Year: 1996
Journal: Oncogene
Title: Association of CD45 with Lck and components of the Ras signalling pathway in pervanadate-treated mouse T-cell lines.
Volume: 12
Issue: 2
Pages: 253-63
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Publication
9013573 | J:38680
First Author: Kannan S
Year: 1997
Journal: J Biol Chem
Title: Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells.
Volume: 272
Issue: 6
Pages: 3330-5
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Publication
2943999 | J:31508
First Author: Heilig JS
Year: 1986
Journal: Nature
Title: Diversity of murine gamma genes and expression in fetal and adult T lymphocytes.
Volume: 322
Issue: 6082
Pages: 836-40
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Publication
8490739 | J:13541
First Author: Ison A
Year: 1993
Journal: Brain Res Bull
Title: Vasopressin- and oxytocin-immunoreactive hypothalamic neurones of inbred polydipsic mice.
Volume: 31
Issue: 3-4
Pages: 405-14
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Publication
9932431 | J:55592
 
First Author: Huang PL
Year: 1998
Journal: Prog Brain Res
Title: Genetic analysis of NOS isoforms using nNOS and eNOS knockout animals.
Volume: 118
Pages: 13-25
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Publication
16520382 | J:107918
First Author: Khanday FA
Year: 2006
Journal: J Cell Biol
Title: Sos-mediated activation of rac1 by p66shc.
Volume: 172
Issue: 6
Pages: 817-22
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Publication
20427720 | J:160977
First Author: Jankord R
Year: 2010
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Stress activation of IL-6 neurons in the hypothalamus.
Volume: 299
Issue: 1
Pages: R343-51
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Publication
22083669 | J:181808
First Author: Nakai M
Year: 2012
Journal: Lab Invest
Title: Characterization of novel germline c-kit gene mutation, KIT-Tyr553Cys, observed in a family with multiple gastrointestinal stromal tumors.
Volume: 92
Issue: 3
Pages: 451-7
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Publication
24226523 | J:205117
First Author: Wei X
Year: 2014
Journal: Am J Physiol Renal Physiol
Title: Kindlin-2 regulates renal tubular cell plasticity by activation of Ras and its downstream signaling.
Volume: 306
Issue: 2
Pages: F271-8
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Publication
28003464 | J:239443
First Author: Sugiyama H
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Nat1 promotes translation of specific proteins that induce differentiation of mouse embryonic stem cells.
Volume: 114
Issue: 2
Pages: 340-345
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Publication
29133588 | J:254728
First Author: Fei J
Year: 2017
Journal: J Cell Sci
Title: Quantitative analysis of multilayer organization of proteins and RNA in nuclear speckles at super resolution.
Volume: 130
Issue: 24
Pages: 4180-4192
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Publication
- | J:23180
 
First Author: Davisson MT
Year: 1977
Journal: Mouse News Lett
Title: Inversions
Volume: 57
Pages: 19-20
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Publication
30455627 | J:310556
 
First Author: Yuan XS
Year: 2018
Journal: Front Neurosci
Title: Whole-Brain Monosynaptic Afferent Projections to the Cholecystokinin Neurons of the Suprachiasmatic Nucleus.
Volume: 12
Pages: 807
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Publication
31845417 | J:337336
First Author: Vaidyanathan R
Year: 2020
Journal: J Neuroendocrinol
Title: Oxytocin receptor gene loss influences expression of the oxytocin gene in C57BL/6J mice in a sex- and age-dependent manner.
Volume: 32
Issue: 2
Pages: e12821
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Publication
14962074 | J:101784
First Author: Ozaki Y
Year: 2004
Journal: J Neuroendocrinol
Title: Expression of the arginine vasopressin gene in response to salt loading in oxytocin gene knockout mice.
Volume: 16
Issue: 1
Pages: 39-44
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Publication
11318878 | J:74118
First Author: Hosoya T
Year: 2001
Journal: Genes Cells
Title: Defective development of secretory neurones in the hypothalamus of Arnt2-knockout mice.
Volume: 6
Issue: 4
Pages: 361-74
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Publication
24681257 | J:212124
 
First Author: St-Louis R
Year: 2014
Journal: Free Radic Biol Med
Title: Reactive oxygen species are physiological mediators of the noradrenergic signaling pathway in the mouse supraoptic nucleus.
Volume: 71
Pages: 231-9
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Publication
22750329 | J:315475
First Author: Nedungadi TP
Year: 2012
Journal: Exp Neurol
Title: Expression and distribution of TRPV2 in rat brain.
Volume: 237
Issue: 1
Pages: 223-37
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Publication
7518772 | J:200362
First Author: den Hertog J
Year: 1994
Journal: EMBO J
Title: Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo.
Volume: 13
Issue: 13
Pages: 3020-32
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Publication
19889866 | J:155334
First Author: Babygirija R
Year: 2010
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Central oxytocin is involved in restoring impaired gastric motility following chronic repeated stress in mice.
Volume: 298
Issue: 1
Pages: R157-65
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Publication
34139240 | J:322409
 
First Author: Wei HH
Year: 2021
Journal: Exp Neurol
Title: Presynaptic inputs to vasopressin neurons in the hypothalamic supraoptic nucleus and paraventricular nucleus in mice.
Volume: 343
Pages: 113784
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Protein Domain
IPR023578 | Ras_GEF_dom_sf
Type: Homologous_superfamily
Description: Small GTPases of the Ras family alternate between 2 conformations induced by the binding of either GTP or GDP. Guanine nucleotide exchange factors (GEFs) induce the dissociation of GDP to allow association of the more abundant GTP. The Ras-like family of small GTPases includes, among others, Ras, Rap1, R-ras, and Ral. The family is characterised by similarities in the effector domain. The Ras GTPase Rap1 is activated rapidly in response to activation of a variety of receptors. Rap1 activation is mediated by several second messengers, including calcium, diacylglycerol, and cAMP. GEFs have been identified that mediate these effects. One such GEF is Epac, an exchange protein directly activated by cAMP, which represents a novel cAMP-induced, protein kinase A-independent pathway [].This superfamily represents a multihelical domain found in Ras GEFs. It can be subdivided in two domains: Ras GEF catalytic domain () and Ras GEF N-terminal domain (). In the nucleotide exchange factor Son of sevenless (SOS), both of these domains are required for the Ras specific nucleotide exchange activity, and both of them together are referred to as SOS-cat [].
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Publication
10805756 | J:175121
First Author: Huang W
Year: 2000
Journal: Mol Cell Biol
Title: Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer.
Volume: 20
Issue: 11
Pages: 4149-58
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Publication
33303677 | J:302994
First Author: Neupane C
Year: 2021
Journal: J Neurosci
Title: High Salt Intake Recruits Tonic Activation of NR2D Subunit-Containing Extrasynaptic NMDARs in Vasopressin Neurons.
Volume: 41
Issue: 6
Pages: 1145-1156
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Publication
- | J:17647
 
First Author: Adler ID
Year: 1987
Journal: Mouse News Lett
Title: Seventeen stocks of mice with reciprocal or Robertsonian translocations
Volume: 77
Pages: 139-42
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Protein
Q9DBM1
Organism: Mus musculus/domesticus
Length: 930  
Fragment?: false
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Protein
Q7TQC7
Organism: Mus musculus/domesticus
Length: 527  
Fragment?: false
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Protein
Q3TFK5
Organism: Mus musculus/domesticus
Length: 415  
Fragment?: false
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Protein
Q9CZX5
Organism: Mus musculus/domesticus
Length: 332  
Fragment?: false
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Protein
Q3UFS4
Organism: Mus musculus/domesticus
Length: 262  
Fragment?: false
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Protein
Q8CEZ8
Organism: Mus musculus/domesticus
Length: 152  
Fragment?: false
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Protein
A0A0A6YWB3
Organism: Mus musculus/domesticus
Length: 239  
Fragment?: true
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Protein
A0A0R4J215
Organism: Mus musculus/domesticus
Length: 264  
Fragment?: false
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Protein
D6RET6
Organism: Mus musculus/domesticus
Length: 883  
Fragment?: false
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Protein
Q3U3V2
Organism: Mus musculus/domesticus
Length: 885  
Fragment?: false
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Protein
E0CZ29
Organism: Mus musculus/domesticus
Length: 196  
Fragment?: false
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Protein
F6X398
Organism: Mus musculus/domesticus
Length: 244  
Fragment?: true
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Publication
10579920 | -
First Author: Zwartkruis FJ
Year: 1999
Journal: Exp Cell Res
Title: Ras and Rap1: two highly related small GTPases with distinct function.
Volume: 253
Issue: 1
Pages: 157-65
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Protein Domain
IPR000467 | G_patch_dom
Type: Domain
Description: The G-patch domain is an approximately 48 amino acid domain, which is found ina single copy in several RNA-associated proteins and in type D retroviralpolyproteins. It is widespread among eukaryotes but is absent in archaea andbacteria. The G-patch domain has been called after its most notable feature,the presence of six highly conserved glycine residues. The position followingthe first conserved glycine is occupied almost invariably by an aromaticresidue, and several other positions are occupied predominantly by eitherhydrophobic or small residues. Several groups of G-patch containing proteinsare conserved in animals, plants and fungi. In some of these proteins the G-patch is the only recognisable domain but in most of them it is combined withother domains, which include well-defined RNA-binding domains, such as theRRM, dsRBD, SURP and R3H. It has been suggested that the G-patch domain has a specific function in RNA processing and, in particular, that it might be a previously undetected RNA-binding domain mediating a distinct type of RNA-protein interaction.Secondary structure prediction indicates that the G-patch domain probablycontains two α-helices, with four out of the six glycines located withinan intervening loop.Proteins known to contain a G-patch domain include:Eukaryotic 45kDa splicing factor (SPF-45).Mammmalian SON protein, a DNA-binding protein.Human LUCA15, a multidomain RNA-binding protein that is the product of a gene deleted in certain lung tumors.Human DAN26/EPROT, a multidomain protein, which, in addition to the G-patch domain, contains an RNA polymerase II C-terminal repeat-binding domain seen in many proteins of the polyA-addition machinery.Arabidopsis thaliana DRT111, a protein which has been shown to partially restore recombination proficiency and DNA-damage resistance to E. coli mutants.Type D retroviral polyprotein, where the G-patch domain is found directly downstream of the protease domain.
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Protein
Q8BIY1
Organism: Mus musculus/domesticus
Length: 525  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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