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Search results 101 to 188 out of 188 for Rangap1

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Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:1059981
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827606
Age: embryonic day 14.5
Image: euxassay_005228_19
Specimen Label: euxassay_005228_19
Detected: true
Specimen Num: 18
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GXD Expression
GXD Expression
 
Probe: MGI:1059981
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827606
Age: embryonic day 14.5
Image: euxassay_005228_20
Specimen Label: euxassay_005228_20
Detected: true
Specimen Num: 19
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GXD Expression
GXD Expression
 
Probe: MGI:1059981
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827606
Age: embryonic day 14.5
Image: euxassay_005228_21
Specimen Label: euxassay_005228_21
Detected: true
Specimen Num: 20
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GXD Expression
GXD Expression
 
Probe: MGI:1059981
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827606
Age: embryonic day 14.5
Image: euxassay_005228_22
Specimen Label: euxassay_005228_22
Detected: true
Specimen Num: 21
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GXD Expression
GXD Expression
 
Probe: MGI:1059981
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827606
Age: embryonic day 14.5
Image: euxassay_005228_23
Specimen Label: euxassay_005228_23
Detected: true
Specimen Num: 22
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GXD Expression
GXD Expression
 
Probe: MGI:1059981
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1689423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827606
Age: embryonic day 14.5
Image: euxassay_005228_24
Specimen Label: euxassay_005228_24
Detected: true
Specimen Num: 23
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Publication
7799964 | J:35455
First Author: Hattori M
Year: 1995
Journal: Mol Cell Biol
Title: Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression.
Volume: 15
Issue: 1
Pages: 552-60
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Publication
9603515 | J:47681
First Author: Itier JM
Year: 1998
Journal: Nature
Title: Imprinted gene in postnatal growth role.
Volume: 393
Issue: 6681
Pages: 125-6
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Publication
10491385 | J:57878
First Author: Kahana JA
Year: 1999
Journal: J Cell Biol
Title: Beyond nuclear transport. Ran-GTP as a determinant of spindle assembly.
Volume: 146
Issue: 6
Pages: 1205-10
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Publication
1317320 | J:151685
First Author: von Melchner H
Year: 1992
Journal: Genes Dev
Title: Selective disruption of genes expressed in totipotent embryonal stem cells.
Volume: 6
Issue: 6
Pages: 919-27
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Publication
8314081 | J:16895
First Author: DeGregori J
Year: 1994
Journal: Genes Dev
Title: A murine homolog of the yeast RNA1 gene is required for postimplantation development.
Volume: 8
Issue: 3
Pages: 265-76
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Publication
15923632 | J:99175
First Author: Yamaguchi T
Year: 2005
Journal: Mol Cell Biol
Title: Mutation of SENP1/SuPr-2 reveals an essential role for desumoylation in mouse development.
Volume: 25
Issue: 12
Pages: 5171-82
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Publication
25299344 | J:228859
First Author: Fu J
Year: 2014
Journal: PLoS Genet
Title: Disruption of SUMO-specific protease 2 induces mitochondria mediated neurodegeneration.
Volume: 10
Issue: 10
Pages: e1004579
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Publication
15569683 | J:96947
First Author: Takahashi H
Year: 2005
Journal: J Biol Chem
Title: Noncovalent SUMO-1 binding activity of thymine DNA glycosylase (TDG) is required for its SUMO-1 modification and colocalization with the promyelocytic leukemia protein.
Volume: 280
Issue: 7
Pages: 5611-21
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Protein
P46061
Organism: Mus musculus/domesticus
Length: 589  
Fragment?: false
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Publication
22155005 | J:183651
First Author: Kim EY
Year: 2012
Journal: J Mol Cell Cardiol
Title: Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction.
Volume: 52
Issue: 3
Pages: 638-49
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Publication
27717094 | J:315590
First Author: Fujiwara K
Year: 2016
Journal: Genes Cells
Title: Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system.
Volume: 21
Issue: 11
Pages: 1176-1194
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Publication
10591541 | J:68421
First Author: Jones BC
Year: 1999
Journal: Pharmacogenetics
Title: Quantitative-trait loci analysis of cocaine-related behaviours and neurochemistry.
Volume: 9
Issue: 5
Pages: 607-17
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Publication
18974875 | J:147414
First Author: Landry J
Year: 2008
Journal: PLoS Genet
Title: Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells.
Volume: 4
Issue: 10
Pages: e1000241
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Publication
15033168 | J:107647
First Author: Thuret S
Year: 2004
Journal: Mol Cell Neurosci
Title: Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta.
Volume: 25
Issue: 3
Pages: 394-405
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Publication
9811942 | J:50869
First Author: Ko MS
Year: 1998
Journal: Hum Mol Genet
Title: Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome.
Volume: 7
Issue: 12
Pages: 1967-78
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
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Publication
- | J:148605
     
First Author: Wellcome Trust Sanger Institute
Year: 2009
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
9019411 | J:38226
First Author: Mahajan R
Year: 1997
Journal: Cell
Title: A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2.
Volume: 88
Issue: 1
Pages: 97-107
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Publication
19011093 | -
First Author: Xu XM
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: RanGAP1 is a continuous marker of the Arabidopsis cell division plane.
Volume: 105
Issue: 47
Pages: 18637-42
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Publication
9427648 | -
First Author: Saitoh H
Year: 1998
Journal: Curr Biol
Title: Ubc9p and the conjugation of SUMO-1 to RanGAP1 and RanBP2.
Volume: 8
Issue: 2
Pages: 121-4
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Publication
9442102 | -
First Author: Mahajan R
Year: 1998
Journal: J Cell Biol
Title: Molecular characterization of the SUMO-1 modification of RanGAP1 and its role in nuclear envelope association.
Volume: 140
Issue: 2
Pages: 259-70
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Publication
26506250 | -
First Author: Cha K
Year: 2015
Journal: PLoS One
Title: The Cellular Distribution of RanGAP1 Is Regulated by CRM1-Mediated Nuclear Export in Mammalian Cells.
Volume: 10
Issue: 10
Pages: e0141309
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Publication
16469311 | -
First Author: Zhu S
Year: 2006
Journal: Exp Cell Res
Title: SUMO modification through rapamycin-mediated heterodimerization reveals a dual role for Ubc9 in targeting RanGAP1 to nuclear pore complexes.
Volume: 312
Issue: 7
Pages: 1042-9
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Protein Domain
IPR009109 | Ran_GTPase_activating_1_C
Type: Domain
Description: Ran GTPase is a ubiquitous protein required for nuclear transport, spindle assembly, nuclear assembly and mitotic cell cycle regulation. RanGTPase activating protein 1 (RanGAP1) is one of several RanGTPase accessory proteins. During interphase, RanGAP1 is located in the cytoplasm, while during mitosis it becomes associated with the kinetochores []. Cytoplasmic RanGAP1 is required for RanGTPase-directed nuclear transport. The activity of RanGAP1 requires the accessory protein RanBP1. RanBP1 facilitates RanGAP1 hydrolysis of Ran-GTP, both directly and by promoting the dissociation of Ran-GTP from transport receptors, which would otherwise block RanGAP1-mediated hydrolysis. RanGAP1 is thought to bind to the Switch 1 and Switch 2 regions of RanGTPase. The Switch 2 region can be buried in complexes with karyopherin-beta2, and requires the interaction with RanBP1 to permit RanGAP1 function. RanGAP1 can undergo SUMO (small ubiquitin-like modifier) modification, which targets RanGAP1 to RanBP2/Nup358 in the nuclear pore complex, and is required for association with the nuclear pore complex and for nuclear transport []. The enzymes involved in SUMO modification are located on the filaments of the nuclear pore complex.The RanGAP1 N-terminal domain is fairly well conserved between vertebrate and fungal proteins, but yeast does not contain the C-terminal domain. The C-terminal domain is SUMO-modified and required for the localisation of RanGAP1 at the nuclear pore complex. The structure of the C-terminal domain is multihelical, consisting of two curved alpha/alpha layers in a right-handed superhelix.
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Protein Domain
IPR036720 | RanGAP1_C_sf
Type: Homologous_superfamily
Description: Ran GTPase is a ubiquitous protein required for nuclear transport, spindle assembly, nuclear assembly and mitotic cell cycle regulation. RanGTPase activating protein 1 (RanGAP1) is one of several RanGTPase accessory proteins. During interphase, RanGAP1 is located in the cytoplasm, while during mitosis it becomes associated with the kinetochores []. Cytoplasmic RanGAP1 is required for RanGTPase-directed nuclear transport. The activity of RanGAP1 requires the accessory protein RanBP1. RanBP1 facilitates RanGAP1 hydrolysis of Ran-GTP, both directly and by promoting the dissociation of Ran-GTP from transport receptors, which would otherwise block RanGAP1-mediated hydrolysis. RanGAP1 is thought to bind to the Switch 1 and Switch 2 regions of RanGTPase. The Switch 2 region can be buried in complexes with karyopherin-beta2, and requires the interaction with RanBP1 to permit RanGAP1 function. RanGAP1 can undergo SUMO (small ubiquitin-like modifier) modification, which targets RanGAP1 to RanBP2/Nup358 in the nuclear pore complex, and is required for association with the nuclear pore complex and for nuclear transport []. The enzymes involved in SUMO modification are located on the filaments of the nuclear pore complex.The RanGAP1 N-terminal domain is fairly well conserved between vertebrate and fungal proteins, but yeast does not contain the C-terminal domain. The C-terminal domain is SUMO-modified and required for the localisation of RanGAP1 at the nuclear pore complex. The structure of the C-terminal domain is multihelical, consisting of two curved alpha/alpha layers in a right-handed superhelix.
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Publication
11853669 | -
First Author: Bernier-Villamor V
Year: 2002
Journal: Cell
Title: Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1.
Volume: 108
Issue: 3
Pages: 345-56
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Protein
Q9CW20
Organism: Mus musculus/domesticus
Length: 58  
Fragment?: true
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Publication
12852855 | -
First Author: Arnaoutov A
Year: 2003
Journal: Dev Cell
Title: The Ran GTPase regulates kinetochore function.
Volume: 5
Issue: 1
Pages: 99-111
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Publication
12061901 | -
First Author: Pay A
Year: 2002
Journal: Plant J
Title: Plant RanGAPs are localized at the nuclear envelope in interphase and associated with microtubules in mitotic cells.
Volume: 30
Issue: 6
Pages: 699-709
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Protein Domain
IPR045203 | RanGAP1/2
Type: Family
Description: This entry includes RanGAP1/2 mostly from plants. They are GTPase activators for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state []. RanGAP1 may have a role in spatial signaling during plant cell division [].
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Protein
A0A2R8W753
Organism: Mus musculus/domesticus
Length: 144  
Fragment?: true
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Protein
Q3UZD8
Organism: Mus musculus/domesticus
Length: 396  
Fragment?: false
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Protein
Q3ULJ9
Organism: Mus musculus/domesticus
Length: 483  
Fragment?: false
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Protein
Q6ZPH4
Organism: Mus musculus/domesticus
Length: 646  
Fragment?: true
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Protein
Q8C2E3
Organism: Mus musculus/domesticus
Length: 589  
Fragment?: false
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Protein Domain
IPR022011 | IR1-M
Type: Domain
Description: This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The family is found in association with , , . There are two conserved sequence motifs: TFFC and EDF. Nup358/RanBP2 is a nucleoporin involved in ubiquitination of many different protein targets from various cellular pathways. It complexes with Ubc9, SUMO-1 and RanGAP1 to perform this function. This is the ligase domain which binds to Ubc9.
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Protein
A0A2R8VHK9
Organism: Mus musculus/domesticus
Length: 257  
Fragment?: true
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Publication
16326389 | J:104945
First Author: Nacerddine K
Year: 2005
Journal: Dev Cell
Title: The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice.
Volume: 9
Issue: 6
Pages: 769-79
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Publication
28384474 | J:256089
First Author: Gasset-Rosa F
Year: 2017
Journal: Neuron
Title: Polyglutamine-Expanded Huntingtin Exacerbates Age-Related Disruption of Nuclear Integrity and Nucleocytoplasmic Transport.
Volume: 94
Issue: 1
Pages: 48-57.e4
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Publication
29725819 | J:320844
First Author: Bennett CL
Year: 2018
Journal: Acta Neuropathol
Title: Senataxin mutations elicit motor neuron degeneration phenotypes and yield TDP-43 mislocalization in ALS4 mice and human patients.
Volume: 136
Issue: 3
Pages: 425-443
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Publication
28344074 | J:244047
 
First Author: Shang J
Year: 2017
Journal: Neuroscience
Title: Aberrant distributions of nuclear pore complex proteins in ALS mice and ALS patients.
Volume: 350
Pages: 158-168
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Publication
18573887 | J:139742
First Author: Zhang FP
Year: 2008
Journal: Mol Cell Biol
Title: Sumo-1 function is dispensable in normal mouse development.
Volume: 28
Issue: 17
Pages: 5381-90
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Publication
7882974 | J:23614
First Author: Bischoff FR
Year: 1995
Journal: EMBO J
Title: Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1.
Volume: 14
Issue: 4
Pages: 705-15
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Publication
34636652 | J:320912
First Author: Sáinz-Jaspeado M
Year: 2021
Journal: Circulation
Title: Palmdelphin Regulates Nuclear Resilience to Mechanical Stress in the Endothelium.
Volume: 144
Issue: 20
Pages: 1629-1645
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Protein
Q9ERU9
Organism: Mus musculus/domesticus
Length: 3053  
Fragment?: false
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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