Type |
Details |
Score |
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1753628 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692044 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1311991 |
|
Specimen Label: |
MRC Harwell_1311991 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1753628 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692044 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1311994 |
|
Specimen Label: |
MRC Harwell_1311994 |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:3667028 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692044 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1311987 |
|
Specimen Label: |
MRC Harwell_1311987 |
Detected: |
true |
Specimen Num: |
1 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3667028 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692044 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1311995 |
|
Specimen Label: |
MRC Harwell_1311995 |
Detected: |
true |
Specimen Num: |
9 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1778728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692044 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1311991 |
|
Specimen Label: |
MRC Harwell_1311991 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1778728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692044 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1311994 |
|
Specimen Label: |
MRC Harwell_1311994 |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1754428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692044 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1311991 |
|
Specimen Label: |
MRC Harwell_1311991 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1754428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692044 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1311992 |
|
Specimen Label: |
MRC Harwell_1311992 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1754428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692044 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1311994 |
|
Specimen Label: |
MRC Harwell_1311994 |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3284528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692044 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1311991 |
|
Specimen Label: |
MRC Harwell_1311991 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3284528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692044 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1311992 |
|
Specimen Label: |
MRC Harwell_1311992 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:3284528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692044 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1311994 |
|
Specimen Label: |
MRC Harwell_1311994 |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1920928 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692044 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1311989 |
|
Specimen Label: |
MRC Harwell_1311989 |
Detected: |
true |
Specimen Num: |
3 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1920928 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692044 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1311996 |
|
Specimen Label: |
MRC Harwell_1311996 |
Detected: |
true |
Specimen Num: |
10 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1797228 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692044 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1311997 |
|
Specimen Label: |
MRC Harwell_1311997 |
Detected: |
true |
Specimen Num: |
11 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1757728 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692044 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1311990 |
|
Specimen Label: |
MRC Harwell_1311990 |
Detected: |
true |
Specimen Num: |
4 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Female |
Emaps: |
EMAPS:2991528 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692044 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1311988 |
|
Specimen Label: |
MRC Harwell_1311988 |
Detected: |
true |
Specimen Num: |
2 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692044 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1311991 |
|
Specimen Label: |
MRC Harwell_1311991 |
Detected: |
true |
Specimen Num: |
5 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692044 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1311992 |
|
Specimen Label: |
MRC Harwell_1311992 |
Detected: |
true |
Specimen Num: |
6 |
|
•
•
•
•
•
|
GXD Expression |
|
Assay Type: |
In situ reporter (knock in) |
Annotation Date: |
2021-04-16 |
Strength: |
Present |
Sex: |
Male |
Emaps: |
EMAPS:1689428 |
Pattern: |
Not Specified |
Stage: |
TS28 |
Assay Id: |
MGI:6692044 |
Age: |
postnatal adult |
Image: |
MRC Harwell_1311994 |
|
Specimen Label: |
MRC Harwell_1311994 |
Detected: |
true |
Specimen Num: |
8 |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
308 |
Description: |
Phosphothreonine; by IKKE, PDPK1 and TBK1 |
Type: |
modified residue |
End: |
308 |
|
•
•
•
•
•
|
UniProt Feature |
Begin: |
36 |
Description: |
Phosphoserine; by IKKA, IKKB, IKKE and TBK1 |
Type: |
modified residue |
End: |
36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Luo W |
Year: |
2022 |
Journal: |
Clin Transl Med |
Title: |
MD2 deficiency prevents high-fat diet-induced AMPK suppression and lipid accumulation through regulating TBK1 in non-alcoholic fatty liver disease. |
Volume: |
12 |
Issue: |
3 |
Pages: |
e777 |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE73911 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
USP1-UAF1 deubiquitinase complex stabilizes TBK1 and enhances antiviral responses. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
TBK1 and IKK prevent TNF-induced cell death by RIPK1 phosphorylation. |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhu L |
Year: |
2018 |
Journal: |
Nat Commun |
Title: |
TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival. |
Volume: |
9 |
Issue: |
1 |
Pages: |
2812 |
|
•
•
•
•
•
|
Allele |
Name: |
TBK1 binding protein 1; gene trap OST262115, Lexicon Genetics |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
TBK1 binding protein 1; gene trap OST372730, Lexicon Genetics |
Allele Type: |
Gene trapped |
|
|
•
•
•
•
•
|
Allele |
Name: |
TBK1 binding protein 1; targeted mutation 1, Shizuo Akira |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Allele |
Name: |
TANK-binding kinase 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
DO Term |
|
•
•
•
•
•
|
Allele |
Name: |
TBK1 binding protein 1; targeted mutation 1e, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
TBK1 binding protein 1; targeted mutation 1b, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
TBK1 binding protein 1; targeted mutation 1a, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, Null/knockout, Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
TBK1 binding protein 1; targeted mutation 1c, Wellcome Trust Sanger Institute |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tbkbp1/Tbkbp1 |
Background: |
Not Specified |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
611
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
596
|
Fragment?: |
false |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
SRA Suppresses Antiviral Innate Immune Response in Macrophages by Limiting TBK1 K63 Ubiquitination via Deubiquitinase USP15. |
|
•
•
•
•
•
|
Publication |
First Author: |
Chariot A |
Year: |
2002 |
Journal: |
J Biol Chem |
Title: |
Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases. |
Volume: |
277 |
Issue: |
40 |
Pages: |
37029-36 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion, Michael G Anderson |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Publication |
First Author: |
Thurston TL |
Year: |
2016 |
Journal: |
EMBO J |
Title: |
Recruitment of TBK1 to cytosol-invading Salmonella induces WIPI2-dependent antibacterial autophagy. |
Volume: |
35 |
Issue: |
16 |
Pages: |
1779-92 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu Z |
Year: |
2017 |
Journal: |
J Exp Med |
Title: |
USP1-UAF1 deubiquitinase complex stabilizes TBK1 and enhances antiviral responses. |
Volume: |
214 |
Issue: |
12 |
Pages: |
3553-3563 |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, targeted mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant strain, coisogenic, targeted mutation |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tbkbp1/Tbkbp1 |
Background: |
C57BL/6N-Tbkbp1/H |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Strain |
Attribute String: |
transgenic, mutant strain, congenic |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(TBK1)#Andm/? |
Background: |
B6J.Cg-Tg(TBK1)#Andm |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(TBK1)#Andm/Tg(TBK1)#Andm |
Background: |
B6J.Cg-Tg(TBK1)#Andm |
Zygosity: |
hm |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin. |
|
•
•
•
•
•
|
Publication |
First Author: |
Tanaka Y |
Year: |
2012 |
Journal: |
Sci Signal |
Title: |
STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway. |
Volume: |
5 |
Issue: |
214 |
Pages: |
ra20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cooper JM |
Year: |
2017 |
Journal: |
Cancer Res |
Title: |
TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer. |
Volume: |
77 |
Issue: |
18 |
Pages: |
5077-5094 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li L |
Year: |
2022 |
Journal: |
Microbiol Spectr |
Title: |
SRA Suppresses Antiviral Innate Immune Response in Macrophages by Limiting TBK1 K63 Ubiquitination via Deubiquitinase USP15. |
Volume: |
10 |
Issue: |
6 |
Pages: |
e0202822 |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant strain, targeted mutation |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Azi2/Azi2 Tbkbp1/Tbkbp1 |
Background: |
Not Specified |
Zygosity: |
cx |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tbkbp1/Tbkbp1<+> |
Background: |
C57BL/6N-Tbkbp1/H |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Publication |
First Author: |
Chien Y |
Year: |
2006 |
Journal: |
Cell |
Title: |
RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival. |
Volume: |
127 |
Issue: |
1 |
Pages: |
157-70 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This is a coiled-coil domain found in TANK-binding kinase 1 (TBK1), it comprises one of two coiled-coil domains found in the scaffold dimerization region. TBK1 is a serine/threonine kinase and a noncanonical member of the IKK family implicated in diverse cellular functions, including innate immune response as well as tumorigenesis and development []. Deletion of the coiled-coil 1 region in TBK1 lead to a severe impairment in TBK1 function even upon over-expression []. |
|
•
•
•
•
•
|
Allele |
Name: |
stimulator of interferon response cGAMP interactor 1; endonuclease-mediated mutation 2, Zhijian Chen |
Allele Type: |
Endonuclease-mediated |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Wang L |
Year: |
2019 |
Journal: |
Science |
Title: |
Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses. |
Volume: |
365 |
Issue: |
6454 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Sirohi K |
Year: |
2015 |
Journal: |
PLoS One |
Title: |
A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin. |
Volume: |
10 |
Issue: |
9 |
Pages: |
e0138289 |
|
•
•
•
•
•
|
Publication |
First Author: |
Oakes JA |
Year: |
2017 |
Journal: |
Mol Brain |
Title: |
TBK1: a new player in ALS linking autophagy and neuroinflammation. |
Volume: |
10 |
Issue: |
1 |
Pages: |
5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li J |
Year: |
2012 |
Journal: |
Protein Cell |
Title: |
Crystal structure of the ubiquitin-like domain of human TBK1. |
Volume: |
3 |
Issue: |
5 |
Pages: |
383-91 |
|
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Protein Domain |
Type: |
Domain |
Description: |
This is the ubiquitin-like domain (ULD) found in TANK-binding kinase 1 (TBK1). TBK1 is a serine/threonine kinase and a noncanonical member of the IKK family implicated in diverse cellular functions, including innate immune response as well as tumorigenesis and development []. It has been reported that the ULD of TBK1 regulates kinase activity, playing an important role in signaling and mediating interactions with other molecules in the IFN pathway. Deletion of ULD indicates that it is required for the kinase domain to form an enzymatically active conformation. TBK1 ULD has a ubiquitin-like structure and an Ile44 hydrophobic patch, which is conserved among ULDs and IKK and IKK-related proteins. This hydrophobic patch is involved in ULD-SDD interactions in TBK1 and other IKK and IKK-related proteins []. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
253
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Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
207
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Fragment?: |
false |
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•
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
172
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Fragment?: |
false |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
124
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Fragment?: |
false |
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•
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
83
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Fragment?: |
true |
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•
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Publication |
First Author: |
Abdeen HH |
Year: |
1999 |
Journal: |
Mol Biochem Parasitol |
Title: |
Molecular cloning and characterization of the polypeptide backbone of Schistosoma mansoni circulating cathodic antigen. |
Volume: |
101 |
Issue: |
1-2 |
Pages: |
149-59 |
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•
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Publication |
First Author: |
Huang J |
Year: |
2005 |
Journal: |
EMBO J |
Title: |
SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways. |
Volume: |
24 |
Issue: |
23 |
Pages: |
4018-28 |
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•
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Publication |
First Author: |
Sukotjo C |
Year: |
2003 |
Journal: |
J Biol Chem |
Title: |
Oral fibroblast expression of wound-inducible transcript 3.0 (wit3.0) accelerates the collagen gel contraction in vitro. |
Volume: |
278 |
Issue: |
51 |
Pages: |
51527-34 |
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•
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Publication |
First Author: |
Van Dam GJ |
Year: |
1994 |
Journal: |
Eur J Biochem |
Title: |
The immunologically reactive O-linked polysaccharide chains derived from circulating cathodic antigen isolated from the human blood fluke Schistosoma mansoni have Lewis x as repeating unit. |
Volume: |
225 |
Issue: |
1 |
Pages: |
467-82 |
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Protein Domain |
Type: |
Family |
Description: |
Suppressor of IKBKE 1 (SIKE) is a physiological suppressor of IKK-epsilon and TBK1 []. IKKepsilon and TBK1 are two IKK-related kinases critically involved in virus- and TLR3-triggered activation of interferon regulatory factor 3 (IRF-3).Other members of this family are circulating cathodic antigen (CCA), found in Schistosoma mansoni (Blood fluke) [, ], and FGFR1 oncogene partner 2, which may be involved in wound healing pathway []. |
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Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
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Ontology Term |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
167
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Fragment?: |
true |
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Publication |
First Author: |
Wang W |
Year: |
2015 |
Journal: |
J Biol Chem |
Title: |
TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase. |
Volume: |
290 |
Issue: |
21 |
Pages: |
13372-85 |
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Publication |
First Author: |
Maruyama K |
Year: |
2012 |
Journal: |
J Biol Chem |
Title: |
TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation. |
Volume: |
287 |
Issue: |
34 |
Pages: |
29114-24 |
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Protein Domain |
Type: |
Family |
Description: |
TANK-binding kinase 1 (TBK1) and inducible IkappaB-kinase (IKK) are central regulators of type-I interferon induction. TANK (TRAF family member-associated NF-kappa-B activator) is aadaptor protein that connects IKK complexes with IKK epsilon and TBK1 kinases [, ]. It negatively regulates NF-kappaB activation by DNA damage via inhibiting ubiquitination of TRAF6 []. It is also a negative regulator of osteoclastogenesis and bone formation []. |
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
717
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Fragment?: |
false |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
729
|
Fragment?: |
false |
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•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
717
|
Fragment?: |
false |
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•
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•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
693
|
Fragment?: |
false |
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
607
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Fragment?: |
false |
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•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
693
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Fragment?: |
false |
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•
•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
360
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Fragment?: |
false |
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•
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Publication |
First Author: |
Liu Y |
Year: |
2018 |
Journal: |
Cell Mol Immunol |
Title: |
ZDHHC11 modulates innate immune response to DNA virus by mediating MITA-IRF3 association. |
Volume: |
15 |
Issue: |
10 |
Pages: |
907-916 |
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Publication |
First Author: |
Meena NP |
Year: |
2016 |
Journal: |
FEBS Lett |
Title: |
The TBK1-binding domain of optineurin promotes type I interferon responses. |
Volume: |
590 |
Issue: |
10 |
Pages: |
1498-508 |
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•
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Publication |
First Author: |
Zhou Y |
Year: |
2016 |
Journal: |
Nat Immunol |
Title: |
The kinase CK1ɛ controls the antiviral immune response by phosphorylating the signaling adaptor TRAF3. |
Volume: |
17 |
Issue: |
4 |
Pages: |
397-405 |
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Publication |
First Author: |
Li X |
Year: |
2013 |
Journal: |
Immunity |
Title: |
Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization. |
Volume: |
39 |
Issue: |
6 |
Pages: |
1019-31 |
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Publication |
First Author: |
Liu D |
Year: |
2018 |
Journal: |
Cell Death Differ |
Title: |
STING directly activates autophagy to tune the innate immune response. |
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Publication |
First Author: |
Zhou Q |
Year: |
2014 |
Journal: |
Cell Host Microbe |
Title: |
The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling. |
Volume: |
16 |
Issue: |
4 |
Pages: |
450-61 |
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