Search our database by keyword

Examples

Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 501 to 548 out of 548 for Irf7

<< First < Previous | Next > Last >>

0.02s

Type

Details

Score

Publication

21357441 | J:337109

First Author:	Sugihara T
Year:	2011
Journal:	Mol Cancer Res
Title:	Activation of interferon-stimulated genes by gamma-ray irradiation independently of the ataxia telangiectasia mutated-p53 pathway.
Volume:	9
Issue:	4
Pages:	476-84

•

Publication

24489947 | J:225165

First Author:	Sriram U
Year:	2014
Journal:	PLoS One
Title:	IL-4 suppresses the responses to TLR7 and TLR9 stimulation and increases the permissiveness to retroviral infection of murine conventional dendritic cells.
Volume:	9
Issue:	1
Pages:	e87668

•

Publication

20389019 | J:161476

First Author:	Watanabe T
Year:	2010
Journal:	J Clin Invest
Title:	NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway.
Volume:	120
Issue:	5
Pages:	1645-62

•

Publication

20957750 | J:171023

First Author:	Siednienko J
Year:	2010
Journal:	Eur J Immunol
Title:	TLR3-mediated IFN-β gene induction is negatively regulated by the TLR adaptor MyD88 adaptor-like.
Volume:	40
Issue:	11
Pages:	3150-60

•

Publication

19191335 | J:156204

First Author:	So EY
Year:	2009
Journal:	Glia
Title:	Theiler's virus infection induces TLR3-dependent upregulation of TLR2 critical for proinflammatory cytokine production.
Volume:	57
Issue:	11
Pages:	1216-26

•

Publication

29799862 | J:262949

First Author:	Pang Z
Year:	2018
Journal:	PLoS One
Title:	Regulator of calcineurin 1 differentially regulates TLR-dependent MyD88 and TRIF signaling pathways.
Volume:	13
Issue:	5
Pages:	e0197491

•

Publication

30017954 | J:267043

First Author:	Markovinovic A
Year:	2018
Journal:	Neuroscience
Title:	Optineurin Insufficiency Disbalances Proinflammatory and Anti-inflammatory Factors by Reducing Microglial IFN-β Responses.
Volume:	388

Pages:	139-151

•

Publication

28928425 | J:287703

First Author:	Manils J
Year:	2017
Journal:	Sci Rep
Title:	Double deficiency of Trex2 and DNase1L2 nucleases leads to accumulation of DNA in lingual cornifying keratinocytes without activating inflammatory responses.
Volume:	7
Issue:	1
Pages:	11902

•

Publication

27228057 | J:252479

First Author:	Wu YY
Year:	2016
Journal:	PLoS One
Title:	BANK1 Regulates IgG Production in a Lupus Model by Controlling TLR7-Dependent STAT1 Activation.
Volume:	11
Issue:	5
Pages:	e0156302

•

Publication

27600904 | J:246481

First Author:	Desnues B
Year:	2016
Journal:	Eur J Immunol
Title:	The transcriptional repressor Gfi1 prevents lupus autoimmunity by restraining TLR7 signaling.
Volume:	46
Issue:	12
Pages:	2801-2811

•

Publication

27355630 | J:249152

First Author:	Körber I
Year:	2016
Journal:	PLoS One
Title:	Gene-Expression Profiling Suggests Impaired Signaling via the Interferon Pathway in Cstb-/- Microglia.
Volume:	11
Issue:	6
Pages:	e0158195

•

Publication

24386204 | J:211122

First Author:	Chiang EY
Year:	2013
Journal:	PLoS One
Title:	EBI2 is a negative regulator of type I interferons in plasmacytoid and myeloid dendritic cells.
Volume:	8
Issue:	12
Pages:	e83457

•

Publication

29610295 | J:261389

First Author:	Chen S
Year:	2018
Journal:	Proc Natl Acad Sci U S A
Title:	SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-κB and interferon pathways.
Volume:	115
Issue:	16
Pages:	E3798-E3807

•

Publication

18922877 | J:197514

First Author:	Pfaller CK
Year:	2008
Journal:	J Virol
Title:	Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction.
Volume:	82
Issue:	24
Pages:	12365-73

•

Publication

18068231 | J:131549

First Author:	Wang RP
Year:	2008
Journal:	Mol Immunol
Title:	Differential regulation of IKK alpha-mediated activation of IRF3/7 by NIK.
Volume:	45
Issue:	7
Pages:	1926-34

•

Publication

18981154 | J:141075

First Author:	Kaur S
Year:	2008
Journal:	J Immunol
Title:	Dual regulatory roles of phosphatidylinositol 3-kinase in IFN signaling.
Volume:	181
Issue:	10
Pages:	7316-23

•

Publication

17277150 | J:143977

First Author:	Balachandran S
Year:	2007
Journal:	J Immunol
Title:	Fas-associated death domain-containing protein-mediated antiviral innate immune signaling involves the regulation of Irf7.
Volume:	178
Issue:	4
Pages:	2429-39

•

Publication

20827270 | J:164494

First Author:	Heinig M
Year:	2010
Journal:	Nature
Title:	A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk.
Volume:	467
Issue:	7314
Pages:	460-4

•

Publication

30457675 | J:270353

First Author:	Chow KT
Year:	2019
Journal:	J Leukoc Biol
Title:	IRF5 regulates unique subset of genes in dendritic cells during West Nile virus infection.
Volume:	105
Issue:	2
Pages:	411-425

•

Publication

30667045 | J:273764

First Author:	Yang L
Year:	2019
Journal:	Immunology
Title:	Attenuation of interferon regulatory factor 7 activity in local infectious sites of trachea and lung for preventing the development of acute lung injury caused by influenza A virus.
Volume:	157
Issue:	1
Pages:	37-51

•

Publication

31616416 | J:281843

First Author:	Ozasa K
Year:	2019
Journal:	Front Immunol
Title:	Cyclic GMP-AMP Triggers Asthma in an IL-33-Dependent Manner That Is Blocked by Amlexanox, a TBK1 Inhibitor.
Volume:	10

Pages:	2212

•

Publication

31318439 | J:295524

First Author:	Garnier A
Year:	2019
Journal:	Eur J Immunol
Title:	CD49d/CD29-integrin controls the accumulation of plasmacytoid dendritic cells into the CNS during neuroinflammation.
Volume:	49
Issue:	11
Pages:	2030-2043

•

Publication

27034232 | J:319209

First Author:	Sim CK
Year:	2016
Journal:	Cancer Immunol Immunother
Title:	2'-5' Oligoadenylate synthetase-like 1 (OASL1) deficiency in mice promotes an effective anti-tumor immune response by enhancing the production of type I interferons.
Volume:	65
Issue:	6
Pages:	663-75

•

Protein Coding Gene

MGI:1276116 | Ep300

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein Coding Gene

MGI:99511 | Ptpn11

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein

B2RWS6

Organism:	Mus musculus/domesticus
Length:	2412
Fragment?:	false

•

Protein

P35235

Organism:	Mus musculus/domesticus
Length:	593
Fragment?:	false

•

Protein

Q4FJP2

Organism:	Mus musculus/domesticus
Length:	314
Fragment?:	false

•

Publication

33488612 | J:303593

First Author:	Zhou B
Year:	2020
Journal:	Front Immunol
Title:	Zdhhc2 Is Essential for Plasmacytoid Dendritic Cells Mediated Inflammatory Response in Psoriasis.
Volume:	11

Pages:	607442

•

Publication

24760883 | J:214415

First Author:	Li W
Year:	2014
Journal:	J Virol
Title:	IRF7-dependent type I interferon production induces lethal immune-mediated disease in STAT1 knockout mice infected with lymphocytic choriomeningitis virus.
Volume:	88
Issue:	13
Pages:	7578-88

•

Publication

25031348 | J:214624

First Author:	Thackray LB
Year:	2014
Journal:	J Virol
Title:	Interferon regulatory factor 5-dependent immune responses in the draining lymph node protect against West Nile virus infection.
Volume:	88
Issue:	19
Pages:	11007-21

•

Protein Domain

IPR042542 | Peptidase_C53_interaction

Type:

Homologous_superfamily

Description:

A cysteine peptidase is a proteolytic enzyme that hydrolyses a peptide bond using the thiol group of a cysteine residue as a nucleophile. Hydrolysis involves usually a catalytic triad consisting of the thiol group of the cysteine, the imidazolium ring of a histidine, and a third residue, usually asparagine or aspartic acid, to orientate and activate the imidazolium ring. In only one family of cysteine peptidases, is the role of the general base assigned to a residue other than a histidine: in peptidases from family C89 (acid ceramidase) an arginine is the general base. Cysteine peptidases can be grouped into fourteen different clans, with members of each clan possessing a tertiary fold unique to the clan. Four clans of cysteine peptidases share structural similarities with serine and threonine peptidases and asparagine lyases. From sequence similarities, cysteine peptidases can be clustered into over 80 different families []. Clans CF, CM, CN, CO, CP and PD contain only one family.Cysteine peptidases are often active at acidic pH and are therefore confined to acidic environments, such as the animal lysosome or plant vacuole. Cysteine peptidases can be endopeptidases, aminopeptidases, carboxypeptidases, dipeptidyl-peptidases or omega-peptidases. They are inhibited by thiol chelators such as iodoacetate, iodoacetic acid, N-ethylmaleimide or p-chloromercuribenzoate.Clan CA includes proteins with a papain-like fold. There is a catalytic triad which occurs in the order: Cys/His/Asn (or Asp). A fourth residue, usually Gln, is important for stabilising the acyl intermediate that forms during catalysis, and this precedes the active site Cys. The fold consists of two subdomains with the active site between them. One subdomain consists of a bundle of helices, with the catalytic Cys at the end of one of them, and the other subdomain is a β-barrel with the active site His and Asn (or Asp). There are over thirty families in the clan, and tertiary structures have been solved for members of most of these. Peptidases in clan CA are usually sensitive to the small molecule inhibitor E64, which is ineffective against peptidases from other clans of cysteine peptidases [].Clan CD includes proteins with a caspase-like fold. Proteins in the clan have an α/β/α sandwich structure. There is a catalytic dyad which occurs in the order His/Cys. The active site His occurs in a His-Gly motif and the active site Cys occurs in an Ala-Cys motif; both motifs are preceded by a block of hydrophobic residues []. Specificity is predominantly directed towards residues that occupy the S1 binding pocket, so that caspases cleave aspartyl bonds, legumains cleave asparaginyl bonds, and gingipains cleave lysyl or arginyl bonds.Clan CE includes proteins with an adenain-like fold. The fold consists of two subdomains with the active site between them. One domain is a bundle of helices, and the other a β-barrell. The subdomains are in the opposite order to those found in peptidases from clan CA, and this is reflected in the order of active site residues: His/Asn/Gln/Cys. This has prompted speculation that proteins in clans CA and CE are related, and that members of one clan are derived from a circular permutation of the structure of the other.Clan CL includes proteins with a sortase B-like fold. Peptidases in the clan hydrolyse and transfer bacterial cell wall peptides. The fold shows a closed β-barrel decorated with helices with the active site at one end of the barrel []. The active site consists of a His/Cys catalytic dyad.This group of cysteine peptidases belong to MEROPS peptidase family C53 (clan C-). The active site residues occur in the order E, H, C in the sequence which is unlike that in any other family. They are unique to pestiviruses. The N-terminal cysteine peptidase (Npro) encoded by the bovine viral diarrhoea virus genome is responsible for the self-cleavage that releases the N terminus of the core protein. This unique protease is dispensable for viral replication, and its coding region can be replaced by a ubiquitin gene directly fused in frame to the core [, , , ].This superfamily represents a domain consisting of 5 anti-parallel beta strands. The domain also contains a TRASH motif connecting the B1-B2 linker to the B3 strand, and this motif means the domain is able to interact with immune-relevant factors IRF3, IRF7 and Hax1.

•

Publication

8972567 | -

First Author:	Muyldermans G
Year:	1996
Journal:	Virus Genes
Title:	Expression in E. coli and purification of the active autoprotease P20 of classical swine fever virus.
Volume:	13
Issue:	2
Pages:	135-42

•

Publication

9499122 | -

First Author:	Rümenapf T
Year:	1998
Journal:	J Virol
Title:	N-terminal protease of pestiviruses: identification of putative catalytic residues by site-directed mutagenesis.
Volume:	72
Issue:	3
Pages:	2544-7

•

Publication

10864644 | -

First Author:	Lai VC
Year:	2000
Journal:	J Virol
Title:	Generation and characterization of a hepatitis C virus NS3 protease-dependent bovine viral diarrhea virus.
Volume:	74
Issue:	14
Pages:	6339-47

•

Protein Coding Gene

MGI:1925544 | Rps27a

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein Coding Gene

MGI:98887 | Uba52

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein Coding Gene

MGI:98888 | Ubb

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein Coding Gene

MGI:98889 | Ubc

Type:	protein_coding_gene
Organism:	mouse, laboratory

•

Protein

P62984

Organism:	Mus musculus/domesticus
Length:	128
Fragment?:	false

•

Protein

P0CG50

Organism:	Mus musculus/domesticus
Length:	734
Fragment?:	false

•

Protein

P62983

Organism:	Mus musculus/domesticus
Length:	156
Fragment?:	false

•

Protein

P0CG49

Organism:	Mus musculus/domesticus
Length:	305
Fragment?:	false

•

Publication

11711606 | -

First Author:	Peng CW
Year:	2001
Journal:	J Virol
Title:	Functional specialization and evolution of leader proteinases in the family Closteroviridae.
Volume:	75
Issue:	24
Pages:	12153-60

•

Publication

9891971 | -

First Author:	Chen JM
Year:	1998
Journal:	FEBS Lett
Title:	Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases.
Volume:	441
Issue:	3
Pages:	361-5

•

Publication

14725770 | -

First Author:	Zong Y
Year:	2004
Journal:	Structure
Title:	The structure of sortase B, a cysteine transpeptidase that tethers surface protein to the Staphylococcus aureus cell wall.
Volume:	12
Issue:	1
Pages:	105-12

•

Publication

7044372 | -

First Author:	Barrett AJ
Year:	1982
Journal:	Biochem J
Title:	L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L.
Volume:	201
Issue:	1
Pages:	189-98

•

Publication

11517925 | -

First Author:	Barrett AJ
Year:	2001
Journal:	Biol Chem
Title:	Evolutionary lines of cysteine peptidases.
Volume:	382
Issue:	5
Pages:	727-33

•

Questions? Comments? Click here!

MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Your name:
Your email address:
Subject:
Message:	---- Current page: ---- /mousemine/keywordSearchResults.do;jsessionid=E7925C859D426F014058B859015DB745?searchOffset=500&searchTerm=Irf7

MouseMine

Search our database by keyword

Examples

Search results 501 to 548 out of 548 for Irf7

Categories

Hits by Pathway

Hits by Strain

Hits by Category