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Search results 501 to 600 out of 606 for Tfeb

0.053s
Type Details Score
Publication      
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
Publication      
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
Publication
First Author: Contreras PS
Year: 2020
Journal: iScience
Title: c-Abl Inhibition Activates TFEB and Promotes Cellular Clearance in a Lysosomal Disorder.
Volume: 23
Issue: 11
Pages: 101691
Publication
First Author: Magini A
Year: 2017
Journal: Hum Mol Genet
Title: TFEB activation restores migration ability to Tsc1-deficient adult neural stem/progenitor cells.
Volume: 26
Issue: 17
Pages: 3303-3312
Publication
First Author: Zhang J
Year: 2019
Journal: Autophagy
Title: Cross-regulation of defective endolysosome trafficking and enhanced autophagy through TFEB in UNC13D deficiency.
Volume: 15
Issue: 10
Pages: 1738-1756
Publication
First Author: Arhzaouy K
Year: 2019
Journal: Autophagy
Title: VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle.
Volume: 15
Issue: 6
Pages: 1082-1099
Publication  
First Author: Palmieri M
Year: 2017
Journal: Nat Commun
Title: mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases.
Volume: 8
Pages: 14338
Publication
First Author: Trivedi PC
Year: 2016
Journal: Biochim Biophys Acta
Title: Glucolipotoxicity diminishes cardiomyocyte TFEB and inhibits lysosomal autophagy during obesity and diabetes.
Volume: 1861
Issue: 12 Pt A
Pages: 1893-1910
Publication
First Author: Matthews I
Year: 2023
Journal: Cell Rep
Title: Skeletal muscle TFEB signaling promotes central nervous system function and reduces neuroinflammation during aging and neurodegenerative disease.
Volume: 42
Issue: 11
Pages: 113436
Publication
First Author: El-Houjeiri L
Year: 2019
Journal: Cell Rep
Title: The Transcription Factors TFEB and TFE3 Link the FLCN-AMPK Signaling Axis to Innate Immune Response and Pathogen Resistance.
Volume: 26
Issue: 13
Pages: 3613-3628.e6
Publication
First Author: Xia Q
Year: 2016
Journal: EMBO J
Title: TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion.
Volume: 35
Issue: 2
Pages: 121-42
Publication
First Author: Comerota MM
Year: 2023
Journal: Mol Neurodegener
Title: Oleoylethanolamide facilitates PPARα and TFEB signaling and attenuates Aβ pathology in a mouse model of Alzheimer's disease.
Volume: 18
Issue: 1
Pages: 56
Publication  
First Author: Wang H
Year: 2016
Journal: eNeuro
Title: TFEB Overexpression in the P301S Model of Tauopathy Mitigates Increased PHF1 Levels and Lipofuscin Puncta and Rescues Memory Deficits.
Volume: 3
Issue: 2
Publication
First Author: Nabar NR
Year: 2022
Journal: Autophagy
Title: LRRK2 is required for CD38-mediated NAADP-Ca2+ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells.
Volume: 18
Issue: 1
Pages: 204-222
Allele
Name: transcription factor EB; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Allele
Name: transcription factor EB; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
DO Term
Publication
First Author: Zhao GQ
Year: 1993
Journal: Mol Cell Biol
Title: TFEC, a basic helix-loop-helix protein, forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation.
Volume: 13
Issue: 8
Pages: 4505-12
Protein
Organism: Mus musculus/domesticus
Length: 32  
Fragment?: true
Protein Domain
Type: Domain
Description: This entry represents a domain found at the N terminus of the MiT/TFE family members, which include MITF (microphthalmia-associated transcription factor) and its related family members TFE3, TFEB and TFEC []. They are basic helix-loop-helix leucine zipper transcription factors found in chordata. These transcription factors heterodimerize with each other and bind to the E-box core sequence (3'-CANNTG-5') [, ].
Protein Domain
Type: Domain
Description: This entry represents a domain found at the C terminus of the MiT/TFE family members, which include MITF (microphthalmia-associated transcription factor) and its related family members TFE3, TFEB and TFEC []. They are basic helix-loop-helix leucine zipper transcription factors found in chordata. These transcription factors heterodimerize with each other and bind to the E-box core sequence (3'-CANNTG-5') [, ].
Protein
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: true
Publication
First Author: Nezich CL
Year: 2015
Journal: J Cell Biol
Title: MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5.
Volume: 210
Issue: 3
Pages: 435-50
Protein Domain
Type: Family
Description: The MiT/TFE family of basic helix-loop-helix leucine zipper transcription factors includes MITF (microphthalmia-associated transcription factor) and related family members TFE3, TFEB and TFEC []. The transcription factors heterodimerize with each other and recognise the same DNA sequences []. They recognise and bind E-box sequences (3'-CANNTG-5').This entry represents the transcription factor E3 (TFE3). In association with TFEB, TFE3 activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. It also has also a role in osteoclast development []. TFE3 specifically recognises the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer []. For efficient DNA-binding, TFE3 requires dimerisation with itself or with another MiT/TFE family member, such as TFEB or MITF.
Protein
Organism: Mus musculus/domesticus
Length: 145  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: true
Publication
First Author: Mansky KC
Year: 2002
Journal: J Leukoc Biol
Title: The microphthalmia transcription factor and the related helix-loop-helix zipper factors TFE-3 and TFE-C collaborate to activate the tartrate-resistant acid phosphatase promoter.
Volume: 71
Issue: 2
Pages: 304-10
Protein
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 127  
Fragment?: false
Protein Domain
Type: Family
Description: The MiT/TFE family of basic helix-loop-helix leucine zipper transcription factors includes MITF (microphthalmia-associated transcription factor) and related family members TFE3, TFEB and TFEC []. The transcription factors heterodimerize with each other and recognise the same DNA sequences []. They recognise and bind E-box sequences (3'-CANNTG-5').This entry represents transcription factor EC (TFEC). TFEC can act as a repressor or an activator. It acts as a transcriptional repressor on minimal promoter containing muE3 enhancer sequence []and as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter []. It binds DNA in a homo or heterodimeric form with MITF and TFE3.
Protein
Organism: Mus musculus/domesticus
Length: 93  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 105  
Fragment?: false
Publication
First Author: Kobayashi T
Year: 2017
Journal: Int Immunol
Title: Lysosome biogenesis regulated by the amino-acid transporter SLC15A4 is critical for functional integrity of mast cells.
Volume: 29
Issue: 12
Pages: 551-566
Publication  
First Author: Sergin I
Year: 2017
Journal: Nat Commun
Title: Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis.
Volume: 8
Pages: 15750
Publication
First Author: Asrani K
Year: 2022
Journal: Nat Commun
Title: An mTORC1-mediated negative feedback loop constrains amino acid-induced FLCN-Rag activation in renal cells with TSC2 loss.
Volume: 13
Issue: 1
Pages: 6808
Publication
First Author: Martínez-Fábregas J
Year: 2018
Journal: Nat Commun
Title: Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis.
Volume: 9
Issue: 1
Pages: 5343
Publication    
First Author: Calcagnì A
Year: 2016
Journal: Elife
Title: Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling.
Volume: 5
Publication
First Author: Dutta D
Year: 2022
Journal: Cell Rep
Title: Treadmill exercise reduces α-synuclein spreading via PPARα.
Volume: 40
Issue: 2
Pages: 111058
Publication
First Author: Li Y
Year: 2016
Journal: Nat Cell Biol
Title: Protein kinase C controls lysosome biogenesis independently of mTORC1.
Volume: 18
Issue: 10
Pages: 1065-77
Publication  
First Author: Wang S
Year: 2022
Journal: Oxid Med Cell Longev
Title: Activation of Transcription Factor EB Alleviates Tubular Epithelial Cell Injury via Restoring Lysosomal Homeostasis in Diabetic Nephropathy.
Volume: 2022
Pages: 2812493
Publication
First Author: Goodwin JM
Year: 2021
Journal: Sci Adv
Title: GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis.
Volume: 7
Issue: 40
Pages: eabj2485
Publication
First Author: Hasan M
Year: 2013
Journal: Nat Immunol
Title: Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes.
Volume: 14
Issue: 1
Pages: 61-71
Publication
First Author: Chauhan S
Year: 2013
Journal: Mol Cell
Title: ZKSCAN3 is a master transcriptional repressor of autophagy.
Volume: 50
Issue: 1
Pages: 16-28
Publication  
First Author: Zhang X
Year: 2016
Journal: Nat Commun
Title: MCOLN1 is a ROS sensor in lysosomes that regulates autophagy.
Volume: 7
Pages: 12109
Publication
First Author: Petri R
Year: 2017
Journal: EMBO J
Title: let-7 regulates radial migration of new-born neurons through positive regulation of autophagy.
Volume: 36
Issue: 10
Pages: 1379-1391
Publication  
First Author: Choy CH
Year: 2018
Journal: J Cell Sci
Title: Lysosome enlargement during inhibition of the lipid kinase PIKfyve proceeds through lysosome coalescence.
Volume: 131
Issue: 10
Publication
First Author: López-Hernández T
Year: 2020
Journal: Nat Cell Biol
Title: Endocytic regulation of cellular ion homeostasis controls lysosome biogenesis.
Volume: 22
Issue: 7
Pages: 815-827
Publication  
First Author: Zhu P
Year: 2022
Journal: Front Cardiovasc Med
Title: Receptor-Interacting Protein Kinase 3 Suppresses Mitophagy Activation via the Yes-Associated Protein/Transcription Factor EB Pathways in Septic Cardiomyopathy.
Volume: 9
Pages: 856041
Publication
First Author: Malik N
Year: 2023
Journal: Science
Title: Induction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1.
Volume: 380
Issue: 6642
Pages: eabj5559
Protein
Organism: Mus musculus/domesticus
Length: 572  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 572  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 539  
Fragment?: true
Protein
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: false
Publication
First Author: Zhang J
Year: 2017
Journal: J Biol Chem
Title: Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A.
Volume: 292
Issue: 25
Pages: 10328-10346
Publication  
First Author: Min SH
Year: 2019
Journal: Mol Cell Biol
Title: PIKfyve Deficiency in Myeloid Cells Impairs Lysosomal Homeostasis in Macrophages and Promotes Systemic Inflammation in Mice.
Volume: 39
Issue: 21
Publication
First Author: Hashimoto Y
Year: 2018
Journal: Genes Cells
Title: TMEM55B contributes to lysosomal homeostasis and amino acid-induced mTORC1 activation.
Volume: 23
Issue: 6
Pages: 418-434
Publication
First Author: Gatto F
Year: 2017
Journal: Sci Rep
Title: AAV-mediated transcription factor EB (TFEB) gene delivery ameliorates muscle pathology and function in the murine model of Pompe Disease.
Volume: 7
Issue: 1
Pages: 15089
Publication
First Author: Baron O
Year: 2017
Journal: Curr Biol
Title: Stall in Canonical Autophagy-Lysosome Pathways Prompts Nucleophagy-Based Nuclear Breakdown in Neurodegeneration.
Volume: 27
Issue: 23
Pages: 3626-3642.e6
Publication
First Author: Biswas VK
Year: 2023
Journal: PLoS Biol
Title: NCoR1 controls Mycobacterium tuberculosis growth in myeloid cells by regulating the AMPK-mTOR-TFEB axis.
Volume: 21
Issue: 8
Pages: e3002231
Publication  
First Author: Song HL
Year: 2019
Journal: Mol Cell Neurosci
Title: Ouabain activates transcription factor EB and exerts neuroprotection in models of Alzheimer's disease.
Volume: 95
Pages: 13-24
Publication
First Author: Wu M
Year: 2017
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Immunomodulators targeting MARCO expression improve resistance to postinfluenza bacterial pneumonia.
Volume: 313
Issue: 1
Pages: L138-L153
Publication  
First Author: Doccini S
Year: 2022
Journal: Cells
Title: Lysosomal Proteomics Links Disturbances in Lipid Homeostasis and Sphingolipid Metabolism to CLN5 Disease.
Volume: 11
Issue: 11
Publication
First Author: McKee CA
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Circadian clock protein BMAL1 broadly influences autophagy and endolysosomal function in astrocytes.
Volume: 120
Issue: 20
Pages: e2220551120
Publication
First Author: Kim S
Year: 2023
Journal: Sci Rep
Title: Disruptive lysosomal-metabolic signaling and neurodevelopmental deficits that precede Purkinje cell loss in a mouse model of Niemann-Pick Type-C disease.
Volume: 13
Issue: 1
Pages: 5665
Publication
First Author: Lin W
Year: 2023
Journal: J Neuroinflammation
Title: TNEA therapy promotes the autophagic degradation of NLRP3 inflammasome in a transgenic mouse model of Alzheimer's disease via TFEB/TFE3 activation.
Volume: 20
Issue: 1
Pages: 21
Publication  
First Author: Chandra S
Year: 2019
Journal: Neurobiol Dis
Title: Cinnamic acid activates PPARα to stimulate Lysosomal biogenesis and lower Amyloid plaque pathology in an Alzheimer's disease mouse model.
Volume: 124
Pages: 379-395
Publication
First Author: Chandra S
Year: 2018
Journal: J Neurosci
Title: Aspirin Induces Lysosomal Biogenesis and Attenuates Amyloid Plaque Pathology in a Mouse Model of Alzheimer's Disease via PPARα.
Volume: 38
Issue: 30
Pages: 6682-6699
Publication      
First Author: Li L
Year: 2024
Journal: Nat Struct Mol Biol
Title: Lineage regulators TFAP2C and NR5A2 function as bipotency activators in totipotent embryos.
Publication
First Author: Kim SH
Year: 2017
Journal: Autophagy
Title: Ezetimibe ameliorates steatohepatitis via AMP activated protein kinase-TFEB-mediated activation of autophagy and NLRP3 inflammasome inhibition.
Volume: 13
Issue: 10
Pages: 1767-1781
Publication
First Author: MacLeod CM
Year: 2023
Journal: PLoS One
Title: Trehalose enhances mitochondria deficits in human NPC1 mutant fibroblasts but disrupts mouse Purkinje cell dendritic growth ex vivo.
Volume: 18
Issue: 11
Pages: e0294312
Publication
First Author: Chua JP
Year: 2014
Journal: Hum Mol Genet
Title: Transcriptional activation of TFEB/ZKSCAN3 target genes underlies enhanced autophagy in spinobulbar muscular atrophy.
Volume: 23
Issue: 5
Pages: 1376-86
Publication
First Author: Sun J
Year: 2022
Journal: Aging Cell
Title: Growth differentiation factor 11 accelerates liver senescence through the inhibition of autophagy.
Volume: 21
Issue: 1
Pages: e13532
Publication
First Author: Lotfi P
Year: 2018
Journal: Autophagy
Title: Trehalose reduces retinal degeneration, neuroinflammation and storage burden caused by a lysosomal hydrolase deficiency.
Volume: 14
Issue: 8
Pages: 1419-1434
Publication
First Author: Paquette M
Year: 2021
Journal: Sci Rep
Title: Loss of hepatic Flcn protects against fibrosis and inflammation by activating autophagy pathways.
Volume: 11
Issue: 1
Pages: 21268
Publication
First Author: Shyam R
Year: 2021
Journal: Invest Ophthalmol Vis Sci
Title: Mitochondrial ROS Induced Lysosomal Dysfunction and Autophagy Impairment in an Animal Model of Congenital Hereditary Endothelial Dystrophy.
Volume: 62
Issue: 12
Pages: 15
Publication
First Author: Ma X
Year: 2015
Journal: Mol Cell Biol
Title: Regulation of the transcription factor EB-PGC1α axis by beclin-1 controls mitochondrial quality and cardiomyocyte death under stress.
Volume: 35
Issue: 6
Pages: 956-76
Publication
First Author: Chen Z
Year: 2018
Journal: Theranostics
Title: Cardiomyocyte-Restricted Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) Deletion Leads to Lethal Dilated Cardiomyopathy Partly Through Drp1 Signaling.
Volume: 8
Issue: 3
Pages: 627-643
Publication  
First Author: Stagi M
Year: 2014
Journal: Mol Cell Neurosci
Title: Lysosome size, motility and stress response regulated by fronto-temporal dementia modifier TMEM106B.
Volume: 61
Pages: 226-40
Publication
First Author: Theeuwes WF
Year: 2020
Journal: Biochim Biophys Acta Mol Cell Res
Title: Regulation of PGC-1α expression by a GSK-3β-TFEB signaling axis in skeletal muscle.
Volume: 1867
Issue: 2
Pages: 118610
Publication
First Author: Lim SW
Year: 2019
Journal: FASEB J
Title: Effect of Klotho on autophagy clearance in tacrolimus-induced renal injury.
Volume: 33
Issue: 2
Pages: 2694-2706
Publication    
First Author: Kim S
Year: 2020
Journal: Autophagy
Title: ESRRA (estrogen related receptor alpha) is a critical regulator of intestinal homeostasis through activation of autophagic flux via gut microbiota.
Pages: 1-20
Publication
First Author: Cinque L
Year: 2020
Journal: EMBO J
Title: MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B.
Volume: 39
Issue: 17
Pages: e105696
Publication
First Author: Yan Q
Year: 2017
Journal: Mol Pharmacol
Title: Activation of AMPK/mTORC1-Mediated Autophagy by Metformin Reverses Clk1 Deficiency-Sensitized Dopaminergic Neuronal Death.
Volume: 92
Issue: 6
Pages: 640-652
Publication
First Author: Ni H
Year: 2020
Journal: Arterioscler Thromb Vasc Biol
Title: Nicotine Modulates CTSS (Cathepsin S) Synthesis and Secretion Through Regulating the Autophagy-Lysosomal Machinery in Atherosclerosis.
Volume: 40
Issue: 9
Pages: 2054-2069
Publication
First Author: Akwa Y
Year: 2023
Journal: Autophagy
Title: Stimulation of synaptic activity promotes TFEB-mediated clearance of pathological MAPT/Tau in cellular and mouse models of tauopathies.
Volume: 19
Issue: 2
Pages: 660-677
Publication
First Author: Reed CB
Year: 2020
Journal: J Neurosci
Title: Deletion of Calcineurin in Schwann Cells Does Not Affect Developmental Myelination, But Reduces Autophagy and Delays Myelin Clearance after Peripheral Nerve Injury.
Volume: 40
Issue: 32
Pages: 6165-6176
Publication
First Author: Nakashima A
Year: 2020
Journal: Autophagy
Title: Evidence for lysosomal biogenesis proteome defect and impaired autophagy in preeclampsia.
Volume: 16
Issue: 10
Pages: 1771-1785
Publication  
First Author: Tanaka Y
Year: 2013
Journal: Neuroscience
Title: Increased lysosomal biogenesis in activated microglia and exacerbated neuronal damage after traumatic brain injury in progranulin-deficient mice.
Volume: 250
Pages: 8-19
Publication
First Author: Kim HK
Year: 2021
Journal: Autophagy
Title: TMBIM6 (transmembrane BAX inhibitor motif containing 6) enhances autophagy through regulation of lysosomal calcium.
Volume: 17
Issue: 3
Pages: 761-778
Publication
First Author: Zhao X
Year: 2018
Journal: J Pathol
Title: Advanced glycation end-products suppress autophagic flux in podocytes by activating mammalian target of rapamycin and inhibiting nuclear translocation of transcription factor EB.
Volume: 245
Issue: 2
Pages: 235-248
Publication
First Author: Gu S
Year: 2020
Journal: Circ Res
Title: Downregulation of LAPTM4B Contributes to the Impairment of the Autophagic Flux via Unopposed Activation of mTORC1 Signaling During Myocardial Ischemia/Reperfusion Injury.
Volume: 127
Issue: 7
Pages: e148-e165
Publication
First Author: Wang YT
Year: 2019
Journal: Am J Physiol Cell Physiol
Title: Contribution of transcription factor EB to adipoRon-induced inhibition of arterial smooth muscle cell proliferation and migration.
Volume: 317
Issue: 5
Pages: C1034-C1047
Publication  
First Author: Albanese F
Year: 2021
Journal: Neurobiol Dis
Title: Constitutive silencing of LRRK2 kinase activity leads to early glucocerebrosidase deregulation and late impairment of autophagy in vivo.
Volume: 159
Pages: 105487
Publication
First Author: Klein M
Year: 2022
Journal: Autophagy
Title: Converging roles of PSENEN/PEN2 and CLN3 in the autophagy-lysosome system.
Volume: 18
Issue: 9
Pages: 2068-2085
Publication
First Author: Wang SM
Year: 2023
Journal: Autophagy
Title: Nucleoporin POM121 signals TFEB-mediated autophagy via activation of SIGMAR1/sigma-1 receptor chaperone by pridopidine.
Volume: 19
Issue: 1
Pages: 126-151
Publication  
First Author: Pan B
Year: 2019
Journal: Front Physiol
Title: Highly Dynamic Changes in the Activity and Regulation of Macroautophagy in Hearts Subjected to Increased Proteotoxic Stress.
Volume: 10
Pages: 758
Publication
First Author: Wang L
Year: 2022
Journal: Autophagy
Title: Torin 1 alleviates impairment of TFEB-mediated lysosomal biogenesis and autophagy in TGFBI (p.G623_H626del)-linked Thiel-Behnke corneal dystrophy.
Volume: 18
Issue: 4
Pages: 765-782
Protein
Organism: Mus musculus/domesticus
Length: 526  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 317  
Fragment?: false