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Search results 401 to 500 out of 597 for Tbk1

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Type Details Score
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1753628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311991
Specimen Label: MRC Harwell_1311991
Detected: true
Specimen Num: 5
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1753628
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311994
Specimen Label: MRC Harwell_1311994
Detected: true
Specimen Num: 8
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:3667028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311987
Specimen Label: MRC Harwell_1311987
Detected: true
Specimen Num: 1
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3667028
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311995
Specimen Label: MRC Harwell_1311995
Detected: true
Specimen Num: 9
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1778728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311991
Specimen Label: MRC Harwell_1311991
Detected: true
Specimen Num: 5
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1778728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311994
Specimen Label: MRC Harwell_1311994
Detected: true
Specimen Num: 8
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1754428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311991
Specimen Label: MRC Harwell_1311991
Detected: true
Specimen Num: 5
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1754428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311992
Specimen Label: MRC Harwell_1311992
Detected: true
Specimen Num: 6
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1754428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311994
Specimen Label: MRC Harwell_1311994
Detected: true
Specimen Num: 8
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3284528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311991
Specimen Label: MRC Harwell_1311991
Detected: true
Specimen Num: 5
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3284528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311992
Specimen Label: MRC Harwell_1311992
Detected: true
Specimen Num: 6
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:3284528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311994
Specimen Label: MRC Harwell_1311994
Detected: true
Specimen Num: 8
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1920928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311989
Specimen Label: MRC Harwell_1311989
Detected: true
Specimen Num: 3
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1920928
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311996
Specimen Label: MRC Harwell_1311996
Detected: true
Specimen Num: 10
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1797228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311997
Specimen Label: MRC Harwell_1311997
Detected: true
Specimen Num: 11
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1757728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311990
Specimen Label: MRC Harwell_1311990
Detected: true
Specimen Num: 4
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Female
Emaps: EMAPS:2991528
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311988
Specimen Label: MRC Harwell_1311988
Detected: true
Specimen Num: 2
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311991
Specimen Label: MRC Harwell_1311991
Detected: true
Specimen Num: 5
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311992
Specimen Label: MRC Harwell_1311992
Detected: true
Specimen Num: 6
GXD Expression    
Assay Type: In situ reporter (knock in)
Annotation Date: 2021-04-16
Strength: Present
Sex: Male
Emaps: EMAPS:1689428
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:6692044
Age: postnatal adult
Image: MRC Harwell_1311994
Specimen Label: MRC Harwell_1311994
Detected: true
Specimen Num: 8
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
UniProt Feature
Begin: 308
Description: Phosphothreonine; by IKKE, PDPK1 and TBK1
Type: modified residue
End: 308
UniProt Feature
Begin: 36
Description: Phosphoserine; by IKKA, IKKB, IKKE and TBK1
Type: modified residue
End: 36
Publication
First Author: Luo W
Year: 2022
Journal: Clin Transl Med
Title: MD2 deficiency prevents high-fat diet-induced AMPK suppression and lipid accumulation through regulating TBK1 in non-alcoholic fatty liver disease.
Volume: 12
Issue: 3
Pages: e777
HT Experiment
Series Id: GSE73911
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
Interaction Experiment
Description: USP1-UAF1 deubiquitinase complex stabilizes TBK1 and enhances antiviral responses.
Interaction Experiment
Description: TBK1 and IKK prevent TNF-induced cell death by RIPK1 phosphorylation.
Publication
First Author: Zhu L
Year: 2018
Journal: Nat Commun
Title: TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival.
Volume: 9
Issue: 1
Pages: 2812
Allele  
Name: TBK1 binding protein 1; gene trap OST262115, Lexicon Genetics
Allele Type: Gene trapped
Allele  
Name: TBK1 binding protein 1; gene trap OST372730, Lexicon Genetics
Allele Type: Gene trapped
Allele
Name: TBK1 binding protein 1; targeted mutation 1, Shizuo Akira
Allele Type: Targeted
Attribute String: Null/knockout
Allele
Name: TANK-binding kinase 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
DO Term
Allele
Name: TBK1 binding protein 1; targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Allele
Name: TBK1 binding protein 1; targeted mutation 1b, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
Allele
Name: TBK1 binding protein 1; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
Allele
Name: TBK1 binding protein 1; targeted mutation 1c, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready
Genotype
Symbol: Tbkbp1/Tbkbp1
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
GO Term
Protein
Organism: Mus musculus/domesticus
Length: 611  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 596  
Fragment?: false
Interaction Experiment
Description: Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity.
Interaction Experiment
Description: TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer.
Interaction Experiment
Description: SRA Suppresses Antiviral Innate Immune Response in Macrophages by Limiting TBK1 K63 Ubiquitination via Deubiquitinase USP15.
Publication
First Author: Chariot A
Year: 2002
Journal: J Biol Chem
Title: Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases.
Volume: 277
Issue: 40
Pages: 37029-36
Allele
Name: transgene insertion, Michael G Anderson
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Publication
First Author: Thurston TL
Year: 2016
Journal: EMBO J
Title: Recruitment of TBK1 to cytosol-invading Salmonella induces WIPI2-dependent antibacterial autophagy.
Volume: 35
Issue: 16
Pages: 1779-92
Publication
First Author: Yu Z
Year: 2017
Journal: J Exp Med
Title: USP1-UAF1 deubiquitinase complex stabilizes TBK1 and enhances antiviral responses.
Volume: 214
Issue: 12
Pages: 3553-3563
GO Term
Strain
Attribute String: coisogenic, targeted mutation
Strain
Attribute String: mutant strain, coisogenic, targeted mutation
Genotype
Symbol: Tbkbp1/Tbkbp1
Background: C57BL/6N-Tbkbp1/H
Zygosity: hm
Has Mutant Allele: true
Strain
Attribute String: transgenic, mutant strain, congenic
Genotype
Symbol: Tg(TBK1)#Andm/?
Background: B6J.Cg-Tg(TBK1)#Andm
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(TBK1)#Andm/Tg(TBK1)#Andm
Background: B6J.Cg-Tg(TBK1)#Andm
Zygosity: hm
Has Mutant Allele: true
Interaction Experiment
Description: A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin.
Publication
First Author: Tanaka Y
Year: 2012
Journal: Sci Signal
Title: STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway.
Volume: 5
Issue: 214
Pages: ra20
Publication
First Author: Cooper JM
Year: 2017
Journal: Cancer Res
Title: TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer.
Volume: 77
Issue: 18
Pages: 5077-5094
Publication
First Author: Li L
Year: 2022
Journal: Microbiol Spectr
Title: SRA Suppresses Antiviral Innate Immune Response in Macrophages by Limiting TBK1 K63 Ubiquitination via Deubiquitinase USP15.
Volume: 10
Issue: 6
Pages: e0202822
Strain
Attribute String: mutant strain, targeted mutation
Genotype
Symbol: Azi2/Azi2 Tbkbp1/Tbkbp1
Background: Not Specified
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tbkbp1/Tbkbp1<+>
Background: C57BL/6N-Tbkbp1/H
Zygosity: ht
Has Mutant Allele: true
Publication
First Author: Chien Y
Year: 2006
Journal: Cell
Title: RalB GTPase-mediated activation of the IkappaB family kinase TBK1 couples innate immune signaling to tumor cell survival.
Volume: 127
Issue: 1
Pages: 157-70
Protein Domain
Type: Domain
Description: This is a coiled-coil domain found in TANK-binding kinase 1 (TBK1), it comprises one of two coiled-coil domains found in the scaffold dimerization region. TBK1 is a serine/threonine kinase and a noncanonical member of the IKK family implicated in diverse cellular functions, including innate immune response as well as tumorigenesis and development []. Deletion of the coiled-coil 1 region in TBK1 lead to a severe impairment in TBK1 function even upon over-expression [].
Allele  
Name: stimulator of interferon response cGAMP interactor 1; endonuclease-mediated mutation 2, Zhijian Chen
Allele Type: Endonuclease-mediated
Publication  
First Author: Wang L
Year: 2019
Journal: Science
Title: Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses.
Volume: 365
Issue: 6454
Publication
First Author: Sirohi K
Year: 2015
Journal: PLoS One
Title: A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin.
Volume: 10
Issue: 9
Pages: e0138289
Publication
First Author: Oakes JA
Year: 2017
Journal: Mol Brain
Title: TBK1: a new player in ALS linking autophagy and neuroinflammation.
Volume: 10
Issue: 1
Pages: 5
Publication
First Author: Li J
Year: 2012
Journal: Protein Cell
Title: Crystal structure of the ubiquitin-like domain of human TBK1.
Volume: 3
Issue: 5
Pages: 383-91
Protein Domain
Type: Domain
Description: This is the ubiquitin-like domain (ULD) found in TANK-binding kinase 1 (TBK1). TBK1 is a serine/threonine kinase and a noncanonical member of the IKK family implicated in diverse cellular functions, including innate immune response as well as tumorigenesis and development []. It has been reported that the ULD of TBK1 regulates kinase activity, playing an important role in signaling and mediating interactions with other molecules in the IFN pathway. Deletion of ULD indicates that it is required for the kinase domain to form an enzymatically active conformation. TBK1 ULD has a ubiquitin-like structure and an Ile44 hydrophobic patch, which is conserved among ULDs and IKK and IKK-related proteins. This hydrophobic patch is involved in ULD-SDD interactions in TBK1 and other IKK and IKK-related proteins [].
Protein
Organism: Mus musculus/domesticus
Length: 253  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 124  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 83  
Fragment?: true
Publication
First Author: Abdeen HH
Year: 1999
Journal: Mol Biochem Parasitol
Title: Molecular cloning and characterization of the polypeptide backbone of Schistosoma mansoni circulating cathodic antigen.
Volume: 101
Issue: 1-2
Pages: 149-59
Publication
First Author: Huang J
Year: 2005
Journal: EMBO J
Title: SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.
Volume: 24
Issue: 23
Pages: 4018-28
Publication
First Author: Sukotjo C
Year: 2003
Journal: J Biol Chem
Title: Oral fibroblast expression of wound-inducible transcript 3.0 (wit3.0) accelerates the collagen gel contraction in vitro.
Volume: 278
Issue: 51
Pages: 51527-34
Publication
First Author: Van Dam GJ
Year: 1994
Journal: Eur J Biochem
Title: The immunologically reactive O-linked polysaccharide chains derived from circulating cathodic antigen isolated from the human blood fluke Schistosoma mansoni have Lewis x as repeating unit.
Volume: 225
Issue: 1
Pages: 467-82
Protein Domain
Type: Family
Description: Suppressor of IKBKE 1 (SIKE) is a physiological suppressor of IKK-epsilon and TBK1 []. IKKepsilon and TBK1 are two IKK-related kinases critically involved in virus- and TLR3-triggered activation of interferon regulatory factor 3 (IRF-3).Other members of this family are circulating cathodic antigen (CCA), found in Schistosoma mansoni (Blood fluke) [, ], and FGFR1 oncogene partner 2, which may be involved in wound healing pathway [].
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Ontology Term
Protein
Organism: Mus musculus/domesticus
Length: 167  
Fragment?: true
Publication
First Author: Wang W
Year: 2015
Journal: J Biol Chem
Title: TRAF Family Member-associated NF-κB Activator (TANK) Inhibits Genotoxic Nuclear Factor κB Activation by Facilitating Deubiquitinase USP10-dependent Deubiquitination of TRAF6 Ligase.
Volume: 290
Issue: 21
Pages: 13372-85
Publication
First Author: Maruyama K
Year: 2012
Journal: J Biol Chem
Title: TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation.
Volume: 287
Issue: 34
Pages: 29114-24
Protein Domain
Type: Family
Description: TANK-binding kinase 1 (TBK1) and inducible IkappaB-kinase (IKK) are central regulators of type-I interferon induction. TANK (TRAF family member-associated NF-kappa-B activator) is aadaptor protein that connects IKK complexes with IKK epsilon and TBK1 kinases [, ]. It negatively regulates NF-kappaB activation by DNA damage via inhibiting ubiquitination of TRAF6 []. It is also a negative regulator of osteoclastogenesis and bone formation [].
Protein
Organism: Mus musculus/domesticus
Length: 717  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 729  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 717  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 693  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 607  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 693  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 360  
Fragment?: false
Publication
First Author: Liu Y
Year: 2018
Journal: Cell Mol Immunol
Title: ZDHHC11 modulates innate immune response to DNA virus by mediating MITA-IRF3 association.
Volume: 15
Issue: 10
Pages: 907-916
Publication
First Author: Meena NP
Year: 2016
Journal: FEBS Lett
Title: The TBK1-binding domain of optineurin promotes type I interferon responses.
Volume: 590
Issue: 10
Pages: 1498-508
Publication
First Author: Zhou Y
Year: 2016
Journal: Nat Immunol
Title: The kinase CK1ɛ controls the antiviral immune response by phosphorylating the signaling adaptor TRAF3.
Volume: 17
Issue: 4
Pages: 397-405
Publication
First Author: Li X
Year: 2013
Journal: Immunity
Title: Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization.
Volume: 39
Issue: 6
Pages: 1019-31
Publication      
First Author: Liu D
Year: 2018
Journal: Cell Death Differ
Title: STING directly activates autophagy to tune the innate immune response.
Publication
First Author: Zhou Q
Year: 2014
Journal: Cell Host Microbe
Title: The ER-associated protein ZDHHC1 is a positive regulator of DNA virus-triggered, MITA/STING-dependent innate immune signaling.
Volume: 16
Issue: 4
Pages: 450-61