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Search results 101 to 157 out of 157 for Fis1

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Type Details Score
Other Genome Feature
MGI:95536 | Fvis1
Type: sequence_feature
Organism: mouse, laboratory
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Publication
23921378 | -
First Author: Palmer CS
Year: 2013
Journal: J Biol Chem
Title: Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission.
Volume: 288
Issue: 38
Pages: 27584-93
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Publication
21183955 | -
First Author: Iwasawa R
Year: 2011
Journal: EMBO J
Title: Fis1 and Bap31 bridge the mitochondria-ER interface to establish a platform for apoptosis induction.
Volume: 30
Issue: 3
Pages: 556-68
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Protein Domain
IPR028058 | Fis1_TPR_N
Type: Repeat
Description: The mitochondrial fission protein Fis1 consists of two tetratricopeptide repeats. This entry represents the N-terminal tetratricopeptide repeat [, ]. Fis1 is an outer mitochondrial membrane protein that plays a role in mitochondrial membrane fission [].
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Protein Domain
IPR028061 | Fis1_TPR_C
Type: Repeat
Description: The mitochondrial fission protein Fis1 consists of two tetratricopeptide repeats. This entry represents the C-terminal tetratricopeptide repeat [, ]. Fis1 is an outer mitochondrial membrane protein that plays a role in mitochondrial membrane fission [].
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Publication
17998537 | -
First Author: Zhang Y
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Structural basis for recruitment of mitochondrial fission complexes by Fis1.
Volume: 104
Issue: 47
Pages: 18526-30
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Publication
17362197 | -
 
First Author: Hoppins S
Year: 2007
Journal: Annu Rev Biochem
Title: The machines that divide and fuse mitochondria.
Volume: 76
Pages: 751-80
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Publication
23300936 | -
First Author: Guo Q
Year: 2012
Journal: PLoS One
Title: The mitochondrial fission adaptors Caf4 and Mdv1 are not functionally equivalent.
Volume: 7
Issue: 12
Pages: e53523
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Protein Domain
IPR033745 | Fis1_cytosol
Type: Domain
Description: Fis1, along with Dnm1 and Mdv1, is an essential protein in mediating mitochondrial fission. Dnm1 and Fis1 are highly conserved, with a common mechanism in disparate species. In mutants of these proteins, mitochondrial fission is impaired, resulting in networks of undivided mitochondria. Fis1 appears to act via the recruitment of division complexes to the mitochondrial outer membrane. Dnm1 is recruited to mitochondria via interactions with the adaptor proteins Caf4 and Mdv1, which bind directly to Fis1 [, ].The Fis1 N terminus is cytosolic andtethered to the mitochondrial outer membrane via a C-terminal transmembrane domain. The cytosolic domain of Fis1 forms a six-helix bundle, in which the central four helices consist of two tandem tetratricopeptide repeat (TPR)-like motifs, known to mediate protein-protein interactions [, , , ].
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Publication
11113136 | -
First Author: Liu HY
Year: 2001
Journal: J Biol Chem
Title: Characterization of CAF4 and CAF16 reveals a functional connection between the CCR4-NOT complex and a subset of SRB proteins of the RNA polymerase II holoenzyme.
Volume: 276
Issue: 10
Pages: 7541-8
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Publication
16835275 | -
First Author: Schauss AC
Year: 2006
Journal: J Cell Sci
Title: Fis1p and Caf4p, but not Mdv1p, determine the polar localization of Dnm1p clusters on the mitochondrial surface.
Volume: 119
Issue: Pt 15
Pages: 3098-106
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Protein Domain
IPR021653 | Caf4
Type: Family
Description: Caf4 is a WD40 repeats containing protein involved in mitochondrial fission. It displays physical interactions with CCR4-NOT complex []. It has a paralogue, Mdv1. Both Caf4 and Mdv1 act as adapter proteins, binding to Fis1 on the mitochondrial outer membrane and recruiting the dynamin-like GTPase Dnm1 to form mitochondrial fission complexes []. However, Fis1 and Caf4, but not Mdv1, determine the polar localization of Dnm1 clusters on the mitochondrial surface [].
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Publication
16009724 | -
First Author: Griffin EE
Year: 2005
Journal: J Cell Biol
Title: The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria.
Volume: 170
Issue: 2
Pages: 237-48
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Publication
18513378 | -
First Author: Nagotu S
Year: 2008
Journal: Traffic
Title: Peroxisome fission in Hansenula polymorpha requires Mdv1 and Fis1, two proteins also involved in mitochondrial fission.
Volume: 9
Issue: 9
Pages: 1471-84
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Publication
16272155 | -
First Author: Naylor K
Year: 2006
Journal: J Biol Chem
Title: Mdv1 interacts with assembled dnm1 to promote mitochondrial division.
Volume: 281
Issue: 4
Pages: 2177-83
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Protein Domain
IPR021061 | Mt_division_protein_1
Type: Family
Description: This entry represents mitochondrial division protein 1 (Mdv1), which is a component of the mitochondrial fission machinery in Saccharomyces cerevisiae. The protein is also involved in peroxisome proliferation []. Mdv1 along with Fis1 is also involved in controlling Dnm-1 dependent devision, a GTPase involved in the mediation of mitochondrial division. In this role, Mdv1 is the linker between Fis1 and Dnm1. Mdv1 plays a key role in the regulation of Dnm1 self-assembly [].Mdv1 has a partially redundant function to CAF4 in acting as an adapter protein, binding to FIS1 on the mitochondrial outer membrane and recruiting the dynamin-like GTPase DNM1 to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division [, ]. Mdv1 interacts with CAF4, DNM1 and FIS1, components of the mitochondrial fission machinery. It interacts via its N-terminal, coiled-coil extension (NTE) with FIS1, and via its WD repeats with DNM1. Mdv1 is uniformly distributed on the cytoplasmic face of the mitochondrial outer membrane. This localisation is dependent on FIS1. It reorganises to punctate structures on mitochondria, corresponding to mitochondrial constriction sites, at a late step in mitochondrial division. This relocalisation is dependent on DNM1.
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Allele
Gt(ROSA)26Sor<tm1(CAG-mCherry/GFP)Ganl> | MGI:5817670
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Ian Ganley
Allele Type: Targeted
Attribute String: Reporter
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Protein
A0A2U3TZF4
Organism: Mus musculus/domesticus
Length: 137  
Fragment?: false
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Publication
21508961 | -
First Author: Palmer CS
Year: 2011
Journal: EMBO Rep
Title: MiD49 and MiD51, new components of the mitochondrial fission machinery.
Volume: 12
Issue: 6
Pages: 565-73
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Publication
29361167 | -
First Author: Bartsakoulia M
Year: 2018
Journal: Hum Mol Genet
Title: A novel mechanism causing imbalance of mitochondrial fusion and fission in human myopathies.
Volume: 27
Issue: 7
Pages: 1186-1195
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Publication
29431643 | -
First Author: Chen KH
Year: 2018
Journal: Circulation
Title: Epigenetic Dysregulation of the Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increases Mitotic Mitochondrial Fission and Promotes Pulmonary Arterial Hypertension: Mechanistic and Therapeutic Implications.
Volume: 138
Issue: 3
Pages: 287-304
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Publication
29899447 | -
First Author: Kalia R
Year: 2018
Journal: Nature
Title: Structural basis of mitochondrial receptor binding and constriction by DRP1.
Volume: 558
Issue: 7710
Pages: 401-405
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Protein Domain
IPR045909 | MID49/MID51
Type: Family
Description: This entry represents the mitochondrial dynamics protein MID49/MID51. Most members of this protein family contain a Mab-21 domain and are found in chordates.In humans, MID49 and MID51 are outer membrane proteins involved in the regulation of mitochondrial organisation and required for mitochondrial fission by promoting the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. They also regulate DNM1L GTPase activity [, , , , ]. Deregulation of these proteins has been linked to human diseases such as pulmonary arterial hypertension [].
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Strain
MGI:6123204 | C57BL/6-Gt(ROSA)26Sor<tm1(CAG-mCherry/GFP)Ganl>/GaniH
Attribute String: mutant strain, coisogenic, targeted mutation
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Publication
27458135 | J:237975
First Author: McWilliams TG
Year: 2016
Journal: J Cell Biol
Title: mito-QC illuminates mitophagy and mitochondrial architecture in vivo.
Volume: 214
Issue: 3
Pages: 333-45
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Publication
32164182 | J:335112
 
First Author: Rosignol I
Year: 2020
Journal: Int J Mol Sci
Title: The mito-QC Reporter for Quantitative Mitophagy Assessment in Primary Retinal Ganglion Cells and Experimental Glaucoma Models.
Volume: 21
Issue: 5
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Publication
29910151 | J:272665
First Author: Pei S
Year: 2018
Journal: Cell Stem Cell
Title: AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells.
Volume: 23
Issue: 1
Pages: 86-100.e6
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Publication
33285261 | J:324401
 
First Author: Naia L
Year: 2021
Journal: Free Radic Biol Med
Title: Mitochondrial SIRT3 confers neuroprotection in Huntington's disease by regulation of oxidative challenges and mitochondrial dynamics.
Volume: 163
Pages: 163-179
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Publication
21149566 | J:167999
First Author: Koirala S
Year: 2010
Journal: J Cell Biol
Title: Molecular architecture of a dynamin adaptor: implications for assembly of mitochondrial fission complexes.
Volume: 191
Issue: 6
Pages: 1127-39
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Publication
38132101 | J:344428
 
First Author: Liu T
Year: 2023
Journal: Cells
Title: Disruption of Mitophagy Flux through the PARL-PINK1 Pathway by CHCHD10 Mutations or CHCHD10 Depletion.
Volume: 12
Issue: 24
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Publication
33980811 | J:337358
First Author: Anzell AR
Year: 2021
Journal: Cell Death Dis
Title: Mitochondrial fission and mitophagy are independent mechanisms regulating ischemia/reperfusion injury in primary neurons.
Volume: 12
Issue: 5
Pages: 475
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Publication
30404819 | J:341592
 
First Author: McWilliams TG
Year: 2018
Journal: Open Biol
Title: Phosphorylation of Parkin at serine 65 is essential for its activation in vivo.
Volume: 8
Issue: 11
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Publication
35952464 | J:328486
 
First Author: Liu W
Year: 2022
Journal: Atherosclerosis
Title: Low shear stress inhibits endothelial mitophagy via caveolin-1/miR-7-5p/SQSTM1 signaling pathway.
Volume: 356
Pages: 9-17
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Publication
20702714 | J:163231
First Author: Xu YF
Year: 2010
Journal: J Neurosci
Title: Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice.
Volume: 30
Issue: 32
Pages: 10851-9
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Publication
22083962 | J:183663
First Author: Jheng HF
Year: 2012
Journal: Mol Cell Biol
Title: Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle.
Volume: 32
Issue: 2
Pages: 309-19
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Publication
26908605 | J:233022
First Author: Yin X
Year: 2016
Journal: Hum Mol Genet
Title: Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease.
Volume: 25
Issue: 9
Pages: 1739-53
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Publication
29408999 | J:260501
First Author: Manczak M
Year: 2018
Journal: Hum Mol Genet
Title: Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer's disease.
Volume: 27
Issue: 8
Pages: 1332-1342
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Publication
27110594 | J:290250
First Author: Hull TD
Year: 2016
Journal: JCI Insight
Title: Heme oxygenase-1 regulates mitochondrial quality control in the heart.
Volume: 1
Issue: 2
Pages: e85817
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Publication
18200046 | J:131413
First Author: Twig G
Year: 2008
Journal: EMBO J
Title: Fission and selective fusion govern mitochondrial segregation and elimination by autophagy.
Volume: 27
Issue: 2
Pages: 433-46
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Publication
22871147 | J:191443
First Author: Zhang Q
Year: 2012
Journal: Biochem J
Title: DJ-1 promotes the proteasomal degradation of Fis1: implications of DJ-1 in neuronal protection.
Volume: 447
Issue: 2
Pages: 261-9
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Publication
28826719 | J:329728
 
First Author: Yu Y
Year: 2017
Journal: Free Radic Biol Med
Title: Advanced glycation end products receptor RAGE controls myocardial dysfunction and oxidative stress in high-fat fed mice by sustaining mitochondrial dynamics and autophagy-lysosome pathway.
Volume: 112
Pages: 397-410
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Publication
34340748 | J:313755
   
First Author: Singh F
Year: 2021
Journal: Elife
Title: Pharmacological rescue of impaired mitophagy in Parkinson's disease-related LRRK2 G2019S knock-in mice.
Volume: 10
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Protein
Q5NCS9
Organism: Mus musculus/domesticus
Length: 454  
Fragment?: false
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Protein
Q8BGV8
Organism: Mus musculus/domesticus
Length: 463  
Fragment?: false
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Protein
B2RPW2
Organism: Mus musculus/domesticus
Length: 463  
Fragment?: false
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Protein
Q3TB59
Organism: Mus musculus/domesticus
Length: 150  
Fragment?: false
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Publication
28942427 | J:271166
First Author: Wu S
Year: 2017
Journal: Circulation
Title: Binding of FUN14 Domain Containing 1 With Inositol 1,4,5-Trisphosphate Receptor in Mitochondria-Associated Endoplasmic Reticulum Membranes Maintains Mitochondrial Dynamics and Function in Hearts in Vivo.
Volume: 136
Issue: 23
Pages: 2248-2266
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Publication
28173111 | J:241780
First Author: Kandimalla R
Year: 2016
Journal: Hum Mol Genet
Title: Reduced dynamin-related protein 1 protects against phosphorylated Tau-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.
Volume: 25
Issue: 22
Pages: 4881-4897
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Publication
29040533 | J:256287
First Author: Kandimalla R
Year: 2018
Journal: Hum Mol Genet
Title: Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease.
Volume: 27
Issue: 1
Pages: 30-40
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Publication
21148472 | J:169040
First Author: White JP
Year: 2011
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Muscle oxidative capacity during IL-6-dependent cancer cachexia.
Volume: 300
Issue: 2
Pages: R201-11
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Publication
21459773 | J:174031
First Author: Manczak M
Year: 2011
Journal: Hum Mol Genet
Title: Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage.
Volume: 20
Issue: 13
Pages: 2495-509
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Publication
35680100 | J:341775
 
First Author: Sun S
Year: 2022
Journal: Metabolism
Title: TBC1D15-Drp1 interaction-mediated mitochondrial homeostasis confers cardioprotection against myocardial ischemia/reperfusion injury.
Volume: 134
Pages: 155239
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Publication
33020660 | J:306036
First Author: Yu YR
Year: 2020
Journal: Nat Immunol
Title: Disturbed mitochondrial dynamics in CD8+ TILs reinforce T cell exhaustion.
Volume: 21
Issue: 12
Pages: 1540-1551
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Publication
36965577 | J:335519
     
First Author: Huang LY
Year: 2023
Journal: J Invest Dermatol
Title: Gasdermin A Is Required for Epidermal Cornification during Skin Barrier Regeneration and in an Atopic Dermatitis-like Model.
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Publication
31066324 | J:346539
First Author: Livingston MJ
Year: 2019
Journal: Autophagy
Title: Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys.
Volume: 15
Issue: 12
Pages: 2142-2162
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Publication
27677309 | J:239247
First Author: Manczak M
Year: 2016
Journal: Hum Mol Genet
Title: Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease.
Volume: 25
Issue: 23
Pages: 5148-5166
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Publication
37095377 | J:337624
First Author: Yazicioglu YF
Year: 2023
Journal: Nat Immunol
Title: Dynamic mitochondrial transcription and translation in B cells control germinal center entry and lymphomagenesis.
Volume: 24
Issue: 6
Pages: 991-1006
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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