This entry represents the PR/SET domain found in PR domain zinc finger protein 12 (PRDM12). PRDM12 is essential for human pain perception []. It is also a key regulator of sensory neuronal specification in Xenopus []. It has been shown to initiate and maintain the expression of TrkA in developing nociceptors [].The PRDM family members are characterised by the presence of a N-terminal PR (PRDI-BF1 and RIZ1 homology) domain followed by multiple zinc fingers which confer DNA binding activity. PR domains are only distantly related to the classical SET methyltransferase domains []. They are involved in epigenetic regulation of gene expression through their intrinsic histone methyltransferase activity or via interactions with other chromatin modifying enzymes [].
