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Search results 101 to 200 out of 287 for Cul3

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Type Details Score
Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
17967808 | J:152068
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
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Publication
- | J:346132
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:60000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2000
Title: Gene Ontology Annotation by electronic association of SwissProt Keywords with GO terms
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Title: Human to Mouse ISO GO annotation transfer
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
25995385 | J:225608
First Author: Dorr C
Year: 2015
Journal: Mol Cancer Res
Title: Transposon Mutagenesis Screen Identifies Potential Lung Cancer Drivers and CUL3 as a Tumor Suppressor.
Volume: 13
Issue: 8
Pages: 1238-47
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Publication
17296727 | -
First Author: Ribar B
Year: 2007
Journal: Mol Cell Biol
Title: ELA1 and CUL3 are required along with ELC1 for RNA polymerase II polyubiquitylation and degradation in DNA-damaged yeast cells.
Volume: 27
Issue: 8
Pages: 3211-6
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Publication
28743001 | -
First Author: Pae J
Year: 2017
Journal: Dev Cell
Title: GCL and CUL3 Control the Switch between Cell Lineages by Mediating Localized Degradation of an RTK.
Volume: 42
Issue: 2
Pages: 130-142.e7
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Publication
23349464 | -
First Author: Canning P
Year: 2013
Journal: J Biol Chem
Title: Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases.
Volume: 288
Issue: 11
Pages: 7803-14
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Interaction Experiment
He X (2006)
Description: Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2 x Keap1 x Cul3 complex and recruiting Nrf2 x Maf to the antioxidant response element enhancer.
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HT Experiment
GSE144046 | Autism-linked Cullin3 germline haploinsufficiency severely impacts mouse brain development and cortical neurogenesis through RhoA signaling
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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GO Term
GO:0031463 | Cul3-RING ubiquitin ligase complex
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Publication
19818708 | -
First Author: Zhuang M
Year: 2009
Journal: Mol Cell
Title: Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases.
Volume: 36
Issue: 1
Pages: 39-50
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Publication
16524876 | -
First Author: Kwon JE
Year: 2006
Journal: J Biol Chem
Title: BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase.
Volume: 281
Issue: 18
Pages: 12664-72
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Publication
23999291 | -
First Author: van Geersdaele LK
Year: 2013
Journal: Acta Crystallogr D Biol Crystallogr
Title: Structural basis of high-order oligomerization of the cullin-3 adaptor SPOP.
Volume: 69
Issue: Pt 9
Pages: 1677-84
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Protein Domain
IPR034089 | SPOP_C
Type: Domain
Description: This entry represents the C-terminal BACK (BTB and C-terminal Kelch) domain of speckle-type POZ protein (SPOP, also known as HIB homologue 1 or Roadkill homologue 1). This domain contains a pair of α-helices which seem to be conserved among Cul3 adaptors [].SPOP is an adaptor protein that forms a complex with Cul3, cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, and is involved in ubiquitination of BMI1, H2AFY, and the death-associated protein 6 (DAXX) []. The C-terminal BACK domain of SPOP, may be involved in oligomer formation and in recruiting Cul3 (together with the adjacent BTB domain), whereas the N-terminal MATH domain recruits substrates [, ].
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Publication
11864988 | -
First Author: Hyman LE
Year: 2002
Journal: J Biol Chem
Title: Binding to Elongin C inhibits degradation of interacting proteins in yeast.
Volume: 277
Issue: 18
Pages: 15586-91
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Publication
18817898 | -
First Author: Lejeune D
Year: 2009
Journal: DNA Repair (Amst)
Title: Yeast Elc1 plays an important role in global genomic repair but not in transcription coupled repair.
Volume: 8
Issue: 1
Pages: 40-50
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Publication
19782033 | -
First Author: Chen Y
Year: 2009
Journal: Mol Cell
Title: Cullin mediates degradation of RhoA through evolutionarily conserved BTB adaptors to control actin cytoskeleton structure and cell movement.
Volume: 35
Issue: 6
Pages: 841-55
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Publication
29085068 | -
First Author: Mao H
Year: 2017
Journal: Nat Plants
Title: Arabidopsis BTB/POZ protein-dependent PENETRATION3 trafficking and disease susceptibility.
Volume: 3
Issue: 11
Pages: 854-858
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Protein Domain
IPR039948 | ELC1
Type: Family
Description: Elongin-C is a highly conserved protein found in a variety of multiprotein complexes in human, rat, fly, worm, and yeast cells []. Budding yeast elongin-C homologue, Elc1, forms a complex with Cul3 that is required for Pol II polyubiquitylation and degradation []. Elc1 also plays a role in global genomic repair []. In humans, elongin-C works as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL) [].
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Protein Domain
IPR045068 | BACURD1-3
Type: Family
Description: This entry represents a group of BTB/POZ domain-containing proteins, such as BACURD1-3 from humans. They act as the substrate-specific adapters of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of RhoA, leading to its degradation by the proteasome []. This entry also includes EAP3 from Arabidopsis. The BTB/POZ domain of EAP3 displays poor conservation of the residues required for CUL3 binding and is not likely to function as an E3 ligase adaptor [].
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Protein Coding Gene
MGI:2685141 | Kbtbd7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2179430 | Klhl8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1917632 | Kctd2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1914113 | Lztr1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1890619 | Gan
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
15367669 | J:279946
First Author: Cullinan SB
Year: 2004
Journal: Mol Cell Biol
Title: The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase.
Volume: 24
Issue: 19
Pages: 8477-86
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Publication
22466964 | J:245285
First Author: den Besten W
Year: 2012
Journal: Nat Struct Mol Biol
Title: NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway.
Volume: 19
Issue: 5
Pages: 511-6, S1
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Publication
33409479 | J:311524
First Author: Madison JM
Year: 2021
Journal: iScience
Title: Regulation of purine metabolism connects KCTD13 to a metabolic disorder with autistic features.
Volume: 24
Issue: 1
Pages: 101935
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Publication
37339955 | J:340706
First Author: Cai C
Year: 2023
Journal: Nat Commun
Title: USP25 regulates KEAP1-NRF2 anti-oxidation axis and its inactivation protects acetaminophen-induced liver injury in male mice.
Volume: 14
Issue: 1
Pages: 3648
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Protein Domain
IPR029959 | NPH3-like
Type: Family
Description: Root phototropism protein 3 (RPT3), also known as nonphototropic hypocotyl 3 (NPH3), and root phototropism 2 (RPT2) () represent the founding members of a novel plant-specific family []. Three domains define the members of this family: an N-terminal BTB (broad complex, tramtrack, bric a brac) domain (), a centrally located NPH3 domain (), and a C-terminal coiled-coil domain.NPH3 assembles with CUL3 to form a E3 complex that ubiquitinates phototropin 1 (phot1) and modulates phototropic responsiveness [, ]. NPH3 is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening or chloroplast relocation []. Coleoptile phototropism protein 1 (CPT1) is a rice orthologue of Arabidopsis NPH3 also required for phototropism []. This entry also includes DOT3 (AT5G10250) that is involved in shoot and primary root growth; DOT3 mutants produce an aberrant parallel venation pattern in juvenile leaves [].
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Protein Coding Gene
MGI:3643058 | Kbtbd6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1920094 | Kctd17
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1916509 | Kctd5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1924107 | Spopl
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2180122 | Klhl9
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1196453 | Klhl7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2661430 | Kbtbd8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2668031 | Klhl25
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1924363 | Klhl2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1914705 | Klhl13
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1923400 | Klhl15
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
15282312 | J:279942
First Author: Kobayashi A
Year: 2004
Journal: Mol Cell Biol
Title: Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2.
Volume: 24
Issue: 16
Pages: 7130-9
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Publication
18268004 | J:133900
First Author: Yamamoto T
Year: 2008
Journal: Mol Cell Biol
Title: Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity.
Volume: 28
Issue: 8
Pages: 2758-70
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Publication
23576762 | J:197369
First Author: Shibata S
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4.
Volume: 110
Issue: 19
Pages: 7838-43
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Publication
30301860 | J:292543
First Author: Cornelius RJ
Year: 2018
Journal: J Am Soc Nephrol
Title: Renal COP9 Signalosome Deficiency Alters CUL3-KLHL3-WNK Signaling Pathway.
Volume: 29
Issue: 11
Pages: 2627-2640
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Publication
30146013 | J:283921
First Author: López-Cayuqueo KI
Year: 2018
Journal: Kidney Int
Title: A mouse model of pseudohypoaldosteronism type II reveals a novel mechanism of renal tubular acidosis.
Volume: 94
Issue: 3
Pages: 514-523
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Publication
30148674 | J:284284
First Author: Lin CM
Year: 2019
Journal: FASEB J
Title: Generation and analysis of a mouse model of pseudohypoaldosteronism type II caused by KLHL3 mutation in BTB domain.
Volume: 33
Issue: 1
Pages: 1051-1061
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Publication
19256485 | J:148999
First Author: Plafker KS
Year: 2009
Journal: Biochemistry
Title: The ubiquitin conjugating enzyme, UbcM2, engages in novel interactions with components of cullin-3 based E3 ligases.
Volume: 48
Issue: 15
Pages: 3527-37
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Publication
31515271 | J:282843
First Author: Frendo-Cumbo S
Year: 2019
Journal: J Biol Chem
Title: Deficiency of the autophagy gene ATG16L1 induces insulin resistance through KLHL9/KLHL13/CUL3-mediated IRS1 degradation.
Volume: 294
Issue: 44
Pages: 16172-16185
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Publication
23454126 | J:201235
First Author: Baird L
Year: 2013
Journal: Biochem Biophys Res Commun
Title: Diffusion dynamics of the Keap1-Cullin3 interaction in single live cells.
Volume: 433
Issue: 1
Pages: 58-65
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Publication
26100637 | J:224601
First Author: Ibeawuchi SR
Year: 2015
Journal: J Biol Chem
Title: Hypertension-causing Mutations in Cullin3 Protein Impair RhoA Protein Ubiquitination and Augment the Association with Substrate Adaptors.
Volume: 290
Issue: 31
Pages: 19208-17
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Publication
34803491 | J:314766
First Author: Zhao M
Year: 2021
Journal: Int J Biol Sci
Title: Cullin3 deficiency shapes tumor microenvironment and promotes cholangiocarcinoma in liver-specific Smad4/Pten mutant mice.
Volume: 17
Issue: 15
Pages: 4176-4191
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Publication
35687106 | J:326771
     
First Author: Lao L
Year: 2022
Journal: Nucleic Acids Res
Title: ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia.
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Protein
A0JLP8
Organism: Mus musculus/domesticus
Length: 143  
Fragment?: true
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Publication
18643975 | -
First Author: Petricka JJ
Year: 2008
Journal: Plant J
Title: Vein patterning screens and the defectively organized tributaries mutants in Arabidopsis thaliana.
Volume: 56
Issue: 2
Pages: 251-63
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Publication
15749712 | -
First Author: Gingerich DJ
Year: 2005
Journal: J Biol Chem
Title: Cullins 3a and 3b assemble with members of the broad complex/tramtrack/bric-a-brac (BTB) protein family to form essential ubiquitin-protein ligases (E3s) in Arabidopsis.
Volume: 280
Issue: 19
Pages: 18810-21
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Publication
25878247 | -
First Author: Weems JC
Year: 2015
Journal: J Biol Chem
Title: Assembly of the Elongin A Ubiquitin Ligase Is Regulated by Genotoxic and Other Stresses.
Volume: 290
Issue: 24
Pages: 15030-41
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Publication
19995937 | -
First Author: Maerki S
Year: 2009
Journal: J Cell Biol
Title: The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis.
Volume: 187
Issue: 6
Pages: 791-800
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Publication
31279627 | -
First Author: Chen Z
Year: 2019
Journal: Structure
Title: Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase.
Volume: 27
Issue: 9
Pages: 1395-1404.e4
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Protein Domain
IPR043454 | NPH3/RPT2-like
Type: Family
Description: The NRL (for NPH3/RPT2-Like) family is formed by signaling molecules specificto higher plants. Several regions of sequence and predicted structuralconservation define members of the NRL family, with three domains being mostnotable: an N-terminal BTB domain, a centrally located NPH3domain, and a C-terminal coiled coil domain. The function of the NPH3 domainis not yet known [, , , , , , , ].Root phototropism protein 3 (RPT3), also known as nonphototropic hypocotyl 3 (NPH3), and root phototropism 2 (RPT2) () represent the founding members of a novel plant-specific family []. Three domains define the members of this family: an N-terminal BTB (broad complex, tramtrack, bric a brac) domain (), a centrally located NPH3 domain (), and a C-terminal coiled-coil domain.NPH3 assembles with CUL3 to form a E3 complex that ubiquitinates phototropin 1 (phot1) and modulates phototropic responsiveness [, ]. NPH3 is necessary for root and hypocotyl phototropisms, but not for the regulation of stomata opening or chloroplast relocation []. Coleoptile phototropism protein 1 (CPT1) is a rice orthologue of Arabidopsis NPH3 also required for phototropism []. This entry also includes DOT3 (AT5G10250) that is involved in shoot and primary root growth; DOT3 mutants produce an aberrant parallel venation pattern in juvenile leaves [].
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Protein Domain
IPR001232 | SKP1-like
Type: Family
Description: This entry includes SKP1 and SKP1-like protein, elongin-C (also known as TCEB1). SKP1 is part of the E3 ubiquitin ligase complexes. Elongin-C has dual functions, works as a component of RNA polymerase II (Pol II) transcription elongation factor and as the substrate recognition subunit of a Cullin-RING E3 ubiquitin ligase []. Mammlian S-phase kinase-associated protein 1 (SKP1) is an essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription []. It is also part of the ubiquitin E3 ligase complex (Skp1-Pam-Fbxo45) that controls the core epithelial-to-mesenchymal transition-inducing transcription factors []. Budding yeast Skp1 is a kinetochore protein found in several complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA [], and the RAVE complex that regulates assembly of the V-ATPase []. Elongin-C is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites []. It forms a complex with SIII regulatory subunits B, which serves as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes []. Elongin-C forms a complex with Cul3 that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis [].
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Protein Domain
IPR030594 | KLHL17/KLHL20
Type: Family
Description: Kelch-like protein 17 (KLHL17, also known as actinfilin) and Kelch-like protein 20 (KLHL20, also known as KLEIP) belong to the KLHL family []. KLHL17 binds to the actin cytoskeleton and serves as a substrate-specific adapter in the Cul3-dependent ubiquitin ligase complex that targets GluR6 kainate receptor subunit for degradation []. Kainate receptors (KAR) are ionotropic receptors that respond to the neurotransmitter glutamate and have been implicated in epilepsy, stroke, Alzheimer's and neuropathic pain [].KLHL20 assembles with CUL3 and RBX1 to form a multi-subunit Cullin-RING E3 ligase []. The KLHL (Kelch-like) proteins generally have a BTB/POZ domain, a BACK domain, and five to six Kelch motifs. They constitute a subgroup at the intersection between the BTB/POZ domain and Kelch domain superfamilies. The BTB/POZ domain facilitates protein binding [], while the Kelch domain (repeats) form β-propellers. The Kelch superfamily of proteins can be subdivided into five groups: (1) N-propeller, C-dimer proteins, (2) N-propeller proteins, (3) propeller proteins, (4) N-dimer, C-propeller proteins, and (5) C-propeller proteins. KLHL family members belong to the N-dimer, C-propeller subclass of Kelch repeat proteins []. In addition to BTB/POZ and Kelch domains, the KLHL family members contain a BACK domain, first described as a 130-residue region of conservation observed amongst BTB-Kelch proteins []. Many of the Kelch-like proteins have been identified as adaptors for the recruitment of substrates to Cul3-based E3 ubiquitin ligases [, ].
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Protein Domain
IPR030577 | KLHL21
Type: Family
Description: Kelch-like protein 21 (KLHL21) is a substrate adaptor protein in the Cul3-KLHL21 E3 ubiquitin ligase complex. During cytokinesis, it localises to midzone microtubules in anaphase and recruits aurora B and Cul3 to this region [].The KLHL (Kelch-like) proteins generally have a BTB/POZ domain, a BACK domain, and five to six Kelch motifs. They constitute a subgroup at the intersection between the BTB/POZ domain and Kelch domain superfamilies. The BTB/POZ domain facilitates protein binding [], while the Kelch domain (repeats) form β-propellers. The Kelch superfamily of proteins can be subdivided into five groups: (1) N-propeller, C-dimer proteins, (2) N-propeller proteins, (3) propeller proteins, (4) N-dimer, C-propeller proteins, and (5) C-propeller proteins. KLHL family members belong to the N-dimer, C-propeller subclass of Kelch repeat proteins []. In addition to BTB/POZ and Kelch domains, the KLHL family members contain a BACK domain, first described as a 130-residue region of conservation observed amongst BTB-Kelch proteins []. Many of the Kelch-like proteins have been identified as adaptors for the recruitment of substrates to Cul3-based E3 ubiquitin ligases [, ].
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Protein Domain
IPR035898 | TAZ_dom_sf
Type: Homologous_superfamily
Description: TAZ (Transcription Adaptor putative Zinc finger) domains are zinc-containing domains found in the homologous transcriptional co-activators CREB-binding protein (CBP) and the P300. CBP and P300 are histone acetyltransferases () that catalyse the reversible acetylation of all four histones in nucleosomes, acting to regulate transcription via chromatin remodelling. These large nuclear proteins interact with numerous transcription factors and viral oncoproteins, including p53 tumour suppressor protein, E1A oncoprotein, MyoD, and GATA-1, and are involved in cell growth, differentiation and apoptosis []. Both CBP and P300 have two copies of the TAZ domain, one in the N-terminal region, the other in the C-terminal region. The TAZ1 domain of CBP and P300 forms a complex with CITED2 (CBP/P300-interacting transactivator with ED-rich tail), inhibiting the activity of the hypoxia inducible factor (HIF-1alpha) and thereby attenuating the cellular response to low tissue oxygen concentration []. Adaptation to hypoxia is mediated by transactivation of hypoxia-responsive genes by hypoxia-inducible factor-1 (HIF-1) in complex with the CBP and p300 transcriptional coactivators [].Proteins containing this domain also include a group of land-plant specific proteins, know as the BTB/POZ and TAZ domain-containing (BT) protein. The reports of their interaction with CUL3 are contradictory. They are multifunctional scaffold proteins essential for male and female gametophyte development []. The TAZ domain adopts an all-alpha fold with zinc-binding sites in the loops connecting the helices. The TAZ1 domain in P300 and the TAZ2 (CH3) domain in CBP have each been shown to have four amphipathic helices, organised by three zinc-binding clusters with HCCC-type coordination [, , ].
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Protein Coding Gene
MGI:109610 | Enc1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1919156 | Zswim8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1923035 | Klhl24
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2141101 | Depdc5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2444786 | Klhl42
Type: protein_coding_gene
Organism: mouse, laboratory
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