Type |
Details |
Score |
Publication |
First Author: |
Economides AN |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Conditionals by inversion provide a universal method for the generation of conditional alleles. |
Volume: |
110 |
Issue: |
34 |
Pages: |
E3179-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mao CA |
Year: |
2008 |
Journal: |
Development |
Title: |
Rewiring the retinal ganglion cell gene regulatory network: Neurod1 promotes retinal ganglion cell fate in the absence of Math5. |
Volume: |
135 |
Issue: |
20 |
Pages: |
3379-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jurberg AD |
Year: |
2014 |
Journal: |
Dev Biol |
Title: |
Compartment-dependent activities of Wnt3a/β-catenin signaling during vertebrate axial extension. |
Volume: |
394 |
Issue: |
2 |
Pages: |
253-63 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang W |
Year: |
2019 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The TGFβ type I receptor TGFβRI functions as an inhibitor of BMP signaling in cartilage. |
Volume: |
116 |
Issue: |
31 |
Pages: |
15570-15579 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pitera JE |
Year: |
2008 |
Journal: |
Hum Mol Genet |
Title: |
Fras1, a basement membrane-associated protein mutated in Fraser syndrome, mediates both the initiation of the mammalian kidney and the integrity of renal glomeruli. |
Volume: |
17 |
Issue: |
24 |
Pages: |
3953-64 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oliver-Krasinski JM |
Year: |
2009 |
Journal: |
J Clin Invest |
Title: |
The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in mice. |
Volume: |
119 |
Issue: |
7 |
Pages: |
1888-98 |
|
•
•
•
•
•
|
Publication |
First Author: |
Young T |
Year: |
2009 |
Journal: |
Dev Cell |
Title: |
Cdx and Hox genes differentially regulate posterior axial growth in mammalian embryos. |
Volume: |
17 |
Issue: |
4 |
Pages: |
516-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dias A |
Year: |
2020 |
Journal: |
Elife |
Title: |
A Tgfbr1/Snai1-dependent developmental module at the core of vertebrate axial elongation. |
Volume: |
9 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Yates LL |
Year: |
2010 |
Journal: |
Hum Mol Genet |
Title: |
The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation. |
Volume: |
19 |
Issue: |
23 |
Pages: |
4663-76 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hu B |
Year: |
2012 |
Journal: |
Cell |
Title: |
Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. |
Volume: |
149 |
Issue: |
6 |
Pages: |
1207-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
Journal: |
Database Download |
Title: |
Integrating Computational Gene Models into the Mouse Genome Informatics (MGI) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Thompson CL |
Year: |
2014 |
Journal: |
Neuron |
Title: |
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. |
Volume: |
83 |
Issue: |
2 |
Pages: |
309-323 |
|
•
•
•
•
•
|
Publication |
First Author: |
Koscielny G |
Year: |
2014 |
Journal: |
Nucleic Acids Res |
Title: |
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |
Volume: |
42 |
Issue: |
Database issue |
Pages: |
D802-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
International Knockout Mouse Consortium |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of modified allele data from IKMC and creation of new knockout alleles |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
International Mouse Strain Resource |
Year: |
2014 |
Journal: |
Database Download |
Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Helmholtz Zentrum Muenchen GmbH |
Year: |
2010 |
Journal: |
MGI Direct Data Submission |
Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
Year: |
2014 |
Journal: |
Database Release |
Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
|
Title: |
Rat to Mouse ISO GO annotation transfer |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Magdaleno S |
Year: |
2006 |
Journal: |
PLoS Biol |
Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
Volume: |
4 |
Issue: |
4 |
Pages: |
e86 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2000 |
|
Title: |
Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
|
Title: |
Human to Mouse ISO GO annotation transfer |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGI Genome Annotation Group and UniGene Staff |
Year: |
2015 |
Journal: |
Database Download |
Title: |
MGI-UniGene Interconnection Effort |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Camaschella C |
Year: |
2019 |
Journal: |
Blood |
Title: |
GDF11 is not the target of luspatercept. |
Volume: |
134 |
Issue: |
6 |
Pages: |
500-501 |
|
•
•
•
•
•
|
Publication |
First Author: |
Bajikar SS |
Year: |
2017 |
Journal: |
Dev Cell |
Title: |
Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer. |
Volume: |
43 |
Issue: |
4 |
Pages: |
418-435.e13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sinha M |
Year: |
2014 |
Journal: |
Science |
Title: |
Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle. |
Volume: |
344 |
Issue: |
6184 |
Pages: |
649-52 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu W |
Year: |
2016 |
Journal: |
Nat Commun |
Title: |
GDF11 decreases bone mass by stimulating osteoclastogenesis and inhibiting osteoblast differentiation. |
Volume: |
7 |
|
Pages: |
12794 |
|
•
•
•
•
•
|
Publication |
First Author: |
Saito S |
Year: |
2024 |
Journal: |
Front Cell Dev Biol |
Title: |
Functional analysis of a first hindlimb positioning enhancer via Gdf11 expression. |
Volume: |
12 |
|
Pages: |
1302141 |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Publication |
First Author: |
Ge G |
Year: |
2005 |
Journal: |
Mol Cell Biol |
Title: |
GDF11 forms a bone morphogenetic protein 1-activated latent complex that can modulate nerve growth factor-induced differentiation of PC12 cells. |
Volume: |
25 |
Issue: |
14 |
Pages: |
5846-58 |
|
•
•
•
•
•
|
Allele |
Name: |
myostatin; endonuclease-mediated mutation 2, Richard T Lee |
Allele Type: |
Endonuclease-mediated |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kondás K |
Year: |
2011 |
Journal: |
Biochem Soc Trans |
Title: |
Biological functions of the WAP domain-containing multidomain proteins WFIKKN1 and WFIKKN2. |
Volume: |
39 |
Issue: |
5 |
Pages: |
1416-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Trexler M |
Year: |
2002 |
Journal: |
Biol Chem |
Title: |
Distinct expression pattern of two related human proteins containing multiple types of protease-inhibitory modules. |
Volume: |
383 |
Issue: |
1 |
Pages: |
223-8 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
WFIKKN proteins are secreted multidomain proteins containing a WAP (whey acidic protein)-, a follistatin/Kazal-, an immunoglobulin-, two Kunitz-type protease inhibitor-domains, and an NTR (netrin) domain. They have been reported to inhibit the activity of trypsin, and to bind GDF11 (growth and differentiation factor 11) and myostatin (GDF8) []. Due to the presence of multiple domains that frequently serve as protease inhibitors, WFIKKN proteins are presumed to control the action of diverse serine proteases as well as metalloproteinases [].In humans, WFIKKN1 expression is observed in pancreas, liver, thymus, kidney, testis and lung and WFIKKN2 (also known as WFIKKNRP) expression is observed in ovary, testis, pancreas, brain and lung []. |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Publication |
First Author: |
Walker RG |
Year: |
2017 |
Journal: |
BMC Biol |
Title: |
Structural basis for potency differences between GDF8 and GDF11. |
Volume: |
15 |
Issue: |
1 |
Pages: |
19 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nomura T |
Year: |
2008 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Skeletal muscle-derived progenitors capable of differentiating into cardiomyocytes proliferate through myostatin-independent TGF-beta family signaling. |
Volume: |
365 |
Issue: |
4 |
Pages: |
863-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang F |
Year: |
2015 |
Journal: |
Oncotarget |
Title: |
Splenocytes derived from young WT mice prevent AD progression in APPswe/PSENldE9 transgenic mice. |
Volume: |
6 |
Issue: |
25 |
Pages: |
20851-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schneyer AL |
Year: |
2008 |
Journal: |
Endocrinology |
Title: |
Differential antagonism of activin, myostatin and growth and differentiation factor 11 by wild-type and mutant follistatin. |
Volume: |
149 |
Issue: |
9 |
Pages: |
4589-95 |
|
•
•
•
•
•
|
Publication |
First Author: |
Harper SC |
Year: |
2016 |
Journal: |
Circ Res |
Title: |
Is Growth Differentiation Factor 11 a Realistic Therapeutic for Aging-Dependent Muscle Defects? |
Volume: |
118 |
Issue: |
7 |
Pages: |
1143-50; discussion 1150 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
272
|
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
552
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
571
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
518
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
571
|
Fragment?: |
false |
|
•
•
•
•
•
|