This entry includes Dolpp1 from animals and Cax4 (also known as Cwh8) from budding yeasts. Dolpp1/Cax4 is a dolichyldiphosphatase required for efficient N-glycosylation [, ]. LPPG is a phosphatidic acid phosphatase found in chloroplast membrane fractions []. This entry also includes a fusion protein, Pdf1, from fission yeasts [].Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate []. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds oflipid intermediate biosynthesis after its release during protein N-glycosylation reactions [].
