NUB1 is an adaptor protein which negatively regulates the ubiquitin-like protein Nedd8 as well as neddylated proteins levels through proteasomal degradation [, ]. It has been shown to be regulated by Mdm2 (E3 ubiquitin ligase) through ubiquitination on its lysine 159 [].
Proteins in this entry have an N-terminal FKBP-type peptidyl-prolyl cis-trans isomerase domain followed by a C-terminal tetratricopeptide repeat-containing domain. Included in this entry are: aryl-hydrocarbon-interacting protein-like 1 (AIPL1), which is associated with inherited blindness and interacts with cell cycle regulator protein NUB1 []; and AH receptor-interacting protein (AIP), which interacts with the tyrosine kinase receptor RET [], and mutations in AIP are associated with familial isolated pituitary adenomas [].
