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Search results 201 to 289 out of 289 for Ak1

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0.027s
Type Details Score
GXD Expression    
Probe: MGI:4416002
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1768022
Stage: TS22
Assay Id: MGI:5421801
Age: embryonic day 14.5
Note: Expression was not detected in the skull (base and vault).
Specimen Label: EG1780; Specimen G0561
Detected: false
Specimen Num: 1
GXD Expression    
Probe: MGI:4416002
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2672022
Stage: TS22
Assay Id: MGI:5421801
Age: embryonic day 14.5
Note: Expression was not detected in whisker follicle.
Specimen Label: EG1780; Specimen G0561
Detected: false
Specimen Num: 1
Publication  
First Author: Burow K
Year: 1977
Journal: Mouse News Lett
Title: Ak-1
Volume: 56
Pages: 65
Publication
First Author: Gustafson LA
Year: 2002
Journal: Am J Physiol Heart Circ Physiol
Title: Activation time of myocardial oxidative phosphorylation in creatine kinase and adenylate kinase knockout mice.
Volume: 282
Issue: 6
Pages: H2259-64
Publication
First Author: Fournier RE
Year: 1983
Journal: Somatic Cell Genet
Title: Complementation mapping in microcell hybrids: localization of Fpgs and Ak-1 on Mus musculus chromosome 2.
Volume: 9
Issue: 1
Pages: 69-84
Publication
First Author: Kuiper JW
Year: 2009
Journal: PLoS One
Title: Local ATP generation by brain-type creatine kinase (CK-B) facilitates cell motility.
Volume: 4
Issue: 3
Pages: e5030
Publication
First Author: Cox DR
Year: 1982
Journal: Proc Natl Acad Sci U S A
Title: Assignment of the gene for beta 2-microglobulin (B2m) to mouse chromosome 2.
Volume: 79
Issue: 6
Pages: 1930-4
Publication
First Author: Guo L
Year: 2013
Journal: J Immunol
Title: CaMKIα regulates AMP kinase-dependent, TORC-1-independent autophagy during lipopolysaccharide-induced acute lung neutrophilic inflammation.
Volume: 190
Issue: 7
Pages: 3620-8
Publication
First Author: Malas S
Year: 1996
Journal: Mamm Genome
Title: The isolation and mapping of PCR markers specific to mouse Chromosome 2.
Volume: 7
Issue: 2
Pages: 145-8
Publication
First Author: Schäfer R
Year: 1980
Journal: Somatic Cell Genet
Title: Assignment of the gene for cytoplasmic glutamate-oxaloacetate transaminase to mouse chromosome 19 using chinese hamster x mouse somatic cell hybrids.
Volume: 6
Issue: 6
Pages: 709-17
Publication
First Author: Francke U
Year: 1977
Journal: Cytogenet Cell Genet
Title: Gene mapping in Mus musculus by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2.
Volume: 19
Issue: 2-3
Pages: 57-84
Publication
First Author: Kasahara M
Year: 1996
Journal: Proc Natl Acad Sci U S A
Title: Chromosomal localization of the proteasome Z subunit gene reveals an ancient chromosomal duplication involving the major histocompatibility complex.
Volume: 93
Issue: 17
Pages: 9096-101
Publication
First Author: Kim HJ
Year: 2013
Journal: PLoS One
Title: Conditional deletion of pten leads to defects in nerve innervation and neuronal survival in inner ear development.
Volume: 8
Issue: 2
Pages: e55609
Publication
First Author: Stallings RL
Year: 1981
Journal: Somatic Cell Genet
Title: Confirmational, provisional, and/or regional assignment of 15 enzyme loci onto Chinese hamster autosomes 1, 2, and 7.
Volume: 7
Issue: 6
Pages: 683-98
Publication
First Author: Pilz A
Year: 1994
Journal: Genomics
Title: Genetic linkage analysis of the Ak1, Col5a1, Epb7.2, Fpgs, Grp78, Pbx3, and Notch1 genes in the region of mouse chromosome 2 homologous to human chromosome 9q.
Volume: 21
Issue: 1
Pages: 104-9
Publication
First Author: Sharma N
Year: 2016
Journal: Development
Title: Tpbpa-Cre-mediated deletion of TFAP2C leads to deregulation of Cdkn1a, Akt1 and the ERK pathway, causing placental growth arrest.
Volume: 143
Issue: 5
Pages: 787-98
Publication
First Author: Bonhomme F
Year: 1984
Journal: Biochem Genet
Title: Biochemical diversity and evolution in the genus Mus.
Volume: 22
Issue: 3-4
Pages: 275-303
Publication
First Author: Pilz A
Year: 1996
Journal: Mouse Genome
Title: High resolution genetic linkage analysis of mouse Chromosome 2 in the region of homology with human Chromosome 9
Volume: 94
Issue: 4
Pages: 877-9
Publication
First Author: Kannan K
Year: 2001
Journal: Oncogene
Title: DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1.
Volume: 20
Issue: 26
Pages: 3449-55
Publication
First Author: Rowe LB
Year: 1994
Journal: Mamm Genome
Title: Maps from two interspecific backcross DNA panels available as a community genetic mapping resource.
Volume: 5
Issue: 5
Pages: 253-74
Publication
First Author: Pilz A
Year: 1995
Journal: Genomics
Title: Comparative mapping of 50 human chromosome 9 loci in the laboratory mouse.
Volume: 25
Issue: 1
Pages: 139-49
Publication
First Author: Rutledge EA
Year: 2017
Journal: Development
Title: Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development.
Volume: 144
Issue: 17
Pages: 3177-3188
Publication        
First Author: UniProt curators
Year: 2014
Title: Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
Publication
First Author: Koss M
Year: 2012
Journal: Dev Cell
Title: Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module.
Volume: 22
Issue: 5
Pages: 913-26
Publication        
First Author: International Committee on Standardized Genetic Nomenclature for Mice
Year: 1993
Title: Nomenclature rule change to delete hyphens and parentheses from mouse locus symbols
Publication        
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
Publication        
First Author: Haiming Tang, Dustin Ebert, Matthias Blum, Robert Finn, Paul Thomas
Year: 2023
Title: TreeGrafter-generated GO annotations
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: Data Curation Using Mouse Genome Assembly
Publication
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
Publication        
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Publication
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
Publication      
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
Publication        
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
Publication        
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
Publication      
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
Publication
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
Publication
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
Publication        
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
Publication        
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Publication        
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Publication      
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
Publication
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
Publication        
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
Publication
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
Publication      
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
Publication        
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
Publication      
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication
First Author: Cook PJ
Year: 1978
Journal: Ann Hum Genet
Title: Segregation of ABO, AK1 and ACONs in families with abnormalities of chromosome 9.
Volume: 41
Issue: 3
Pages: 365-77
Publication      
First Author: Ito C
Year: 2022
Journal: MGI Direct Data Submission
Title: The association of ODF4 with AK1 and AK2 in mice is essential for fertility through its contribution to flagellar shape.
Protein Domain
Type: Family
Description: Adenylate kinases (AKs) are nucleoside monophosphate kinases, which catalyse the phosphorylation of AMP by using ATP or GTP as phosphate donors. In humans, nine different AK isoenzymes have been identified (AK1-9). This entry includes AK1 and AK5. AK1 is the major cytosolic isoform and is present in all tissues with its highest expression levels in skeletal muscle, brain and erythrocytes []. AK5 expression is limited to brain tissue [].
Publication
First Author: Allderdice PW
Year: 1986
Journal: Am J Hum Genet
Title: Segregation of marker loci in families with an inherited paracentric insertion of chromosome 9.
Volume: 39
Issue: 5
Pages: 612-7
Protein Domain
Type: Conserved_site
Description: Aspartate kinase () (AK) catalyzes the first reaction in the aspartate pathway; the phosphorylation of aspartate. The product of this reaction can then be used in the biosynthesis of lysine or in the pathway leading to homoserine, which participates in the biosynthesis of threonine, isoleucine and methionine [].In bacteria there are three different aspartate kinase isozymes which differ in sensitivity to repression and inhibition by Lys, Met and Thr. AK1 and AK2 are bifunctional enzymes which both consist of an N-terminal AK domain and a C-terminal homoserine dehydrogenase domain. AK1 is involved in threonine biosynthesis and AK2, in that of methionine. The third isozyme, AK3 is monofunctional and involved in lysine synthesis. In archaea and plants there may be a single isozyme of AK which in plants is multifunctional.This entry represents a region encoding aspartate kinase activity found in both the monofunctional and bifunctional enzymes.Synonym(s): Aspartokinase
Publication
First Author: Rafalski JA
Year: 1988
Journal: J Biol Chem
Title: Structure of the yeast HOM3 gene which encodes aspartokinase.
Volume: 263
Issue: 5
Pages: 2146-51
Protein Domain
Type: Domain
Description: Bacteria, plants and fungi metabolise aspartic acid to produce four amino acids - lysine, threonine, methionine and isoleucine - in a series of reactions known as the aspartate pathway. Additionally, several important metabolic intermediates are produced by these reactions, such as diaminopimelic acid, an essential component of bacterial cell wall biosynthesis, and dipicolinic acid, which is involved in sporulation in Gram-positive bacteria. Members of the animal kingdom do not posses this pathway and must therefore acquire these essential amino acids through their diet. Research into improving the metabolic flux through this pathway has the potential to increase the yield of the essential amino acids in important crops, thus improving their nutritional value. Additionally, since the enzymes are not present in animals, inhibitors of them are promising targets for the development of novel antibiotics and herbicides. For more information see [].Aspartate kinase () (AK) catalyzes the first reaction in the aspartate pathway; the phosphorylation of aspartate. The product of this reaction can then be used in the biosynthesis of lysine or in the pathway leading to homoserine, which participates in the biosynthesis of threonine, isoleucine and methionine [].In bacteria there are three different aspartate kinase isozymes which differ in sensitivity to repression and inhibition by Lys, Met and Thr. AK1 and AK2 are bifunctional enzymes which both consist of an N-terminal AK domain and a C-terminal homoserine dehydrogenase domain. AK1 is involved in threonine biosynthesis and AK2, in that of methionine. The third isozyme, AK3 is monofunctional and involved in lysine synthesis. In archaea and plants there may be a single isozyme of AK which in plants is multifunctional.
Publication
First Author: Pollock A
Year: 2014
Journal: Cell Rep
Title: Growth of the developing cerebral cortex is controlled by microRNA-7 through the p53 pathway.
Volume: 7
Issue: 4
Pages: 1184-96
Publication
First Author: Stallings RL
Year: 1982
Journal: J Hered
Title: Assignment of ADA, ITPA, AK1, and AK2 to Chinese hamster chromosomes. Genetic and structural evidence for the conservation of mammalian autosomal synteny.
Volume: 73
Issue: 6
Pages: 399-404
Publication
First Author: Smith CA
Year: 1999
Journal: J Mol Biol
Title: Calcium-mediated thermostability in the subtilisin superfamily: the crystal structure of Bacillus Ak.1 protease at 1.8 A resolution.
Volume: 294
Issue: 4
Pages: 1027-40
Publication  
First Author: Dauter Z
Year: 1991
Journal: Acta Crystallogr B
Title: Complex between the subtilisin from a mesophilic bacterium and the leech inhibitor eglin-C.
Volume: 47 ( Pt 5)
Pages: 707-30
Publication
First Author: Kleine R
Year: 1982
Journal: Acta Biol Med Ger
Title: Properties of thermitase, a thermostable serine protease from Thermoactinomyces vulgaris.
Volume: 41
Issue: 1
Pages: 89-102
Publication
First Author: Dauter Z
Year: 1988
Journal: FEBS Lett
Title: Crystal structure of a complex between thermitase from Thermoactinomyces vulgaris and the leech inhibitor eglin.
Volume: 236
Issue: 1
Pages: 171-8
Publication
First Author: Peek K
Year: 1993
Journal: Appl Environ Microbiol
Title: Some characteristics of a proteinase from a thermophilic Bacillus sp. expressed in Escherichia coli: comparison with the native enzyme and its processing in E. coli and in vitro.
Volume: 59
Issue: 4
Pages: 1168-75
Publication
First Author: Kamekura M
Year: 1996
Journal: Biochim Biophys Acta
Title: Halolysin R4, a serine proteinase from the halophilic archaeon Haloferax mediterranei; gene cloning, expression and structural studies.
Volume: 1294
Issue: 2
Pages: 159-67
Protein Domain
Type: Domain
Description: This entry represents an S8 family domain found in thermitase as well as other thermostable subtilisin homologues, all of which are stablized by calcium ions [].Thermitase (MEROPS identifier S08.007) is a calcium-dependent, non-specific, serine protease from the thermophilic bacterium Thermoactinomyces vulgaris. The peptidase is maximally active between pH 7.5 and 9.5, and at 85 degrees Celsius. It cleaves a wide variety of proteins including native collagen and elastin []. The tertiary structure of thermitase is similar to that of subtilisin BPN' []. Mesentericopeptidase (MEROPS identifier S08.002) is from the mesophilic bacterium Bacillus mesentericus and has been crystallized []. Subtilisin Ak1 (MEROPS identifier S08.009) from Geobacillus stearothermophilis is stable at 70 degrees Celsius and maximally active at pH 7.5 []. From the crystal structure, subtilisin Ak1 possesses three calcium ions, only two of which correspond to positions in other thermostable subtilisins, and it is this third calcium that provides the greater thermostability []. Halolysin R4 (MEROPS identifier S08.102) from the halophilic archaean Haloferax mediterranei is also included in this entry, but unlike its bacterial relatives, its protein sequence has a long C-terminal extension which if removed abolishes peptidase activity [].This domain is part of a family of domains found in serine peptidases belonging to the MEROPS peptidase families S8 (subfamilies S8A (subtilisin) and S8B (kexin)) and S53 (sedolisin), both of which are members of clan SB [, , , ].Members of the peptidases S8 (subtilisin and kexin) and S53 (sedolisin) clan include endopeptidases and exopeptidases. The S8 family has an Asp/His/Ser catalytic triad similar to that found in trypsin-like proteases, but do not share their three-dimensional structure and are not homologous to trypsin. Serine acts as a nucleophile, aspartate as an electrophile, and histidine as a base. The S53 family contains a catalytic triad Glu/Asp/Ser with an additional acidic residue Asp in the oxyanion hole, similar to that of subtilisin. The serine residue here is the nucleophilic equivalent of the serine residue in the S8 family, while glutamic acid has the same role here as the histidine base. However, the aspartic acid residue that acts as an electrophile is quite different. In S53 it follows glutamic acid, while in S8 it precedes histidine. The stability of these enzymes may be enhanced by calcium, some members have been shown to bind up to 4 ions via binding sites with different affinity. There is a great diversity in the characteristics of their members: some contain disulfide bonds, some are intracellular while others are extracellular, some function at extreme temperatures, and others at high or low pH values [, , , ].
Publication
First Author: Silva DF
Year: 2017
Journal: Mol Neurobiol
Title: Mitochondrial Metabolism Power SIRT2-Dependent Deficient Traffic Causing Alzheimer's-Disease Related Pathology.
Volume: 54
Issue: 6
Pages: 4021-4040
Publication
First Author: Kurtzman AL
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Ubc9 interacts with a nuclear localization signal and mediates nuclear localization of the paired-like homeobox protein Vsx-1 independent of SUMO-1 modification.
Volume: 98
Issue: 10
Pages: 5602-7
Publication
First Author: Mohandas T
Year: 1979
Journal: Am J Hum Genet
Title: Regional localization of human gene loci on chromosome 9: studies of somatic cell hybrids containing human translocations.
Volume: 31
Issue: 5
Pages: 586-600
Publication
First Author: Tanabe T
Year: 1993
Journal: J Biochem
Title: Tissue-specific and developmentally regulated expression of the genes encoding adenylate kinase isozymes.
Volume: 113
Issue: 2
Pages: 200-7
Publication
First Author: Inouye S
Year: 1998
Journal: J Neurochem
Title: Increase of adenylate kinase isozyme 1 protein during neuronal differentiation in mouse embryonal carcinoma P19 cells and in rat brain primary cultured cells.
Volume: 71
Issue: 1
Pages: 125-33
Publication  
First Author: Zervou S
Year: 2021
Journal: Front Physiol
Title: Subtle Role for Adenylate Kinase 1 in Maintaining Normal Basal Contractile Function and Metabolism in the Murine Heart.
Volume: 12
Pages: 623969
Protein
Organism: Mus musculus/domesticus
Length: 562  
Fragment?: false
Publication  
First Author: Barton DE
Year: 1987
Journal: Cytogenet Cell Genet
Title: NEAS encoding a non-erthyroid alpha-spectrin is on Chromosome 9, region q33-q34 and on mouse Chromosome 2.
Volume: 46
Pages: 578 (Abstr.)
Publication
First Author: Wlodawer A
Year: 2003
Journal: Acta Biochim Pol
Title: Structural and enzymatic properties of the sedolisin family of serine-carboxyl peptidases.
Volume: 50
Issue: 1
Pages: 81-102
Publication
First Author: Siezen RJ
Year: 1991
Journal: Protein Eng
Title: Homology modelling and protein engineering strategy of subtilases, the family of subtilisin-like serine proteinases.
Volume: 4
Issue: 7
Pages: 719-37
Publication
First Author: Van de Ven WJ
Year: 1993
Journal: Crit Rev Oncog
Title: Structure and function of eukaryotic proprotein processing enzymes of the subtilisin family of serine proteases.
Volume: 4
Issue: 2
Pages: 115-36
Publication
First Author: Viola RE
Year: 2001
Journal: Acc Chem Res
Title: The central enzymes of the aspartate family of amino acid biosynthesis.
Volume: 34
Issue: 5
Pages: 339-49
Publication
First Author: Siezen RJ
Year: 1997
Journal: Protein Sci
Title: Subtilases: the superfamily of subtilisin-like serine proteases.
Volume: 6
Issue: 3
Pages: 501-23
Publication  
First Author: Rawlings ND
Year: 1994
Journal: Methods Enzymol
Title: Families of serine peptidases.
Volume: 244
Pages: 19-61
Publication  
First Author: Rawlings ND
Year: 1993
Journal: Biochem J
Title: Evolutionary families of peptidases.
Volume: 290 ( Pt 1)
Pages: 205-18