|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 501 to 568 out of 568 for Irf7

<< First    < Previous  |  Next >    Last >>
0.029s

Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Publication
First Author: Georgel P
Year: 2007
Journal: Virology
Title: Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway.
Volume: 362
Issue: 2
Pages: 304-13
Publication  
First Author: Qi Z
Year: 2021
Journal: Sci Adv
Title: SRSF1 serves as a critical posttranscriptional regulator at the late stage of thymocyte development.
Volume: 7
Issue: 16
Publication
First Author: Ma Z
Year: 2013
Journal: PLoS Pathog
Title: DDX24 negatively regulates cytosolic RNA-mediated innate immune signaling.
Volume: 9
Issue: 10
Pages: e1003721
Publication
First Author: Ramalho T
Year: 2024
Journal: Cell Metab
Title: Itaconate impairs immune control of Plasmodium by enhancing mtDNA-mediated PD-L1 expression in monocyte-derived dendritic cells.
Volume: 36
Issue: 3
Pages: 484-497.e6
Publication
First Author: Qi F
Year: 2022
Journal: FASEB J
Title: E3 ubiquitin ligase NEURL3 promotes innate antiviral response through catalyzing K63-linked ubiquitination of IRF7.
Volume: 36
Issue: 8
Pages: e22409
Publication
First Author: Gracias DT
Year: 2013
Journal: Nat Immunol
Title: The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling.
Volume: 14
Issue: 6
Pages: 593-602
Publication
First Author: Milon B
Year: 2021
Journal: Cell Rep
Title: A cell-type-specific atlas of the inner ear transcriptional response to acoustic trauma.
Volume: 36
Issue: 13
Pages: 109758
Publication
First Author: Cheng Y
Year: 2018
Journal: J Exp Med
Title: Mycobacterium tuberculosis-induced IFN-β production requires cytosolic DNA and RNA sensing pathways.
Volume: 215
Issue: 11
Pages: 2919-2935
Publication
First Author: Nguyen BC
Year: 2006
Journal: Genes Dev
Title: Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation.
Volume: 20
Issue: 8
Pages: 1028-42
Publication
First Author: Ma S
Year: 2017
Journal: J Exp Med
Title: Epigenetic regulator CXXC5 recruits DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs.
Volume: 214
Issue: 5
Pages: 1471-1491
Publication
First Author: Lu X
Year: 2013
Journal: Cell Res
Title: miR-142-3p regulates the formation and differentiation of hematopoietic stem cells in vertebrates.
Volume: 23
Issue: 12
Pages: 1356-68
Protein
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: false
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 2441  
Fragment?: false
Publication
First Author: Renga B
Year: 2013
Journal: PLoS One
Title: The bile acid sensor FXR is required for immune-regulatory activities of TLR-9 in intestinal inflammation.
Volume: 8
Issue: 1
Pages: e54472
Publication
First Author: So EY
Year: 2009
Journal: Glia
Title: Theiler's virus infection induces TLR3-dependent upregulation of TLR2 critical for proinflammatory cytokine production.
Volume: 57
Issue: 11
Pages: 1216-26
Publication
First Author: Sriram U
Year: 2014
Journal: PLoS One
Title: IL-4 suppresses the responses to TLR7 and TLR9 stimulation and increases the permissiveness to retroviral infection of murine conventional dendritic cells.
Volume: 9
Issue: 1
Pages: e87668
Publication
First Author: Wu YY
Year: 2016
Journal: PLoS One
Title: BANK1 Regulates IgG Production in a Lupus Model by Controlling TLR7-Dependent STAT1 Activation.
Volume: 11
Issue: 5
Pages: e0156302
Publication
First Author: Sugihara T
Year: 2011
Journal: Mol Cancer Res
Title: Activation of interferon-stimulated genes by gamma-ray irradiation independently of the ataxia telangiectasia mutated-p53 pathway.
Volume: 9
Issue: 4
Pages: 476-84
Publication
First Author: Watanabe T
Year: 2010
Journal: J Clin Invest
Title: NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway.
Volume: 120
Issue: 5
Pages: 1645-62
Publication
First Author: Siednienko J
Year: 2010
Journal: Eur J Immunol
Title: TLR3-mediated IFN-β gene induction is negatively regulated by the TLR adaptor MyD88 adaptor-like.
Volume: 40
Issue: 11
Pages: 3150-60
Publication
First Author: Xing J
Year: 2021
Journal: Nat Commun
Title: Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells.
Volume: 12
Issue: 1
Pages: 2681
Publication
First Author: Piret J
Year: 2018
Journal: J Gen Virol
Title: Predominant role of IPS-1 over TRIF adaptor proteins in early innate immune response against Zika virus in mice.
Volume: 99
Issue: 2
Pages: 209-218
Publication
First Author: Manils J
Year: 2017
Journal: Sci Rep
Title: Double deficiency of Trex2 and DNase1L2 nucleases leads to accumulation of DNA in lingual cornifying keratinocytes without activating inflammatory responses.
Volume: 7
Issue: 1
Pages: 11902
Publication
First Author: Pang Z
Year: 2018
Journal: PLoS One
Title: Regulator of calcineurin 1 differentially regulates TLR-dependent MyD88 and TRIF signaling pathways.
Volume: 13
Issue: 5
Pages: e0197491
Publication  
First Author: Markovinovic A
Year: 2018
Journal: Neuroscience
Title: Optineurin Insufficiency Disbalances Proinflammatory and Anti-inflammatory Factors by Reducing Microglial IFN-β Responses.
Volume: 388
Pages: 139-151
Publication
First Author: Desnues B
Year: 2016
Journal: Eur J Immunol
Title: The transcriptional repressor Gfi1 prevents lupus autoimmunity by restraining TLR7 signaling.
Volume: 46
Issue: 12
Pages: 2801-2811
Publication
First Author: Körber I
Year: 2016
Journal: PLoS One
Title: Gene-Expression Profiling Suggests Impaired Signaling via the Interferon Pathway in Cstb-/- Microglia.
Volume: 11
Issue: 6
Pages: e0158195
Publication
First Author: Chiang EY
Year: 2013
Journal: PLoS One
Title: EBI2 is a negative regulator of type I interferons in plasmacytoid and myeloid dendritic cells.
Volume: 8
Issue: 12
Pages: e83457
Publication
First Author: Chen S
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: SAMHD1 suppresses innate immune responses to viral infections and inflammatory stimuli by inhibiting the NF-κB and interferon pathways.
Volume: 115
Issue: 16
Pages: E3798-E3807
Publication
First Author: Pfaller CK
Year: 2008
Journal: J Virol
Title: Measles virus V protein is a decoy substrate for IkappaB kinase alpha and prevents Toll-like receptor 7/9-mediated interferon induction.
Volume: 82
Issue: 24
Pages: 12365-73
Publication
First Author: Wang RP
Year: 2008
Journal: Mol Immunol
Title: Differential regulation of IKK alpha-mediated activation of IRF3/7 by NIK.
Volume: 45
Issue: 7
Pages: 1926-34
Publication
First Author: Kaur S
Year: 2008
Journal: J Immunol
Title: Dual regulatory roles of phosphatidylinositol 3-kinase in IFN signaling.
Volume: 181
Issue: 10
Pages: 7316-23
Publication
First Author: Balachandran S
Year: 2007
Journal: J Immunol
Title: Fas-associated death domain-containing protein-mediated antiviral innate immune signaling involves the regulation of Irf7.
Volume: 178
Issue: 4
Pages: 2429-39
Publication
First Author: Heinig M
Year: 2010
Journal: Nature
Title: A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk.
Volume: 467
Issue: 7314
Pages: 460-4
Publication
First Author: Chow KT
Year: 2019
Journal: J Leukoc Biol
Title: IRF5 regulates unique subset of genes in dendritic cells during West Nile virus infection.
Volume: 105
Issue: 2
Pages: 411-425
Publication
First Author: Yang L
Year: 2019
Journal: Immunology
Title: Attenuation of interferon regulatory factor 7 activity in local infectious sites of trachea and lung for preventing the development of acute lung injury caused by influenza A virus.
Volume: 157
Issue: 1
Pages: 37-51
Publication  
First Author: Ozasa K
Year: 2019
Journal: Front Immunol
Title: Cyclic GMP-AMP Triggers Asthma in an IL-33-Dependent Manner That Is Blocked by Amlexanox, a TBK1 Inhibitor.
Volume: 10
Pages: 2212
Publication
First Author: Garnier A
Year: 2019
Journal: Eur J Immunol
Title: CD49d/CD29-integrin controls the accumulation of plasmacytoid dendritic cells into the CNS during neuroinflammation.
Volume: 49
Issue: 11
Pages: 2030-2043
Publication
First Author: Sim CK
Year: 2016
Journal: Cancer Immunol Immunother
Title: 2'-5' Oligoadenylate synthetase-like 1 (OASL1) deficiency in mice promotes an effective anti-tumor immune response by enhancing the production of type I interferons.
Volume: 65
Issue: 6
Pages: 663-75
Publication
First Author: Weizman OE
Year: 2023
Journal: J Immunol
Title: Type 2 Dendritic Cells Orchestrate a Local Immune Circuit to Confer Antimetastatic Immunity.
Volume: 210
Issue: 8
Pages: 1146-1155
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 2412  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 593  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: false
Publication  
First Author: Zhou B
Year: 2020
Journal: Front Immunol
Title: Zdhhc2 Is Essential for Plasmacytoid Dendritic Cells Mediated Inflammatory Response in Psoriasis.
Volume: 11
Pages: 607442
Publication
First Author: Li W
Year: 2014
Journal: J Virol
Title: IRF7-dependent type I interferon production induces lethal immune-mediated disease in STAT1 knockout mice infected with lymphocytic choriomeningitis virus.
Volume: 88
Issue: 13
Pages: 7578-88
Publication
First Author: Zou J
Year: 2024
Journal: J Neuroinflammation
Title: Microglia either promote or restrain TRAIL-mediated excitotoxicity caused by Aβ(1-42) oligomers.
Volume: 21
Issue: 1
Pages: 215
Publication
First Author: Thackray LB
Year: 2014
Journal: J Virol
Title: Interferon regulatory factor 5-dependent immune responses in the draining lymph node protect against West Nile virus infection.
Volume: 88
Issue: 19
Pages: 11007-21
Protein Domain
Type: Homologous_superfamily
Description: A cysteine peptidase is a proteolytic enzyme that hydrolyses a peptide bond using the thiol group of a cysteine residue as a nucleophile. Hydrolysis involves usually a catalytic triad consisting of the thiol group of the cysteine, the imidazolium ring of a histidine, and a third residue, usually asparagine or aspartic acid, to orientate and activate the imidazolium ring. In only one family of cysteine peptidases, is the role of the general base assigned to a residue other than a histidine: in peptidases from family C89 (acid ceramidase) an arginine is the general base. Cysteine peptidases can be grouped into fourteen different clans, with members of each clan possessing a tertiary fold unique to the clan. Four clans of cysteine peptidases share structural similarities with serine and threonine peptidases and asparagine lyases. From sequence similarities, cysteine peptidases can be clustered into over 80 different families []. Clans CF, CM, CN, CO, CP and PD contain only one family.Cysteine peptidases are often active at acidic pH and are therefore confined to acidic environments, such as the animal lysosome or plant vacuole. Cysteine peptidases can be endopeptidases, aminopeptidases, carboxypeptidases, dipeptidyl-peptidases or omega-peptidases. They are inhibited by thiol chelators such as iodoacetate, iodoacetic acid, N-ethylmaleimide or p-chloromercuribenzoate.Clan CA includes proteins with a papain-like fold. There is a catalytic triad which occurs in the order: Cys/His/Asn (or Asp). A fourth residue, usually Gln, is important for stabilising the acyl intermediate that forms during catalysis, and this precedes the active site Cys. The fold consists of two subdomains with the active site between them. One subdomain consists of a bundle of helices, with the catalytic Cys at the end of one of them, and the other subdomain is a β-barrel with the active site His and Asn (or Asp). There are over thirty families in the clan, and tertiary structures have been solved for members of most of these. Peptidases in clan CA are usually sensitive to the small molecule inhibitor E64, which is ineffective against peptidases from other clans of cysteine peptidases [].Clan CD includes proteins with a caspase-like fold. Proteins in the clan have an α/β/α sandwich structure. There is a catalytic dyad which occurs in the order His/Cys. The active site His occurs in a His-Gly motif and the active site Cys occurs in an Ala-Cys motif; both motifs are preceded by a block of hydrophobic residues []. Specificity is predominantly directed towards residues that occupy the S1 binding pocket, so that caspases cleave aspartyl bonds, legumains cleave asparaginyl bonds, and gingipains cleave lysyl or arginyl bonds.Clan CE includes proteins with an adenain-like fold. The fold consists of two subdomains with the active site between them. One domain is a bundle of helices, and the other a β-barrell. The subdomains are in the opposite order to those found in peptidases from clan CA, and this is reflected in the order of active site residues: His/Asn/Gln/Cys. This has prompted speculation that proteins in clans CA and CE are related, and that members of one clan are derived from a circular permutation of the structure of the other.Clan CL includes proteins with a sortase B-like fold. Peptidases in the clan hydrolyse and transfer bacterial cell wall peptides. The fold shows a closed β-barrel decorated with helices with the active site at one end of the barrel []. The active site consists of a His/Cys catalytic dyad.This group of cysteine peptidases belong to MEROPS peptidase family C53 (clan C-). The active site residues occur in the order E, H, C in the sequence which is unlike that in any other family. They are unique to pestiviruses. The N-terminal cysteine peptidase (Npro) encoded by the bovine viral diarrhoea virus genome is responsible for the self-cleavage that releases the N terminus of the core protein. This unique protease is dispensable for viral replication, and its coding region can be replaced by a ubiquitin gene directly fused in frame to the core [, , , ].This superfamily represents a domain consisting of 5 anti-parallel beta strands. The domain also contains a TRASH motif connecting the B1-B2 linker to the B3 strand, and this motif means the domain is able to interact with immune-relevant factors IRF3, IRF7 and Hax1.
Publication
First Author: Muyldermans G
Year: 1996
Journal: Virus Genes
Title: Expression in E. coli and purification of the active autoprotease P20 of classical swine fever virus.
Volume: 13
Issue: 2
Pages: 135-42
Publication
First Author: Rümenapf T
Year: 1998
Journal: J Virol
Title: N-terminal protease of pestiviruses: identification of putative catalytic residues by site-directed mutagenesis.
Volume: 72
Issue: 3
Pages: 2544-7
Publication
First Author: Lai VC
Year: 2000
Journal: J Virol
Title: Generation and characterization of a hepatitis C virus NS3 protease-dependent bovine viral diarrhea virus.
Volume: 74
Issue: 14
Pages: 6339-47
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 156  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 305  
Fragment?: false
Publication
First Author: Peng CW
Year: 2001
Journal: J Virol
Title: Functional specialization and evolution of leader proteinases in the family Closteroviridae.
Volume: 75
Issue: 24
Pages: 12153-60
Publication
First Author: Chen JM
Year: 1998
Journal: FEBS Lett
Title: Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases.
Volume: 441
Issue: 3
Pages: 361-5
Publication
First Author: Zong Y
Year: 2004
Journal: Structure
Title: The structure of sortase B, a cysteine transpeptidase that tethers surface protein to the Staphylococcus aureus cell wall.
Volume: 12
Issue: 1
Pages: 105-12
Publication
First Author: Barrett AJ
Year: 1982
Journal: Biochem J
Title: L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L.
Volume: 201
Issue: 1
Pages: 189-98
Publication
First Author: Barrett AJ
Year: 2001
Journal: Biol Chem
Title: Evolutionary lines of cysteine peptidases.
Volume: 382
Issue: 5
Pages: 727-33