This entry represents the TMEM33/Pom33 family. Budding yeast Pom33 is a transmembrane nucleoporin that contributes to proper distribution and/or efficient assembly of nuclear pores []. Proteins in this entry also include Tts1 from fission yeasts [], Kr-h2 (krueppel homologue 2) from flies []and TMEM33 from vertebrates []. Tts1 is required for the correct positioning of the cellular division plane by delimiting the actomyosin ring assembly at the cell equator [].Kr-h2 is a member of the dosage-dependent hierarchy effective upon white gene expression [].TMEM33 regulates the tubular structure of endoplasmic reticulum by suppressing the membrane-shaping activity of reticulons []. It was also demonstrated that TMEM33 regulates the unfolded protein response which is activated during endoplasmic reticulum stress [].
