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Search results 1101 to 1200 out of 1214 for Vwf

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0.035s

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Hits by Pathway

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Hits by Category

Type Details Score
Protein
A0A0N4SVZ4
Organism: Mus musculus/domesticus
Length: 1773  
Fragment?: false
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Publication
15016353 | -
First Author: Bhattacharya AA
Year: 2004
Journal: Structure
Title: Crystal structure of the A domain from complement factor B reveals an integrin-like open conformation.
Volume: 12
Issue: 3
Pages: 371-8
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Publication
10637221 | -
First Author: Jing H
Year: 2000
Journal: EMBO J
Title: New structural motifs on the chymotrypsin fold and their potential roles in complement factor B.
Volume: 19
Issue: 2
Pages: 164-73
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Protein Domain
IPR011360 | Compl_C2_B
Type: Family
Description: These proteins belong to MEROPS peptidase family S1 (chymotrypsin family, clan PA(S)), subfamily S1A.This family contains two mammalian proteins, complement C2 and complement factor B, which, respectively, have analogous roles in the classical and alternative pathways of complement activation. These proteins are composed of three regions, an N-terminal three-module complement control protein domain, a von Willebrand factor A domain, and a C-terminal serine protease domain. Briefly, they are activated by cleavage and function as the serine protease components of the C3/C5 convertases, which play similar roles in these pathways although composed of different proteins. Homologs in non-mammalian species are often more or less equally related to mammalian C2 and B and may be designated as complement B/C2. Strongylocentrotus purpuratus (Purple sea urchin) has an atypical factor B with a five-module complement control protein domain.The structures of the von Willebrand factor A and serine protease domains from human complement factor B () have been analysed [, ]. The A domain forms the classical vWF A domain fold, which consists of a central β-sheet flanked on both sides by amphipathic alpha helices. It contains an integrin-like MIDAS (metal ion-dependent adhesion site) motif that adopts the open conformation typical of integrin-ligand complexes, with an acidic residue from another A domain (provided by a fortuitous crystal contact) completing the coordination of the metal ion. Although a closed conformation was not observed, modelling studies suggest that the A domain could adopt this conformation, implying that as with integrins, ligand-binding may induce conformational changes which transduce a signal to other domains in the protein []. The serine protease domain forms a chymotrypsin fold with several novel features []. Like other serine proteases it forms two β-sheets, composed of six β-strands each, surrounded by surface helices and loops. However, several novel deletions and insertions occur within these surface helices and loops, and differences in active site conformation also exist.
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Protein
Q5FW85
Organism: Mus musculus/domesticus
Length: 670  
Fragment?: false
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Protein
Q8CG66
Organism: Mus musculus/domesticus
Length: 446  
Fragment?: true
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Protein
Q3UZE8
Organism: Mus musculus/domesticus
Length: 400  
Fragment?: true
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Protein
Q9JLL0
Organism: Mus musculus/domesticus
Length: 1037  
Fragment?: false
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Protein
Q80T14
Organism: Mus musculus/domesticus
Length: 4010  
Fragment?: false
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Protein
Q3U515
Organism: Mus musculus/domesticus
Length: 929  
Fragment?: false
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Protein
Q80V54
Organism: Mus musculus/domesticus
Length: 608  
Fragment?: false
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Protein
Q3TS72
Organism: Mus musculus/domesticus
Length: 473  
Fragment?: true
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Protein
D3YWD8
Organism: Mus musculus/domesticus
Length: 763  
Fragment?: false
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Protein
P21180
Organism: Mus musculus/domesticus
Length: 760  
Fragment?: false
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Protein
P04186
Organism: Mus musculus/domesticus
Length: 761  
Fragment?: false
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Protein
P23475
Organism: Mus musculus/domesticus
Length: 608  
Fragment?: false
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Protein
F6VQX8
Organism: Mus musculus/domesticus
Length: 971  
Fragment?: true
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Protein
Q3U9W1
Organism: Mus musculus/domesticus
Length: 436  
Fragment?: true
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Protein
Q6NXL1
Organism: Mus musculus/domesticus
Length: 1032  
Fragment?: false
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Protein
Q3U925
Organism: Mus musculus/domesticus
Length: 400  
Fragment?: false
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Protein
F6VJC5
Organism: Mus musculus/domesticus
Length: 765  
Fragment?: true
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Protein
Q792Q3
Organism: Mus musculus/domesticus
Length: 470  
Fragment?: true
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Protein
F6WZA2
Organism: Mus musculus/domesticus
Length: 81  
Fragment?: true
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Protein
Q3U882
Organism: Mus musculus/domesticus
Length: 716  
Fragment?: true
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Protein
B8JJM9
Organism: Mus musculus/domesticus
Length: 483  
Fragment?: false
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Protein
B8JJN0
Organism: Mus musculus/domesticus
Length: 1276  
Fragment?: false
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Protein
B8JJN2
Organism: Mus musculus/domesticus
Length: 623  
Fragment?: false
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Protein
Q3UEG8
Organism: Mus musculus/domesticus
Length: 761  
Fragment?: false
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Protein
Q8CDS4
Organism: Mus musculus/domesticus
Length: 615  
Fragment?: false
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Protein
M0QWA7
Organism: Mus musculus/domesticus
Length: 480  
Fragment?: false
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Protein
B8JJM5
Organism: Mus musculus/domesticus
Length: 763  
Fragment?: false
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Protein
D3YYP8
Organism: Mus musculus/domesticus
Length: 130  
Fragment?: true
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Protein
A0A0R4J187
Organism: Mus musculus/domesticus
Length: 608  
Fragment?: false
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Protein
O70309
Organism: Mus musculus/domesticus
Length: 798  
Fragment?: false
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Protein
A2AVA0
Organism: Mus musculus/domesticus
Length: 3567  
Fragment?: false
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Protein
Q6PE70
Organism: Mus musculus/domesticus
Length: 799  
Fragment?: false
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Protein
Q8CG65
Organism: Mus musculus/domesticus
Length: 4998  
Fragment?: false
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Protein
E9Q0I4
Organism: Mus musculus/domesticus
Length: 5144  
Fragment?: false
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Protein
A0A1D5RLZ9
Organism: Mus musculus/domesticus
Length: 5135  
Fragment?: false
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Protein
Q61220
Organism: Mus musculus/domesticus
Length: 819  
Fragment?: false
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Protein
Q9QYE5
Organism: Mus musculus/domesticus
Length: 1247  
Fragment?: false
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Protein
Q2VWQ2
Organism: Mus musculus/domesticus
Length: 810  
Fragment?: false
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Protein
Q9QXX0
Organism: Mus musculus/domesticus
Length: 1218  
Fragment?: false
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Protein
Q8BM06
Organism: Mus musculus/domesticus
Length: 858  
Fragment?: false
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Protein
Q3UVN4
Organism: Mus musculus/domesticus
Length: 1218  
Fragment?: false
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Protein
A0A2R8VHV8
Organism: Mus musculus/domesticus
Length: 806  
Fragment?: false
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Protein
Q8BM43
Organism: Mus musculus/domesticus
Length: 784  
Fragment?: true
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Protein
Q0VBD0
Organism: Mus musculus/domesticus
Length: 767  
Fragment?: false
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Protein
O54890
Organism: Mus musculus/domesticus
Length: 787  
Fragment?: false
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Protein
P11835
Organism: Mus musculus/domesticus
Length: 771  
Fragment?: false
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Protein
Q9Z0T9
Organism: Mus musculus/domesticus
Length: 787  
Fragment?: false
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Protein
Q3UV74
Organism: Mus musculus/domesticus
Length: 738  
Fragment?: false
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Protein
P26011
Organism: Mus musculus/domesticus
Length: 806  
Fragment?: false
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Protein
Q9D662
Organism: Mus musculus/domesticus
Length: 767  
Fragment?: false
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Protein
Q01405
Organism: Mus musculus/domesticus
Length: 765  
Fragment?: false
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Protein
Q3U2P1
Organism: Mus musculus/domesticus
Length: 1090  
Fragment?: false
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Protein
A0A2I3BRN3
Organism: Mus musculus/domesticus
Length: 1449  
Fragment?: false
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Protein
E9Q1S3
Organism: Mus musculus/domesticus
Length: 736  
Fragment?: false
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Protein
B1AYG7
Organism: Mus musculus/domesticus
Length: 755  
Fragment?: true
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Protein
A0A338P795
Organism: Mus musculus/domesticus
Length: 486  
Fragment?: false
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Protein
A2AA71
Organism: Mus musculus/domesticus
Length: 1089  
Fragment?: false
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Protein
Q3TAW4
Organism: Mus musculus/domesticus
Length: 767  
Fragment?: false
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Protein
Q3UDH4
Organism: Mus musculus/domesticus
Length: 1023  
Fragment?: true
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Protein
Q3TIS3
Organism: Mus musculus/domesticus
Length: 767  
Fragment?: false
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Protein
G3X972
Organism: Mus musculus/domesticus
Length: 1096  
Fragment?: false
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Protein
D3YXH8
Organism: Mus musculus/domesticus
Length: 795  
Fragment?: false
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Protein
Q8CGF4
Organism: Mus musculus/domesticus
Length: 1096  
Fragment?: false
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Protein
A0A286YDI8
Organism: Mus musculus/domesticus
Length: 1020  
Fragment?: false
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Protein
A0A0F7DDK0
Organism: Mus musculus/domesticus
Length: 787  
Fragment?: false
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Protein
Q3UKB4
Organism: Mus musculus/domesticus
Length: 767  
Fragment?: false
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Protein
Q3V222
Organism: Mus musculus/domesticus
Length: 803  
Fragment?: true
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Protein
Q3TYS4
Organism: Mus musculus/domesticus
Length: 767  
Fragment?: false
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Protein
Q80U83
Organism: Mus musculus/domesticus
Length: 1028  
Fragment?: true
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Protein
Q8C1E4
Organism: Mus musculus/domesticus
Length: 765  
Fragment?: false
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Protein
B1AYG6
Organism: Mus musculus/domesticus
Length: 764  
Fragment?: false
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Protein
Q80ZX0
Organism: Mus musculus/domesticus
Length: 1251  
Fragment?: false
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Protein
Q542I8
Organism: Mus musculus/domesticus
Length: 770  
Fragment?: false
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Protein
P29268
Organism: Mus musculus/domesticus
Length: 348  
Fragment?: false
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Protein
Q9Z0G4
Organism: Mus musculus/domesticus
Length: 251  
Fragment?: false
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Protein
Q64299
Organism: Mus musculus/domesticus
Length: 354  
Fragment?: false
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Protein
P98154
Organism: Mus musculus/domesticus
Length: 548  
Fragment?: false
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Protein
O54775
Organism: Mus musculus/domesticus
Length: 367  
Fragment?: false
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Protein
P18406
Organism: Mus musculus/domesticus
Length: 379  
Fragment?: false
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Protein
P35441
Organism: Mus musculus/domesticus
Length: 1170  
Fragment?: false
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Protein
Q03350
Organism: Mus musculus/domesticus
Length: 1172  
Fragment?: false
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Protein
Q6P5A9
Organism: Mus musculus/domesticus
Length: 549  
Fragment?: false
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Protein
Q80YQ1
Organism: Mus musculus/domesticus
Length: 1171  
Fragment?: false
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Protein
Q8CGB2
Organism: Mus musculus/domesticus
Length: 1171  
Fragment?: false
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Protein
A0A0R4J1M6
Organism: Mus musculus/domesticus
Length: 546  
Fragment?: false
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Protein
Q6ZQH9
Organism: Mus musculus/domesticus
Length: 466  
Fragment?: true
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Protein
A2AHD1
Organism: Mus musculus/domesticus
Length: 251  
Fragment?: false
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Protein
Q3TQ62
Organism: Mus musculus/domesticus
Length: 546  
Fragment?: false
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Protein
E9Q548
Organism: Mus musculus/domesticus
Length: 580  
Fragment?: false
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Protein
Q3TR40
Organism: Mus musculus/domesticus
Length: 1170  
Fragment?: false
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Protein
Q3U2X7
Organism: Mus musculus/domesticus
Length: 354  
Fragment?: false
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Protein
Q7TMT3
Organism: Mus musculus/domesticus
Length: 1172  
Fragment?: false
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Protein
E9QNU3
Organism: Mus musculus/domesticus
Length: 548  
Fragment?: false
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Protein
Q8CB23
Organism: Mus musculus/domesticus
Length: 580  
Fragment?: false
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Protein
Q3UFJ5
Organism: Mus musculus/domesticus
Length: 367  
Fragment?: false
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Protein
H3BJW0
Organism: Mus musculus/domesticus
Length: 293  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom