Proteins in this entry are probable cytosolic iron-sulfur (FeS) protein assembly proteins from eucaryotes, including Cia1 from Saccharomyces cerevisiae and CIAO1 from humans. Iron-sulfur [Fe-S]clusters are ubiquitous and evolutionary ancient prosthetic groups that are required to sustain fundamental life processes []. They can be used as part of catalytic centres for chemicalsensing, stabilise protein structure and determine protein function []. In Saccharomyces cerevisiae, Cia1 is a component of cytosolic iron-sulfur cluster assembly (CIA) system (consists of Nar1, Nbp35 and Cia1). It is involved in a late step of Fe/S cluster incorporation into target proteins []. In humans, it is also a component of the human CIA system. Moreover, it binds to IOP1 and forms the MMXD complex (MMS19, XPD, MIP18 and ANT2), which is involved in chromosome segregation [, ].
