|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 301 to 400 out of 421 for Ciita

<< First    < Previous  |  Next >    Last >>
0.044s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Publication
17627890 | J:125272
First Author: Guleria I
Year: 2007
Journal: Clin Immunol
Title: Mechanisms of PDL1-mediated regulation of autoimmune diabetes.
Volume: 125
Issue: 1
Pages: 16-25
•
•
•
•
•
Publication
18292501 | J:131725
First Author: Jay DC
Year: 2008
Journal: J Immunol
Title: Polyclonal MHC Ib-restricted CD8+ T cells undergo homeostatic expansion in the absence of conventional MHC-restricted T cells.
Volume: 180
Issue: 5
Pages: 2805-14
•
•
•
•
•
Publication
10637268 | J:59409
First Author: Green EA
Year: 2000
Journal: J Exp Med
Title: Neonatal tumor necrosis factor alpha promotes diabetes in nonobese diabetic mice by CD154-independent antigen presentation to CD8(+) T cells.
Volume: 191
Issue: 2
Pages: 225-38
•
•
•
•
•
Publication
15596523 | J:95337
First Author: Baguet A
Year: 2004
Journal: J Exp Med
Title: A Leishmania major response locus identified by interval-specific congenic mapping of a T helper type 2 cell bias-controlling quantitative trait locus.
Volume: 200
Issue: 12
Pages: 1605-12
•
•
•
•
•
Publication
10438942 | J:56753
First Author: Hussain S
Year: 1999
Journal: J Immunol
Title: Mycobacterium avium infection of mouse macrophages inhibits IFN-gamma Janus kinase-STAT signaling and gene induction by down-regulation of the IFN-gamma receptor.
Volume: 163
Issue: 4
Pages: 2041-8
•
•
•
•
•
Publication
34852236 | J:316085
First Author: Cui C
Year: 2021
Journal: Cell
Title: Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses.
Volume: 184
Issue: 25
Pages: 6101-6118.e13
•
•
•
•
•
Publication
23144170 | J:192819
First Author: Pihlgren M
Year: 2013
Journal: Blood
Title: TLR4- and TRIF-dependent stimulation of B lymphocytes by peptide liposomes enables T cell-independent isotype switch in mice.
Volume: 121
Issue: 1
Pages: 85-94
•
•
•
•
•
Publication
23300712 | J:195832
First Author: Irla M
Year: 2012
Journal: PLoS One
Title: Antigen recognition by autoreactive CD4⁺ thymocytes drives homeostasis of the thymic medulla.
Volume: 7
Issue: 12
Pages: e52591
•
•
•
•
•
Publication
16717113 | J:124381
First Author: Sawa S
Year: 2006
Journal: J Exp Med
Title: Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells.
Volume: 203
Issue: 6
Pages: 1459-70
•
•
•
•
•
Publication
16280321 | J:107465
First Author: Shang L
Year: 2006
Journal: J Biol Chem
Title: The heat shock protein 90-CDC37 chaperone complex is required for signaling by types I and II interferons.
Volume: 281
Issue: 4
Pages: 1876-84
•
•
•
•
•
Publication
25908663 | J:223811
First Author: Hepworth MR
Year: 2015
Journal: Science
Title: Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells.
Volume: 348
Issue: 6238
Pages: 1031-5
•
•
•
•
•
Publication
34183650 | J:336544
First Author: Toulmin SA
Year: 2021
Journal: Nat Commun
Title: Type II alveolar cell MHCII improves respiratory viral disease outcomes while exhibiting limited antigen presentation.
Volume: 12
Issue: 1
Pages: 3993
•
•
•
•
•
Publication
22908323 | J:191814
First Author: Ochi A
Year: 2012
Journal: J Exp Med
Title: MyD88 inhibition amplifies dendritic cell capacity to promote pancreatic carcinogenesis via Th2 cells.
Volume: 209
Issue: 9
Pages: 1671-87
•
•
•
•
•
Publication
27659424 | J:240505
First Author: Takashima S
Year: 2016
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Glycine prevents metabolic steatohepatitis in diabetic KK-Ay mice through modulation of hepatic innate immunity.
Volume: 311
Issue: 6
Pages: G1105-G1113
•
•
•
•
•
Publication
19234195 | J:146244
First Author: Zuklys S
Year: 2009
Journal: J Immunol
Title: Stabilized beta-catenin in thymic epithelial cells blocks thymus development and function.
Volume: 182
Issue: 5
Pages: 2997-3007
•
•
•
•
•
Publication
20211142 | J:160776
First Author: Ravasi T
Year: 2010
Journal: Cell
Title: An atlas of combinatorial transcriptional regulation in mouse and man.
Volume: 140
Issue: 5
Pages: 744-52
•
•
•
•
•
Publication
12819136 | J:84168
First Author: Reed JC
Year: 2003
Journal: Genome Res
Title: Comparative analysis of apoptosis and inflammation genes of mice and humans.
Volume: 13
Issue: 6B
Pages: 1376-88
•
•
•
•
•
Publication
16783635 | J:109795
First Author: Kenney-Hunt JP
Year: 2006
Journal: Mamm Genome
Title: Quantitative trait loci for body size components in mice.
Volume: 17
Issue: 6
Pages: 526-37
•
•
•
•
•
Allele
Tg(CD4-CIITA)357Ccum | MGI:4454654
Name: transgene insertion 357, Cheong-Hee Chang
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
•
•
•
•
•
Publication
- | J:165964
     
First Author: Mammalian Functional Genomics Centre
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba
•
•
•
•
•
Publication
- | J:72245
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
•
•
•
•
•
Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
•
•
•
•
•
Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
•
•
•
•
•
Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
•
•
•
•
•
Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
•
•
•
•
•
Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
•
•
•
•
•
Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
•
•
•
•
•
Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
•
•
•
•
•
Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
•
•
•
•
•
Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
•
•
•
•
•
Publication
- | J:155856
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Rat to Mouse ISO GO annotation transfer
•
•
•
•
•
Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
•
•
•
•
•
Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
•
•
•
•
•
Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
•
•
•
•
•
Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
•
•
•
•
•
Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
•
•
•
•
•
Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
•
•
•
•
•
Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
•
•
•
•
•
Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
•
•
•
•
•
Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
•
•
•
•
•
Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
Publication
35760800 | J:326770
First Author: Liu H
Year: 2022
Journal: Nat Commun
Title: Osteocyte CIITA aggravates osteolytic bone lesions in myeloma.
Volume: 13
Issue: 1
Pages: 3684
•
•
•
•
•
Publication
15351782 | J:93641
First Author: Park WS
Year: 2004
Journal: Int Immunol
Title: T cell expression of CIITA represses Th1 immunity.
Volume: 16
Issue: 10
Pages: 1355-64
•
•
•
•
•
Publication
9716648 | J:50014
First Author: Lennon AM
Year: 1998
Journal: Immunogenetics
Title: CIITA B-cell-specific promoter suppression in MHC class II-silenced cell hybrids.
Volume: 48
Issue: 4
Pages: 283-91
•
•
•
•
•
Publication
11438649 | -
First Author: Sisk TJ
Year: 2001
Journal: Mol Cell Biol
Title: Self-association of CIITA and its transactivation potential.
Volume: 21
Issue: 15
Pages: 4919-28
•
•
•
•
•
Publication
17043423 | J:127565
First Author: Kim TW
Year: 2006
Journal: J Korean Med Sci
Title: Overexpression of CIITA in T cells aggravates Th2-mediated colitis in mice.
Volume: 21
Issue: 5
Pages: 877-82
•
•
•
•
•
Publication
16785500 | J:134410
First Author: Yao Y
Year: 2006
Journal: J Immunol
Title: ERK and p38 MAPK signaling pathways negatively regulate CIITA gene expression in dendritic cells and macrophages.
Volume: 177
Issue: 1
Pages: 70-6
•
•
•
•
•
Publication
19502584 | J:150283
First Author: Ito T
Year: 2009
Journal: Int Immunol
Title: Roles of PU.1 in monocyte- and mast cell-specific gene regulation: PU.1 transactivates CIITA pIV in cooperation with IFN-gamma.
Volume: 21
Issue: 7
Pages: 803-16
•
•
•
•
•
Protein
P79621
Organism: Mus musculus/domesticus
Length: 1155  
Fragment?: false
•
•
•
•
•
Publication
11792431 | -
First Author: Towey M
Year: 2002
Journal: Mol Immunol
Title: Nuclear localisation of CIITA is controlled by a carboxy terminal leucine-rich repeat region.
Volume: 38
Issue: 8
Pages: 627-34
•
•
•
•
•
Allele
Ciita<tm1Jpyt> | MGI:2158705
Name: class II transactivator; targeted mutation 1, Jenny P Y Ting
Allele Type: Targeted
Attribute String: Null/knockout
•
•
•
•
•
Publication
9600954 | -
First Author: Wright KL
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: CIITA stimulation of transcription factor binding to major histocompatibility complex class II and associated promoters in vivo.
Volume: 95
Issue: 11
Pages: 6267-72
•
•
•
•
•
Publication
10809673 | -
First Author: Masternak K
Year: 2000
Journal: Genes Dev
Title: CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex.
Volume: 14
Issue: 9
Pages: 1156-66
•
•
•
•
•
Protein
P79621-2
Organism: Mus musculus/domesticus
Length: 1078  
Fragment?: false
•
•
•
•
•
Protein
P79621-3
Organism: Mus musculus/domesticus
Length: 1054  
Fragment?: false
•
•
•
•
•
Allele
Ciita<tm2Wrth> | MGI:3052223
Name: class II transactivator; targeted mutation 2, Walter Reith
Allele Type: Targeted
Attribute String: Null/knockout
•
•
•
•
•
Allele
Ciita<tm1Ccum> | MGI:1857456
Name: class II transactivator; targeted mutation 1, Cheong-Hee Chang
Allele Type: Targeted
Attribute String: Null/knockout
•
•
•
•
•
Allele
Tg(Lck-CIITA)16Spark | MGI:6107219
Name: transgene insertion 16, Seong Park
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
•
•
•
•
•
Strain
MGI:6107224 | C57BL/6-Tg(Lck-CIITA)16Spark/J
Attribute String: coisogenic, transgenic
•
•
•
•
•
Interaction Experiment
Yoon HS (2012)
Description: ZBTB32 is an early repressor of the CIITA and MHC class II gene expression during B cell differentiation to plasma cells.
•
•
•
•
•
Protein
Q3KND9
Organism: Mus musculus/domesticus
Length: 302  
Fragment?: false
•
•
•
•
•
Protein
A0A2R8VHL9
Organism: Mus musculus/domesticus
Length: 104  
Fragment?: true
•
•
•
•
•
Protein
Q3KNE0
Organism: Mus musculus/domesticus
Length: 320  
Fragment?: false
•
•
•
•
•
Publication
11413136 | -
First Author: Kretsovali A
Year: 2001
Journal: J Biol Chem
Title: Self-association of class II transactivator correlates with its intracellular localization and transactivation.
Volume: 276
Issue: 34
Pages: 32191-7
•
•
•
•
•
Publication
11777970 | -
First Author: Holling TM
Year: 2002
Journal: J Immunol
Title: Activated human T cells accomplish MHC class II expression through T cell-specific occupation of class II transactivator promoter III.
Volume: 168
Issue: 2
Pages: 763-70
•
•
•
•
•
Publication
11823510 | -
First Author: Nagarajan UM
Year: 2002
Journal: J Immunol
Title: Class II transactivator is required for maximal expression of HLA-DOB in B cells.
Volume: 168
Issue: 4
Pages: 1780-6
•
•
•
•
•
Protein Domain
IPR008095 | MHC_II_transact
Type: Family
Description: Class II transactivator (CIITA) determines the level, cell type specificity,inducibility and extinction of MHC-II expression. CIITA is also the obligatory mediator of INF-gamma inducible MHC-II expression. Thus controlof MHC-II expression is ultimately dependent on the control of expressionof the CIITA gene itself. Defective CIITA has been shown to be responsiblefor one class of base lymphocyte syndrome (BLS). BLS is an often fatal genetic defect, characterised by severe immunodeficiency as a result of failure to express MHC class II genes. Expression of CIITA is controlled byfour independent CIITA promoters, leading to CIITA transcripts with four distinct first exons. The individual promoters are used in an alternativeand tissue-specific manner. CIITA promoter (CIITA-P)I is the promoter usedin dentritic cells; CIITA-PII is expressed at insignificant levels and is as yet functionally poorly understood; CIITA-PIII is constitutivelyexpressed in B lymphocytes and can drive CIITA expression after INF-gammastimulation in a number of different cell types, including endothelial cellsand fibroblasts; and CIITA-PIV is the principal INF-gamma-inducible promoter.The cellular and temporal diversity in MHC class II expression is thus regulated via the different usage of the CIITA promoters[, , , , , ].CIITA contains four domains: acidic (A), proline-serine-threonine-rich (PST), GTP-binding (GBD), and leucine-rich repeat (LRR). All of these are requiredto activate the MHC class II promoter. The acidic transcriptional activationdomain interacts with TAFII32. Recruitment of the coactivator protein CBP bythe acidic domain has also been shown to lead to synergistic activation ofMHC class II promoters and the repression of the interleukin-4 promoter. ThePST domain is essential for CIITA function, but its exact role remains unknown. The central region containing the GTP-binding and LXXLL motifs plays an important role in CIITA self-association. This region interacts with itself, the N-terminal domain of CIITA (A/PST) and C-terminal LRR. In addition to their role in CIITA self-association, which is generally necessary for the association of the protein with the import machinery, bothGBD (where GTP binding is believed to cause a conformational change compatible with nuclear translocation) and LRR domains have been shown toplay important roles in the nuclear localisation of CIITA. Human CIITA appears to contain a NLS. Export of a protein depends on the presence of a specific export signal (NES). NESs are short leucine-rich motifs - in CIITA, they have the consensus LXXXLXXLXL, and arelocalised in the N- and C-terminal regions[, , ].Numerous in vitro and functional studies have implicated CIITA in multiplesteps of the transcriptional activation process: e.g., (i) it may facilitatechromatin remodelling, as it interacts with histone acetyltransferases;moreover, it has intrinsic acetyltransferase activity; (ii) it interactswith the general transcription factors TFIIB, HTAFII32 and HTAFI70, implyingthat it may recruit the transcriptional apparatus directly; (iii) itinteracts with TFIIH and P-TEFb, and may therefore enhance promoterclearance and transcription elongation.
•
•
•
•
•
Publication
18031696 | J:127619
First Author: Li W
Year: 2007
Journal: Immunity
Title: The SLAM-associated protein signaling pathway is required for development of CD4+ T cells selected by homotypic thymocyte interaction.
Volume: 27
Issue: 5
Pages: 763-74
•
•
•
•
•
Genotype
Genotype
Symbol: Tg(CD4-CIITA)357Ccum/?
Background: involves: C57BL/6 * C57BL/6J * SJL
Zygosity: ot
Has Mutant Allele: true
•
•
•
•
•
Protein
Q8HW99
Organism: Mus musculus/domesticus
Length: 977  
Fragment?: false
•
•
•
•
•
Protein
Q3U2F8
Organism: Mus musculus/domesticus
Length: 917  
Fragment?: true
•
•
•
•
•
Protein
Q3U2P0
Organism: Mus musculus/domesticus
Length: 1078  
Fragment?: false
•
•
•
•
•
Protein
Q3UU40
Organism: Mus musculus/domesticus
Length: 1053  
Fragment?: false
•
•
•
•
•
Protein
Q3U5G4
Organism: Mus musculus/domesticus
Length: 1078  
Fragment?: false
•
•
•
•
•
Protein
Q3UNW8
Organism: Mus musculus/domesticus
Length: 1155  
Fragment?: false
•
•
•
•
•
Protein
A0A2R8VHC7
Organism: Mus musculus/domesticus
Length: 1075  
Fragment?: false
•
•
•
•
•
Publication
18982019 | J:160865
First Author: Li W
Year: 2009
Journal: Immunol Cell Biol
Title: MHC class II-expressing thymocytes suppress invariant NKT cell development.
Volume: 87
Issue: 2
Pages: 186-9
•
•
•
•
•
Publication
21282512 | J:169377
First Author: Sofi MH
Year: 2011
Journal: J Immunol
Title: Induction and maintenance of IL-4 expression are regulated differently by the 3' enhancer in CD4 T cells.
Volume: 186
Issue: 5
Pages: 2792-9
•
•
•
•
•
Publication
10781943 | J:62089
First Author: Rohm B
Year: 2000
Journal: Mech Dev
Title: Plexin/neuropilin complexes mediate repulsion by the axonal guidance signal semaphorin 3A.
Volume: 93
Issue: 1-2
Pages: 95-104
•
•
•
•
•
Publication
16715077 | J:110786
First Author: Takegahara N
Year: 2006
Journal: Nat Cell Biol
Title: Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis.
Volume: 8
Issue: 6
Pages: 615-22
•
•
•
•
•
Publication
18649144 | -
First Author: O'Connor BP
Year: 2008
Journal: Immunol Res
Title: The evolving role of semaphorins and plexins in the immune system: Plexin-A1 regulation of dendritic cell function.
Volume: 41
Issue: 3
Pages: 217-22
•
•
•
•
•
Protein Domain
IPR042744 | Plexin-A1_Sema
Type: Domain
Description: Plexin A1 is found in both the nervous and immune systems. Its external Sema domain is also shared by semaphorin proteins. In the nervous system, Plexin A1 mediates Sema3A axon guidance function by interacting with the Sema3A coreceptor neuropilin, resulting in actin depolarization and cell repulsion [, ]. In the immune system, Plexin A1 mediates Sema6D signaling by binding to the Sema6D-Trem2-DAP12 complex on immune cells and osteoclasts to promote Rac activation and DAP12 phosphorylation []. In gene profiling experiments, Plexin A1 was identified as a CIITA (class II transactivator) regulated gene in primary dendritic cells (DCs) []. The Sema domain is located at the N terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.
•
•
•
•
•
Publication
33863906 | J:317587
First Author: Georgiev H
Year: 2021
Journal: Nat Commun
Title: Classical MHC expression by DP thymocytes impairs the selection of non-classical MHC restricted innate-like T cells.
Volume: 12
Issue: 1
Pages: 2308
•
•
•
•
•
Publication
23776174 | J:205450
First Author: Zhu L
Year: 2013
Journal: J Immunol
Title: A transgenic TCR directs the development of IL-4+ and PLZF+ innate CD4 T cells.
Volume: 191
Issue: 2
Pages: 737-44
•
•
•
•
•
Publication
37327784 | J:338142
First Author: He K
Year: 2023
Journal: Cell
Title: Gasdermin D licenses MHCII induction to maintain food tolerance in small intestine.
Volume: 186
Issue: 14
Pages: 3033-3048.e20
•
•
•
•
•
Publication
11486010 | J:76184
First Author: Peretti M
Year: 2001
Journal: Mol Cell Biol
Title: Expression of the three human major histocompatibility complex class II isotypes exhibits a differential dependence on the transcription factor RFXAP.
Volume: 21
Issue: 17
Pages: 5699-709
•
•
•
•
•
Publication
9806546 | J:50539
First Author: Masternak K
Year: 1998
Journal: Nat Genet
Title: A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients.
Volume: 20
Issue: 3
Pages: 273-7
•
•
•
•
•
Publication
9126988 | J:39790
First Author: Hobart M
Year: 1997
Journal: J Immunol
Title: IFN regulatory factor-1 plays a central role in the regulation of the expression of class I and II MHC genes in vivo.
Volume: 158
Issue: 9
Pages: 4260-9
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom