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Search results 1001 to 1057 out of 1057 for Dicer1

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Type Details Score
Protein Domain
IPR033363 | PRKRA
Type: Family
Description: Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PRKRA), also known as PACT or RAX, acts as an activator of PKR (theIFN-induced double-stranded RNA-dependent protein kinase) in response to diverse stress signals, such as serum starvation, and peroxide or arsenite treatment []. It is an important regulator of PKR dependent signalling pathways in the absence of viral infections []. It is also required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing [, ].
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Publication
11985496 | -
First Author: Huang X
Year: 2002
Journal: Biochem J
Title: The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR).
Volume: 366
Issue: Pt 1
Pages: 175-86
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Publication
22473766 | -
First Author: Singh M
Year: 2012
Journal: J Cell Biochem
Title: Increased interaction between PACT molecules in response to stress signals is required for PKR activation.
Volume: 113
Issue: 8
Pages: 2754-64
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Protein Domain
IPR044465 | PRKRA_DSRM_1
Type: Domain
Description: Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PRKRA), also known as PACT or RAX, acts as an activator of PKR (the IFN-induced double-stranded RNA-dependent protein kinase) in response to diverse stress signals, such as serum starvation, and peroxide or arsenite treatment []. It is an important regulator of PKR dependent signalling pathways in the absence of viral infections []. It is also required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing [, ].PRKRA contains three double-stranded RNA binding motifs (DSRMs). This entry represents the first DSRM of PRKRA.
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Protein Domain
IPR044466 | PRKRA_DSRM_2
Type: Domain
Description: Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PRKRA), also known as PACT or RAX, acts as an activator of PKR (the IFN-induced double-stranded RNA-dependent protein kinase) in response to diverse stress signals, such as serum starvation, and peroxide or arsenite treatment []. It is an important regulator of PKR dependent signalling pathways in the absence of viral infections []. It is also required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing [, ].PRKRA contains three double-stranded RNA binding motifs (DSRMs). This entry represents the second DSRM of PRKRA.
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Protein Domain
IPR044467 | PRKRA_DSRM_3
Type: Domain
Description: Interferon-inducible double-stranded RNA-dependent protein kinase activator A (PRKRA), also known as PACT or RAX, acts as an activator of PKR (the IFN-induced double-stranded RNA-dependent protein kinase) in response to diverse stress signals, such as serum starvation, and peroxide or arsenite treatment []. It is an important regulator of PKR dependent signalling pathways in the absence of viral infections []. It is also required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing [, ].PRKRA contains three double-stranded RNA binding motifs (DSRMs). This entry represents the third DSRM of PRKRA.
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Strain
MGI:6200046 | C57BL/6J-Dicer1<m1Btlr>
Attribute String: mutant strain, chemically induced mutation, coisogenic
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Strain
MGI:4417924 | B6;129S7-Dicer1<tm1Smr>/J
Attribute String: mutant stock, targeted mutation
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Genotype
Genotype
Symbol: Dicer1/Dicer1
Background: C57BL/6J-Dicer1
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dicer1/Dicer1
Background: involves: 129S7/SvEvBrd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dicer1/Dicer1
Background: involves: 129S7/SvEvBrd * FVB/N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dicer1/Dicer1<+>
Background: involves: 129S7/SvEvBrd * FVB/N
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dicer1/Dicer1
Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dicer1/Dicer1
Background: involves: 129S7/SvEvBrd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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HT Experiment
E-GEOD-69882 | MicroRNAs of the RPE are essential for RPE differentiation and photoreceptor maturation (microRNA)
Series Id: GSE69882
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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HT Experiment
E-GEOD-69881 | MicroRNAs of the RPE are essential for RPE differentiation and photoreceptor maturation (mRNA)
Series Id: GSE69881
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Publication
22698397 | J:189287
First Author: Davalos V
Year: 2012
Journal: Cancer Cell
Title: Rolling the dice to discover the role of DICER in tumorigenesis.
Volume: 21
Issue: 6
Pages: 717-9
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Genotype
Genotype
Symbol: Dicer1/Dicer1 Tg(KRT14-cre)52Smr/?
Background: involves: 129S7/SvEvBrd * C57BL/6J * SJL/J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dicer1/Dicer1 Tg(Zp3-cre)93Knw/?
Background: involves: 129S7/SvEvBrd * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Protein
Q9WTX2
Organism: Mus musculus/domesticus
Length: 313  
Fragment?: false
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Publication
16424907 | -
First Author: Lee Y
Year: 2006
Journal: EMBO J
Title: The role of PACT in the RNA silencing pathway.
Volume: 25
Issue: 3
Pages: 522-32
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Genotype
Genotype
Symbol: Dicer1/Dicer1 Tg(Myh6-cre)2182Mds/?
Background: involves: 129S7/SvEvBrd * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dicer1/Dicer1 Tg(Pax6-cre,GFP)1Pgr/?
Background: involves: 129S7/SvEvBrd * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dicer1/Dicer1 Emx1/Emx1<+>
Background: involves: 129S2/SvPas * 129S7/SvEvBrd
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dicer1/Dicer1 Tg(Pax6-cre,GFP)1Pgr/?
Background: involves: 129S7/SvEvBrd * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dicer1/Dicer1 Tg(Dhh-cre)1Mejr/?
Background: involves: 129S7/SvEvBrd * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dicer1/Dicer1 Tg(Dhh-cre)1Mejr/?
Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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HT Experiment
E-GEOD-22023 | Ablation of Dicer from murine Schwann cells increases their proliferation while blocking myelination
Series Id: GSE22023
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Genotype
Genotype
Symbol: Dicer1/Dicer1 Tg(KRT5-rtTA)1Glk/? Tg(tetO-cre)1Jaw/?
Background: involves: 129S7/SvEvBrd * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dicer1/Dicer1 Pax8/Pax8<+>
Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dicer1/Dicer1 Emx1/Emx1<+>
Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dicer1/Dicer1<+> Emx1/Emx1<+>
Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dicer1/Dicer1 Tg(Stra8-icre)1Reb/?
Background: involves: 129S1/SvImJ * 129S7/SvEvBrd * FVB/NJ
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dicer1/Dicer1 Emx1/Emx1<+>
Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd
Zygosity: cn
Has Mutant Allele: true
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Publication
17259983 | J:141670
First Author: Wang Y
Year: 2007
Journal: Nat Genet
Title: DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal.
Volume: 39
Issue: 3
Pages: 380-5
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Publication
20505045 | J:227896
First Author: Cao H
Year: 2010
Journal: J Dent Res
Title: MicroRNAs play a critical role in tooth development.
Volume: 89
Issue: 8
Pages: 779-84
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Publication
26074074 | J:228689
First Author: Gelfand BD
Year: 2015
Journal: Cell Rep
Title: Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome.
Volume: 11
Issue: 11
Pages: 1686-93
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Publication
18311128 | J:170443
First Author: Yi R
Year: 2008
Journal: Nature
Title: A skin microRNA promotes differentiation by repressing 'stemness'.
Volume: 452
Issue: 7184
Pages: 225-9
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HT Experiment
E-GEOD-68537 | MicroRNA-122 Regulates Postnatal Polyploidization in the Murine Liver
Series Id: GSE68537
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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HT Experiment
GSE66171 | Epithelial inactivation of Yy1 abrogates lung branching morphogenesis
 
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Genotype
Genotype
Symbol: Dicer1/Dicer1 Tg(Ddx4-cre)1Dcas/?
Background: involves: 129S7/SvEvBrd * C57BL/6J * FVB/NJ
Zygosity: cn
Has Mutant Allele: true
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HT Experiment
E-GEOD-46264 | Murine FAE and VE in BALB/cA mice
Series Id: GSE46264
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
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Publication
29176737 | J:255750
First Author: Kerur N
Year: 2018
Journal: Nat Med
Title: cGAS drives noncanonical-inflammasome activation in age-related macular degeneration.
Volume: 24
Issue: 1
Pages: 50-61
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Publication
29491350 | J:263363
First Author: Lin HP
Year: 2018
Journal: Sci Rep
Title: Egr2-dependent microRNA-138 is dispensable for peripheral nerve myelination.
Volume: 8
Issue: 1
Pages: 3817
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Publication
22362746 | J:197708
First Author: Chuang CH
Year: 2012
Journal: Nucleic Acids Res
Title: Post-transcriptional homeostasis and regulation of MCM2-7 in mammalian cells.
Volume: 40
Issue: 11
Pages: 4914-24
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Publication
30985893 | J:277152
First Author: Chen Y
Year: 2019
Journal: Biol Reprod
Title: CFTR mutation compromises spermatogenesis by enhancing miR-15b maturation and suppressing its regulatory target CDC25A†.
Volume: 101
Issue: 1
Pages: 50-62
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Publication
21806957 | J:176306
First Author: Goettsch C
Year: 2011
Journal: Am J Pathol
Title: miR-125b regulates calcification of vascular smooth muscle cells.
Volume: 179
Issue: 4
Pages: 1594-600
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Publication
33158935 | J:299669
 
First Author: Landry-Truchon K
Year: 2020
Journal: Dis Model Mech
Title: Deletion of Yy1 in mouse lung epithelium unveils molecular mechanisms governing pleuropulmonary blastoma pathogenesis.
Volume: 13
Issue: 12
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Publication
24792773 | J:214406
First Author: Tiwari P
Year: 2014
Journal: Toxicol Appl Pharmacol
Title: Modulation of miR-203 and its regulators as a function of time during the development of 7, 12 dimethylbenz [a] anthracene induced mouse skin tumors in presence or absence of the antitumor agents.
Volume: 278
Issue: 2
Pages: 148-58
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Publication
26655220 | J:230929
First Author: Akpa MM
Year: 2016
Journal: J Biol Chem
Title: Wilms Tumor Suppressor, WT1, Cooperates with MicroRNA-26a and MicroRNA-101 to Suppress Translation of the Polycomb Protein, EZH2, in Mesenchymal Stem Cells.
Volume: 291
Issue: 8
Pages: 3785-95
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Publication
28486664 | J:245073
First Author: Han X
Year: 2017
Journal: Biol Reprod
Title: MicroRNA-21 plays a pivotal role in the oocyte-secreted factor-induced suppression of cumulus cell apoptosis.
Volume: 96
Issue: 6
Pages: 1167-1180
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Publication
32742270 | J:308510
 
First Author: Ruiz-Roso MB
Year: 2020
Journal: Front Genet
Title: Intestinal Lipid Metabolism Genes Regulated by miRNAs.
Volume: 11
Pages: 707
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Publication
24114535 | J:214872
First Author: Kerur N
Year: 2013
Journal: Invest Ophthalmol Vis Sci
Title: TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy.
Volume: 54
Issue: 12
Pages: 7395-401
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Publication
24348261 | J:207519
First Author: Anderegg A
Year: 2013
Journal: PLoS Genet
Title: An Lmx1b-miR135a2 regulatory circuit modulates Wnt1/Wnt signaling and determines the size of the midbrain dopaminergic progenitor pool.
Volume: 9
Issue: 12
Pages: e1003973
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Publication
30707741 | J:270671
First Author: Ota H
Year: 2019
Journal: PLoS One
Title: Identification of the X-linked germ cell specific miRNAs (XmiRs) and their functions.
Volume: 14
Issue: 2
Pages: e0211739
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Publication
27047334 | J:336550
 
First Author: Tapocik JD
Year: 2016
Journal: Front Mol Neurosci
Title: MicroRNAs Are Involved in the Development of Morphine-Induced Analgesic Tolerance and Regulate Functionally Relevant Changes in Serpini1.
Volume: 9
Pages: 20
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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