Signal peptide peptidase-like 2B (MEROPS identifier A22.004) is a transmembrane, aspartic endopeptidase that performs regulated intramembrane proteolysis of type II transmembrane proteins []. It is primarily expressed at the cell surface []. It is known to cleave tumour necrosis factor alpha at multiple sites, releasing an intracellular domain that moves to the nucleus and triggers interleukin-12 production [, ]. Other proteins are cleaved, including the membrane stubs of transferrin receptor 1, the British dementia protein 2 and neuroregulin 1 following the shedding of the ectodomain mediated by other peptidases such as ADAM-10 and BACE-1 [, , ].
