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Search results 801 to 900 out of 929 for Alk

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Categories

Hits by Pathway

Hits by Strain

Hits by Category

Type Details Score
Strain
MGI:6440957 | B6;129S5-Fam150a<tm1Lex>/Tac
Attribute String: mutant stock, targeted mutation
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Protein
Q80YV2
Organism: Mus musculus/domesticus
Length: 501  
Fragment?: false
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Allele
Alk<em1Smoc> | MGI:7288231
Name: anaplastic lymphoma kinase; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
25331893 | J:216664
First Author: Zhang H
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome.
Volume: 111
Issue: 44
Pages: 15741-5
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Protein
Q80YV2-2
Organism: Mus musculus/domesticus
Length: 481  
Fragment?: false
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Publication
30061385 | -
First Author: Reshetnyak AV
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Identification of a biologically active fragment of ALK and LTK-Ligand 2 (augmentor-α).
Volume: 115
Issue: 33
Pages: 8340-8345
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Protein Coding Gene
MGI:96949 | Mdk
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97804 | Ptn
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P12025
Organism: Mus musculus/domesticus
Length: 140  
Fragment?: false
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Protein
P63089
Organism: Mus musculus/domesticus
Length: 168  
Fragment?: false
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Allele
Tg(TH-ALK*F1174L)5Homy | MGI:7517126
Name: transgene insertion 5, Hiroaki Honda
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Tg(TH-ALK*F1174L)9Homy | MGI:7518330
Name: transgene insertion 9, Hiroaki Honda
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Allele
Col1a1<tm1(tetO-EML4/ALK)Kkw> | MGI:5527336
Name: collagen, type I, alpha 1; targeted mutation 1, Kwok-Kin Wong
Allele Type: Targeted
Attribute String: Humanized sequence, Inducible, Inserted expressed sequence
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DO Term
DOID:0080372 | epithelioid inflammatory myofibroblastic sarcoma
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Strain
MGI:6146095 | C57BL/6-Tg(TH-ALK*F1174L)5Homy/Rbrc
Attribute String: mutant strain, coisogenic, transgenic
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Strain
MGI:6146127 | C57BL/6-Tg(TH-ALK*F1174L)9Homy/HomyRbrc
Attribute String: mutant strain, coisogenic, transgenic
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Publication
20952506 | J:166724
First Author: Chen Z
Year: 2010
Journal: Cancer Res
Title: Inhibition of ALK, PI3K/MEK, and HSP90 in murine lung adenocarcinoma induced by EML4-ALK fusion oncogene.
Volume: 70
Issue: 23
Pages: 9827-36
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Protein Coding Gene
MGI:97816 | Ptprz1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
B9EKR1
Organism: Mus musculus/domesticus
Length: 2312  
Fragment?: false
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Allele
Tg(Th-ALK*F1174L)2Loch | MGI:5636485
Name: transgene insertion 2, Louis Chesler
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(CAG-Alk*F1174L,-luc)60Jhsc | MGI:6196043
Name: transgene insertion 60, Johannes H Schulte
Allele Type: Transgenic
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
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Allele
Alk<tm1Swm> | MGI:5700377
Name: anaplastic lymphoma kinase; targeted mutation 1, Stephan W Morris
Allele Type: Targeted
Attribute String: Null/knockout
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Protein Coding Gene
MGI:99928 | Jak3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q62137
Organism: Mus musculus/domesticus
Length: 1100  
Fragment?: false
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Genotype
Genotype
Symbol: Alk/Alk
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Alk/Alk
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
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Allele
Alk<tm1.1(ALK*F1174L)Heno> | MGI:6476969
Name: anaplastic lymphoma kinase; targeted mutation 1.1, Hideki Enomoto
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence
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Genotype
Genotype
Symbol: Col1a1/Col1a1<+> Tg(Scgb1a1-rtTA)1Jaw/?
Background: involves: 129 * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Alk/Alk Ltk/Ltk
Background: involves: 129 * 129P2/OlaHsd
Zygosity: cx
Has Mutant Allele: true
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Publication
16009132 | -
First Author: Bassermann F
Year: 2005
Journal: Cell
Title: NIPA defines an SCF-type mammalian E3 ligase that regulates mitotic entry.
Volume: 122
Issue: 1
Pages: 45-57
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Protein Domain
IPR013909 | NIPA/Rsm1_C
Type: Domain
Description: This entry contains Nuclear-interacting partner of ALK (NIPA) and NIPA like proteins, as well as mRNA export factor Rsm1, all of which contain a C3HC-type zinc finger. The domain represented in this entry is found C-terminal to the zinc-finger like domain . Rsm1 is involved in mRNA export from the nucleus []. NIPA is an essential component of an SCF-type E3 ligase complex, SCF(NIPA), a complex that controls mitotic entry by mediating ubiquitination and subsequent degradation of cyclin B1 (CCNB1). Its cell-cycle-dependent phosphorylation regulates the assembly of the SCF(NIPA) complex, restricting CCNB1 ubiquitination activity to interphase. Its inactivation results in nuclear accumulation of CCNB1 in interphase and premature mitotic entry [].
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Protein Coding Gene
MGI:99454 | Irs1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:103038 | Stat3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1343091 | Hdac3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96055 | Ptpn6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P35569
Organism: Mus musculus/domesticus
Length: 1233  
Fragment?: false
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Protein
O88895
Organism: Mus musculus/domesticus
Length: 428  
Fragment?: false
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Protein
P42227
Organism: Mus musculus/domesticus
Length: 770  
Fragment?: false
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Protein
P29351
Organism: Mus musculus/domesticus
Length: 595  
Fragment?: false
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Publication
32142683 | J:305984
First Author: Cohen MA
Year: 2020
Journal: Cell Stem Cell
Title: Formation of Human Neuroblastoma in Mouse-Human Neural Crest Chimeras.
Volume: 26
Issue: 4
Pages: 579-592.e6
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Genotype
Genotype
Symbol: Tg(Th-ALK*F1174L)2Loch/? Tg(Th-MYCN)41Waw/?
Background: involves: 129X1/SvJ * BALB/c * C57BL/6J * CBA
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(CAG-Alk*F1174L,-luc)60Jhsc/? Tg(Dbh-icre)1Gsc/?
Background: involves: C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(CAG-Alk*F1174L,-luc)60Jhsc/? Th/Th<+>
Background: involves: 129X1/SvJ * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Protein Coding Gene
MGI:1097691 | Hdac2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P70288
Organism: Mus musculus/domesticus
Length: 488  
Fragment?: false
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Genotype
Genotype
Symbol: Tg(CAG-Alk*F1174L,-luc)60Jhsc/? Tg(Dbh-icre)1Gsc/? Tg(Th-MYCN)41Waw/?
Background: involves: 129X1/SvJ * BALB/c * C57BL/6 * C57BL/6J * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Alk/Alk
Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6N * SJL
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Alk/Alk Tg(Mpz-cre)94Imeg/?
Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6N * SJL
Zygosity: cn
Has Mutant Allele: true
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Publication
26637667 | J:237661
First Author: Lastwika KJ
Year: 2016
Journal: Cancer Res
Title: Control of PD-L1 Expression by Oncogenic Activation of the AKT-mTOR Pathway in Non-Small Cell Lung Cancer.
Volume: 76
Issue: 2
Pages: 227-38
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Publication
15895073 | J:101120
First Author: Chiarle R
Year: 2005
Journal: Nat Med
Title: Stat3 is required for ALK-mediated lymphomagenesis and provides a possible therapeutic target.
Volume: 11
Issue: 6
Pages: 623-9
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Publication
23178117 | J:196210
First Author: Huang S
Year: 2012
Journal: Cell
Title: MED12 controls the response to multiple cancer drugs through regulation of TGF-β receptor signaling.
Volume: 151
Issue: 5
Pages: 937-50
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Publication
19833155 | J:157199
First Author: Yanagisawa H
Year: 2010
Journal: Neurosci Res
Title: Pleiotrophin induces neurite outgrowth and up-regulates growth-associated protein (GAP)-43 mRNA through the ALK/GSK3beta/beta-catenin signaling in developing mouse neurons.
Volume: 66
Issue: 1
Pages: 111-6
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Publication
8605036 | J:164795
First Author: Agrotis A
Year: 1996
Journal: Biochem Biophys Res Commun
Title: Vascular smooth muscle cells express multiple type I receptors for TGF-beta, activin, and bone morphogenetic proteins.
Volume: 219
Issue: 2
Pages: 613-8
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Publication
20934803 | J:165797
First Author: Ardini E
Year: 2010
Journal: Cancer Lett
Title: Anaplastic Lymphoma Kinase: role in specific tumours, and development of small molecule inhibitors for cancer therapy.
Volume: 299
Issue: 2
Pages: 81-94
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Publication
22614325 | J:193069
First Author: Mano H
Year: 2012
Journal: Cancer Discov
Title: ALKoma: a cancer subtype with a shared target.
Volume: 2
Issue: 6
Pages: 495-502
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Publication
26122839 | J:223000
First Author: Tucker ER
Year: 2015
Journal: Cancer Res
Title: Tackling Crizotinib Resistance: The Pathway from Drug Discovery to the Pediatric Clinic.
Volume: 75
Issue: 14
Pages: 2770-4
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Publication
26387958 | J:316709
First Author: Wong CO
Year: 2015
Journal: Cell Rep
Title: Diminished MTORC1-Dependent JNK Activation Underlies the Neurodevelopmental Defects Associated with Lysosomal Dysfunction.
Volume: 12
Issue: 12
Pages: 2009-20
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Publication
37244438 | J:336409
 
First Author: Giaccone G
Year: 2023
Journal: Semin Cancer Biol
Title: Current knowledge of small cell lung cancer transformation from non-small cell lung cancer.
Volume: 94
Pages: 1-10
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Protein Coding Gene
MGI:97615 | Plcg1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:108086 | Hdac1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1922019 | Pik3cb
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
O09106
Organism: Mus musculus/domesticus
Length: 482  
Fragment?: false
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Protein
P98083-3
Organism: Mus musculus/domesticus
Length: 424  
Fragment?: false
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Protein
Q8BTI9
Organism: Mus musculus/domesticus
Length: 1064  
Fragment?: false
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Protein
Q62077
Organism: Mus musculus/domesticus
Length: 1302  
Fragment?: false
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Publication
29054992 | J:253753
First Author: Rusan M
Year: 2018
Journal: Cancer Discov
Title: Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression.
Volume: 8
Issue: 1
Pages: 59-73
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Genotype
Genotype
Symbol: Alk/Alk Tmem163/Tmem163<+>
Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6N * FVB/N * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Alk/Alk Tg(Mpz-cre)94Imeg/? Tg(Th-MYCN)41Waw/?
Background: involves: 129X1/SvJ * BALB/c * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Alk/Alk<+> Tg(Mpz-cre)94Imeg/? Tg(Th-MYCN)41Waw/?
Background: involves: 129X1/SvJ * BALB/c * C57BL/6 * SJL
Zygosity: cn
Has Mutant Allele: true
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Publication
26258416 | J:226256
First Author: Hoareau-Aveilla C
Year: 2015
Journal: J Clin Invest
Title: Reversal of microRNA-150 silencing disadvantages crizotinib-resistant NPM-ALK(+) cell growth.
Volume: 125
Issue: 9
Pages: 3505-18
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Publication
20223922 | J:160236
First Author: Giuriato S
Year: 2010
Journal: Blood
Title: Conditional TPM3-ALK and NPM-ALK transgenic mice develop reversible ALK-positive early B-cell lymphoma/leukemia.
Volume: 115
Issue: 20
Pages: 4061-70
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Publication
32338640 | J:302065
First Author: Kreutmair S
Year: 2020
Journal: J Clin Invest
Title: Loss of the Fanconi anemia-associated protein NIPA causes bone marrow failure.
Volume: 130
Issue: 6
Pages: 2827-2844
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Publication
25382630 | J:218259
First Author: Hill CR
Year: 2015
Journal: Dev Dyn
Title: Type III transforming growth factor beta receptor regulates vascular and osteoblast development during palatogenesis.
Volume: 244
Issue: 2
Pages: 122-33
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Publication
12424201 | J:82127
First Author: Chiarle R
Year: 2003
Journal: Blood
Title: NPM-ALK transgenic mice spontaneously develop T-cell lymphomas and plasma cell tumors.
Volume: 101
Issue: 5
Pages: 1919-27
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Publication
20805506 | J:164359
First Author: Merkel O
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Identification of differential and functionally active miRNAs in both anaplastic lymphoma kinase (ALK)+ and ALK- anaplastic large-cell lymphoma.
Volume: 107
Issue: 37
Pages: 16228-33
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Publication
29184034 | J:260312
 
First Author: Umapathy G
Year: 2017
Journal: Sci Signal
Title: MEK inhibitor trametinib does not prevent the growth of anaplastic lymphoma kinase (ALK)-addicted neuroblastomas.
Volume: 10
Issue: 507
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Publication
22761782 | J:225098
First Author: Guillot N
Year: 2012
Journal: PLoS One
Title: BAMBI regulates angiogenesis and endothelial homeostasis through modulation of alternative TGFβ signaling.
Volume: 7
Issue: 6
Pages: e39406
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Publication
19064915 | J:142679
First Author: Soda M
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: A mouse model for EML4-ALK-positive lung cancer.
Volume: 105
Issue: 50
Pages: 19893-7
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Publication
16105984 | J:124030
First Author: Ambrogio C
Year: 2005
Journal: Blood
Title: p130Cas mediates the transforming properties of the anaplastic lymphoma kinase.
Volume: 106
Issue: 12
Pages: 3907-16
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Publication
21778999 | J:178812
First Author: Dejean E
Year: 2011
Journal: Leukemia
Title: Hypoxia-microRNA-16 downregulation induces VEGF expression in anaplastic lymphoma kinase (ALK)-positive anaplastic large-cell lymphomas.
Volume: 25
Issue: 12
Pages: 1882-90
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Publication
25337876 | J:217482
First Author: Maddalo D
Year: 2014
Journal: Nature
Title: In vivo engineering of oncogenic chromosomal rearrangements with the CRISPR/Cas9 system.
Volume: 516
Issue: 7531
Pages: 423-7
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Publication
26372962 | J:226993
First Author: Davare MA
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Structural insight into selectivity and resistance profiles of ROS1 tyrosine kinase inhibitors.
Volume: 112
Issue: 39
Pages: E5381-90
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Publication
26301689 | J:228797
First Author: Hrustanovic G
Year: 2015
Journal: Nat Med
Title: RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer.
Volume: 21
Issue: 9
Pages: 1038-47
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Publication
26747246 | J:232574
First Author: Choudhari R
Year: 2016
Journal: Blood
Title: Redundant and nonredundant roles for Cdc42 and Rac1 in lymphomas developed in NPM-ALK transgenic mice.
Volume: 127
Issue: 10
Pages: 1297-306
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Publication
28122866 | J:239601
First Author: Lin JJ
Year: 2017
Journal: Cancer Discov
Title: Targeting ALK: Precision Medicine Takes on Drug Resistance.
Volume: 7
Issue: 2
Pages: 137-155
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Publication
28717217 | J:258365
First Author: Ogura H
Year: 2017
Journal: Sci Rep
Title: TKI-addicted ROS1-rearranged cells are destined to survival or death by the intensity of ROS1 kinase activity.
Volume: 7
Issue: 1
Pages: 5519
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Publication
30115695 | J:266837
First Author: Eleveld TF
Year: 2018
Journal: Cancer Res
Title: RAS-MAPK Pathway-Driven Tumor Progression Is Associated with Loss of CIC and Other Genomic Aberrations in Neuroblastoma.
Volume: 78
Issue: 21
Pages: 6297-6307
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Publication
30125543 | J:270291
First Author: Nikitski AV
Year: 2018
Journal: Am J Pathol
Title: Mouse Model of Poorly Differentiated Thyroid Carcinoma Driven by STRN-ALK Fusion.
Volume: 188
Issue: 11
Pages: 2653-2661
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Publication
32238360 | J:290437
First Author: Clarke M
Year: 2020
Journal: Cancer Discov
Title: Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes.
Volume: 10
Issue: 7
Pages: 942-963
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Publication
8940033 | J:342924
First Author: Rydén M
Year: 1996
Journal: J Biol Chem
Title: A novel type I receptor serine-threonine kinase predominantly expressed in the adult central nervous system.
Volume: 271
Issue: 48
Pages: 30603-9
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Publication
33500353 | J:302050
 
First Author: Hanemaaijer ES
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype.
Volume: 118
Issue: 5
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Publication
27352867 | J:315587
First Author: Ma L
Year: 2016
Journal: Transl Stroke Res
Title: Integrin β8 Deletion Enhances Vascular Dysplasia and Hemorrhage in the Brain of Adult Alk1 Heterozygous Mice.
Volume: 7
Issue: 6
Pages: 488-496
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Publication
30643194 | J:313371
First Author: Huang JF
Year: 2019
Journal: Oncogene
Title: Genome-wide screening identifies oncofetal lncRNA Ptn-dt promoting the proliferation of hepatocellular carcinoma cells by regulating the Ptn receptor.
Volume: 38
Issue: 18
Pages: 3428-3445
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Publication
37379367 | J:338017
First Author: Mastini C
Year: 2023
Journal: Sci Transl Med
Title: Targeting CCR7-PI3Kγ overcomes resistance to tyrosine kinase inhibitors in ALK-rearranged lymphoma.
Volume: 15
Issue: 702
Pages: eabo3826
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Protein Coding Gene
MGI:1276116 | Ep300
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1206581 | Pik3ca
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1098772 | Pik3r2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
B2RWS6
Organism: Mus musculus/domesticus
Length: 2412  
Fragment?: false
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Protein
O08908
Organism: Mus musculus/domesticus
Length: 722  
Fragment?: false
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Protein
P42337
Organism: Mus musculus/domesticus
Length: 1068  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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