Glucocorticoid modulatory element-binding (GMEB) proteins 1 and 2 are homologous sequences that form a heteromeric complex that binds to glucocorticoid modulatory elements and increases sensitivity to low concentrations of glucocorticoids [, ]. The GMEB1/2 complex is also an essential auxiliary factor for the replication of parvoviruses, critically regulating the viral nickase during infection []. GMEB1 has been shown to inhibit caspase, preventing hypoxia- and oxidative stress-induced neuronal apoptosis []. This entry also includes Transcription regulator spe-44 from Caenorhabditis elegans, a transcription factor that controls spermatogenesis and sperm cell fate by regulation of sperm gene expression, highly similar to the mammalian GMEB1/2 [].
