Type |
Details |
Score |
Publication |
First Author: |
Georgel P |
Year: |
2007 |
Journal: |
Virology |
Title: |
Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway. |
Volume: |
362 |
Issue: |
2 |
Pages: |
304-13 |
|
•
•
•
•
•
|
Publication |
First Author: |
Qi Z |
Year: |
2021 |
Journal: |
Sci Adv |
Title: |
SRSF1 serves as a critical posttranscriptional regulator at the late stage of thymocyte development. |
Volume: |
7 |
Issue: |
16 |
|
|
•
•
•
•
•
|
Publication |
First Author: |
Ma Z |
Year: |
2013 |
Journal: |
PLoS Pathog |
Title: |
DDX24 negatively regulates cytosolic RNA-mediated innate immune signaling. |
Volume: |
9 |
Issue: |
10 |
Pages: |
e1003721 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ramalho T |
Year: |
2024 |
Journal: |
Cell Metab |
Title: |
Itaconate impairs immune control of Plasmodium by enhancing mtDNA-mediated PD-L1 expression in monocyte-derived dendritic cells. |
Volume: |
36 |
Issue: |
3 |
Pages: |
484-497.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Qi F |
Year: |
2022 |
Journal: |
FASEB J |
Title: |
E3 ubiquitin ligase NEURL3 promotes innate antiviral response through catalyzing K63-linked ubiquitination of IRF7. |
Volume: |
36 |
Issue: |
8 |
Pages: |
e22409 |
|
•
•
•
•
•
|
Publication |
First Author: |
Gracias DT |
Year: |
2013 |
Journal: |
Nat Immunol |
Title: |
The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling. |
Volume: |
14 |
Issue: |
6 |
Pages: |
593-602 |
|
•
•
•
•
•
|
Publication |
First Author: |
Milon B |
Year: |
2021 |
Journal: |
Cell Rep |
Title: |
A cell-type-specific atlas of the inner ear transcriptional response to acoustic trauma. |
Volume: |
36 |
Issue: |
13 |
Pages: |
109758 |
|
•
•
•
•
•
|
Publication |
First Author: |
Cheng Y |
Year: |
2018 |
Journal: |
J Exp Med |
Title: |
Mycobacterium tuberculosis-induced IFN-β production requires cytosolic DNA and RNA sensing pathways. |
Volume: |
215 |
Issue: |
11 |
Pages: |
2919-2935 |
|
•
•
•
•
•
|
Publication |
First Author: |
Nguyen BC |
Year: |
2006 |
Journal: |
Genes Dev |
Title: |
Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation. |
Volume: |
20 |
Issue: |
8 |
Pages: |
1028-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ma S |
Year: |
2017 |
Journal: |
J Exp Med |
Title: |
Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs. |
Volume: |
214 |
Issue: |
5 |
Pages: |
1471-1491 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lu X |
Year: |
2013 |
Journal: |
Cell Res |
Title: |
miR-142-3p regulates the formation and differentiation of hematopoietic stem cells in vertebrates. |
Volume: |
23 |
Issue: |
12 |
Pages: |
1356-68 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
314
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
314
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2441
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Renga B |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
The bile acid sensor FXR is required for immune-regulatory activities of TLR-9 in intestinal inflammation. |
Volume: |
8 |
Issue: |
1 |
Pages: |
e54472 |
|
•
•
•
•
•
|
Publication |
First Author: |
So EY |
Year: |
2009 |
Journal: |
Glia |
Title: |
Theiler's virus infection induces TLR3-dependent upregulation of TLR2 critical for proinflammatory cytokine production. |
Volume: |
57 |
Issue: |
11 |
Pages: |
1216-26 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sriram U |
Year: |
2014 |
Journal: |
PLoS One |
Title: |
IL-4 suppresses the responses to TLR7 and TLR9 stimulation and increases the permissiveness to retroviral infection of murine conventional dendritic cells. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e87668 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wu YY |
Year: |
2016 |
Journal: |
PLoS One |
Title: |
BANK1 Regulates IgG Production in a Lupus Model by Controlling TLR7-Dependent STAT1 Activation. |
Volume: |
11 |
Issue: |
5 |
Pages: |
e0156302 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sugihara T |
Year: |
2011 |
Journal: |
Mol Cancer Res |
Title: |
Activation of interferon-stimulated genes by gamma-ray irradiation independently of the ataxia telangiectasia mutated-p53 pathway. |
Volume: |
9 |
Issue: |
4 |
Pages: |
476-84 |
|
•
•
•
•
•
|
Publication |
First Author: |
Watanabe T |
Year: |
2010 |
Journal: |
J Clin Invest |
Title: |
NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway. |
Volume: |
120 |
Issue: |
5 |
Pages: |
1645-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Siednienko J |
Year: |
2010 |
Journal: |
Eur J Immunol |
Title: |
TLR3-mediated IFN-β gene induction is negatively regulated by the TLR adaptor MyD88 adaptor-like. |
Volume: |
40 |
Issue: |
11 |
Pages: |
3150-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xing J |
Year: |
2021 |
Journal: |
Nat Commun |
Title: |
Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells. |
Volume: |
12 |
Issue: |
1 |
Pages: |
2681 |
|
•
•
•
•
•
|
Publication |
First Author: |
Piret J |
Year: |
2018 |
Journal: |
J Gen Virol |
Title: |
Predominant role of IPS-1 over TRIF adaptor proteins in early innate immune response against Zika virus in mice. |
Volume: |
99 |
Issue: |
2 |
Pages: |
209-218 |
|
•
•
•
•
•
|
Publication |
First Author: |
Manils J |
Year: |
2017 |
Journal: |
Sci Rep |
Title: |
Double deficiency of Trex2 and DNase1L2 nucleases leads to accumulation of DNA in lingual cornifying keratinocytes without activating inflammatory responses. |
Volume: |
7 |
Issue: |
1 |
Pages: |
11902 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pang Z |
Year: |
2018 |
Journal: |
PLoS One |
Title: |
Regulator of calcineurin 1 differentially regulates TLR-dependent MyD88 and TRIF signaling pathways. |
Volume: |
13 |
Issue: |
5 |
Pages: |
e0197491 |
|
•
•
•
•
•
|
Publication |
First Author: |
Markovinovic A |
Year: |
2018 |
Journal: |
Neuroscience |
Title: |
Optineurin Insufficiency Disbalances Proinflammatory and Anti-inflammatory Factors by Reducing Microglial IFN-β Responses. |
Volume: |
388 |
|
Pages: |
139-151 |
|
•
•
•
•
•
|
Publication |
First Author: |
Desnues B |
Year: |
2016 |
Journal: |
Eur J Immunol |
Title: |
The transcriptional repressor Gfi1 prevents lupus autoimmunity by restraining TLR7 signaling. |
Volume: |
46 |
Issue: |
12 |
Pages: |
2801-2811 |
|
•
•
•
•
•
|
Publication |
First Author: |
Körber I |
Year: |
2016 |
Journal: |
PLoS One |
Title: |
Gene-Expression Profiling Suggests Impaired Signaling via the Interferon Pathway in Cstb-/- Microglia. |
Volume: |
11 |
Issue: |
6 |
Pages: |
e0158195 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chiang EY |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
EBI2 is a negative regulator of type I interferons in plasmacytoid and myeloid dendritic cells. |
Volume: |
8 |
Issue: |
12 |
Pages: |
e83457 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen S |
Year: |
2018 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-κB and interferon pathways. |
Volume: |
115 |
Issue: |
16 |
Pages: |
E3798-E3807 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pfaller CK |
Year: |
2008 |
Journal: |
J Virol |
Title: |
Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction. |
Volume: |
82 |
Issue: |
24 |
Pages: |
12365-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
Wang RP |
Year: |
2008 |
Journal: |
Mol Immunol |
Title: |
Differential regulation of IKK alpha-mediated activation of IRF3/7 by NIK. |
Volume: |
45 |
Issue: |
7 |
Pages: |
1926-34 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kaur S |
Year: |
2008 |
Journal: |
J Immunol |
Title: |
Dual regulatory roles of phosphatidylinositol 3-kinase in IFN signaling. |
Volume: |
181 |
Issue: |
10 |
Pages: |
7316-23 |
|
•
•
•
•
•
|
Publication |
First Author: |
Balachandran S |
Year: |
2007 |
Journal: |
J Immunol |
Title: |
Fas-associated death domain-containing protein-mediated antiviral innate immune signaling involves the regulation of Irf7. |
Volume: |
178 |
Issue: |
4 |
Pages: |
2429-39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Heinig M |
Year: |
2010 |
Journal: |
Nature |
Title: |
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk. |
Volume: |
467 |
Issue: |
7314 |
Pages: |
460-4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chow KT |
Year: |
2019 |
Journal: |
J Leukoc Biol |
Title: |
IRF5 regulates unique subset of genes in dendritic cells during West Nile virus infection. |
Volume: |
105 |
Issue: |
2 |
Pages: |
411-425 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang L |
Year: |
2019 |
Journal: |
Immunology |
Title: |
Attenuation of interferon regulatory factor 7 activity in local infectious sites of trachea and lung for preventing the development of acute lung injury caused by influenza A virus. |
Volume: |
157 |
Issue: |
1 |
Pages: |
37-51 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ozasa K |
Year: |
2019 |
Journal: |
Front Immunol |
Title: |
Cyclic GMP-AMP Triggers Asthma in an IL-33-Dependent Manner That Is Blocked by Amlexanox, a TBK1 Inhibitor. |
Volume: |
10 |
|
Pages: |
2212 |
|
•
•
•
•
•
|
Publication |
First Author: |
Garnier A |
Year: |
2019 |
Journal: |
Eur J Immunol |
Title: |
CD49d/CD29-integrin controls the accumulation of plasmacytoid dendritic cells into the CNS during neuroinflammation. |
Volume: |
49 |
Issue: |
11 |
Pages: |
2030-2043 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sim CK |
Year: |
2016 |
Journal: |
Cancer Immunol Immunother |
Title: |
2'-5' Oligoadenylate synthetase-like 1 (OASL1) deficiency in mice promotes an effective anti-tumor immune response by enhancing the production of type I interferons. |
Volume: |
65 |
Issue: |
6 |
Pages: |
663-75 |
|
•
•
•
•
•
|
Publication |
First Author: |
Weizman OE |
Year: |
2023 |
Journal: |
J Immunol |
Title: |
Type 2 Dendritic Cells Orchestrate a Local Immune Circuit to Confer Antimetastatic Immunity. |
Volume: |
210 |
Issue: |
8 |
Pages: |
1146-1155 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2412
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
593
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
314
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhou B |
Year: |
2020 |
Journal: |
Front Immunol |
Title: |
Zdhhc2 Is Essential for Plasmacytoid Dendritic Cells Mediated Inflammatory Response in Psoriasis. |
Volume: |
11 |
|
Pages: |
607442 |
|
•
•
•
•
•
|
Publication |
First Author: |
Li W |
Year: |
2014 |
Journal: |
J Virol |
Title: |
IRF7-dependent type I interferon production induces lethal immune-mediated disease in STAT1 knockout mice infected with lymphocytic choriomeningitis virus. |
Volume: |
88 |
Issue: |
13 |
Pages: |
7578-88 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zou J |
Year: |
2024 |
Journal: |
J Neuroinflammation |
Title: |
Microglia either promote or restrain TRAIL-mediated excitotoxicity caused by Aβ(1-42) oligomers. |
Volume: |
21 |
Issue: |
1 |
Pages: |
215 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thackray LB |
Year: |
2014 |
Journal: |
J Virol |
Title: |
Interferon regulatory factor 5-dependent immune responses in the draining lymph node protect against West Nile virus infection. |
Volume: |
88 |
Issue: |
19 |
Pages: |
11007-21 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Homologous_superfamily |
Description: |
A cysteine peptidase is a proteolytic enzyme that hydrolyses a peptide bond using the thiol group of a cysteine residue as a nucleophile. Hydrolysis involves usually a catalytic triad consisting of the thiol group of the cysteine, the imidazolium ring of a histidine, and a third residue, usually asparagine or aspartic acid, to orientate and activate the imidazolium ring. In only one family of cysteine peptidases, is the role of the general base assigned to a residue other than a histidine: in peptidases from family C89 (acid ceramidase) an arginine is the general base. Cysteine peptidases can be grouped into fourteen different clans, with members of each clan possessing a tertiary fold unique to the clan. Four clans of cysteine peptidases share structural similarities with serine and threonine peptidases and asparagine lyases. From sequence similarities, cysteine peptidases can be clustered into over 80 different families []. Clans CF, CM, CN, CO, CP and PD contain only one family.Cysteine peptidases are often active at acidic pH and are therefore confined to acidic environments, such as the animal lysosome or plant vacuole. Cysteine peptidases can be endopeptidases, aminopeptidases, carboxypeptidases, dipeptidyl-peptidases or omega-peptidases. They are inhibited by thiol chelators such as iodoacetate, iodoacetic acid, N-ethylmaleimide or p-chloromercuribenzoate.Clan CA includes proteins with a papain-like fold. There is a catalytic triad which occurs in the order: Cys/His/Asn (or Asp). A fourth residue, usually Gln, is important for stabilising the acyl intermediate that forms during catalysis, and this precedes the active site Cys. The fold consists of two subdomains with the active site between them. One subdomain consists of a bundle of helices, with the catalytic Cys at the end of one of them, and the other subdomain is a β-barrel with the active site His and Asn (or Asp). There are over thirty families in the clan, and tertiary structures have been solved for members of most of these. Peptidases in clan CA are usually sensitive to the small molecule inhibitor E64, which is ineffective against peptidases from other clans of cysteine peptidases [].Clan CD includes proteins with a caspase-like fold. Proteins in the clan have an α/β/α sandwich structure. There is a catalytic dyad which occurs in the order His/Cys. The active site His occurs in a His-Gly motif and the active site Cys occurs in an Ala-Cys motif; both motifs are preceded by a block of hydrophobic residues []. Specificity is predominantly directed towards residues that occupy the S1 binding pocket, so that caspases cleave aspartyl bonds, legumains cleave asparaginyl bonds, and gingipains cleave lysyl or arginyl bonds.Clan CE includes proteins with an adenain-like fold. The fold consists of two subdomains with the active site between them. One domain is a bundle of helices, and the other a β-barrell. The subdomains are in the opposite order to those found in peptidases from clan CA, and this is reflected in the order of active site residues: His/Asn/Gln/Cys. This has prompted speculation that proteins in clans CA and CE are related, and that members of one clan are derived from a circular permutation of the structure of the other.Clan CL includes proteins with a sortase B-like fold. Peptidases in the clan hydrolyse and transfer bacterial cell wall peptides. The fold shows a closed β-barrel decorated with helices with the active site at one end of the barrel []. The active site consists of a His/Cys catalytic dyad.This group of cysteine peptidases belong to MEROPS peptidase family C53 (clan C-). The active site residues occur in the order E, H, C in the sequence which is unlike that in any other family. They are unique to pestiviruses. The N-terminal cysteine peptidase (Npro) encoded by the bovine viral diarrhoea virus genome is responsible for the self-cleavage that releases the N terminus of the core protein. This unique protease is dispensable for viral replication, and its coding region can be replaced by a ubiquitin gene directly fused in frame to the core [, , , ].This superfamily represents a domain consisting of 5 anti-parallel beta strands. The domain also contains a TRASH motif connecting the B1-B2 linker to the B3 strand, and this motif means the domain is able to interact with immune-relevant factors IRF3, IRF7 and Hax1. |
|
•
•
•
•
•
|
Publication |
First Author: |
Muyldermans G |
Year: |
1996 |
Journal: |
Virus Genes |
Title: |
Expression in E. coli and purification of the active autoprotease P20 of classical swine fever virus. |
Volume: |
13 |
Issue: |
2 |
Pages: |
135-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rümenapf T |
Year: |
1998 |
Journal: |
J Virol |
Title: |
N-terminal protease of pestiviruses: identification of putative catalytic residues by site-directed mutagenesis. |
Volume: |
72 |
Issue: |
3 |
Pages: |
2544-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Lai VC |
Year: |
2000 |
Journal: |
J Virol |
Title: |
Generation and characterization of a hepatitis C virus NS3 protease-dependent bovine viral diarrhea virus. |
Volume: |
74 |
Issue: |
14 |
Pages: |
6339-47 |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
128
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
734
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
156
|
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
305
|
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Peng CW |
Year: |
2001 |
Journal: |
J Virol |
Title: |
Functional specialization and evolution of leader proteinases in the family Closteroviridae. |
Volume: |
75 |
Issue: |
24 |
Pages: |
12153-60 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen JM |
Year: |
1998 |
Journal: |
FEBS Lett |
Title: |
Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases. |
Volume: |
441 |
Issue: |
3 |
Pages: |
361-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Zong Y |
Year: |
2004 |
Journal: |
Structure |
Title: |
The structure of sortase B, a cysteine transpeptidase that tethers surface protein to the Staphylococcus aureus cell wall. |
Volume: |
12 |
Issue: |
1 |
Pages: |
105-12 |
|
•
•
•
•
•
|
Publication |
First Author: |
Barrett AJ |
Year: |
1982 |
Journal: |
Biochem J |
Title: |
L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L. |
Volume: |
201 |
Issue: |
1 |
Pages: |
189-98 |
|
•
•
•
•
•
|
Publication |
First Author: |
Barrett AJ |
Year: |
2001 |
Journal: |
Biol Chem |
Title: |
Evolutionary lines of cysteine peptidases. |
Volume: |
382 |
Issue: |
5 |
Pages: |
727-33 |
|
•
•
•
•
•
|