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Search results 101 to 200 out of 810 for Htt

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Category: Publication
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Type Details Score
Publication
28715425 | J:244131
First Author: Dietrich P
Year: 2017
Journal: PLoS Genet
Title: Elimination of huntingtin in the adult mouse leads to progressive behavioral deficits, bilateral thalamic calcification, and altered brain iron homeostasis.
Volume: 13
Issue: 7
Pages: e1006846
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Publication
25035419 | J:215617
First Author: Sun X
Year: 2014
Journal: Hum Mol Genet
Title: Phosphorodiamidate morpholino oligomers suppress mutant huntingtin expression and attenuate neurotoxicity.
Volume: 23
Issue: 23
Pages: 6302-17
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Publication
20616151 | J:163641
First Author: Heng MY
Year: 2010
Journal: Hum Mol Genet
Title: Early autophagic response in a novel knock-in model of Huntington disease.
Volume: 19
Issue: 19
Pages: 3702-20
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Publication
18337408 | J:133021
First Author: Orr AL
Year: 2008
Journal: J Neurosci
Title: N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial trafficking.
Volume: 28
Issue: 11
Pages: 2783-92
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Publication
16403806 | J:106763
First Author: Clabough EB
Year: 2006
Journal: Hum Mol Genet
Title: Deletion of the triplet repeat encoding polyglutamine within the mouse Huntington's disease gene results in subtle behavioral/motor phenotypes in vivo and elevated levels of ATP with cellular senescence in vitro.
Volume: 15
Issue: 4
Pages: 607-23
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Publication
15829505 | J:99272
First Author: Van Raamsdonk JM
Year: 2005
Journal: Hum Mol Genet
Title: Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease.
Volume: 14
Issue: 10
Pages: 1379-92
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Publication
16571604 | J:108220
First Author: Van Raamsdonk JM
Year: 2006
Journal: Hum Mol Genet
Title: Body weight is modulated by levels of full-length huntingtin.
Volume: 15
Issue: 9
Pages: 1513-23
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Publication
26659666 | J:234676
First Author: Yan J
Year: 2016
Journal: J Cell Sci
Title: Germline deletion of huntingtin causes male infertility and arrested spermiogenesis in mice.
Volume: 129
Issue: 3
Pages: 492-501
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Publication
21248135 | J:168558
First Author: Rozas JL
Year: 2011
Journal: J Neurosci
Title: Increased neurotransmitter release at the neuromuscular junction in a mouse model of polyglutamine disease.
Volume: 31
Issue: 3
Pages: 1106-13
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Publication
28743452 | J:261948
 
First Author: Moily NS
Year: 2017
Journal: Mol Cell Neurosci
Title: Transcriptional profiles for distinct aggregation states of mutant Huntingtin exon 1 protein unmask new Huntington's disease pathways.
Volume: 83
Pages: 103-112
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Publication
21106706 | J:168742
First Author: Mughal MR
Year: 2011
Journal: Hum Mol Genet
Title: Electroconvulsive shock ameliorates disease processes and extends survival in huntingtin mutant mice.
Volume: 20
Issue: 4
Pages: 659-69
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Publication
15190011 | J:91795
First Author: Schilling G
Year: 2004
Journal: Hum Mol Genet
Title: Nuclear-targeting of mutant huntingtin fragments produces Huntington's disease-like phenotypes in transgenic mice.
Volume: 13
Issue: 15
Pages: 1599-610
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Publication
16150600 | J:105730
First Author: Tanaka Y
Year: 2006
Journal: Neurobiol Dis
Title: Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin.
Volume: 21
Issue: 2
Pages: 381-91
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Publication
19710014 | J:157814
First Author: Aiken CT
Year: 2009
Journal: J Biol Chem
Title: Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity.
Volume: 284
Issue: 43
Pages: 29427-36
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Publication
22556411 | J:187532
First Author: Culver BP
Year: 2012
Journal: J Biol Chem
Title: Proteomic analysis of wild-type and mutant huntingtin-associated proteins in mouse brains identifies unique interactions and involvement in protein synthesis.
Volume: 287
Issue: 26
Pages: 21599-614
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Publication
23829302 | J:214788
First Author: Lee CY
Year: 2013
Journal: FEBS J
Title: Genetic manipulations of mutant huntingtin in mice: new insights into Huntington's disease pathogenesis.
Volume: 280
Issue: 18
Pages: 4382-94
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Publication
27203582 | J:231880
First Author: Liu X
Year: 2016
Journal: PLoS Genet
Title: N-terminal Huntingtin Knock-In Mice: Implications of Removing the N-terminal Region of Huntingtin for Therapy.
Volume: 12
Issue: 5
Pages: e1006083
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Publication
27525439 | J:237242
First Author: Kratter IH
Year: 2016
Journal: J Clin Invest
Title: Serine 421 regulates mutant huntingtin toxicity and clearance in mice.
Volume: 126
Issue: 9
Pages: 3585-97
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Publication
28104789 | J:241664
First Author: Southwell AL
Year: 2017
Journal: Hum Mol Genet
Title: A novel humanized mouse model of Huntington disease for preclinical development of therapeutics targeting mutant huntingtin alleles.
Volume: 26
Issue: 6
Pages: 1115-1132
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Publication
29274742 | J:259024
 
First Author: Dragatsis I
Year: 2018
Journal: Neurobiol Dis
Title: Effect of early embryonic deletion of huntingtin from pyramidal neurons on the development and long-term survival of neurons in cerebral cortex and striatum.
Volume: 111
Pages: 102-117
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Publication
22892315 | J:316808
 
First Author: Zheng S
Year: 2012
Journal: Mol Brain
Title: A series of N-terminal epitope tagged Hdh knock-in alleles expressing normal and mutant huntingtin: their application to understanding the effect of increasing the length of normal Huntingtin's polyglutamine stretch on CAG140 mouse model pathogenesis.
Volume: 5
Pages: 28
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Publication
22191580 | J:318097
First Author: Wegrzynowicz M
Year: 2012
Journal: J Proteome Res
Title: Changes in the striatal proteome of YAC128Q mice exhibit gene-environment interactions between mutant huntingtin and manganese.
Volume: 11
Issue: 2
Pages: 1118-32
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Publication
26165689 | J:225983
First Author: El-Daher MT
Year: 2015
Journal: EMBO J
Title: Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation.
Volume: 34
Issue: 17
Pages: 2255-71
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Publication
16423528 | J:111314
First Author: Kim YJ
Year: 2006
Journal: Neurobiol Dis
Title: Lysosomal proteases are involved in generation of N-terminal huntingtin fragments.
Volume: 22
Issue: 2
Pages: 346-56
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Publication
32747555 | J:296802
First Author: Liu Q
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Loss of Hap1 selectively promotes striatal degeneration in Huntington disease mice.
Volume: 117
Issue: 33
Pages: 20265-20273
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Publication
26141599 | J:227429
 
First Author: Zeng L
Year: 2015
Journal: Neurobiol Dis
Title: Differential recruitment of UBQLN2 to nuclear inclusions in the polyglutamine diseases HD and SCA3.
Volume: 82
Pages: 281-288
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Publication
34233199 | J:330751
First Author: Benraiss A
Year: 2021
Journal: Cell Rep
Title: Cell-intrinsic glial pathology is conserved across human and murine models of Huntington's disease.
Volume: 36
Issue: 1
Pages: 109308
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Publication
28017473 | J:253262
First Author: Barnat M
Year: 2017
Journal: Neuron
Title: Huntingtin-Mediated Multipolar-Bipolar Transition of Newborn Cortical Neurons Is Critical for Their Postnatal Neuronal Morphology.
Volume: 93
Issue: 1
Pages: 99-114
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Publication
21768291 | J:176978
First Author: Ju TC
Year: 2011
Journal: J Cell Biol
Title: Nuclear translocation of AMPK-alpha1 potentiates striatal neurodegeneration in Huntington's disease.
Volume: 194
Issue: 2
Pages: 209-27
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Publication
28194040 | J:243965
 
First Author: Gomez-Pastor R
Year: 2017
Journal: Nat Commun
Title: Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease.
Volume: 8
Pages: 14405
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Publication
24706802 | J:208633
First Author: Bhat KP
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Differential ubiquitination and degradation of huntingtin fragments modulated by ubiquitin-protein ligase E3A.
Volume: 111
Issue: 15
Pages: 5706-11
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Publication
18065495 | J:132047
First Author: Luo S
Year: 2008
Journal: Hum Mol Genet
Title: p21-activated kinase 1 promotes soluble mutant huntingtin self-interaction and enhances toxicity.
Volume: 17
Issue: 6
Pages: 895-905
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Publication
22891683 | J:190569
First Author: Dong G
Year: 2012
Journal: J Neurochem
Title: Calretinin interacts with huntingtin and reduces mutant huntingtin-caused cytotoxicity.
Volume: 123
Issue: 3
Pages: 437-46
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Publication
32574176 | J:293450
First Author: Goodliffe J
Year: 2020
Journal: PLoS One
Title: Structural and functional features of medium spiny neurons in the BACHDΔN17 mouse model of Huntington's Disease.
Volume: 15
Issue: 6
Pages: e0234394
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Publication
32004439 | J:293473
First Author: Wertz MH
Year: 2020
Journal: Neuron
Title: Genome-wide In Vivo CNS Screening Identifies Genes that Modify CNS Neuronal Survival and mHTT Toxicity.
Volume: 106
Issue: 1
Pages: 76-89.e8
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Publication
30239724 | J:269327
First Author: Cheng C
Year: 2018
Journal: Hum Mol Genet
Title: The long non-coding RNA NEAT1 is elevated in polyglutamine repeat expansion diseases and protects from disease gene-dependent toxicities.
Volume: 27
Issue: 24
Pages: 4303-4314
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Publication
36278490 | J:333052
 
First Author: Marchionini DM
Year: 2022
Journal: JCI Insight
Title: Benefits of global mutant huntingtin lowering diminish over time in a Huntington's disease mouse model.
Volume: 7
Issue: 20
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Publication
25101683 | J:228599
First Author: Mielcarek M
Year: 2014
Journal: PLoS Genet
Title: Dysfunction of the CNS-heart axis in mouse models of Huntington's disease.
Volume: 10
Issue: 8
Pages: e1004550
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Publication
37187609 | J:345998
 
First Author: Brown TG
Year: 2023
Journal: Front Cell Neurosci
Title: Striatal spatial heterogeneity, clustering, and white matter association of GFAP(+) astrocytes in a mouse model of Huntington's disease.
Volume: 17
Pages: 1094503
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Publication
22508027 | J:196830
First Author: Ritch JJ
Year: 2012
Journal: Mol Cell Neurosci
Title: Multiple phenotypes in Huntington disease mouse neural stem cells.
Volume: 50
Issue: 1
Pages: 70-81
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Publication
31040226 | J:294485
First Author: Federspiel JD
Year: 2019
Journal: Mol Cell Proteomics
Title: Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.
Volume: 18
Issue: 8 suppl 1
Pages: S92-S113
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Publication
23284644 | J:195638
First Author: Heikkinen T
Year: 2012
Journal: PLoS One
Title: Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease.
Volume: 7
Issue: 12
Pages: e50717
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Publication
26293574 | J:225968
 
First Author: Thion MS
Year: 2015
Journal: J Natl Cancer Inst
Title: Unraveling the Role of Huntingtin in Breast Cancer Metastasis.
Volume: 107
Issue: 10
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Publication
21897851 | J:176142
First Author: Lee JM
Year: 2011
Journal: PLoS One
Title: Quantification of age-dependent somatic CAG repeat instability in Hdh CAG knock-in mice reveals different expansion dynamics in striatum and liver.
Volume: 6
Issue: 8
Pages: e23647
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Publication
26464486 | J:226831
First Author: Manczak M
Year: 2015
Journal: Hum Mol Genet
Title: Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington's disease.
Volume: 24
Issue: 25
Pages: 7308-25
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Publication
25762686 | J:220155
First Author: Estrada-Sánchez AM
Year: 2015
Journal: J Neurosci
Title: Cortical efferents lacking mutant huntingtin improve striatal neuronal activity and behavior in a conditional mouse model of Huntington's disease.
Volume: 35
Issue: 10
Pages: 4440-51
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Publication
25619660 | J:221683
First Author: Francelle L
Year: 2015
Journal: Neurobiol Aging
Title: Striatal long noncoding RNA Abhd11os is neuroprotective against an N-terminal fragment of mutant huntingtin in vivo.
Volume: 36
Issue: 3
Pages: 1601.e7-16
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Publication
25398949 | J:219382
First Author: Francelle L
Year: 2015
Journal: Hum Mol Genet
Title: Loss of the thyroid hormone-binding protein Crym renders striatal neurons more vulnerable to mutant huntingtin in Huntington's disease.
Volume: 24
Issue: 6
Pages: 1563-73
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Publication
11788820 | J:83173
First Author: Gervais FG
Year: 2002
Journal: Nat Cell Biol
Title: Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.
Volume: 4
Issue: 2
Pages: 95-105
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Publication
32452382 | J:290298
   
First Author: Bruyère J
Year: 2020
Journal: Elife
Title: Presynaptic APP levels and synaptic homeostasis are regulated by Akt phosphorylation of huntingtin.
Volume: 9
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Publication
36044862 | J:328312
First Author: Wennagel D
Year: 2022
Journal: Cell Rep
Title: Huntingtin coordinates dendritic spine morphology and function through cofilin-mediated control of the actin cytoskeleton.
Volume: 40
Issue: 9
Pages: 111261
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Publication
30742117 | J:277509
First Author: Shen M
Year: 2019
Journal: Nat Neurosci
Title: Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1-mutant mice.
Volume: 22
Issue: 3
Pages: 386-400
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20064390 | J:157723
First Author: Gu X
Year: 2009
Journal: Neuron
Title: Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.
Volume: 64
Issue: 6
Pages: 828-40
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31017573 | J:274702
   
First Author: Carrillo-Reid L
Year: 2019
Journal: Elife
Title: Mutant huntingtin enhances activation of dendritic Kv4 K+ channels in striatal spiny projection neurons.
Volume: 8
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Publication
25661181 | J:219890
First Author: Gu X
Year: 2015
Journal: Neuron
Title: N17 Modifies mutant Huntingtin nuclear pathogenesis and severity of disease in HD BAC transgenic mice.
Volume: 85
Issue: 4
Pages: 726-41
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Publication
22512000 | J:217581
 
First Author: Oakeshott S
Year: 2011
Journal: PLoS Curr
Title: HD mouse models reveal clear deficits in learning to perform a simple instrumental response.
Volume: 3
Pages: RRN1282
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Publication
21184755 | J:170728
First Author: Kudo T
Year: 2011
Journal: Exp Neurol
Title: Dysfunctions in circadian behavior and physiology in mouse models of Huntington's disease.
Volume: 228
Issue: 1
Pages: 80-90
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Publication
19464370 | J:185262
First Author: Menalled L
Year: 2009
Journal: Neurobiol Dis
Title: Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models.
Volume: 35
Issue: 3
Pages: 319-36
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Publication
27601642 | J:235571
First Author: Zhao X
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease.
Volume: 113
Issue: 38
Pages: E5655-64
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Publication
28986324 | J:259072
First Author: Wang B
Year: 2018
Journal: Neurobiol Dis
Title: The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin.
Volume: 109
Issue: Pt A
Pages: 127-136
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Publication
25009276 | J:215303
First Author: McKinstry SU
Year: 2014
Journal: J Neurosci
Title: Huntingtin is required for normal excitatory synapse development in cortical and striatal circuits.
Volume: 34
Issue: 28
Pages: 9455-72
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27147652 | J:231731
First Author: Covey DP
Year: 2016
Journal: J Neurosci
Title: Compromised Dopaminergic Encoding of Reward Accompanying Suppressed Willingness to Overcome High Effort Costs Is a Prominent Prodromal Characteristic of the Q175 Mouse Model of Huntington's Disease.
Volume: 36
Issue: 18
Pages: 4993-5002
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Publication
30626701 | J:273845
First Author: Mehler MF
Year: 2019
Journal: J Neurosci
Title: Loss-of-Huntingtin in Medial and Lateral Ganglionic Lineages Differentially Disrupts Regional Interneuron and Projection Neuron Subtypes and Promotes Huntington's Disease-Associated Behavioral, Cellular, and Pathological Hallmarks.
Volume: 39
Issue: 10
Pages: 1892-1909
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Publication
26295712 | J:243035
First Author: Carroll JB
Year: 2015
Journal: PLoS One
Title: HdhQ111 Mice Exhibit Tissue Specific Metabolite Profiles that Include Striatal Lipid Accumulation.
Volume: 10
Issue: 8
Pages: e0134465
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Publication
18502655 | J:144442
First Author: Zhang H
Year: 2008
Journal: Neurobiol Dis
Title: Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease.
Volume: 31
Issue: 1
Pages: 80-8
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Publication
33907289 | J:316351
First Author: Gomez-Paredes C
Year: 2021
Journal: Sci Rep
Title: The heat shock response, determined by QuantiGene multiplex, is impaired in HD mouse models and not caused by HSF1 reduction.
Volume: 11
Issue: 1
Pages: 9117
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Publication
36867535 | J:334081
First Author: Mansky RH
Year: 2023
Journal: Cell Rep
Title: Tumor suppressor p53 regulates heat shock factor 1 protein degradation in Huntington's disease.
Volume: 42
Issue: 3
Pages: 112198
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Publication
31913581 | J:323676
First Author: Ehinger Y
Year: 2020
Journal: EMBO Mol Med
Title: Huntingtin phosphorylation governs BDNF homeostasis and improves the phenotype of Mecp2 knockout mice.
Volume: 12
Issue: 2
Pages: e10889
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Publication
32990597 | J:298667
   
First Author: Kovalenko M
Year: 2020
Journal: Elife
Title: Histone deacetylase knockouts modify transcription, CAG instability and nuclear pathology in Huntington disease mice.
Volume: 9
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Publication
25942483 | J:222962
First Author: Elias S
Year: 2015
Journal: PLoS Biol
Title: Huntingtin Is Required for Epithelial Polarity through RAB11A-Mediated Apical Trafficking of PAR3-aPKC.
Volume: 13
Issue: 5
Pages: e1002142
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Publication
31015293 | J:275798
First Author: Ferrari Bardile C
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Intrinsic mutant HTT-mediated defects in oligodendroglia cause myelination deficits and behavioral abnormalities in Huntington disease.
Volume: 116
Issue: 19
Pages: 9622-9627
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24946181 | J:217949
First Author: Ju TC
Year: 2014
Journal: Biochim Biophys Acta
Title: AMPK-α1 functions downstream of oxidative stress to mediate neuronal atrophy in Huntington's disease.
Volume: 1842
Issue: 9
Pages: 1668-80
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Publication
15749339 | J:96770
First Author: Tallaksen-Greene SJ
Year: 2005
Journal: Neuroscience
Title: Neuronal intranuclear inclusions and neuropil aggregates in HdhCAG(150) knockin mice.
Volume: 131
Issue: 4
Pages: 843-52
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Publication
24453320 | J:206857
First Author: Wong YC
Year: 2014
Journal: J Neurosci
Title: The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation.
Volume: 34
Issue: 4
Pages: 1293-305
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Publication
23852340 | J:200090
First Author: Marco S
Year: 2013
Journal: Nat Med
Title: Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models.
Volume: 19
Issue: 8
Pages: 1030-8
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Publication
25760041 | J:224237
First Author: Cheng HM
Year: 2015
Journal: PLoS Genet
Title: Effects on murine behavior and lifespan of selectively decreasing expression of mutant huntingtin allele by supt4h knockdown.
Volume: 11
Issue: 3
Pages: e1005043
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Publication
29891550 | J:267137
First Author: Pan Y
Year: 2018
Journal: J Biol Chem
Title: The role of Twist1 in mutant huntingtin-induced transcriptional alterations and neurotoxicity.
Volume: 293
Issue: 30
Pages: 11850-11866
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Publication
17213233 | J:121854
First Author: Chiang MC
Year: 2007
Journal: Hum Mol Genet
Title: Dysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease.
Volume: 16
Issue: 5
Pages: 483-98
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Publication
22589249 | J:185361
First Author: Chaturvedi RK
Year: 2012
Journal: Hum Mol Genet
Title: Transducer of regulated CREB-binding proteins (TORCs) transcription and function is impaired in Huntington's disease.
Volume: 21
Issue: 15
Pages: 3474-88
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Publication
29789657 | J:263818
First Author: McClory H
Year: 2018
Journal: Sci Rep
Title: The COOH-terminal domain of huntingtin interacts with RhoGEF kalirin and modulates cell survival.
Volume: 8
Issue: 1
Pages: 8000
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Publication
24948797 | J:212083
First Author: Wade BE
Year: 2014
Journal: J Neurosci
Title: Ubiquitin-activating enzyme activity contributes to differential accumulation of mutant huntingtin in brain and peripheral tissues.
Volume: 34
Issue: 25
Pages: 8411-22
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Publication
32820193 | J:294905
First Author: Mason MA
Year: 2020
Journal: Sci Rep
Title: Silencing Srsf6 does not modulate incomplete splicing of the huntingtin gene in Huntington's disease models.
Volume: 10
Issue: 1
Pages: 14057
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Publication
24105466 | J:205992
First Author: McFarland KN
Year: 2014
Journal: Hum Mol Genet
Title: MeCP2: a novel Huntingtin interactor.
Volume: 23
Issue: 4
Pages: 1036-44
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Publication
24960609 | J:213778
First Author: Tourette C
Year: 2014
Journal: PLoS Biol
Title: The Wnt receptor Ryk reduces neuronal and cell survival capacity by repressing FOXO activity during the early phases of mutant huntingtin pathogenicity.
Volume: 12
Issue: 6
Pages: e1001895
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Publication
27199664 | J:244546
 
First Author: Agostoni E
Year: 2016
Journal: Front Cell Neurosci
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